公开(公告)号：US06518268B1

公开(公告)日：2003-02-11

申请号：US09608636

申请日：2000-06-30

Applicant: Allison C. Chin ,  Ryan Holcomb ,  Mieczyslaw A. Piatyszek ,  Upinder Singh ,  Richard L. Tolman ,  Tsutomu Akama ,  Yutaka Kanda ,  Akira Asai ,  Yoshinori Yamashita ,  Kaori Endo ,  Hiroyuki Yamaguchi

Inventor： Allison C. Chin ,  Ryan Holcomb ,  Mieczyslaw A. Piatyszek ,  Upinder Singh ,  Richard L. Tolman ,  Tsutomu Akama ,  Yutaka Kanda ,  Akira Asai ,  Yoshinori Yamashita ,  Kaori Endo ,  Hiroyuki Yamaguchi

IPC: A61K31535

CPC classification number: A61K31/426 ,  A61K31/4439 ,  A61K31/506 ,  C07D277/34 ,  C07D277/36 ,  C07D417/06 ,  C07D417/10 ,  C07D513/04

Abstract: Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

Abstract translation: 提供噻唑烷二酮化合物，组合物和在体外抑制端粒酶活性的方法以及离体和体内治疗端粒酶介导的病症或疾病。 本发明的方法，化合物和组合物可以单独使用或与其它药理学活性剂组合用于治疗由端粒酶活性介导的病症或疾病，例如治疗癌症。 还公开了用于测定或筛选端粒酶活性抑制剂的新方法。

公开(公告)号：US06449232B1

公开(公告)日：2002-09-10

申请号：US09601379

申请日：2000-08-01

Applicant: Masaya Kuwahara ,  Shinichi Yamada ,  Hiroyuki Yamaguchi ,  Masuo Maruyama ,  Masanari Mohri ,  Akihiro Sakaguchi ,  Yasuo Nishihara ,  Masayoshi Shioya

Inventor： Masaya Kuwahara ,  Shinichi Yamada ,  Hiroyuki Yamaguchi ,  Masuo Maruyama ,  Masanari Mohri ,  Akihiro Sakaguchi ,  Yasuo Nishihara ,  Masayoshi Shioya

IPC: G11B700

CPC classification number: G11B19/12 ,  G11B7/08511 ,  G11B7/08517 ,  G11B7/0945 ,  G11B2007/0006

Abstract: Optical disks compliant with different standards are recorded or reproduced by a single recording/reproducing apparatus by a first step of determining a substrate thickness of the disk based on a focusing error signal, when a focusing section for bringing the light beam into a focus on the disk is moved in such a way as to approach or withdraw from the recording surface of the disk; a second step of performing any one step of determining the number of recording surfaces of the disk when the focusing section is moved in such a way as to approach or withdraw from the recording surface of the disk, and determining whether or not the disk can be recorded and reproduced using a tracking error signal detected when the light beam crosses the track.

Abstract translation: 通过第一步骤，通过单个记录/再现装置记录或再现基于聚焦误差信号的盘的基板厚度的光盘，当聚焦部分将光束聚焦在 盘以从盘的记录表面接近或退出的方式移动; 执行以下步骤：当聚焦部分以从盘的记录表面接近或退出的方式移动时确定盘的记录表面的数量的步骤，并且确定盘是否可以是 使用当光束穿过轨道时检测到的跟踪误差信号来记录和再现。

公开(公告)号：US06230505B1

公开(公告)日：2001-05-15

申请号：US09479882

申请日：2000-01-10

Applicant: Yoshitoshi Noda ,  Hiroyuki Yamaguchi ,  Toshio Ohashi ,  Kaoru Kamiyama ,  Tadayoshi Tajima ,  Toshiharu Watanabe ,  Yasuhito Okawara ,  Hiroki Yoshioka

Inventor： Yoshitoshi Noda ,  Hiroyuki Yamaguchi ,  Toshio Ohashi ,  Kaoru Kamiyama ,  Tadayoshi Tajima ,  Toshiharu Watanabe ,  Yasuhito Okawara ,  Hiroki Yoshioka

IPC: B60H100

CPC classification number: F25B5/00 ,  B60H1/00914 ,  B60H1/3208 ,  B60H2001/00949 ,  F25B6/00 ,  F25B27/00 ,  F25B41/04

