公开(公告)号：US08685005B2

公开(公告)日：2014-04-01

申请号：US12445061

申请日：2007-10-11

申请人： Jonathan S. Dahm ,  William Louis Barnard ,  James C. Chen ,  David B. Shine

发明人： Jonathan S. Dahm ,  William Louis Barnard ,  James C. Chen ,  David B. Shine

IPC分类号： A61B18/18 ,  A61N5/06 ,  A61B19/00 ,  A61N1/30

CPC分类号： A61N5/062 ,  A61B18/24 ,  A61N5/0601 ,  A61N2005/0652

摘要： A light delivery system to provide light treatment to a patient includes a catheter assembly having a plurality of light sources that transmit light towards a target site within a patient. In one embodiment, the light delivery system has a plurality of light sources mounted to a flexible transparent base that extends at least partially through a distal tip of the catheter assembly. The light sources can be wire bonded or mounted in a flip chip arrangement onto the base. In one embodiment to produce the distal tip, an array of light energy sources can be held by an array of holders of a fixture device. A vacuum is applied to secure each light energy source in a corresponding holder. While the vacuum is applied, the energy sources are electrically connected by wire bonding. The vacuum can be reduced or stopped thereby permitting removal of the light energy sources from the fixture device.

摘要翻译： 向患者提供光治疗的光递送系统包括具有多个光源的导管组件，所述多个光源向患者内的目标部位透射光。 在一个实施例中，光输送系统具有安装到柔性透明基底的多个光源，其至少部分延伸穿过导管组件的远端。 光源可以引线键合或以倒装芯片布置安装在基座上。 在产生远端的一个实施例中，光能源阵列可以由固定装置的支架阵列保持。 施加真空以将每个光能源固定在相应的支架中。 当施加真空时，能量源通过引线接合电连接。 可以减少或停止真空，从而允许从固定装置移除光能源。

公开(公告)号：US20120149986A1

公开(公告)日：2012-06-14

申请号：US13401747

申请日：2012-02-21

申请人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichtlenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick YEO ,  Hugh Narciso

发明人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichtlenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick YEO ,  Hugh Narciso

IPC分类号： A61B1/06

CPC分类号： A61N5/062 ,  A61N2005/0652

摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

公开(公告)号：US08057464B2

公开(公告)日：2011-11-15

申请号：US11416783

申请日：2006-05-03

申请人： James C. Chen ,  Steven R. Daly ,  Zihong Guo ,  Llew Keltner ,  Jeffrey R. Storm

发明人： James C. Chen ,  Steven R. Daly ,  Zihong Guo ,  Llew Keltner ,  Jeffrey R. Storm

IPC分类号： A61B18/18

CPC分类号： A61N5/062 ,  A61B50/30 ,  A61N5/0601 ,  A61N2005/0645 ,  A61N2005/0652

摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.

摘要翻译： 向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。 集成光导管和控制模块与光活化药物组合使用。 所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。 防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。 为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

公开(公告)号：US20110236402A1

公开(公告)日：2011-09-29

申请号：US13154156

申请日：2011-06-06

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： A61K39/395 ,  A61P35/00

CPC分类号： A61K41/0038 ,  A61K2039/545 ,  A61N5/06 ,  C07K16/2818

摘要： The efficacy of light activated therapy treatment is enhanced by stimulating the immune system of the patient substantially above a normal level. Abnormal tissue that is destroyed by the light activated therapy releases factors that stimulate the immune system, leading to systemic reductions in abnormal tissue (i.e., reduction beyond the region treated using light). By further stimulating the immune system using an anti-CTLA-4 antibody, the systemic destruction of abnormal tissue is enhanced.

