公开(公告)号：USD666418S1

公开(公告)日：2012-09-04

申请号：US29420022

申请日：2012-05-03

申请人： Scott A. Meyer

设计人： Scott A. Meyer

公开(公告)号：US08145310B2

公开(公告)日：2012-03-27

申请号：US12217652

申请日：2008-07-07

申请人： Yanting Dong ,  Scott A. Meyer ,  Kevin John Stalsberg

发明人： Yanting Dong ,  Scott A. Meyer ,  Kevin John Stalsberg

IPC分类号： A61N1/37

CPC分类号： A61N1/371 ,  A61B5/04525

摘要： Cardiac devices and methods discriminate non-captured intrinsic beats during evoked response detection and classification by comparing the features of a post-pace cardiac signal with expected features associated with a non-captured response with intrinsic activation. Detection of a non-captured response with intrinsic activation may be based on the peak amplitude and timing of the cardiac signal. The methods may be used to discriminate between a fusion or capture beat and a non-captured intrinsic beat. Discriminating between possible cardiac responses to the pacing pulse may be useful, for example, during automatic capture verification and/or a capture threshold test.

摘要翻译： 心脏装置和方法通过将后期心脏信号的特征与与未捕获的应答相关联的预期特征与内在激活进行比较来区分诱发反应检测和分类期间的非捕获固有搏动。 利用内在激活的非捕获响应的检测可以基于心脏信号的峰值振幅和定时。 该方法可以用于区分融合或捕获节拍和未捕获的固有节拍。 对起搏脉冲的可能的心脏反应之间的区分可能是有用的，例如在自动捕获验证和/或捕获阈值测试期间。

公开(公告)号：US08116871B2

公开(公告)日：2012-02-14

申请号：US12409348

申请日：2009-03-23

申请人： Yi Zhang ,  Jiang Ding ,  Aaron McCabe ,  Scott A. Meyer

发明人： Yi Zhang ,  Jiang Ding ,  Aaron McCabe ,  Scott A. Meyer

IPC分类号： A61N1/08 ,  A61N1/37 ,  A61B5/0452

CPC分类号： A61N1/3712 ,  A61N1/365

摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed for automatic capture verification using cardiac activation sequence information. Devices and methods sense composite cardiac signals using implantable electrodes. A source separation is performed using the composite signals. One or more signal vectors are produced that are associated with all or a portion of one or more cardiac activation sequences based on the source separation. A cardiac response to the pacing pulses is classified using characteristics associated with cardiac signal vectors and the signals associated with the vectors. Further embodiments may involve classifying the cardiac response as capture or non-capture, fusion or intrinsic cardiac activity. The characteristics may include an angle or an angle change of the cardiac signal vectors, such as a predetermined range of angles of the one or more cardiac signal vectors.

摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离被用于使用心脏激活序列信息的自动捕获验证。 装置和方法使用可植入电极感测复合心脏信号。 使用复合信号进行源分离。 产生与基于源分离的一个或多个心脏激活序列的全部或一部分相关联的一个或多个信号载体。 使用与心脏信号矢量相关联的特征和与矢量相关联的信号来分类对起搏脉冲的心脏反应。 进一步的实施方案可以包括将心脏反应分类为捕获或非捕获，融合或内在心脏活动。 特征可以包括心脏信号矢量的角度或角度变化，例如一个或多个心脏信号矢量的预定角度范围。

公开(公告)号：US08073202B2

公开(公告)日：2011-12-06

申请号：US12709234

申请日：2010-02-19

申请人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

发明人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

IPC分类号： G06K9/00 ,  G11B9/02

CPC分类号： A61B5/0066 ,  G06T7/0014 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10101 ,  G06T2207/30041 ,  G06T2210/41

摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

摘要翻译： 本发明公开了一种用于产生相对于拟合的参考表面的组织层/边界的仰角图或图像的方法，包括以下步骤：找到并分割所需的组织层/边界; 将平滑的参考表面拟合到分段的组织层/边界; 计算相对于拟合参考表面的相同或其它组织层/边界的高度; 并产生相对于拟合表面的高程图。 高程可以以各种方式显示，包括三维表面效果图，地形轮廓图，轮廓图，面孔颜色图和面对灰度图。 也可以将高程组合并同时显示另一个组织层/边界依赖的图像数据集，以提供用于诊断的附加信息。

公开(公告)号：US20110137192A1

公开(公告)日：2011-06-09

申请号：US13027608

申请日：2011-02-15

申请人： Yi Zhang ,  Carlos Alberto Ricci ,  Jeffrey E. Stahmann ,  Aaron R. McCabe ,  Scott A. Meyer ,  Yinghong Yu

发明人： Yi Zhang ,  Carlos Alberto Ricci ,  Jeffrey E. Stahmann ,  Aaron R. McCabe ,  Scott A. Meyer ,  Yinghong Yu

IPC分类号： A61B5/0402

CPC分类号： A61B5/04011 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些功能的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。 本发明的实施方案一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。 本发明的实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。 使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。 使用一个或多个心脏信号载体来区分心律失常。

公开(公告)号：US07878651B2

公开(公告)日：2011-02-01

申请号：US12336252

申请日：2008-12-16

申请人： Keith E. O'Hara ,  Scott A. Meyer

发明人： Keith E. O'Hara ,  Scott A. Meyer

IPC分类号： A61B3/107

CPC分类号： G01B9/02077 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02072 ,  G01B9/02078 ,  G01B9/02091 ,  G01B11/2441

摘要： An optical coherence tomography apparatus and method for measuring refractive power of the human cornea is disclosed. The apparatus collects both the specularly reflected light from the anterior surface of the cornea and diffusely reflected light from the interior of the cornea. The combined refractive power of both surfaces of the cornea is determined.