Abstract: A heat pump type air conditioning system (A) for an automotive vehicle. The heat type air conditioning system (A) comprises a first unit (10) including a heater core (11) through which an engine coolant of an engine flows, and a first heat exchanger (12) which forms part of a refrigeration cycle including a compressor (1) and a first condenser (3), in which a refrigerant circulates in the refrigeration cycle. A second unit (20) is provided including a second condenser (21) and a second heat exchanger (22) which are fluidly connected in parallel with the first heat exchanger (12). A valve (V2) is fluidly connected in series with the second condenser (21) and disposed such that a part of the refrigerant is introduced through the valve into the second condenser (21) and the second heat exchanger (22). A sub-heat exchanger (30) is disposed outside the first and second units and fluidly connected in series with the second heat exchanger (22), in which the refrigerant flowing from the second heat exchanger (22) is introduced into the sub-heat exchanger to be heated by a part of the engine coolant, the refrigerant discharged from the sub-heat exchanger being returned to the compressor. An electromagnetic clutch (40) is provided such that the compressor (1) is drivably connectable with the engine therethrough. The electromagnetic clutch is engaged to establish a driving connection between the compressor so as to operate the compressor and disengaged to cut the driving connection so as to make the compressor inoperative. A control device (C) is operatively connected to the electromagnetic clutch (40) for controlling the electromagnetic clutch to be disengageable in accordance with a temperature within the air conditioning system (A).

Abstract translation: 一种用于汽车的热泵式空调系统（A）。 热式空调系统（A）包括第一单元（10），第一单元（10）包括加热器芯（11），发动机的发动机冷却剂通过该加热器芯流动;以及第一热交换器（12），其形成包括 压缩机（1）和第一冷凝器（3），其中制冷剂在制冷循环中循环。 提供了包括与第一热交换器（12）并联流体连接的第二冷凝器（21）和第二热交换器（22）的第二单元（20）。 阀（V2）与第二冷凝器（21）串联流体连接并且被布置成使得一部分制冷剂通过阀被引入第二冷凝器（21）和第二热交换器（22）。 副热交换器（30）设置在第一和第二单元的外部并与第二热交换器（22）串联地流体连接，其中从第二热交换器（22）流出的制冷剂被引入次热 交换器被发动机冷却剂的一部分加热，从副热交换器排出的制冷剂返回压缩机。 设置电磁离合器（40），使得压缩机（1）可与发动机驱动地连接。 电磁离合器被接合以在压缩机之间建立驱动连接，以便操作压缩机并脱开以切断驱动连接，从而使压缩机不起作用。 控制装置（C）可操作地连接到电磁离合器（40），用于根据空调系统（A）内的温度控制电磁离合器脱离接合。

公开(公告)号：US06182001B2

公开(公告)日：2001-01-30

申请号：US08996316

申请日：1997-12-22

Applicant: Masaru Sugai ,  Katsuhiro Asano ,  Takaji Umeno ,  Eiichi Ono ,  Hiroyuki Yamaguchi

Inventor： Masaru Sugai ,  Katsuhiro Asano ,  Takaji Umeno ,  Eiichi Ono ,  Hiroyuki Yamaguchi

IPC: G06F700

CPC classification number: B60T8/885 ,  B60T2270/413

Abstract: An apparatus for diagnosing a fault in a dynamic system includes a controller which controls the dynamic system through use of a control input signal and vibrates the dynamic system through use of an vibration signal irrelevant to the internal state quantity of the dynamic system; an observer for estimating, on the basis of a response output from the vibration dynamic system, total disturbance which is a sum of an internal disturbance vector stemming from a fault in the dynamic system and a vibration disturbance vector occurring in the dynamic system through vibration; a correlation calculation unit which calculates cross-correlation between the thus-estimated total disturbance and the internal state quantity of the dynamic system and separates a component related to the internal disturbance from the total disturbance; and a diagnostic unit for diagnosing a fault in the dynamic system on the basis of the thus-separated component related to the internal disturbance. Since the dynamic system is vibrated, the response output can be increased even when there exists small external disturbance. As a result, a fault or a variation in air pressure in a tire can be highly accurately diagnosed.