摘要翻译： 通过刺激患者的免疫系统显着高于正常水平，提高了光活化治疗的疗效。 由光活化治疗破坏的异常组织释放刺激免疫系统的因素，导致异常组织的系统性减少（即，减少超过使用光治疗的区域）。 通过使用抗CTLA-4抗体进一步刺激免疫系统，增强了异常组织的系统性破坏。

公开(公告)号：US20110077464A1

公开(公告)日：2011-03-31

申请号：US12890480

申请日：2010-09-24

申请人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61B1/06

CPC分类号： A61N5/062 ,  A61N2005/0652

摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

公开(公告)号：US20100121252A1

公开(公告)日：2010-05-13

申请号：US12522375

申请日：2008-01-08

申请人： Llew Keltner ,  James C. Chen

发明人： Llew Keltner ,  James C. Chen

IPC分类号： A61M35/00

CPC分类号： A61N5/062 ,  A61B18/203 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2090/0436 ,  A61B2090/049 ,  A61N5/0616 ,  A61N2005/0645 ,  A61N2005/0652

摘要： An energy treatment system to treat a patient includes an energy delivery device having a plurality of energy emitters used in combination with an energy activatable drug. A mask can be used to define a treatment area. Energy from the energy emitters passes through an optical window of the mask to activate a cosmetically and/or therapeutically effective amount of the activatable drug at the target site to bring about a desired change of tissue, for example, to reduce visibility of one or more blood vessels, while energy from the energy emitters directed outside of the target site is blocked by the mask.

摘要翻译： 用于治疗患者的能量治疗系统包括具有与能量可激活药物组合使用的多个能量发射器的能量输送装置。 面罩可用于定义治疗区域。 来自能量发射器的能量通过掩模的光学窗口，以在目标位置激活美容和/或治疗有效量的可激活药物，以产生组织的期望变化，例如降低一个或多个 而来自引导到目标部位外部的能量发射器的能量被掩模阻挡。

公开(公告)号：US07117118B2

公开(公告)日：2006-10-03

申请号：US10911904

申请日：2004-08-04

申请人： Matthew J. Kalos ,  Michael T. Benhase ,  James C. Chen ,  Patricia C. Lu

发明人： Matthew J. Kalos ,  Michael T. Benhase ,  James C. Chen ,  Patricia C. Lu

IPC分类号： G06F15/00 ,  G06F17/18 ,  G06F19/00

CPC分类号： G06F11/3409 ,  G06F3/0605 ,  G06F3/0653 ,  G06F3/067 ,  G06F11/3485 ,  G06F2201/88

摘要： Computer networks are provided with a resource efficient ability to generate link performance statistics. Two counters accumulates the number of I/O operations processed by a link and the time required by the link to complete each I/O operation. The average link utilization per I/O operation may then be calculated. The number of operations per second for a link may be computed by dividing the output from the first counter by a predetermined period of time and the average number of operations using the link may be computed by dividing the output from the second counter by the predetermined period of time. An optional third counter may be employed to accumulate the number of bytes transferred by a link during each I/O operation and used to compute the average size of an I/O operation. The generated statistics are useful for such activities as problem resolution, load balancing and capacity planning.

摘要翻译： 计算机网络具有生成链路性能统计资源的资源有效能力。 两个计数器累加链接处理的I / O操作的数量以及链接完成每个I / O操作所需的时间。 然后可以计算每个I / O操作的平均链路利用率。 可以通过将来自第一计数器的输出除以预定时间段来计算链路每秒的操作次数，并且可以通过将来自第二计数器的输出除以预定周期来计算使用该链路的平均操作次数 的时间。 可以使用可选的第三计数器来累积每个I / O操作期间由链路传送的字节数，并用于计算I / O操作的平均大小。 生成的统计信息对于解决问题，负载平衡和容量规划等活动非常有用。

公开(公告)号：US06657351B2

公开(公告)日：2003-12-02

申请号：US09910364

申请日：2001-07-20

申请人： James C. Chen ,  Darrin Huston ,  Brian D. Wilkerson

发明人： James C. Chen ,  Darrin Huston ,  Brian D. Wilkerson

IPC分类号： H02K3300

CPC分类号： A61N1/08 ,  A47J36/02 ,  A47J36/26 ,  A61F2250/0001 ,  A61N1/3787 ,  H01F38/12 ,  H01F38/14 ,  H01M10/46 ,  H01M10/48 ,  H02K5/1282 ,  H02K7/1807 ,  H02K7/1876 ,  H02K21/12 ,  H02K21/24 ,  H02K35/02 ,  H05B6/1236 ,  Y02B40/123

摘要： A flux generator base unit electromagnetically coupled with a receiving unit to transfer energy into the receiving unit. The base unit includes one or more permanent magnets that produce a magnetic flux, which passes through a receiver coil in the receiving unit. The receiver coil is either disposed in a separate housing that is electrically connected with a portable device, or integrated into the housing of the portable device. Either the permanent magnets or a flux shunt is moved in the base unit to produce the varying magnetic flux that is coupled to the receiver coil. As a result of the varying magnetic field experienced by the receiver coil, an electric current is induced in the receiver coil, which is conditioned (e.g., rectified, filtered, and regulated) by a conditioning circuit to charge a battery or energize electronics contained in the portable device. Various embodiments of both the base unit and receiving unit are disclosed, including “universal” base units suitable for operation with different size receiving units.

