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公开(公告)号：US08108043B2
公开(公告)日：2012-01-31
申请号：US12686082
申请日：2010-01-12
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/365 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： A method and an apparatus for treating cardiac arrhythmias are provided. An interval between first and second consecutive beats of a heart, having first and second chamber types, is determined. The heart is paced at a first rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is less than a predetermined amount of time or if the first and second beats are both from the second chamber type. The heart is paced at a second rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is more than the predetermined amount of time.
摘要翻译： 提供了一种治疗心律失常的方法和装置。 确定具有第一和第二室类型的心脏的第一和第二连续节拍之间的间隔。 如果第一节拍来自第一室型，并且第二节拍来自第二室型，并且间隔小于预定量的时间，或者如果第一和第二节拍都来自第一室，则心脏以第一速度进行起搏 第二室型。 如果第一搏动来自第一腔室类型，第二搏动来自第二腔室类型，并且间隔大于预定时间量，心脏以第二速度进行起搏。
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公开(公告)号：US07941213B2
公开(公告)日：2011-05-10
申请号：US12183796
申请日：2008-07-31
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/3706
摘要： An IMD can be implanted into a patient to address various conditions. The IMD case and leads can have various electrodes and other portions to measure various physiological conditions. For example, a selected current can be generated between two electrodes, either external or internal in the patient, and a voltage can be measured by one or more electrodes of the IMD. A voltage can be measured at two or more locations to determine a relative motion of different electrodes. If the electrodes are in different portions of the heart, a determination can be made of a relative motion or position of the heart or portions of the heart.
摘要翻译： 可以将IMD植入患者中以解决各种情况。 IMD外壳和引线可以具有各种电极和其他部分来测量各种生理条件。 例如，可以在患者的外部或内部的两个电极之间产生所选择的电流，并且可以通过IMD的一个或多个电极来测量电压。 可以在两个或更多个位置处测量电压以确定不同电极的相对运动。 如果电极位于心脏的不同部分，则可以确定心脏或心脏部分的相对运动或位置。
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公开(公告)号：US20110106203A1
公开(公告)日：2011-05-05
申请号：US12609734
申请日：2009-10-30
CPC分类号： A61N1/37 , A61B5/0422 , A61B5/06 , A61B5/063 , A61B34/20 , A61B2034/2051 , A61B2034/2072 , A61N1/372
摘要： A method and apparatus for tracking and illustrating the location of leads positioned within the volume is disclosed. For example, the lead electrodes can be positioned within a heart of a patient that can be tracked over time. The lead electrodes can be tracked with an electrode potential or bioimpedance tracking system to determine the position of the lead electrodes. A method and apparatus is disclosed to analyze the position information for analyzing the selected position of the lead electrodes.
摘要翻译： 公开了一种用于跟踪和示出位于体积内的引线的位置的方法和装置。 例如，引线电极可以位于可以随时间跟踪的患者的心脏内。 可以用电极电位或生物阻抗跟踪系统跟踪引线电极以确定引线电极的位置。 公开了分析用于分析引线电极的选定位置的位置信息的方法和装置。
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公开(公告)号：US07647105B2
公开(公告)日：2010-01-12
申请号：US11565188
申请日：2006-11-30
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/365 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： A method and an apparatus for treating cardiac arrhythmias are provided. An interval between first and second consecutive beats of a heart, having first and second chamber types, is determined. The heart is paced at a first rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is less than a predetermined amount of time or if the first and second beats are both from the second chamber type. The heart is paced at a second rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is more than the predetermined amount of time.
摘要翻译： 提供了一种治疗心律失常的方法和装置。 确定具有第一和第二室类型的心脏的第一和第二连续节拍之间的间隔。 如果第一节拍来自第一室型，并且第二节拍来自第二室型，并且间隔小于预定量的时间，或者如果第一和第二节拍都来自第一室，则心脏以第一速度进行起搏 第二室型。 如果第一搏动来自第一腔室类型，第二搏动来自第二腔室类型，并且间隔大于预定时间量，心脏以第二速度进行起搏。
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公开(公告)号：US20090093857A1
公开(公告)日：2009-04-09
申请号：US12183796
申请日：2008-07-31
IPC分类号： A61N1/368
CPC分类号： A61N1/05 , A61N1/3706
摘要： An IMD can be implanted into a patient to address various conditions. The IMD case and leads can have various electrodes and other portions to measure various physiological conditions. For example, a selected current can be generated between two electrodes, either external or internal in the patient, and a voltage can be measured by one or more electrodes of the IMD. A voltage can be measured at two or more locations to determine a relative motion of different electrodes. If the electrodes are in different portions of the heart, a determination can be made of a relative motion or position of the heart or portions of the heart.
