公开(公告)号：US08079278B2

公开(公告)日：2011-12-20

申请号：US11989036

申请日：2006-07-21

申请人： Ning Xi ,  Uchechukwu Wejinya ,  Yantao Shen

发明人： Ning Xi ,  Uchechukwu Wejinya ,  Yantao Shen

IPC分类号： B01L3/02 ,  G01N1/02 ,  G01L23/10

CPC分类号： B81C99/002 ,  Y10S977/872 ,  Y10T29/49998 ,  Y10T29/53991

摘要： An end-effector is provided for use on a micro/nano manipulation device. The end-effector is comprised of: a micropump fluidly coupled to a microtube; a piezoelectric sensing structure disposed in the microtube; and a processing circuit electrically coupled to the sensing structure for determining the force of the fluid flowing through the microtube. The end-effector is a closed loop control-enabled micro/nano manipulation system.

摘要翻译： 提供用于微/纳米操纵装置的末端执行器。 末端执行器包括：流体耦合到微管的微型泵; 设置在微管中的压电感测结构; 以及电耦合到感测结构以用于确定流过微管的流体的力的处理电路。 末端执行器是一个闭环控制的微/纳米操纵系统。

公开(公告)号：US20090217508A1

公开(公告)日：2009-09-03

申请号：US11989036

申请日：2006-07-21

申请人： Ning Xi ,  Uchechukwu Wejinya ,  Yantao Shen

发明人： Ning Xi ,  Uchechukwu Wejinya ,  Yantao Shen

IPC分类号： B81C3/00 ,  B81C5/00

CPC分类号： B81C99/002 ,  Y10S977/872 ,  Y10T29/49998 ,  Y10T29/53991

摘要： An end-effector is provided for use on a micro/nano manipulation device. The end-effector is comprised of: a micropump fluidly coupled to a microtube; a piezoelectric sensing structure disposed in the microtube; and a processing circuit electrically coupled to the sensing structure for determining the force of the fluid flowing through the microtube. The end-effector is a closed loop control-enabled micro/nano manipulation system.

摘要翻译： 提供用于微/纳米操纵装置的末端执行器。 末端执行器包括：流体耦合到微管的微型泵; 设置在微管中的压电感测结构; 以及电耦合到感测结构以用于确定流过微管的流体的力的处理电路。 末端执行器是一个闭环控制的微/纳米操纵系统。

公开(公告)号：US07134349B2

公开(公告)日：2006-11-14

申请号：US10886497

申请日：2004-07-07

申请人： Ning Xi ,  Yantao Shen ,  Fathi Salem

发明人： Ning Xi ,  Yantao Shen ,  Fathi Salem

IPC分类号： G01F3/02

CPC分类号： G01Q20/04 ,  G01Q70/14

摘要： An improved microforce sensing system is provided. The microforce sensing system includes: a force sensor configured to detect a contact force exerted on a contact tip of the cantilever and operable to generate a signal indicative of the contact force, where the cantilever is constructed from a polyvinylidene fluoride material in the form of a substantially rectangular plate or other suitable shapes; and a processing circuit adapted to receive the signal from the force sensor and operable to determine the contact force exerted on the tip by integrating the signal from the force sensor.

摘要翻译： 提供了一种改进的微力传感系统。 微力感测系统包括：力传感器，其被配置为检测施加在悬臂的接触尖端上的接触力，并且可操作以产生指示接触力的信号，其中悬臂由聚偏二氟乙烯材料构成，形式为 大致矩形板或其他合适的形状; 以及处理电路，其适于从力传感器接收信号并且可操作以通过积分来自力传感器的信号来确定施加在尖端上的接触力。

公开(公告)号：US07367242B2

公开(公告)日：2008-05-06

申请号：US11366014

申请日：2006-02-27

申请人： Ning Xi ,  Yantao Shen

发明人： Ning Xi ,  Yantao Shen

IPC分类号： G01L1/10

CPC分类号： G01L1/08

摘要： An active micro-force sensor is provided for use on a micromanipulation device. The active micro-force sensor includes a cantilever structure having an actuator layer of piezoelectric material and a sensing layer of piezoelectric material bonded together. When an external force is exerted on the sensor, the sensor deforms and an applied force signal is recorded by the sensing layer. The applied force signal is then fed back to the actuating layer of the sensor via a servoed transfer function or servo controller, so that a counteracting deformation can be generated by the bending moment from the servoed actuating layer to quickly balance the deformation caused by the external micro-force. Once balanced, the sensor beam comes back to straight status and the tip will remain in its equilibrium position, thus the sensor stiffness seems to be virtually improved so that the accurate motion control of the sensor tip can be reached, especially, at the same time, the micro-force can also be obtained by solving the counteracting balance voltage applied to the actuating layer.