Abstract translation: 用于诊断动态系统中的故障的装置包括控制器，其通过使用控制输入信号来控制动态系统，并通过使用与动态系统的内部状态量无关的振动信号来振动动态系统; 基于来自振动动态系统的响应输出，基于动态系统中的故障产生的内部干扰矢量与通过振动在动态系统中发生的振动干扰矢量之和的总干扰来估计观测器; 相关计算单元，其计算由此估计的总干扰与动态系统的内部状态量之间的互相关，并将与内部干扰有关的分量与全部干扰分离; 以及用于基于与内部干扰相关的如此分离的分量来诊断动态系统中的故障的诊断单元。 由于动态系统振动，即使存在小的外部干扰，响应输出也可以增加。 结果，可以高精度地诊断轮胎中的故障或空气压力的变化。

公开(公告)号：US6125643A

公开(公告)日：2000-10-03

申请号：US970806

申请日：1997-11-14

Applicant: Yoshitoshi Noda ,  Hiroyuki Yamaguchi ,  Toshio Ohashi ,  Kaoru Kamiyama ,  Tadayoshi Tajima ,  Toshiharu Watanabe ,  Yasuhito Okawara ,  Hiroki Yoshioka

Inventor： Yoshitoshi Noda ,  Hiroyuki Yamaguchi ,  Toshio Ohashi ,  Kaoru Kamiyama ,  Tadayoshi Tajima ,  Toshiharu Watanabe ,  Yasuhito Okawara ,  Hiroki Yoshioka

IPC: B60H1/00 ,  B60H1/32 ,  F25B5/00 ,  F25B6/00 ,  F25B27/00 ,  F25B41/04

CPC classification number: F25B5/00 ,  B60H1/00914 ,  B60H1/3208 ,  F25B6/00 ,  B60H2001/00949 ,  F25B27/00 ,  F25B41/04

Abstract: A heat pump type air conditioning system (A) for an automotive vehicle. The heat type air conditioning system (A) comprises a first unit (10) including a heater core (11) through which an engine coolant of an engine flows, and a first heat exchanger (12) which forms part of a refrigeration cycle including a compressor (1) and a first condenser (3), in which a refrigerant circulates in the refrigeration cycle. A second unit (20) is provided including a second condenser (21) and a second heat exchanger (22) which are fluidly connected in parallel with the first heat exchanger (12). A valve (V2) is fluidly connected in series with the second condenser (21) and disposed such that a part of the refrigerant is introduced through the valve into the second condenser (21) and the second heat exchanger (22). A sub-heat exchanger (30) is disposed outside the first and second units and fluidly connected in series with the second heat exchanger (22), in which the refrigerant flowing from the second heat exchanger (22) is introduced into the sub-heat exchanger to be heated by a part of the engine coolant, the refrigerant discharged from the sub-heat exchanger being returned to the compressor. An electromagnetic clutch (40) is provided such that the compressor (1) is drivably connectable with the engine therethrough. The electromagnetic clutch is engaged to establish a driving connection between the compressor so as to operate the compressor and disengaged to cut the driving connection so as to make the compressor inoperative. A control device (C) is operatively connected to the electromagnetic clutch (40) for controlling the electromagnetic clutch to be disengageable in accordance with a temperature within the air conditioning system (A).

Abstract translation: 一种用于汽车的热泵式空调系统（A）。 热式空调系统（A）包括第一单元（10），第一单元（10）包括加热器芯（11），发动机的发动机冷却剂通过该加热器芯流动;以及第一热交换器（12），其形成包括 压缩机（1）和第一冷凝器（3），其中制冷剂在制冷循环中循环。 提供了包括与第一热交换器（12）并联流体连接的第二冷凝器（21）和第二热交换器（22）的第二单元（20）。 阀（V2）与第二冷凝器（21）串联流体连接并且被布置成使得一部分制冷剂通过阀被引入第二冷凝器（21）和第二热交换器（22）。 副热交换器（30）设置在第一和第二单元的外部并与第二热交换器（22）串联地流体连接，其中从第二热交换器（22）流出的制冷剂被引入次热 交换器被发动机冷却剂的一部分加热，从副热交换器排出的制冷剂返回到压缩机。 设置电磁离合器（40），使得压缩机（1）可与发动机驱动地连接。 电磁离合器被接合以在压缩机之间建立驱动连接，以便操作压缩机并脱开以切断驱动连接，从而使压缩机不起作用。 控制装置（C）可操作地连接到电磁离合器（40），用于根据空调系统（A）内的温度控制电磁离合器脱离接合。

公开(公告)号：US6080771A

公开(公告)日：2000-06-27

申请号：US133363

申请日：1998-08-13

Applicant: Yutaka Kanda ,  Hitoshi Arai ,  Hiroyuki Yamaguchi ,  Tadashi Ashizawa ,  Shun-ichi Ikeda ,  Chikara Murakata ,  Tatsuya Tamaoki