摘要翻译： 公开了一种用于测量人角膜屈光力的光学相干断层摄影装置和方法。 该装置收集来自角膜前表面的镜面反射光和来自角膜内部的漫反射光。 确定角膜两个表面的组合屈光力。

公开(公告)号：US20100298729A1

公开(公告)日：2010-11-25

申请号：US12847657

申请日：2010-07-30

申请人： Yi Zhang ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Marina Brockway ,  Aaron R. McCabe ,  Yinghong Yu ,  Donald L. Hopper

发明人： Yi Zhang ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Marina Brockway ,  Aaron R. McCabe ,  Yinghong Yu ,  Donald L. Hopper

IPC分类号： A61B5/0452

CPC分类号： A61N1/3702 ,  A61B5/0452 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.

摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。 缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。 可以使用后续分离来检测信号矢量的变化。 该变化可以是心​​脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。 该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。 与矢量相关联的信息可以被存储并用于跟踪矢量。

公开(公告)号：US20100256703A1

公开(公告)日：2010-10-07

申请号：US12818066

申请日：2010-06-17

申请人： Scott A. Meyer ,  Yanting Dong ,  Jeremy Maniak ,  Doug Birholz ,  John Voegele

发明人： Scott A. Meyer ,  Yanting Dong ,  Jeremy Maniak ,  Doug Birholz ,  John Voegele

IPC分类号： A61N1/08 ,  A61N1/362

CPC分类号： A61B5/7264 ,  A61B5/04525 ,  A61B5/7217 ,  A61N1/371

摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a retriggerable cardiac response classification window. A first cardiac response classification window is established subsequent to delivery of a pacing pulse. A cardiac signal following the pacing stimulation is sensed in the first classification window. A second cardiac response classification may be triggered if a trigger characteristic is detected in the first classification window. The cardiac signal is sensed in the second classification window if the second classification window is established. The cardiac response to the pacing stimulation is determined based on characteristics of the cardiac signal. The cardiac response may be determined to be one of a captured response, a non-captured response, a non-captured response added to an intrinsic beat, and a fusion/pseudofusion beat, for example.

摘要翻译： 用于分类心脏起搏应答的方法和装置包括建立可再触发的心脏反应分类窗口。 在递送起搏脉冲之后建立第一心脏响应分类窗口。 起搏刺激后的心脏信号在第一分类窗口中被感测。 如果在第一分类窗口中检测到触发特性，则可以触发第二心跳响应分类。 如果建立第二分类窗口，则在第二分类窗口中感测到心脏信号。 基于心脏信号的特征来确定对起搏刺激的心脏反应。 可以将心脏反应确定为例如捕获的应答，非捕获响应，添加到固有搏动的非捕获响应以及融合/假融合搏动之一。

公开(公告)号：USD624341S1

公开(公告)日：2010-09-28

申请号：US29351318

申请日：2009-12-03

申请人： Phillip L. Noren ,  Scott A. Meyer ,  Michael M. Habig ,  Sam J. Clavette ,  Stacy L. Abel

设计人： Phillip L. Noren ,  Scott A. Meyer ,  Michael M. Habig ,  Sam J. Clavette ,  Stacy L. Abel

公开(公告)号：US07798647B2

公开(公告)日：2010-09-21

申请号：US12207303

申请日：2008-09-09

申请人： Scott A. Meyer ,  Mary K. Durbin ,  Paul F. Stetson ,  Bagrat Amirbekian

发明人： Scott A. Meyer ,  Mary K. Durbin ,  Paul F. Stetson ,  Bagrat Amirbekian

IPC分类号： A61B3/00

CPC分类号： A61B3/12 ,  A61B3/1241

摘要： One embodiment of the present invention accounts for individual anatomical variation when evaluating optical nerve fiber measurements. In one aspect, contextual information is used to compensate or correct measurement data. In another aspect, reference coordinates are remapped for improved comparison or visualization. In one embodiment of this latter aspect, the method uses measurements of nerve fiber capacity and maps of nerve fiber retinal service to improve sensitivity and specificity in eye function metrics. In one instance, we use the birefringence of nerve fibers to determine the orientation of the fibers within the RNFL. Orientation of the fibers about the ONH is indicative of the service provided by the fibers and is used to improve the interpretation of thickness measurements of the nerve fiber layer. Normalized nerve fiber measurements about the optic nerve head improve specificity and sensitivity as compared to the standard model. These improvements are a result of partitioning the normative database or modifying the measurement data prior to comparison. Statistics on normalized measurements of nerve fiber bundles also show improvements in specificity and sensitivity.

摘要翻译： 评估光学神经纤维测量时，本发明的一个实施例解释了个体解剖学变化。 在一个方面，使用上下文信息来补偿或校正测量数据。 在另一方面，重新映射参考坐标以改善比较或可视化。 在后一方面的一个实施例中，该方法使用神经纤维能力的测量和神经纤维视网膜服务的图来提高眼睛功能度量中的灵敏度和特异性。 在一种情况下，我们使用神经纤维的双折射来确定RNFL内纤维的取向。 关于ONH的纤维的取向指示由纤维提供的服务，并且用于改善对神经纤维层的厚度测量的解释。 与标准模型相比，关于视神经头的规范化神经纤维测量提高了特异性和灵敏度。 这些改进是在比较之前划分规范性数据库或修改测量数据的结果。 关于神经纤维束的归一化测量的统计数据也显示出特异性和灵敏度的改善。