摘要翻译： 提供用于显微操作装置的主动微力传感器。 有源微力传感器包括具有压电材料的致动器层和压电材料的感测层结合在一起的悬臂结构。 当外力施加在传感器上时，传感器变形，施加的力信号由传感层记录。 所施加的力信号然后通过伺服传递函数或伺服控制器反馈到传感器的致动层，使得可以通过来自伺服致动层的弯矩产生抵消变形，以快速平衡由外部引起的变形 微力。 一旦平衡，传感器光束返回到直线状态，并且尖端将保持在其平衡位置，因此传感器刚度似乎被实际改善，使得可以达到传感器尖端的精确运动控制，特别是同时 ，也可以通过求解施加到致动层的抵消平衡电压来获得微力。

公开(公告)号：US20050034543A1

公开(公告)日：2005-02-17

申请号：US10886497

申请日：2004-07-07

申请人： Ning Xi ,  Yantao Shen ,  Fathi Salem

发明人： Ning Xi ,  Yantao Shen ,  Fathi Salem

IPC分类号： G01Q70/16 ,  G01N29/00

CPC分类号： G01Q20/04 ,  G01Q70/14

摘要： An improved microforce sensing system is provided. The microforce sensing system includes: a force sensor configured to detect a contact force exerted on a contact tip of the cantilever and operable to generate a signal indicative of the contact force, where the cantilever is constructed from a polyvinylidene fluoride material in the form of a substantially rectangular plate or other suitable shapes; and a processing circuit adapted to receive the signal from the force sensor and operable to determine the contact force exerted on the tip by integrating the signal from the force sensor.

摘要翻译： 提供了一种改进的微力传感系统。 微力感测系统包括：力传感器，其被配置为检测施加在悬臂的接触尖端上的接触力，并且可操作以产生指示接触力的信号，其中悬臂由聚偏二氟乙烯材料构成，形式为 大致矩形板或其他合适的形状; 以及处理电路，其适于从力传感器接收信号并且可操作以通过积分来自力传感器的信号来确定施加在尖端上的接触力。

公开(公告)号：US07982375B2

公开(公告)日：2011-07-19

申请号：US12519099

申请日：2007-12-12

申请人： Xiaobo Tan ,  Ning Xi ,  Zheng Chen ,  Yantao Shen

发明人： Xiaobo Tan ,  Ning Xi ,  Zheng Chen ,  Yantao Shen

IPC分类号： H01L41/04

CPC分类号： H01L41/042 ,  H01L41/0825 ,  Y10S310/80

摘要： An integrated sensory actuator (10) which uses an electroactive polymer is provided. The sensory actuator is comprised of an actuating member (12) made of an ionic polymer-metal composite; a sensing member (14) made of a piezoelectric material; and an insulating member (16) interposed between the actuating member and the sensing member. The sensory actuator may further include a compensation circuit adapted to receive a sensed signal from the sensing member and an actuation signal from the actuating member and compensate the sensed signal for feedthrough coupling between the actuating member and the sensing member.

摘要翻译： 提供使用电活性聚合物的综合感觉致动器（10）。 感官致动器包括由离子聚合物 - 金属复合材料制成的致动构件（12）; 由压电材料制成的检测构件（14）; 以及介于所述致动构件和所述感测构件之间的绝缘构件（16）。 感觉致动器还可以包括补偿电路，其适于从感测构件接收感测到的信号和来自致动构件的致动信号，并且补偿感测到的信号以用于致动构件和感测构件之间的馈通联接。