Inventor： Yutaka Kanda ,  Hitoshi Arai ,  Hiroyuki Yamaguchi ,  Tadashi Ashizawa ,  Shun-ichi Ikeda ,  Chikara Murakata ,  Tatsuya Tamaoki

IPC: C07D513/08 ,  C07D513/18 ,  C07D513/20 ,  C07H15/26 ,  C07H17/02 ,  A61K31/425 ,  A61K31/70 ,  C07D519/00

CPC classification number: C07D513/08 ,  C07H15/26 ,  C07H17/02

Abstract: DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents CO(CR.sup.4A R.sup.4B).sub.n1 (O(CH.sub.2).sub.p1).sub.n2 OR.sup.5 {wherein n1 represents an integer of 1 or 2; R.sup.4A and R.sup.4B are the same or different, and each represents hydrogen or lower alkyl; p1 and n2 each represents an integer of 1 to 10; and R.sup.5 represents hydrogen, lower alkyl, or the like), or ##STR2##

Abstract translation: 提供了具有抗微生物活性和抗肿瘤活性的由式​​（I）表示的DC107衍生物或其药学上可接受的盐，其中R1表示CO（CR4AR4B）n1（O（CH2）p1）n2OR5 {其中n1表示1或2的整数; R4A和R4B相同或不同，各自表示氢或低级烷基; p1和n2各自表示1〜10的整数， 和R 5表示氢，低级烷基等）

公开(公告)号：US06044049A

公开(公告)日：2000-03-28

申请号：US951140

申请日：1997-10-15

Applicant: Kenji Fujiune ,  Mitsuro Moriya ,  Hiroyuki Yamaguchi ,  Shin-ichi Yamada ,  Katsuya Watanabe

Inventor： Kenji Fujiune ,  Mitsuro Moriya ,  Hiroyuki Yamaguchi ,  Shin-ichi Yamada ,  Katsuya Watanabe

IPC: G11B7/007 ,  G11B7/085 ,  G11B7/09 ,  G11B7/095 ,  G11B19/12 ,  G11B7/00

CPC classification number: G11B19/12 ,  G11B7/08505 ,  G11B7/0901 ,  G11B7/00718

Abstract: An optical information apparatus for performing at least one of a reproduction operation and a recording operation for an information medium by radiating a light beam on the information medium is provided, wherein the information medium has a first region, including a first track having information recorded thereon in the form of convex and concave pits, and a second region, including a second track formed in the form of convex and concave guide grooves. The apparatus includes: first tracking error detection component for detecting an error in position between the light beam and the first track in the first region; second tracking error detection component for detecting an error in position between the light beam and the second track in the second region; tracking control component for performing tracking control for locating the light beam on a predetermined track; determination component for determining whether the light beam is located in the first region or the second region; and switching component for selecting either one of an output signal of the first tracking error detection component or an output signal of the second tracking error detection component based on a result of determination by the determination component, and sending the selected output signal to the tracking control component.

Abstract translation: 提供了一种用于通过在信息介质上照射光束来进行信息介质的再现操作和记录操作中的至少一个的光学信息设备，其中信息介质具有第一区域，其包括具有记录在其上的信息的第一轨道 呈凹凸形状的第二区域，以及第二区域，该第二区域包括以凸形和凹形引导槽形式形成的第二轨道。 该装置包括：第一跟踪误差检测部件，用于检测第一区域中的光束与第一轨道之间的位置误差; 第二跟踪误差检测部件，用于检测第二区域中的光束与第二光道之间的位置误差; 跟踪控制部件，用于执行用于将光束定位在预定轨道上的跟踪控制; 确定部件，用于确定光束是否位于第一区域或第二区域中; 以及用于基于所述确定部件的确定结果来选择所述第一跟踪误差检测部件的输出信号中的任一个或所述第二跟踪误差检测部件的输出信号的开关部件，以及将所选择的输出信号发送到所述跟踪控制 零件。

公开(公告)号：US5878007A

公开(公告)日：1999-03-02

申请号：US57172

申请日：1998-04-08

Applicant: Yasuki Matsumoto ,  Mitsuro Moriya ,  Hiroyuki Yamaguchi ,  Shin-ichi Yamada

Inventor： Yasuki Matsumoto ,  Mitsuro Moriya ,  Hiroyuki Yamaguchi ,  Shin-ichi Yamada

IPC: G11B7/007 ,  G11B7/09 ,  G11B7/095

CPC classification number: G11B7/00718 ,  G11B7/094 ,  G11B7/00745 ,  G11B7/0901 ,  G11B7/0938

Abstract: In the optical recording medium of the invention, land and groove tracks are arranged in a spiral manner, and a completion information region having identification reading completion information indicative of a rear end of an identification region is disposed between data regions. A pair of wobble pits are disposed immediately behind the identification reading completion information region, and therefore the wobble pits can accurately be detected by reading out the wobble pits on the basis of the identification reading completion information.

