公开(公告)号：US08715655B2

公开(公告)日：2014-05-06

申请号：US12810939

申请日：2008-12-26

申请人： Masaharu Torikai ,  Daisuke Ishikawa ,  Toshihiro Nakashima ,  Hirofumi Higuchi ,  Fumihiko Sakai ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Katsunari Taguchi

发明人： Masaharu Torikai ,  Daisuke Ishikawa ,  Toshihiro Nakashima ,  Hirofumi Higuchi ,  Fumihiko Sakai ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Katsunari Taguchi

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C07K16/28 ,  G01N33/53

CPC分类号： C07K16/2839 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00

摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.

摘要翻译： 本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段， 编码抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗-α9整联蛋白抗体的制备方法或抗体片段，以及预防或治疗类风湿性关节炎 其含有抗体或抗体片段。

公开(公告)号：US20110304749A1

公开(公告)日：2011-12-15

申请号：US13150848

申请日：2011-06-01

申请人： Daisuke Ishikawa

发明人： Daisuke Ishikawa

IPC分类号： H04N5/262

CPC分类号： H04N5/23296 ,  G03B2205/0046 ,  H04N5/23219

摘要： The image pickup apparatus includes an image production unit producing an image by using an output signal from an image pickup unit, a size detection unit detecting a size of a specific object in the image, a storage unit storing a target value of the size of the specific object, a control unit performing auto zoom control that automatically provides a zoom operation to make the size of the specific object equal or closer to the target value, and a position detection unit detecting a position of the specific object in the image. The control unit controls, in the auto zoom control, a speed of the zoom operation depending on the position of the specific object detected by the position detection unit. The apparatus can prevent easy disappearance of the specific object from the image when the auto zoom operation is performed.

摘要翻译： 图像拾取装置包括通过使用来自图像拾取单元的输出信号产生图像的图像生成单元，检测图像中的特定对象的大小的尺寸检测单元，存储图像的尺寸的目标值的存储单元 执行自动变焦控制的控制单元，其自动提供变焦操作以使所述特定对象的尺寸等于或接近所述目标值;以及位置检测单元，其检测所述特定对象在所述图像中的位置。 控制单元在自动变焦控制中，根据由位置检测单元检测到的特定对象的位置来控制变焦操作的速度。 当执行自动变焦操作时，该装置可以防止特定对象从图像中容易消失。

公开(公告)号：US20110194189A1

公开(公告)日：2011-08-11

申请号：US13014461

申请日：2011-01-26

申请人： Daisuke Ishikawa

发明人： Daisuke Ishikawa

IPC分类号： G02B15/10 ,  G02B15/14 ,  G02B7/04

CPC分类号： G03B17/12 ,  G02B7/102

摘要： An image pickup lens includes an optical system that includes a magnification variable lens used for a magnification variation, and a focus lens configured to adjust an in-focus state, a wide attachment lens being configured to change an enlargement ratio of the image pickup lens and attachable to the optical system, and a manipulator manipulated so as to instruct driving of the magnification variable lens. A moving amount of the magnification variable lens per a predetermined manipulated amount of the manipulator when the wide attachment lens is attached is smaller than that when the wide attachment lens is not attached.

摘要翻译： 一种图像拾取透镜包括：包括用于放大变化的放大率可变透镜的光学系统和配置为调节对焦状态的聚焦透镜;宽附加透镜，被配置为改变图像拾取透镜的放大率;以及 可附接到光学系统，以及操纵器来指示放大倍率可变透镜的驱动。 当安装宽附加透镜时，每个操纵器的预定操作量的倍率可变透镜的移动量小于不附加宽附加透镜时的移动量。

公开(公告)号：US20110115933A1

公开(公告)日：2011-05-19

申请号：US12946088

申请日：2010-11-15

申请人： Tatsuya Yamazaki ,  Masahiro Shibata ,  Yoshikazu Ishikawa ,  Kazunori Ishii ,  Hideo Kawahara ,  Hitoshi Yasuda ,  Daisuke Ishikawa

发明人： Tatsuya Yamazaki ,  Masahiro Shibata ,  Yoshikazu Ishikawa ,  Kazunori Ishii ,  Hideo Kawahara ,  Hitoshi Yasuda ,  Daisuke Ishikawa

IPC分类号： H04N5/225

CPC分类号： G01B11/272 ,  G03B5/00 ,  G03B17/18 ,  H04N5/232 ,  H04N5/23222 ,  H04N5/23248 ,  H04N5/23254 ,  H04N5/23258 ,  H04N5/23264 ,  H04N5/23293 ,  H04N5/77 ,  H04N5/772 ,  H04N5/907 ,  H04N7/025 ,  H04N9/7921

摘要： An image pickup apparatus is disclosed which provides an appropriate inclination guide display in accordance with an aspect ratio of a picked-up image and the like. The image pickup apparatus includes an inclination detector which detects an inclination of the image pickup apparatus, a display device capable of superimposedly showing an inclination guide display corresponding to a detection output from the inclination detector, on a picked-up image, and an aspect ratio setter which sets the aspect ratio of a picked-up image. The apparatus includes a display controller which controls whether or not to show the inclination guide display on the display device on the basis of the aspect ratio set by the aspect ratio setter.

