-
公开(公告)号:US08293897B2
公开(公告)日:2012-10-23
申请号:US12576375
申请日:2009-10-09
申请人: Ning Xi
发明人: Ning Xi
IPC分类号: A61P35/04 , C07D403/14 , C07D413/14 , C07D471/04
CPC分类号: A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D471/04 , C07D491/107 , C07D493/10 , C07D495/04 , C07D498/04 , C07D519/00
摘要: The present invention provides novel compounds useful in modulating the protein tyrosine kinase activity, and in modulating inter—and/or intra—cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
摘要翻译: 本发明提供了可用于调节蛋白酪氨酸激酶活性和调节细胞间和/或细胞内信号传导的新型化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗哺乳动物,特别是人类中过度增殖性疾病的方法。
-
公开(公告)号:US20120107275A1
公开(公告)日:2012-05-03
申请号:US13323692
申请日:2011-12-12
申请人: Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
发明人: Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号: A61K31/5025 , A61K31/5377 , C07D498/04 , A61K31/538 , A61K38/21 , A61P31/00 , A61P3/00 , A61P5/00 , A61P37/00 , C07D487/04 , A61P35/00
CPC分类号: C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
-
公开(公告)号:US20120070413A1
公开(公告)日:2012-03-22
申请号:US13308310
申请日:2011-11-30
申请人: Tae-Seong KIM , David Bauer , Steven Bellon , Alessadro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人: Tae-Seong KIM , David Bauer , Steven Bellon , Alessadro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号: A61K38/21 , A61K31/497 , A61K31/5377 , A61P35/00 , A61K31/437 , A61K31/519 , A61K31/4184 , A61K31/501 , A61K31/4709 , A61K31/4365
CPC分类号: C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号:US08079278B2
公开(公告)日:2011-12-20
申请号:US11989036
申请日:2006-07-21
申请人: Ning Xi , Uchechukwu Wejinya , Yantao Shen
发明人: Ning Xi , Uchechukwu Wejinya , Yantao Shen
CPC分类号: B81C99/002 , Y10S977/872 , Y10T29/49998 , Y10T29/53991
摘要: An end-effector is provided for use on a micro/nano manipulation device. The end-effector is comprised of: a micropump fluidly coupled to a microtube; a piezoelectric sensing structure disposed in the microtube; and a processing circuit electrically coupled to the sensing structure for determining the force of the fluid flowing through the microtube. The end-effector is a closed loop control-enabled micro/nano manipulation system.
摘要翻译: 提供用于微/纳米操纵装置的末端执行器。 末端执行器包括:流体耦合到微管的微型泵; 设置在微管中的压电感测结构; 以及电耦合到感测结构以用于确定流过微管的流体的力的处理电路。 末端执行器是一个闭环控制的微/纳米操纵系统。
-
公开(公告)号:US07928140B2
公开(公告)日:2011-04-19
申请号:US12221416
申请日:2008-08-01
申请人: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
发明人: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
IPC分类号: A61K31/38
CPC分类号: C07D277/82 , C07D413/04 , C07D417/04 , C07D417/14 , C07D513/04
摘要: The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译: 本发明包括能够调节PI3激酶活性的新一类化合物,因此可用于治疗PI3激酶介导的疾病,包括黑素瘤,癌和其它癌症相关病症。 所述化合物具有通式I,其中A1,A2,A3,A4,X,R1和R2各自在本文中定义。 本发明还包括药物组合物,治疗PI3激酶介导的疾病的方法,以及可用于制备本发明化合物的中间体和方法。
-
公开(公告)号:US20090318436A1
公开(公告)日:2009-12-24
申请号:US12287791
申请日:2008-10-14
申请人: Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michelle Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
发明人: Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michelle Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号: A61K31/5355 , C07D487/02 , A61K31/5025 , C07D413/14 , C07D471/02 , A61K31/437 , A61K31/53 , C07D498/02 , A61K31/4355 , A61P35/00
CPC分类号: C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
-
公开(公告)号:US20090124612A1
公开(公告)日:2009-05-14
申请号:US11879034
申请日:2007-07-13
申请人: Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
发明人: Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号: A61K31/5377 , C07D487/04 , C07D471/04 , A61P35/04 , A61K31/437 , A61K31/5025
CPC分类号: C07D471/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号:US20090124609A1
公开(公告)日:2009-05-14
申请号:US12009123
申请日:2008-01-15
申请人: Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
发明人: Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号: A61K31/538 , C07D487/02 , A61K31/5025 , C07D413/14 , A61K31/5377 , A61P35/00 , C07D471/02 , A61K31/437 , A61K31/53 , C07D265/36
CPC分类号: A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
-
公开(公告)号:US07297946B2
公开(公告)日:2007-11-20
申请号:US11205201
申请日:2005-08-16
申请人: Ning Xi , Guangyong Li , Heping Chen
发明人: Ning Xi , Guangyong Li , Heping Chen
摘要: An automated nanomanipulation system is provided for manufacturing a nanoscale structure. The system includes: a design model for the nanoscale structure; image data of a sample surface upon which the nanoscale structure is to be manufactured; a movable member configured to perform a nanomanipulation operation on the sample surface; and a path planning subsystem adapted to receive the design model and the image data. The path planning subsystem generates path data indicative of a path for traversing the movable member along the sample surface such that the movable member manipulates one or more randomly distributed nanoobjects in accordance with the design model.
-
公开(公告)号:US20060284118A1
公开(公告)日:2006-12-21
申请号:US11452891
申请日:2006-06-14
申请人: Jes Asmussen , Timothy Grotjohn , Ning Xi , Timothy Hogan
发明人: Jes Asmussen , Timothy Grotjohn , Ning Xi , Timothy Hogan
IPC分类号: H01J37/08
CPC分类号: H01J37/32366 , H01J37/32357
摘要: An apparatus and process for manufacturing changes of a substrate in a work region which is 100×100×100 microns or smaller is described. The apparatus uses a plasma source adjacent to the work region to produce radiation or matter which changes the surface. An atomic force microscope or laser can be used in addition. The process and apparatus can be used to produce MEMS devices on a substrate for use in a wide variety of applications.
摘要翻译: 描述了用于制造100×100×100微米或更小的工作区域中的衬底的变化的装置和工艺。 该设备使用与工作区域相邻的等离子体源产生改变表面的辐射或物质。 另外还可以使用原子力显微镜或激光。 该方法和装置可用于在基板上制造用于各种应用的MEMS器件。
-
-
-
-
-
-
-
-
-