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    Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV)
    82.
    发明授权
    Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV) 有权
    使用重组减毒副流感病毒（PIV）作为载体，以防止由PIV和呼吸道合胞病毒（RSV）引起的疾病

    公开(公告)号：US07314631B1

    公开(公告)日：2008-01-01

    申请号：US09458813

    申请日：1999-12-10

    申请人： Brian R. Murphy ,  Peter L. Collins ,  Anna P. Durbin ,  Mario H. Skiadopoulos ,  Tao Tao

    发明人： Brian R. Murphy ,  Peter L. Collins ,  Anna P. Durbin ,  Mario H. Skiadopoulos ,  Tao Tao

    IPC分类号： A61K39/155 ,  C12N7/00

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/155 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C07K14/005 ,  C12N2760/18422 ,  C12N2760/18434 ,  C12N2760/18634 ,  C12N2760/18643 ,  C12N2760/18734

    摘要： Chimeric parainfluenza viruses (PIVs) are provided that incorporate a PIV vector genome or antigenome and one or more antigenic determinant(s) of a heterologous PIV or non-PIV pathogen. These chimeric viruses are infectious and attenuated in humans and other mammals and are useful in vaccine formulations for eliciting and immune responses against one or more PIVs, or against a PIV and non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a partial or complete PIV vector genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) encoding antigenic determinant(s) of a heterologous PIV or non-PIV pathogen. In preferred aspects of the invention, chimeric PIV incorporate a partial or complete human PIV vector genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a heterologous PIV or non-PIV pathogen, wherein the chimeric virus is attenuated for use as a vaccine agent by any of a variety of mutations and nucleotide modifications introduced into the chimeric genome or antigenome.

    摘要翻译： 提供了嵌合副流感病毒（PIV），其包含PIV载体基因组或反义基因组以及异源PIV或非PIV病原体的一个或多个抗原决定簇。 这些嵌合病毒在人类和其他哺乳动物中是感染性和减毒性的，并且可用于针对一种或多种PIV或针对PIV和非PIV病原体的引发和免疫应答的疫苗制剂。 还提供了分离的多核苷酸分子和掺入嵌合PIV基因组或抗原组的载体，其包括与编码抗原决定簇的一个或多个异源基因或基因组片段组合或整合的部分或完整PIV载体基因组或反义基因， 的异源PIV或非PIV病原体。 在本发明的优选方面，嵌合PIV掺入与来自异源PIV或非PIV病原体的一个或多个异源基因或基因组片段组合的部分或完整的人PIV载体基因组或反向异构体，其中所述嵌合病毒 通过引入到嵌合基因组或反基因组中的各种突变和核苷酸修饰中的任一种减毒用作疫苗剂。

    Components for electrochemical devices including multi-unit device arrangements
    84.
    发明申请
    Components for electrochemical devices including multi-unit device arrangements 审中-公开
    包括多单元设备布置的电化学装置的组件

    公开(公告)号：US20060040167A1

    公开(公告)日：2006-02-23

    申请号：US11167079

    申请日：2005-06-24

    申请人： Adam Blake ,  Jason Kwa ,  Tao Tao ,  Garrett Bingle ,  Reinder Boersma ,  Jack Shindle ,  Wei Bai

    发明人： Adam Blake ,  Jason Kwa ,  Tao Tao ,  Garrett Bingle ,  Reinder Boersma ,  Jack Shindle ,  Wei Bai

    IPC分类号： H01M8/24 ,  H01M8/10

    CPC分类号： H01M8/2485 ,  H01M6/42 ,  H01M8/0247 ,  H01M8/0271 ,  H01M8/04089 ,  H01M8/2415

    摘要： Systems for interconnecting two or more electrochemical devices such as fuel-to-energy conversion devices are described. A unitary manifold structure can include a manifold for delivery of a reactant gas to two or more devices, and/or electrical circuitry addressing the two or more devices. Electrical circuitry can be provided in combination with conduits for delivery of reactant gases. Inter-device connecting apparatus can define boundaries for separation of at least two reactant gases addressing the devices, and a plurality of inter-device connecting apparatuses can be interconnected themselves to form larger arrangements of essentially infinite size.

    摘要翻译： 描述了用于互连两个或更多个电化学装置（例如燃料 - 能量转换装置）的系统。 单一歧管结构可以包括用于将反应物气体输送到两个或更多个装置的歧管和/或寻址两个或更多个装置的电路。 电路可以与用于递送反应气体的导管组合提供。 装置间连接装置可以界定用于分离至少两种针对装置的反应气体的边界，并且多个装置间连接装置可以自身互连以形成基本上无限尺寸的较大布置。