公开(公告)号：US20060196280A1

公开(公告)日：2006-09-07

申请号：US11366014

申请日：2006-02-27

申请人： Ning Xi ,  Yantao Shen

发明人： Ning Xi ,  Yantao Shen

IPC分类号： G01L1/10

CPC分类号： G01L1/08

摘要： An active micro-force sensor is provided for use on a micromanipulation device. The active micro-force sensor includes a cantilever structure having an actuator layer of piezoelectric material and a sensing layer of piezoelectric material bonded together. When an external force is exerted on the sensor, the sensor deforms and an applied force signal is recorded by the sensing layer. The applied force signal is then fed back to the actuating layer of the sensor via a servoed transfer function or servo controller, so that a counteracting deformation can be generated by the bending moment from the servoed actuating layer to quickly balance the deformation caused by the external micro-force. Once balanced, the sensor beam comes back to straight status and the tip will remain in its equilibrium position, thus the sensor stiffness seems to be virtually improved so that the accurate motion control of the sensor tip can be reached, especially, at the same time, the micro-force can also be obtained by solving the counteracting balance voltage applied to the actuating layer.

摘要翻译： 提供用于显微操作装置的主动微力传感器。 有源微力传感器包括具有压电材料的致动器层和压电材料的感测层结合在一起的悬臂结构。 当外力施加在传感器上时，传感器变形，施加的力信号由传感层记录。 所施加的力信号然后通过伺服传递函数或伺服控制器反馈到传感器的致动层，使得可以通过来自伺服致动层的弯矩产生抵消变形，以快速平衡由外部引起的变形 微力。 一旦平衡，传感器光束返回到直线状态，并且尖端将保持在其平衡位置，因此传感器刚度似乎被实际改善，使得可以达到传感器尖端的精确运动控制，特别是同时 ，也可以通过求解施加到致动层的抵消平衡电压来获得微力。

公开(公告)号：US20160229837A1

公开(公告)日：2016-08-11

申请号：US14880199

申请日：2015-10-10

申请人： Ning Xi ,  Minxiong Li ,  Xiaobo Li ,  Weilong Dai ,  Haiyang Hu ,  Tao Zhang ,  Wuhong Chen

发明人： Ning Xi ,  Minxiong Li ,  Xiaobo Li ,  Weilong Dai ,  Haiyang Hu ,  Tao Zhang ,  Wuhong Chen

IPC分类号： C07D401/14 ,  A61K45/06 ,  A61K31/506

CPC分类号： C07D401/14 ,  A61K31/506 ,  A61K45/06

摘要： The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

摘要翻译： 本发明提供了用于预防，控制，治疗或减轻蛋白激酶介导的疾病的严重性的新颖的杂芳基化合物，其药学上可接受的盐和制剂。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗蛋白激酶介导的疾病的方法。

公开(公告)号：US20150274704A1

公开(公告)日：2015-10-01

申请号：US14670421

申请日：2015-03-27

申请人： Ning Xi ,  Minxiong Li ,  Haiyang Hu ,  Weilong Dai

发明人： Ning Xi ,  Minxiong Li ,  Haiyang Hu ,  Weilong Dai

IPC分类号： C07D403/14 ,  A61K45/06 ,  C07D401/14 ,  A61K31/527 ,  A61K31/506

CPC分类号： C07D403/14 ,  A61K31/506 ,  A61K31/527 ,  A61K45/06 ,  C07D401/14 ,  C07D403/12 ,  C07D493/04

摘要： The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

摘要翻译： 本发明提供了用于预防，治疗或减轻蛋白激酶介导的疾病的严重性的新颖的杂芳基化合物，其药学上可接受的盐和制剂。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗蛋白激酶介导的疾病的方法。

公开(公告)号：US20150087658A1

公开(公告)日：2015-03-26

申请号：US14488296

申请日：2014-09-17

申请人： Ning Xi ,  Liang Wang ,  Tingjin Wang

发明人： Ning Xi ,  Liang Wang ,  Tingjin Wang

IPC分类号： C07D413/14 ,  C07D401/14

CPC分类号： C07D413/14 ,  A61K31/506 ,  A61K31/517 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  Y02A50/409 ,  A61K2300/00

摘要： The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.

摘要翻译： 本发明涉及新的氨基嘧啶衍生物作为游离形式的候选药物或其药学上可接受的盐形式及其制剂用于调节由PI3K酶的活性介导的病症或疾病的制备和用途。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗疾病或疾病的方法，例如PI3K酶在白细胞功能中起作用的免疫和炎症紊乱，以及与PI3K活性相关的过度增生性疾病， 包括但不限于白血病和实体瘤，哺乳动物，特别是人类。