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81.发明申请公开(公告)号：US20080286214A1
公开(公告)日：2008-11-20
申请号：US12094817
申请日：2006-11-21
申请人： James R. Brown , Linh Fruge , Tao Xu , Michael Prencipe
发明人： James R. Brown , Linh Fruge , Tao Xu , Michael Prencipe
CPC分类号： A61K8/21 , A61K8/03 , A61K8/19 , A61K8/20 , A61K8/24 , A61K8/25 , A61K8/55 , A61K8/69 , A61K8/8164 , A61K2800/28 , A61K2800/591 , A61Q11/00
摘要： Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1% of the compositions Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) immediately prior to dental care usage.
摘要翻译： 提供含有亚锡盐和三聚磷酸钠的口腔护理组合物，其中三聚磷酸三钠离子中间体包含少于组合物的约1％焦磷酸四钠，甲基乙烯基醚 - 马来酸酐共聚物和/或二氧化硅口服抛光剂可用于进一步的功效 。 在单相共混物中，口腔护理组合物可以有效地限制为包含小于约10％的水。 在双相混合物中，在牙齿保健使用之前，可以从双室存储管（每个相位由独立的室提供）产生具有第一相中的亚锡盐和第二相中的三聚磷酸钠的混合物。
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公开(公告)号：US20080274065A1
公开(公告)日：2008-11-06
申请号：US12028782
申请日：2008-02-08
申请人： Richard Scott Robinson , Richard J. Sullivan , Michael Prencipe , Rajnish Kohli , Isabelle Van Rycke , Richard Lovell , Sergio Leite , Eric A. Simon , Ralph Peter Santarpia , Diane Cummins , Sarita V. Mello , Suman Chopra , Karen J. DePierro , Lynette Zaidel , Constantina Christopoulou , Ravi Subramanyam , Donghui Wu , Andre M. Morgan , Qin Wang , Gary Edward Tambs , Virginia Monsul Barnes
发明人： Richard Scott Robinson , Richard J. Sullivan , Michael Prencipe , Rajnish Kohli , Isabelle Van Rycke , Richard Lovell , Sergio Leite , Eric A. Simon , Ralph Peter Santarpia , Diane Cummins , Sarita V. Mello , Suman Chopra , Karen J. DePierro , Lynette Zaidel , Constantina Christopoulou , Ravi Subramanyam , Donghui Wu , Andre M. Morgan , Qin Wang , Gary Edward Tambs , Virginia Monsul Barnes
CPC分类号： A61K8/25 , A61K8/44 , A61K2800/28 , A61K2800/412 , A61K2800/88 , A61Q11/00
摘要： The invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, contacting the oral surface with a periodic oral care maintenance composition at least once monthly, wherein the periodic oral care maintenance composition comprises a basic amino acid, in free or salt form and optionally contacting the oral surface with a periodic oral care cleaning composition at least once monthly. The periodic oral care cleaning compositions suitable for use in the method comprise an abrasive system.
摘要翻译： 本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。 这样的方法包括每天至少一次使口腔表面与主要口腔护理组合物接触，使口腔表面与定期的口腔护理维持组合物每月至少一次接触，其中定期口腔护理维持组合物包含游离或 任选地使口腔表面与定期的口腔护理清洁组合物每月至少一次接触。 适用于该方法的定期口腔护理清洁组合物包括研磨系统。
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公开(公告)号：US20080267891A1
公开(公告)日：2008-10-30
申请号：US12103919
申请日：2008-04-16
CPC分类号： A61K8/04 , A61K8/25 , A61K8/8164 , A61K2800/412 , A61Q11/00
摘要： The invention includes an oral care composition that reduces and/or eliminates the perception of tooth sensitivity. The composition includes an adherent material and particles having an average particle size of about 8 microns or less. The particles are present in the composition in an amount of about 5% by weight. Also included within the scope of the invention are related methods, such as methods of occluding a dentin tubule.
摘要翻译： 本发明包括减少和/或消除牙齿敏感性感觉的口腔护理组合物。 组合物包括粘附材料和具有约8微米或更小的平均粒度的颗粒。 颗粒在组合物中的存在量为约5重量％。 也包括在本发明的范围内的是相关方法，例如封闭牙本质小管的方法。
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公开(公告)号：US20080145321A1
公开(公告)日：2008-06-19
申请号：US12036674
申请日：2008-02-25
CPC分类号： A61K8/8176 , A61K8/0208 , A61K8/22 , A61K8/24 , A61K8/49 , A61K8/817 , A61K8/891 , A61K8/90 , A61K2800/805 , A61Q11/00 , A61Q11/02
摘要： Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.
