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公开(公告)号：US06699278B2
公开(公告)日：2004-03-02
申请号：US09899142
申请日：2001-07-06
IPC分类号： A61F206
CPC分类号： A61F2/915 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2002/91583 , A61F2210/0076 , A61F2230/0013 , A61F2250/0032 , A61F2250/0036 , A61F2250/0098
摘要： A stent in the form of a thin-walled, multi-cellular tubular structure is provided. The tubular structure has a longitudinal axis and the stent includes a plurality of circumferential sets of strut members. Each set of the strut members is longitudinally displaced from each other and connected to each other by longitudinally extending links. Each set of the strut members forms a closed and cylindrical portion of the stent. Further, each set of the strut members includes a plurality of connected curve sections and diagonal sections. The sets of the strut members further include end sets of strut members located at each end of the stent and central sets of strut members located between the end sets of the strut members. The diagonal sections of the end sets of the strut members have a center portion and two ends. At least one of the diagonal sections of the end sets of the strut members includes a tapered shape with width of one diagonal section is greater at the center of the diagonal section than the width at either end of the diagonal section.
摘要翻译： 提供了薄壁多孔管状结构形式的支架。 管状结构具有纵向轴线，并且支架包括多个圆周组的支柱构件。 每组支柱构件彼此纵向移位并通过纵向延伸的连杆相互连接。 每组支柱构件形成支架的闭合和圆柱形部分。 此外，每组支柱构件包括多个连接的曲线部分和对角线部分。 支柱构件的组还包括位于支架的每个端部处的支柱构件的端组和位于支柱构件的端部组之间的支柱构件的中心组。 支柱构件的端部组的对角部分具有中心部分和两端。 支柱构件的端部组的至少一个对角部分包括在对角线部分的中心比在对角线部分的任一端处的宽度更大的一个对角线部分的宽度的锥形形状。
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公开(公告)号：US06375660B1
公开(公告)日：2002-04-23
申请号：US09444104
申请日：1999-11-22
IPC分类号： A61F1100
CPC分类号： A61F2/95 , A61M2025/0186 , A61M2025/1004
摘要： The present invention is a stent delivery system that uses a short section of a guide wire that is fixedly attached to a distal section of a balloon angioplasty catheter. By not having a guide wire that slides through the balloon of the balloon angioplasty catheter, the balloon on which the stent is mounted can have a reduced diameter. Therefore, the outside diameter of the undeployed stent mounted onto that balloon is also minimized. This provides a minimum profile, i.e., a minimum outside diameter, for the stent. A minimum profile at the distal section of the stent delivery system is highly advantageous for improving the percentage of cases that can be treated by direct stenting; i.e., without requiring pre-dilation of a stenosis.
摘要翻译： 本发明是一种支架输送系统，其使用固定地附接到球囊血管成形术导管的远端部分的导线的短部分。 通过不具有滑动通过球囊血管成形术导管的球囊的导丝，安装支架的气囊可以具有减小的直径。 因此，安装在该球囊上的未部署的支架的外径也被最小化。 这为支架提供了最小外形，即最小外径。 在支架输送系统的远端部分的最小轮廓对于改善可通过直接支架置入治疗的病例的百分比是非常有利的; 即不需要预扩张狭窄。
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83.发明授权
公开(公告)号：US6161045A
公开(公告)日：2000-12-12
申请号：US323407
申请日：1999-06-01
IPC分类号： A61B5/0484 , A61N1/36
CPC分类号： A61N1/3615 , A61B5/04842 , A61B5/4094 , A61N1/36064 , A61N1/36167
摘要： Disclosed is a method for determining the optimal electrical stimulation parameters for intracranial stimulation therapy before implantation of a device for electrical stimulation therapy for epilepsy. This method would be used during intracranial electrical stimulation and monitoring procedures which are currently used to identify an epileptic region and map regional brain function prior to resective surgery. This method is used to determine therapeutic stimulation parameters during an evaluation procedure that can be carried out prior to the implantation of a closed-loop electrical stimulation device that is responsive to the onset of an epileptic seizure.