摘要翻译： 与接收单元电磁耦合以将能量传递到接收单元中的通量发生器基座单元。 基座单元包括产生磁通的一个或多个永久磁铁，其通过接收单元中的接收器线圈。 接收器线圈或者被布置在与便携式设备电连接或者集成到便携式设备的外壳中的分离的外壳中。 永磁体或磁通分流器在基本单元中移动以产生耦合到接收器线圈的变化的磁通量。 作为接收器线圈所经历的变化的磁场的结果，在接收器线圈中感应出电流，该接收器线圈由调节电路调节（例如，整流，滤波和调节），以对电池充电或激励包含在 便携式设备。 公开了基本单元和接收单元的各种实施例，包括适用于具有不同尺寸接收单元的操作的“通用”基本单元。

公开(公告)号：US06470421B1

公开(公告)日：2002-10-22

申请号：US09632413

申请日：2000-08-04

申请人： Thao B. Bui ,  James C. Chen ,  Chan Y. Ng

发明人： Thao B. Bui ,  James C. Chen ,  Chan Y. Ng

IPC分类号： G06F1200

CPC分类号： G06F3/061 ,  G06F3/0638 ,  G06F3/065 ,  G06F3/0689 ,  G06F12/0866

摘要： A staging method and means for both device read and update write operations in which messages and commands between a storage subsystem and a fixed-block formatted RAID array emulating a variable-length record (CKD) formatted device for both read and write operations are evaluated to ascertain whether the record addressing was random and truly in record mode. If they are in that mode, then partial track staging by the RAID array control from the fixed-block formatted HDDs to a subsystem cache or the like would reduce device contention by reading and staging less than full track.

摘要翻译： 用于设备读取和更新写入操作的分段方法和装置，其中存储子系统和固定块格式的RAID阵列之间的消息和命令模拟用于读取和写入操作的可变长度记录（CKD）格式化的设备被评估为 确定记录寻址是否是随机的，真正的记录模式。 如果它们处于该模式，则通过RAID阵列控制从固定块格式的HDD到子系统高速缓存等的部分跟踪分级将通过读取和分期小于全部轨道来减少设备争用。

公开(公告)号：US06222644B1

公开(公告)日：2001-04-24

申请号：US08679595

申请日：1996-07-19

申请人： James C. Chen ,  Lin Sung-Hui

发明人： James C. Chen ,  Lin Sung-Hui

IPC分类号： G03G2100

CPC分类号： G06K9/2054 ,  H04N1/00795 ,  H04N2201/0422

摘要： The invention relates to a card reader kit for scanning a plurality of small documents by using an image scanner and a computer system, and generating a document image file for each of the small documents automatically. The card reader kit comprises a plurality of blocks for placing the small documents and the system comprises a form file which comprises the location of each block on the card reader kit. The method comprises the steps of: (1) placing each of the small documents on one block of the card reader kit; (2) scanning the card reader kit coupled with the small documents into the system to generate a master image file; (3) processing the master image file by using the form file to generate a document image file for each of the small documents.

摘要翻译： 本发明涉及一种用于通过使用图像扫描仪和计算机系统来扫描多个小文档的读卡器套件，并且自动生成每个小文件的文档图像文件。 读卡器套件包括用于放置小文件的多个块，并且系统包括一个格式文件，其中包括每个块在读卡器套件上的位置。 该方法包括以下步骤：（1）将每个小文档放置在读卡器的一个块上;（2）将与小文档耦合的读卡器套件扫描到系统中以生成主映像文件;（3） ）通过使用表单文件来处理主图像文件，以生成每个小文档的文档图像文件。