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81.发明授权Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer 有权称为251P5G2的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US08604169B2
公开(公告)日：2013-12-10
申请号：US12651336
申请日：2009-12-31
IPC分类号： C07K16/00 , C12P21/08 , G01N33/53 , A61K39/395 , A61K39/21
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 251P5G2 and its encoded protein, and variants thereof, are described wherein 251P5G2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 251P5G2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 251P5G2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 251P5G2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因251P5G2及其编码的蛋白及其变体，其中251P5G2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，251P5G2提供诊断，预后，预防和/ 或癌症的治疗靶标。 251P5G2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与251P5G2反应的抗体或T细胞可用于主动或被动免疫。
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82.发明授权Nucleic acids and corresponding proteins entitled 282P1G3 useful in treatment and detection of cancer 有权题为282P1G3的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US07612172B2
公开(公告)日：2009-11-03
申请号：US11438944
申请日：2006-05-23
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 282P1G3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 282P1G3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 282P1G3 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因282P1G3及其编码的蛋白及其变体，其中282P1G3在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，282P1G3提供诊断，预后，预防和/ 或癌症的治疗靶标。 282P1G3基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与282P1G3反应的抗体或T细胞可用于主动或被动免疫。
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83.发明申请NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 282P1G3 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开核酸和相关蛋白质完成282P1G3有用的治疗和检测癌症公开(公告)号：US20090252747A1
公开(公告)日：2009-10-08
申请号：US12400679
申请日：2009-03-09
IPC分类号： A61K39/395 , C07K16/00 , A01K67/027 , C12N5/12 , C12N15/63 , A61P35/00
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 282P1G3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 282P1G3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 282P1G3 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因282P1G3及其编码的蛋白及其变体，其中282P1G3在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，282P1G3提供诊断，预后，预防和/ 或癌症的治疗靶标。 282P1G3基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与282P1G3反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07361338B2
公开(公告)日：2008-04-22
申请号：US10147368
申请日：2002-05-15
申请人： Aya Jakobovits , Mary Faris , Arthur B. Raitano , Robert Kendall Morrison , Douglas Saffran , Wangmao Ge , Pia M. Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Arthur B. Raitano , Robert Kendall Morrison , Douglas Saffran , Wangmao Ge , Pia M. Challita-Eid
IPC分类号： A61K39/395
CPC分类号： G01N33/68 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2317/34 , G01N33/5017 , G01N33/57434
摘要： A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 101P3A11 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为101P3A11或PHOR-1）及其编码蛋白及其变体，其中101P3A11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，101P3A11提供 诊断，预后，预防和/或治疗靶标。 101P3A11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与101P3A11反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08008442B2
公开(公告)日：2011-08-30
申请号：US11587197
申请日：2004-04-22
申请人： Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
发明人： Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , A61K39/39533 , A61K45/06 , A61K47/48607 , A61K47/6861 , A61K51/106 , A61K51/1075 , A61K2039/505 , C07H21/04 , C07K16/3069 , C07K2317/24 , C07K2317/565 , G01N33/6887 , A61K2300/00
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
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86.发明授权公开(公告)号：US07947276B2
公开(公告)日：2011-05-24
申请号：US11584413
申请日：2006-10-19
申请人： Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
发明人： Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
IPC分类号： A61K39/00
CPC分类号： C07K14/4748 , A01K67/0271 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/705 , C07K14/723 , C07K16/30 , C07K2317/34 , C07K2317/77 , C07K2319/00 , C12N9/0091 , G01N33/57484
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
摘要翻译： 描述了结合于新型STEAP-1蛋白质的抗体和衍生自其的变体及其变体，其中STEAP-1在正常成人组织中显示组织特异性表达，并且在表I中列出的癌症中异常表达。因此，STEAP-1 提供癌症的诊断，预后，预防和/或治疗靶标。 STEAP-1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与STEAP-1反应的抗体或T细胞可用于主动或被动免疫。
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87.发明授权Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer 有权核酸和相应的标题为STEAP-1的蛋白质可用于治疗和检测癌症公开(公告)号：US07884179B2
公开(公告)日：2011-02-08
申请号：US11581227
申请日：2006-10-12
IPC分类号： A61K38/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/705 , C07K14/723 , C07K16/30 , C07K2319/00 , G01N33/57484
摘要： A novel gene 08P1D4 (also designated STEAP-1) and its encoded protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
摘要翻译： 描述了新型基因08P1D4（也称为STEAP-1）及其编码的蛋白及其变体，其中STEAP-1在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，STEAP -1提供了癌症的诊断，预后，预防和/或治疗靶标。 STEAP-1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与STEAP-1反应的抗体或T细胞可用于主动或被动免疫。
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88.发明申请公开(公告)号：US20100297006A1
公开(公告)日：2010-11-25
申请号：US12821016
申请日：2010-06-22
IPC分类号： A61K49/16 , A61K39/395 , A61P35/00 , C12N5/02
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P4D12(b) can be used in active or passive immunization.
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89.发明授权Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer 有权称为251P5G2的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US07696336B2
公开(公告)日：2010-04-13
申请号：US11549900
申请日：2006-10-16
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 251P5G2 and its encoded protein, and variants thereof, are described wherein 251P5G2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 251P5G2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 251P5G2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 251P5G2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因251P5G2及其编码的蛋白及其变体，其中251P5G2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，251P5G2提供诊断，预后，预防和/ 或癌症的治疗靶标。 251P5G2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与251P5G2反应的抗体或T细胞可用于主动或被动免疫。
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90.发明授权Nucleic acids and corresponding proteins entitled 273P4B7 useful in treatment and detection of cancer 失效核酸和相应的蛋白质，名称为273P4B7，可用于治疗和检测癌症公开(公告)号：US07250498B2
公开(公告)日：2007-07-31
申请号：US10641633
申请日：2003-08-15
IPC分类号： C07H21/02
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 273P4B7 and its encoded protein, and variants thereof, are described wherein 273P4B7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 273P4B7 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 273P4B7 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 273P4B7 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因273P4B7及其编码的蛋白及其变体，其中273P4B7在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，273P4B7提供诊断，预后，预防和/ 或癌症的治疗靶标。 273P4B7基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与273P4B7反应的抗体或T细胞可用于主动或被动免疫。
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