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    Treatment of urinary incontinence and other disorders by application of energy and drugs
    5.
    发明授权
    Treatment of urinary incontinence and other disorders by application of energy and drugs 有权
    通过应用能量和药物治疗尿失禁和其他疾病

    公开(公告)号：US06692490B1

    公开(公告)日：2004-02-17

    申请号：US09407658

    申请日：1999-09-28

    Applicant: Stuart D. Edwards

    Inventor： Stuart D. Edwards

    IPC: A61B1818

    CPC classification number: A61F5/0026 ,  A61B18/02 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/24 ,  A61B2017/00084 ,  A61B2017/22062 ,  A61B2018/00029 ,  A61B2018/00065 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00238 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00482 ,  A61B2018/00494 ,  A61B2018/00505 ,  A61B2018/00517 ,  A61B2018/00523 ,  A61B2018/00654 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00898 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/0436 ,  A61B2090/3614 ,  A61B2218/002 ,  A61B2218/007 ,  A61M25/1011 ,  A61M2025/105 ,  A61M2210/1053 ,  A61N1/06 ,  A61N1/36007 ,  A61N1/36017 ,  A61N5/0601 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/061

    Abstract: The invention provides a method and system for treating disorders of the genito-urinary tract and other disorders in other parts of the body. A particular treatment can include one or more of, or some combination of ablation, nerve modulation, three-dimensional tissue shaping, drug delivery, mapping, stimulating, shrinking (by creation of a pattern of thermal lesions) and reducing strain on structures by altering the geometry thereof and providing bulk to particularly defined regions. The particular body structures or tissues can include one or more of, or some combination of regions, including the bladder, esophagus, vagina, penis, larynx, pharynx, aortic arch, abdominal aorta, thoracic aorta, large intestine, small intestine, sinus, auditory canal, uterus, vas deferens, trachea and all associated sphincters. In one aspect of the invention, a catheter is deployed in the body. It may enter the body via a natural orifice, a stoma, or a surgically created opening that is made for the purpose of inserting the catheter. Insertion may be facilitated with the use of a guide wire or a generic support structure or visualization apparatus. In second aspect of the invention, the treatment can include application of energy and substances to effect changes in the target tissue. Types of energy that can be applied include radiofrequency, laser, microwave, infrared waves, ultrasound or some combination thereof. Types of substances that can be applied include pharmaceutical agents such as analgesics, antibiotics and anti-inflammatory drugs, bulking agents such as biologically nonreactive particles, cooling fluids or dessicants such as liquid nitrogen for use in cryo-based treatments.

    Abstract translation: 本发明提供了一种治疗身体其他部位的泌尿系泌尿系疾病和其他疾病的方法和系统。 特定治疗可以包括消融，神经调节，三维组织形成，药物递送，映射，刺激，收缩（通过产生热病变的模式）中的一种或多种或一些组合，并通过改变减少结构上的应变 其几何形状并且向特别限定的区域提供体积。 特定的身体结构或组织可以包括一些或多个区域，包括膀胱，食管，阴道，阴茎，喉，咽，主动脉弓，腹主动脉，胸主动脉，大肠，小肠，窦， 听觉器官，子宫，输精管，气管和所有相关的括约肌。 在本发明的一个方面，导管部署在体内。 它可以通过自然孔，造口或外科手术创建的开口进入身体，该开口用于插入导管。 通过使用导丝或通用支撑结构或可视化装置可以促进插入。 在本发明的第二方面，治疗可以包括施加能量和物质以实现目标组织的变化。 可应用的能量类型包括射频，激光，微波，红外波，超声波或其某些组合。 可以应用的物质的类型包括药剂如镇痛药，抗生素和抗炎药，膨胀剂如生物非反应性颗粒，冷却液或干燥剂如液氮，用于低温治疗。

    Endoscope utilizing a fiber optic holding tube with a jacket slit for lateral placement of the fiber optic
    6.
    发明授权
    Endoscope utilizing a fiber optic holding tube with a jacket slit for lateral placement of the fiber optic 失效
    内窥镜利用具有护套狭缝的光纤保持管用于光纤的横向放置

    公开(公告)号：US5921916A

    公开(公告)日：1999-07-13

    申请号：US612886

    申请日：1996-06-11

    Applicant: Bernhard Aeikens ,  Thorsten Ahrens ,  Rudiger Schwagler ,  Clemens Scholz