摘要翻译： 口腔护理组合物，其包含：（a）包含过氧化物组分和N-乙烯基杂环聚合物（例如聚-N-乙烯基聚内酰胺或聚-N-乙烯基 - 聚酰亚胺）的过氧化物络合物; （b）增白剂（例如过氧化氢）; 和（c）口头可接受的承运人。 在一个实施方案中，载体包括成膜材料。 还提供了用于制备口腔护理组合物的方法，其包括：（a）将增白剂，硅氧烷粘合剂和载体流体混合以形成均匀的混合物; （b）向所述均匀混合物中加入过氧化物络合物，其中所述络合物包含过氧化氢和N-乙烯基杂环聚合物; 和（c）在真空下混合。
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公开(公告)号：US20060029554A1
公开(公告)日：2006-02-09
申请号：US11191501
申请日：2005-07-28
IPC分类号： A61K8/66
CPC分类号： A61Q11/00 , A61K8/66 , A61K2800/88
摘要： A two component desensitizing dentifrice composition is disclosed which comprises a first dentifrice component containing an enzyme such as papain and a second dentifrice component containing an ionic surfactant such as sodium lauryl sulfate, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth whereby enzyme activity is maintained with improved dentifrice foaming characteristics.
摘要翻译： 公开了一种双组分脱敏洁牙剂组合物，其包含含有酶如木瓜蛋白酶的第一洁齿剂组分和含有离子表面活性剂如十二烷基硫酸钠的第二洁齿剂组分，第一和第二洁齿剂组分彼此分离直到分配 应用于牙齿，由此保持酶活性并提高洁牙剂发泡特性。
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公开(公告)号：US20050281757A1
公开(公告)日：2005-12-22
申请号：US10870848
申请日：2004-06-17
申请人： Sayed Ibrahim , Suman Chopra , Michael Prencipe
发明人： Sayed Ibrahim , Suman Chopra , Michael Prencipe
CPC分类号： A61K8/0208 , A61K8/8135 , A61K8/8176 , A61K8/8182 , A61Q11/00
摘要： A composition for delivery of an oral care substance to a dental surface upon application of the composition thereto is a flexible film comprising the oral care substance dispersed in a film-forming effective amount of a polymeric matrix having a hydrophilic component, e.g., vinylpyrrolidone (VP), and a hydrophobic component, e.g., vinyl acetate (VA), in a weight ratio selected such that the film is substantially dissolvable in saliva in a period of time effective for delivery of the oral care substance. The polymeric matrix illustratively comprises a poly(VP/VA) copolymer having a VP/VA weight ratio of about 90:10 to about 10:90.
摘要翻译： 用于将组合物施用于口腔护理物质到牙齿表面的组合物是包含分散在成膜有效量的具有亲水组分的聚合物基质例如乙烯基吡咯烷酮（VP）的柔性膜 ）和疏水组分，例如乙酸乙烯酯（VA），其选择的重量比使得该膜在有效递送口腔护理物质的时间段内基本上可溶于唾液中。 聚合物基体示例性地包含VP / VA重量比为约90:10至约10:90的聚（VP / VA）共聚物。
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87.发明授权公开(公告)号：US06447758B1
公开(公告)日：2002-09-10
申请号：US09847819
申请日：2001-05-02
IPC分类号： A61K716
CPC分类号： A61K31/4425 , A61K8/463 , A61K8/4926 , A61Q11/00
摘要： A dual component antiplaque oral composition having superior foaming properties in which a first component contains a cationic antibacterial agent and the second component contains a anionic surfactant normally incompatible with the cationic antibacterial agent, the first and second components are simultaneously combined for application to the teeth, the first and second components being physically segregated prior to use, the components when mixed upon application to teeth providing substantially unimpaired antiplaque effect with superior foaming properties.