摘要翻译： 可以将IMD植入患者中以解决各种情况。 IMD外壳和引线可以具有各种电极和其他部分来测量各种生理条件。 例如，可以在患者的外部或内部的两个电极之间产生所选择的电流，并且可以通过IMD的一个或多个电极来测量电压。 可以在两个或更多个位置处测量电压以确定不同电极的相对运动。 如果电极位于心脏的不同部分，则可以确定心脏或心脏部分的相对运动或位置。
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86.发明授权Implantable medical device and method for delivering therapy for sleep-disordered breathing 有权植入式医疗装置和方法，用于为睡眠呼吸障碍提供治疗公开(公告)号：US07130687B2
公开(公告)日：2006-10-31
申请号：US10693375
申请日：2003-10-24
申请人： Yong K. Cho , H. Toby Markowitz
发明人： Yong K. Cho , H. Toby Markowitz
IPC分类号： A61N1/362
CPC分类号： A61N1/3601 , A61B5/08 , A61B5/082 , A61N1/36521 , A61N1/36557
摘要： An implantable medical device delivers augmentation therapy to intervene in a pattern of sleep-disordered breathing. Augmentation therapy includes the delivery of electrical stimulation to cardiac tissue above and/or below a capture threshold. PESP and NES/CCM are possible augmentation therapies that are used alone or in combination. In addition, augmentation therapies can be used with other pacing therapies such as atrial overdrive pacing and atrial coordinated pacing as a therapy for sleep-disordered breathing.
摘要翻译： 可植入的医疗装置提供增强疗法以介入睡眠呼吸障碍的模式。 增强疗法包括将电刺激递送到高于和/或低于捕获阈值的心脏组织。 PESP和NES / CCM是单独使用或组合使用的可能的增强疗法。 此外，增强疗法可以与其他起搏疗法一起使用，例如心房超速起搏和心房协调起搏作为睡眠呼吸障碍的治疗方法。
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87.发明授权System and method for automatically monitoring and delivering therapy for sleep-related disordered breathing 失效用于自动监测和输送睡眠相关无序呼吸治疗的系统和方法公开(公告)号：US07025730B2
公开(公告)日：2006-04-11
申请号：US10419465
申请日：2003-04-21
申请人： Yong K. Cho , Mark K. Erickson , H. Toby Markowitz
发明人： Yong K. Cho , Mark K. Erickson , H. Toby Markowitz
IPC分类号： A61B5/08
CPC分类号： A61N1/3601 , A61N1/36514
摘要： The invention relates generally to a system and method for monitoring and automatically delivering a therapy for sleep-related disordered breathing. In one form the present invention relates to an external device for monitoring for sleep-related disordered breathing in communication with an implantable medical device for delivering an electrical stimulation therapy. In another form the present invention relates to an implantable medical device for detecting sleep-related disordered breathing episode(s) and an external apparatus (e.g., a CPAP machine) for providing therapy to terminate, and/or reduce, said episode(s). In this form of the invention, the implantable medical device communicates with the external apparatus so that the therapy provided corresponds in magnitude and duration to the severity and/or length of the episode(s). In yet another form, an implantable apparatus detects said disordered breathing episode(s) and a hybrid therapy is provided by both the implantable apparatus and an external apparatus.