    Inventor： Bernhard Aeikens ,  Thorsten Ahrens ,  Rudiger Schwagler ,  Clemens Scholz

    IPC: A61B17/00 ,  A61B18/14 ,  A61B18/24 ,  A61N5/06 ,  A61B17/36

    CPC classification number: A61B18/245 ,  A61B18/14 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61N2005/061

    Abstract: An endoscope, in particular for applications in urology, has a hollow shaft (10), an optical viewing system (12) which can be inserted in the hollow shaft (10) and has a fiber-optic illumination system, an optical fiber (16) which can be introduced with the optical system (12) into the hollow shaft (10) and connected at its proximal end to an external laser source and is bent at its distal end away from the shaft axis. In order to allow irradiation of tissue lying closely packed around the hollow shaft, an indeformable holding tube (14) which is parallel to the optical system (12) and passes through the hollow shaft (10) is provided; this tube accommodates the optical fiber (16) and its distal end is bent at a fixed angle in relation to the shaft axis and accommodated entirely within the shaft cross-section. A spacer (36) with a radiation window (32) ensures that the tissue to be irradiated cannot lie next to the point (18) at which light emerges from the optical fiber (16).

    Abstract translation: PCT No.PCT / EP95 / 02623 Sec。 371日期：1996年6月11日 102（e）日期1996年6月11日PCT提交1995年7月6日PCT公布。 公开号WO96 / 01589 日期1996年1月25日内窥镜，特别是在泌尿科应用中，具有中空轴（10），可以插入中空轴（10）中的光学观察系统（12）并具有光纤照明系统， 可以将光学系统（12）引入中空轴（10）并且在其近端处连接到外部激光源并且在其远端处远离轴线弯曲的光纤（16）。 为了允许照射密封在中空轴周围的组织，提供了平行于光学系统（12）并穿过中空轴（10）的不可变形的保持管（14）。 该管容纳光纤（16），其远端相对于轴线以固定角度弯曲并且完全容纳在轴横截面内。 具有辐射窗（32）的间隔物（36）确保被照射的组织不能位于光从光纤（16）出射的点（18）旁边。

    Implanting and fixing a flexible probe for administering a medical therapy at a treatment site within a patient'body
    7.
    发明授权
    Implanting and fixing a flexible probe for administering a medical therapy at a treatment site within a patient'body 失效
    植入和固定用于在患者体内的治疗部位进行药物治疗的柔性探针

    公开(公告)号：US5766234A

    公开(公告)日：1998-06-16

    申请号：US633171

    申请日：1996-04-16

    Applicant: James C. Chen ,  Brent Wiscombe

    Inventor： James C. Chen ,  Brent Wiscombe

    IPC: A61B5/04 ,  A61B17/00 ,  A61B17/04 ,  A61B19/00 ,  A61N1/00 ,  A61N5/06 ,  A61N7/00

    CPC classification number: A61B17/00234 ,  A61N5/0601 ,  A61N5/062 ,  A61B2017/00243 ,  A61B2017/00274 ,  A61B2017/0404 ,  A61B2017/0458 ,  A61B2018/00547 ,  A61N2005/061 ,  A61N2005/0645 ,  A61N2005/0652

    Abstract: A plurality of embodiments for a flexible probe used to provide photodynamic therapy (PDT) and to effect other medical procedures at an internal treatment site inside a patient's body. Each of the embodiments of the flexible probe (100, 108, 130, 158, 182, 190, 220, 280, 370, 390, 440, 460, 520) includes a flexible substrate (102, 184, 196, 222, 250, 282, 412, 462, 482, 502, 522) on which are disposed conductive traces (414, 466, 468, 488, 490, 504, 506, 524, 526) electrically connected to leads through which electrical current and signals are conveyed. A plurality of light sources (104, 192, 256, 286, 418, 436, 470, 492, 508, 542) or other micro-electronic circuits are connected to the conductive traces and mounted on the flexible substrate. Each of the embodiments of the flexible probes is enclosed within a transparent, biocompatible polymer envelope (106, 110, 464, 522). Due to the characteristic elastic properties of the flexible substrate, the flexible probe can readily be bent, folded, or rolled while being disposed at the internal treatment site. Thus, for example, a curved surgical needle (650) can be used to implant a flexible probe at the treatment site by drawing the flexible probe through tissue along a curved path to a desired position; one or more disk-shaped buttons (660, 670) that are attached to the ends of the flexible probe can be used to secure the flexible probe so that it does not move from the desired position.