公开(公告)号：US20110109757A1

公开(公告)日：2011-05-12

申请号：US12946073

申请日：2010-11-15

申请人： Tatsuya Yamazaki ,  Masahiro Shibata ,  Yoshikazu Ishikawa ,  Kazunori Ishii ,  Hideo Kawahara ,  Hitoshi Yasuda ,  Daisuke Ishikawa

发明人： Tatsuya Yamazaki ,  Masahiro Shibata ,  Yoshikazu Ishikawa ,  Kazunori Ishii ,  Hideo Kawahara ,  Hitoshi Yasuda ,  Daisuke Ishikawa

IPC分类号： H04N5/228

CPC分类号： G01B11/272 ,  G03B5/00 ,  G03B17/18 ,  H04N5/232 ,  H04N5/23222 ,  H04N5/23248 ,  H04N5/23254 ,  H04N5/23258 ,  H04N5/23264 ,  H04N5/23293 ,  H04N5/77 ,  H04N5/772 ,  H04N5/907 ,  H04N7/025 ,  H04N9/7921

摘要： An image pickup apparatus is disclosed which provides an appropriate inclination guide display in accordance with an aspect ratio of a picked-up image and the like. The image pickup apparatus includes an inclination detector which detects an inclination of the image pickup apparatus, a display device capable of superimposedly showing an inclination guide display corresponding to a detection output from the inclination detector, on a picked-up image, and an aspect ratio setter which sets the aspect ratio of a picked-up image. The apparatus includes a display controller which controls whether or not to show the inclination guide display on the display device on the basis of the aspect ratio set by the aspect ratio setter.

公开(公告)号：US20110059077A1

公开(公告)日：2011-03-10

申请号：US12812341

申请日：2009-01-09

申请人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

发明人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

IPC分类号： C07K16/28 ,  C12N15/13 ,  C12N15/70 ,  C12N1/21 ,  C12P21/08 ,  A61K39/395

CPC分类号： C07K16/2839 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.

摘要翻译： 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即包含重链可变区的人源化抗人α9整联蛋白抗体，其包含 的SEQ ID NO：11所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体由 由SEQ ID NO：13所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，包含由SEQ ID NO：17所示的重链可变区组成的人源化抗人α9整联蛋白抗体 由SEQ ID NO：15所示的氨基酸序列和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及用于预防或治疗涉及人α9整数的各种疾病的手段 rin在发病机制中，其使用抗体。

公开(公告)号：US20110014193A1

公开(公告)日：2011-01-20

申请号：US12812368

申请日：2009-07-09

申请人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

发明人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12P21/06 ,  A61P19/02

CPC分类号： C07K16/2839 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 1 or the amino acid sequence shown by SEQ ID NO: 1 wherein one or several amino acids are substituted, deleted, inserted and/or added and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 61 or the amino acid sequence shown by SEQ ID NO: 61 wherein one or several amino acids are substituted, deleted, inserted and/or added, as well as a means for preventing or treating various diseases involving human α9 integrin in their pathogenesis, which uses the antibody.

摘要翻译： 本发明提供了与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即人源化抗人α9整联蛋白抗体，其包含由以下组成的重链可变区： SEQ ID NO：1所示的氨基酸序列或SEQ ID NO：1所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及由氨基酸组成的轻链可变区 SEQ ID NO：61所示的酸序列或SEQ ID NO：61所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及用于预防或治疗涉及 人α9整合素在其发病机制中，其使用抗体。

公开(公告)号：US07697218B2

公开(公告)日：2010-04-13

申请号：US12323320

申请日：2008-11-25

申请人： Daisuke Ishikawa ,  Toshihiko Tomosada

发明人： Daisuke Ishikawa ,  Toshihiko Tomosada

IPC分类号： G02B15/14 ,  G02B7/02

CPC分类号： G02B7/102 ,  G02B7/028

摘要： A lens control apparatus includes a temperature detection unit configured to detect a temperature near a zoom lens and a focus lens, a zoom lens drive unit configured to drive the zoom lens, and a controller configured, if it is determined that a current temperature near the zoom lens and the focus lens detected by the temperature detection unit is higher than a reference temperature, to acquire a telephoto end position to be set at the current temperature, to compare the telephoto end position with a current position of the zoom lens, and to cause the zoom lens drive unit to move the zoom lens to the telephoto end position if the current position of the zoom lens is located beyond the telephoto end position on a telephoto side.

摘要翻译： 一种透镜控制装置，包括：温度检测单元，被配置为检测变焦透镜附近的温度和聚焦透镜;变焦透镜驱动单元，被配置为驱动变焦透镜;以及控制器，其被配置为，如果确定当前温度接近 变焦透镜和由温度检测单元检测的对焦透镜高于参考温度，以获取要设置在当前温度的远摄端位置，以将远摄端位置与变焦镜头的当前位置进行比较，并且将 如果变焦镜头的当前位置位于远摄端的远摄端位置，则变焦镜头驱动单元将变焦镜头移动到远摄端位置。