公开(公告)号：US5741316A

公开(公告)日：1998-04-21

申请号：US756945

申请日：1996-12-02

申请人： James C. Chen ,  Brian D. Wilkerson ,  Darrin Huston ,  David J. Brown

发明人： James C. Chen ,  Brian D. Wilkerson ,  Darrin Huston ,  David J. Brown

IPC分类号： A61N1/362 ,  A61M1/12 ,  A61N1/378 ,  A61N2/04 ,  H02J17/00 ,  A61N1/00 ,  A61N1/36

CPC分类号： A61N1/3787

摘要： Several embodiments of relatively compact transmitter coils and receiver coils having an improved transcutaneous power transfer efficiency. The transmitter coils are preferably applied to the outer surface of a cutaneous layer on a patient's body and held in place using adhesive tape or other appropriate supporting material. Implanted within the patient's body is a receiver coil. To improve the power transfer efficiency of one embodiment, a transmitter coil and receiver coil include cores having pole faces with a substantially larger area than the cross section of the core at other locations. In addition, the core of the receiver coil is substantially shorter than that of the transmitter coil so that the lines of flux produced by the transmitter coil tend to pass through the pole faces of the receiver coil in greater density than they would if the pole faces of the transmitter and receiver cores were spaced identically. Relatively compact configurations for the transmitter core include an angled portion adjacent each of the pole faces so that the main portion of the transmitter core is disposed generally parallel and closely spaced to the surface of the cutaneous layer against which the transmitter core is placed. Further, two separate transmitter windings are provided on the transmitter core with an intermediate section joining the portions of the core on which these windings are disposed. This configuration provides enhanced power transfer capability compared to using a single winding around the intermediate section of the core.

摘要翻译： 具有改进的经皮功率传递效率的相对紧凑的发射器线圈和接收器线圈的几个实施例。 发射器线圈优选地应用于患者身体上的皮肤层的外表面并且使用粘合带或其它合适的支撑材料保持在适当的位置。 植入患者体内的是接收线圈。 为了提高一个实施例的功率传递效率，发射器线圈和接收器线圈包括具有比其它位置处的芯的横截面大得多的面积的极面的芯。 此外，接收器线圈的芯部基本上短于发射器线圈的芯部，使得由发射器线圈产生的磁通线倾向于以比如果极面部分更大的密度穿过接收器线圈的极面 发射机和接收机核心间隔相同。 用于发射器芯的相对紧凑的构造包括邻近每个极面的成角度部分，使得发射器芯的主要部分大致平行并且与皮肤层的与发射器芯放置的表面紧密地间隔开。 此外，两个单独的发射器绕组设置在发射机芯上，其中间部分连接在其上设置这些绕组的芯部分。 与在芯的中间部分周围使用单个绕组相比，该配置提供增强的功率传递能力。

公开(公告)号：US5571152A

公开(公告)日：1996-11-05

申请号：US451831

申请日：1995-05-26

申请人： James C. Chen ,  Brian D. Swanson

发明人： James C. Chen ,  Brian D. Swanson

IPC分类号： A61N1/372 ,  A61N5/06 ,  A61N1/30

CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61N1/37205 ,  A61N2005/0651

摘要： A plurality of microminiature light sources (10, 10') are injected at a treatment site to effect photodynamic therapy (PDT). Each of the microminiature light source beads includes an LED chip (12), a rectifier chip (14), and a plurality of electromagnetic receivers (18, 18') encapsulated within a biocompatible, light transmitting material such as silicone, forming a spherical bead that is only a few millimeters in diameter. The light source beads are sufficiently small so that they can be injected into a treatment site such as a tumor (46) from a syringe (58) through a needle (60). A photoreactive agent, which can serve as a carrier fluid for the microminiature light source beads, sensitizes the tissue at the treatment site so that light emitted by the LED chip when energized with an external electromagnetic transmitter (34) kills the tissue or other pathogens at the treatment site that have absorbed the photoreactive agent. Alternatively, a catheter (66) can be used for emplacing the microminiature light source beads at the treatment site.

摘要翻译： 在治疗部位注射多个微型光源（10,10'）以实现光动力疗法（PDT）。 每个微型光源珠包括LED芯片（12），整流器芯片（14）以及封装在诸如硅树脂之类的生物相容的透光材料内的多个电磁接收器（18,18'），形成球形珠 直径只有几毫米。 光源珠足够小，使得它们可以通过针（60）从注射器（58）注射到诸如肿瘤（46）的治疗部位中。 可用作微型光源珠粒的载体流体的光反应剂使得处理部位处的组织致敏，使得当通过外部电磁发射器（34）通电时由LED芯片发射的光在组织或其它病原体处杀死 已经吸收光反应剂的处理部位。 或者，导管（66）可以用于在处理部位放置微型光源珠。

公开(公告)号：US5445608A

公开(公告)日：1995-08-29

申请号：US107276

申请日：1993-08-16

申请人： James C. Chen ,  Elric W. Saaski

发明人： James C. Chen ,  Elric W. Saaski

IPC分类号： A61K41/00 ,  A61N5/06 ,  A61N1/30

CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61N2005/0609 ,  A61N2005/061 ,  A61N2005/0647 ,  A61N2005/0652

摘要： Light developed by an implantable probe is used to illuminate a treatment site that has been perfused with a photoreactive agent. A number of different embodiments of implantable probes are disclosed. Preferably, an array of light emitting diodes (LEDs) or solid-state laser diodes (LDs) are mounted on a light bar inside the implantable probe and are energized either using a storage battery power source, an inductively coupled external transformer, or with current provided in leads running through a flexible catheter that extends outside the patient's body to an external source. The implantable probe is normally intended to be disposed inside a patient's body during a surgical procedure, at a treatment site, and left in place for several days (or longer) after an incision is closed, while light produced by the array of LEDs or solid-state LDs irradiates the treatment site. Alternatively, light from an external light source can be conveyed over one or more optical fibers to an implantable probe that is disposed inside the patient's body to irradiate the treatment site. Waste heat produced by the array of LEDs or LDs disposed on the implantable probe can be employed to augment the PDT by increasing the temperature of the tissue at the treatment site.

摘要翻译： 通过可植入探针开发的光用于照射已经用光反应剂​​灌注的治疗部位。 公开了可植入探针的许多不同实施例。 优选地，发光二极管（LED）阵列或固体激光二极管（LD）安装在可植入探针内部的光条上，并且使用蓄电池电源，电感耦合外部变压器或电流 提供在穿过穿过患者身体外部的柔性导管到外部源的引线中。 植入式探针通常意在在外科手术过程中，在治疗部位放置在患者体内，并在切口闭合后留在原位数天（或更长时间），而由LED阵列或固体产生的光 状态LD照射治疗部位。 或者，来自外部光源的光可以通过一根或多根光纤传送到设置在患者身体内部以照射治疗部位的可植入探针。 通过设置在可植入探针上的LED阵列或LD产生的废热可用于通过增加治疗部位的组织的温度来增加PDT。