    Abstract translation: 用于提供光动力治疗（PDT）的柔性探针的多个实施例，并且在患者体内的内部治疗部位进行其它医疗程序。 柔性探针（100,108,130,158,182,190,220,280,370,390,440,460,520）的每个实施例包括柔性基底（102,184,196,222,250， 282,412,462,482,502,522），其上设置有电连接到通过其传送电流和信号的引线的导电迹线（414,466,468,48,490,504,506,524,526）。 多个光源（104,192,256,286,418,436,470,492,504,542）或其它微电子电路连接到导电迹线并且安装在柔性基板上。 柔性探针的每个实施例被封装在透明的生物相容性聚合物封套（106,110,464,522）内。 由于柔性基板的特征弹性特性，柔性探针可以容易地弯曲，折叠或卷起，同时处于内部处理部位。 因此，例如，弯曲外科手术针（650）可以用于通过将柔性探针通过组织沿弯曲路径拉伸到期望位置来在治疗部位植入柔性探针; 可以使用附接到柔性探针的端部的一个或多个盘形按钮（660,670）来固定柔性探针，使得其不会从期望的位置移动。

    Urethral inserted applicator prostate hyperthermia
    8.
    发明授权
    Urethral inserted applicator prostate hyperthermia 失效

    公开(公告)号：US5344435A

    公开(公告)日：1994-09-06

    申请号：US609372

    申请日：1990-11-05

    Applicant: Paul F. Turner ,  Theron N. Schaefermeyer ,  Amer M. Tumeh ,  Philip A. Terry

    Inventor： Paul F. Turner ,  Theron N. Schaefermeyer ,  Amer M. Tumeh ,  Philip A. Terry

    IPC: A61N5/04 ,  A61B5/00 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/18 ,  A61F7/12 ,  A61M1/00 ,  A61N5/00 ,  A61N5/06 ,  A61N7/02 ,  A61N5/02

    CPC classification number: A61N5/0601 ,  A61B18/18 ,  A61B18/1815 ,  A61B5/01 ,  A61N7/022 ,  A61B17/2202 ,  A61B2017/00057 ,  A61B2017/00084 ,  A61B2017/00132 ,  A61B2017/00274 ,  A61B2017/22021 ,  A61B2018/00035 ,  A61B2018/00166 ,  A61B2018/00547 ,  A61F7/12 ,  A61M2025/0177 ,  A61N2005/007 ,  A61N2005/061

    Abstract: A method for the treatment of the prostate gland which heats the tissues which would otherwise be surgically removed with a trans-urethral resection of the prostate. This method is accomplished by combining a radiating energy device integrated with a urinary drainage Foley type catheter, which is modified to provide cooling along the urethra surfaces. The radiating device also serves as a means to measure the tissue radiated thermal energy for the control or monitoring of temperature of the prostate tissues being heated. A urethral inserted applicator for prostate hyperthermia includes a multi-tube, balloon type catheter. The catheter includes a fluid dry tube for an energy radiator antenna applicator which also serves as a radiometric temperature sensor for measuring the temperature of the prostate tissue, and an open fluid receiving tube. An electromagnetic energy generator supplies electromagnetic energy to the applicator. A comparator is connected to the temperature output of the radiometer, and a temperature reference potentiometer for comparing the actual tissue temperature level with a desired temperature level and outputting control signals to the electromagnetic generator for controlling the output to the applicator. The microwave operated applicator is preferably an elongated coil having the tip end connected to the center conductor of a coaxial cable and the opposite end connected to the outer conductor of the coaxial cable. A sheet or sheath of insulation material covers the microwave coil antenna for insulating the coil from the tissue and the thickness of the sheet may be varied to provide uniform tissue heating along the length of the coil. The ultrasound operated applicator is preferably one or more ultrasound crystal cylinders to radiate energy into the tissue and convert tissue thermal ultrasonic energy into electrical energy for measurement by a radiometer, The balloon of the catheter engages the body's bladder to position the applicator properly during the treatment.

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