Abstract translation: 在本发明的光记录介质中，以脊线和凹槽轨迹布置螺旋状，并且在数据区域之间设置具有表示识别区域的后端的识别读取完成信息的完成信息区域。 在识别读取完成信息区域之后立即设置一对摆动凹坑，因此可以通过基于识别读取完成信息读出摆动坑来精确地检测摆动坑。

公开(公告)号：US5839046A

公开(公告)日：1998-11-17

申请号：US820006

申请日：1997-03-18

Applicant: Masatoshi Takano ,  Yutaka Ishikawa ,  Hiroyuki Yamaguchi ,  Hiroyuki Saito

Inventor： Masatoshi Takano ,  Yutaka Ishikawa ,  Hiroyuki Yamaguchi ,  Hiroyuki Saito

IPC: B41J11/00 ,  B41J11/30 ,  B41J11/42 ,  G03G15/00

CPC classification number: B41J11/008 ,  B41J11/002 ,  B41J11/30 ,  B41J11/42

Abstract: A printer includes a tractor unit for feeding continuous form paper, encoders driven in synchronization with the tractor unit, and detecting sensors for detecting the encoders to generate feed pulses at a standard interval. The printer further includes a paper top sensor for detecting a leading edge of the continuous form paper to generate paper top signal and is arranged to control the feed of the paper based on the feed pulse generated after the paper top signal. In order to adjust the printing position on the paper in case where the scanning position is misaligned due to a manufacturing error, the position of the detecting sensors is adjustable with respect to the encoders to compensate for the error. Further, the position of the paper top sensor is adjustable with respect to the tractor unit in order to keep the relationship between the feed pulse and the paper top signal unchanged regardless of the adjustment of the detecting sensors.

Abstract translation: 一种打印机包括用于供给连续成型纸的拖拉机单元，与拖拉机单元同步驱动的编码器，以及检测传感器，用于检测编码器以标准间隔产生进给脉冲。 打印机还包括纸顶传感器，用于检测连续纸张的前缘以产生纸顶信号，并且布置成基于在纸张顶部信号之后产生的进给脉冲来控制纸张的进给。 为了在由于制造误差而导致扫描位置不对准的情况下调节纸张上的打印位置，检测传感器的位置可相对于编码器调节以补偿错误。 此外，纸顶传感器的位置相对于拖拉机单元是可调节的，以便保持进给脉冲和纸顶信号之间的关系，而与检测传感器的调节无关。

公开(公告)号：US5758247A

公开(公告)日：1998-05-26

申请号：US618804

申请日：1996-03-20

Applicant: Tsukasa Yanashima ,  Hiroyuki Saito ,  Hiroyuki Yamaguchi

Inventor： Tsukasa Yanashima ,  Hiroyuki Saito ,  Hiroyuki Yamaguchi

IPC: G03G15/16 ,  G03G21/06 ,  G03G21/00

CPC classification number: G03G15/164 ,  G03G2215/00455 ,  G03G2215/1609

Abstract: A charge removing member is arranged just upstream of an image transfer area along a continuous form transport path, between the last guiding portion and the transfer area, to remove accumulated charge on the continuous form. The charge removing member is alternatively a brush contactable to the form, a non-contact conductive member, a brush movable toward and away from the form, or a brush that acts as a guide member. Further alternatively, the brush contacts the form only during reverse feeding of the form, and in this case, is alternatively movable toward and away from the form, movable toward and away from the form in association with a transfer unit, or positioned to contact a straight form while being out of contact with a form bent by a transfer unit.

Abstract translation: 电荷去除部件沿着连续形式传送路径在最后的引导部分和传送区域之间的图像传送区域的正上方布置，以消除连续形式上的累积电荷。 电荷去除构件可选地是可与该形式接触的刷子，非接触导电构件，可朝向和远离形式移动的刷子，或用作引导构件的刷子。 或者，刷子仅在形式的反向馈送期间接触该形式，并且在这种情况下，可替代地可移动地朝向和远离形状移动，可移动地朝向和远离与传送单元相关联的形式移动，或者定位成接触 与转移单元弯曲的形式脱离接触时的直线形式。