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公开(公告)号：US06627735B2
公开(公告)日：2003-09-30
申请号：US09876527
申请日：2001-06-07
申请人： Wayne Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , William A. Hagopian , James M. LaGasse
发明人： Wayne Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , William A. Hagopian , James M. LaGasse
IPC分类号： C07K100
CPC分类号： C07K14/4713 , A61K38/00 , C12N9/16
摘要： A mammalian islet cell antigen polypeptide involved in the development of insulin-dependent diabetes mellitus (IDDM) is disclosed. This islet cell antigen polypeptide, 1851, was found to contain regions of homology to the protein tyrosine phosphatase family. Methods for diagnosis and treatment, including use in immunoprecipitation assays and the induction of immune tolerance using the recombinant mammalian polypeptides and antibodies specific to mammalian islet cell antigen 1851 polypeptides are presented.
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公开(公告)号：US06566499B1
公开(公告)日：2003-05-20
申请号：US09506852
申请日：2000-02-17
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
IPC分类号： C07K1700
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/022
摘要： The present invention relates to polynucleotide and polypeptide molecules for zsig37, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig37 polypeptides.
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公开(公告)号：US06524836B2
公开(公告)日：2003-02-25
申请号：US09846996
申请日：2001-05-01
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
IPC分类号： C12N964
CPC分类号： C12N9/6489 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Y304/15001
摘要： Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the production of the potent vasopressor angiotensin II from angiotensin I, and the inactivation of the vasodilatory peptide bradykinin. Zace1 is a new form of human zinc metallopeptidase, which includes one zinc-dependent catalytic domain containing the motif “HEXXH” and one downstream “EX(I/V)X(D/S)” motif.
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公开(公告)号：US6022847A
公开(公告)日：2000-02-08
申请号：US81180
申请日：1998-05-19
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
IPC分类号： A61K38/00 , C07K14/47 , A61K38/17 , C07K14/435
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/02
摘要： The present invention relates to polynucleotide and polypeptide molecules for secreted salivary zsig32 polypeptides. The polypeptides, and polynucleotides encoding them modulate adhesion or modulate or indicate salivary gland function. The present invention also includes antibodies and binding proteins for the zsig32 polypeptides.
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85.发明申请USE OF TRUNCATED CYSTEINE IL28 AND IL29 MUTANTS TO TREAT CANCERS AND AUTOIMMUNE DISORDERS 审中-公开使用截短的CYSTEINE IL28和IL29突变体治疗癌症和自身免疫性疾病公开(公告)号：US20120251488A1
公开(公告)日：2012-10-04
申请号：US13440066
申请日：2012-04-05
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
CPC分类号： C07K14/54 , A61K38/20 , A61K38/21 , A61K47/60 , A61K2300/00
摘要： Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and/or autoimmune therapeutics.
摘要翻译： 使用IL-28和IL-29分子治疗患有癌症和自身免疫疾病的患者的方法。 IL-28和IL-29分子包括与人IL-28或IL-29多肽序列具有同源性的多肽，以及与具有IL-28和IL-29功能活性的多肽融合的蛋白质。 分子可以用作单一疗法或与其它已知的癌症和/或自身免疫治疗剂组合使用。
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公开(公告)号：US08231866B2
公开(公告)日：2012-07-31
申请号：US13353524
申请日：2012-01-19
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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公开(公告)号：US20110151480A1
公开(公告)日：2011-06-23
申请号：US13016537
申请日：2011-01-28
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33多肽及其受体以及抗体形成肽 - 受体复合物的方法。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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88.发明授权Method of using interferon-like potein ZCYTO20 (IL-28A) or ZCYTO22(IL-28B) to treat hepatitis B 有权使用干扰素样potein ZCYTO20（IL-28A）或ZCYTO22（IL-28B）治疗乙型肝炎的方法公开(公告)号：US07829076B2
公开(公告)日：2010-11-09
申请号：US12630571
申请日：2009-12-03
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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89.发明授权Method of using IL-29 cysteine mutant to treat hepatitis C and hepatitis B 有权使用IL-29半胱氨酸突变体治疗丙型肝炎和乙型肝炎的方法公开(公告)号：US07727518B2
公开(公告)日：2010-06-01
申请号：US12043885
申请日：2008-03-06
申请人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
发明人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
摘要翻译： 已经通过在编码成熟蛋白的多核苷酸序列中突变一个或多个半胱氨酸残基来产生IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白与其同源受体结合或表现出生物活性。 所示的一种生物活性是抗病毒活性。
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公开(公告)号：US20100104531A1
公开(公告)日：2010-04-29
申请号：US12572167
申请日：2009-10-01
申请人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
发明人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
摘要翻译： 已经通过在编码成熟蛋白的多核苷酸序列中突变一个或多个半胱氨酸残基来产生IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白与其同源受体结合或表现出生物活性。 所示的一种生物活性是抗病毒活性。
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