摘要翻译： 一种具有优异发泡性能的双组分抗菌素口服组合物，其中第一组分含有阳离子抗菌剂，第二组分含有通常与阳离子抗菌剂不相容的阴离子表面活性剂，第一和第二组分同时组合施用于牙齿， 第一和第二组分在使用前被物理隔离，组分在施用于牙齿上混合时提供基本上未受损的抗牙斑效应和优异的发泡性能。
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公开(公告)号：US06290933B1
公开(公告)日：2001-09-18
申请号：US09567402
申请日：2000-05-09
申请人： Gary A. Durga , Michael Prencipe , Peter J. Priolo , Peter Ren
发明人： Gary A. Durga , Michael Prencipe , Peter J. Priolo , Peter Ren
IPC分类号： A61K716
CPC分类号： A61K8/042 , A61K8/25 , A61K2800/412 , A61Q11/00
摘要： A high cleaning low abrasion dentifrice containing a silica hydrogel having a mean particle size from about 5 to about 11 microns; an Einlehner hardness of from 1 to about 20; an oil absorption of about 40 to less about 100 cc/g, a BET surface area from 100 to 700 m2/g of silica, the particles having a morphology characterized by glass conchoidal fracture surfaces whereby, the dentifrice composition has a RDA of 110 to 200 and a PCR from about 150 to about 300.
摘要翻译： 含有平均粒度约5至约11微米的二氧化硅水凝胶的高清洁低磨损洁齿剂; Einlehner硬度为1至约20; 约40至少约100cc / g的吸油量，100-700m2 / g二氧化硅的BET表面积，所述颗粒具有以玻璃花岗岩骨折表面为特征的形态，因此洁齿剂组合物的RDA为110〜 200和约150至约300的PCR。
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公开(公告)号：US6106812A
公开(公告)日：2000-08-22
申请号：US231042
申请日：1999-01-13
申请人： Michael Prencipe , Mike Wong , Vincent O. Drago , Marcus Bentley , Mahmoud Hassan , Nagaraj S. Dixit
发明人： Michael Prencipe , Mike Wong , Vincent O. Drago , Marcus Bentley , Mahmoud Hassan , Nagaraj S. Dixit
CPC分类号： A61Q11/00 , A61K8/22 , A61K8/24 , A61K8/73 , A61K8/8147 , A61K2800/88
摘要： A dual component tooth whitening composition is disclosed, which composition contains a peroxide whitening and a second ingredient incompatible with the peroxide compound, the second ingredient and the peroxide compound each being incorporated in separate dentifrice components which are physically separated until dispensed for use, the components retaining their original physical state when in contact, the first component being a composition containing a peroxide whitening compound in a vehicle thickened with a combination of a particulated water insoluble inorganic compound and an organic thickener other than an alkylene oxide polymer, and the second component containing the ingredient incompatible with the peroxide.
摘要翻译： 公开了双组分牙齿增白组合物，该组合物含有过氧化物增白剂和与过氧化物化合物不相容的第二成分，第二成分和过氧化合物各自被并入分离的洁齿剂组分中，这些成分物理分离直到分配使用，组分 在接触时保持其原始的物理状态，第一组分是在混合有不溶于水的不溶性无机化合物和除了烯化氧聚合物之外的有机增稠剂的混合物中加入过氧化物增白化合物的组合物，和含有 该成分与过氧化物不相容。
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公开(公告)号：US5976507A
公开(公告)日：1999-11-02
申请号：US90293
申请日：1998-06-04
申请人： Mike Wong , Michael Prencipe
发明人： Mike Wong , Michael Prencipe
IPC分类号： A61K8/21 , A61K20060101 , A61K8/11 , A61K8/20 , A61K8/73 , A61K9/48 , A61Q11/00 , A61K7/16 , A61K7/18
CPC分类号： A61Q11/00 , A61K8/11 , A61K2800/412 , A61K2800/88
摘要： An aqueous dentifrice composition comprising an aqueous vehicle containing at least two active ingredients reactive with each other, at least one of the active ingredients being encapsulated in a substantially water immiscible, pressure rupturable shell which is rupturable during use of the dentifrice, causing the same to be released for interaction with the other active ingredient, the shell being formed from a plasticized alkyl cellulose polymer. The dentifrice exhibits increased efficacy for fluoridation of teeth when the active ingredients are soluble fluoride salt and a calcium salt encapsulated in the plasticized alkyl cellulose polymer.
摘要翻译： 一种含水洁牙剂组合物，其包含含有至少两种彼此反应的活性成分的水性载体，所述活性成分中的至少一种被包封在基本上不与水混溶的压力破裂的壳体中，所述壳体在使用洁齿剂期间是可破裂的， 被释放以与其它活性成分相互作用，壳由增塑的烷基纤维素聚合物形成。 当活性成分是可溶性氟化物盐和包封在增塑的烷基纤维素聚合物中的钙盐时，洁牙剂表现出增加的牙齿氟化功效。
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