摘要翻译： 本发明一般涉及用于监测和自动递送针对睡眠相关无序呼吸的治疗的系统和方法。 在一种形式中，本发明涉及一种用于监测与可植入医疗装置进行通信以进行电刺激治疗的与睡眠有关的无序呼吸的外部装置。 在另一种形式中，本发明涉及一种用于检测睡眠相关的无序呼吸发作的可植入医疗装置和用于提供终止和/或减少所述发作的治疗的外部装置（例如，CPAP机） 。 在本发明的这种形式中，可植入医疗装置与外部装置通信，使得所提供的治疗的大小和持续时间与发作的严重性和/或长度相对应。 在另一种形式中，可植入装置检测所述无序呼吸事件，并且可植入装置和外部装置都提供混合治疗。
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88.发明授权Adaptive search AV and auto PVARP adaptation to same with additional benefit 失效自适应搜索AV和自动PVARP适应相同，具有额外的好处
公开(公告)号：US5861007A
公开(公告)日：1999-01-19
申请号：US806302
申请日：1997-02-26
CPC分类号： A61N1/3627 , A61N1/3682
摘要： An AV search method and apparatus is taught with some variation described. It allows a pacemaker to find the appropriate AV interval so as to avoid pacing in the ventricle when it is not necessary, even if there is intermittent AV conduction in the patient. Also, an adaptive PVARP method and apparatus is disclosed that allows the PVARP and AV interval to be adjusted together automatically.
摘要翻译： 教导具有一些变化的AV搜索方法和装置。 它允许起搏器找到适当的AV间隔，以避免在不必要的情况下在心室起搏，即使在患者中存在间歇性AV传导。 此外，公开了一种自适应PVARP方法和装置，其允许PVARP和AV间隔自动调整。
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公开(公告)号：US5522859A
公开(公告)日：1996-06-04
申请号：US343166
申请日：1994-11-22
CPC分类号： A61N1/368 , A61N1/36585
摘要： A dual chamber, rate-responsive pacemaker for pacing a patient's heart novelly allows tracking of the patient's sinus rate when the sinus rate is slightly less than the sensor rate; i.e., within a predetermined "Sinus Preference Window Maximum Rate Drop." Pacing at the sensor rate occurs when the sensor rate exceeds the sinus rate by more than the Sinus Preference Window Maximum Rate Drop. In the preferred embodiment a Sinus Preference Window, which occurs at the end of the ventricle-to-atrium interval, is decremented with successive heart beats by a programmable delta to increase the pacing rate until the Sinus Preference Window reaches zero, in which case the pacemaker paces at the sensor rate. The Sinus Preference Window is reset to its maximum value upon either the detection of an atrial sensed event, or upon the expiration of a programmable Sinus Check Interval. The pacemaker paces at the sinus rate or the maximum rate drop rate, whichever is faster, for a number of recovery beats, and then increments the pacing rate up to the sensor rate.
摘要翻译： 双室，速率响应的心脏起搏器用于起搏患者的心脏新颖地允许跟踪患者的窦速率，当窦速率略低于传感器速率时; 即在预定的“窦性偏好窗口最大速率下降”内。 当传感器速率超过窦性速率超过窦性偏好窗口最大速率下降时，会以传感器速率进行起搏。 在优选实施例中，在心室至心房间隔的末端发生的窦偏好窗口以连续的心跳递减可编程的增量以增加起搏速率直到窦偏好窗口达到零，在这种情况下 起搏器以传感器速率步进。 当检测到心房感应事件时，或者在可编程窦性检查间隔期满时，窦偏好窗口被重置为最大值。 起搏器以窦速率或最大速率下降速率（以更快者为准）起搏，以进行多次恢复搏动，然后将起搏速率递增至传感器速率。
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公开(公告)号：US5501701A
公开(公告)日：1996-03-26
申请号：US309285
申请日：1994-09-20
申请人： H. Toby Markowitz , Michael F. Hess
发明人： H. Toby Markowitz , Michael F. Hess
CPC分类号： A61N1/365 , A61N1/36514
摘要： A method and apparatus for cardiac pacing, in which pacing pulses are provided at an increased rate in response to a detected rapid drop in heart rate. A rapid drop is detected in response to heart rate falling from a persistent rate above a first threshold rate to a stable rate below a second threshold rate. If spontaneous depolarizations are detected while pacing at the increased rate, pacing at the increased rate is terminated.
摘要翻译： 用于心脏起搏的方法和装置，其中响应于检测到的心率快速下降以增加的速率提供起搏脉冲。 响应于心率从高于第一阈值速率的持续速率下降到低于第二阈值速率的稳定速率，检测到快速下降。 如果在以增加的速率起搏时检测到自发去极化，则以增加的速率起搏起止。
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