摘要翻译： 公开了一种用于在植入用于癫痫的电刺激治疗的装置之前确定用于颅内刺激治疗的最佳电刺激参数的方法。 该方法将用于颅内电刺激和监测程序，目前用于鉴定癫痫区域并在切除手术之前绘制局部脑功能。 该方法用于在评估过程期间确定治疗刺激参数，其可以在植入针对癫痫发作发作的闭环电刺激装置之前进行。
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公开(公告)号：US5976153A
公开(公告)日：1999-11-02
申请号：US40939
申请日：1998-03-18
CPC分类号： A61F2/958
摘要： The present invention is a stent delivery catheter system for placing a stent within a stenosis in a vessel of a human body. The stent delivery catheter system utilizes a slideable sheath with a thin-walled distal portion that is situated coaxially over a stent that is placed onto a balloon located at the distal portion of a balloon angioplasty catheter. The distal end of a central portion of the sheath has an interior shoulder which is capable of exerting a distally directed push force on the balloon angioplasty catheter at a point that is just proximal to the stent. This push force is then transferred through the non-deployed stent to a gradually tapered, highly flexible, lubricity coated distal tip of the balloon angioplasty catheter. The structure of a continuous outer surface extending backward from the distal tip and onto the distal section of the sheath, plus the lubricity coating of the outer surfaces of the distal tip and the sheath, plus the increased stent delivery catheter system pushability provided by the sheath and the stent itself makes it possible for the stent delivery catheter system to be pushed through even very tight stenoses.
摘要翻译： 本发明是用于将支架置于人体血管狭窄的支架输送导管系统中。 支架输送导管系统利用具有薄壁远侧部分的可滑动护套，所述远侧部分同轴地位于支架上，所述支架放置在位于球囊血管成形术导管的远端部分的球囊上。 鞘的中心部分的远端具有内肩部，其能够在刚好靠近支架的点处在球囊血管成形术导管上施加远端指向的推力。 然后将该推力通过未展开的支架转移到球囊血管成形术导管的逐渐变细，高度柔性，润滑的涂覆的远端。 连续的外表面从远端延伸到护套的远端部分上的结构以及远端尖端和护套的外表面的润滑性涂层加上由护套提供的增加的支架输送导管系统推进性 并且支架本身使支架输送导管系统能够通过甚至非常紧的狭窄被推动。
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公开(公告)号：US5879282A
公开(公告)日：1999-03-09
申请号：US786677
申请日：1997-01-21
CPC分类号： A61N5/1002 , A61N2005/1004
摘要： A balloon catheter for irradiation with or without dilatation of an arterial stenosis has an inflatable balloon and a generally cylindrical, thin-walled, elastic radioactive source both located coaxially at a distal section of the balloon catheter. The elastic radioactive source is moved radially outward as a result of injection of an inflation fluid into the inflatable balloon thus placing the radioactive source in close proximity to the wall of a vessel of the human body into which the balloon catheter has been inserted.
摘要翻译： 用于在有或没有动脉狭窄扩张的情况下照射的球囊导管具有可充气的球囊和大致圆柱形的薄壁弹性放射源，两者同轴地位于气囊导管的远端部分。 弹性放射源由于将充气流体注入到可膨胀气囊中而径向向外移动，从而将放射源放置在靠近人体容器的壁上，气球导管插入其中。
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86.发明授权Radioisotope impregnated sheet of biocompatible material for preventing scar tissue formation 失效用于防止瘢痕组织形成的生物相容性材料的放射性同位素浸渍片
公开(公告)号：US5795286A
公开(公告)日：1998-08-18
申请号：US698577
申请日：1996-08-15
CPC分类号： A61N5/1029
摘要： This invention is a radioisotope impregnated material sheet or mesh designed to be placed between internal body tissues to prevent the formation of post-operative adhesions, which adhesions are really scar tissue formation. This mesh or gauze into which the isotope is placed may be either a permanent implant or it may be biodegradable. By impregnating an existing product such as the Johnson & Johnson SURGICEL.TM. absorbable hemostat gauze-like sheet with a beta emitting radioisotope such as phosphorous-32 with has a relatively short effective range of approximately 4 mm, the biodegradable mesh would act as a barrier to cell proliferation and hence be a deterrent to the formation of adhesions.
摘要翻译： 本发明是放射性同位素浸渍的材料片或网格，其被设置成放置在内部身体组织之间以防止术后粘连的形成，这些粘连真的是瘢痕组织形成。 放置同位素的网状物或纱布可以是永久植入物，也可以是可生物降解的。 通过用诸如磷32的β发射放射性同位素浸渍现有产品，例如Johnson＆Johnson SURGICEL TM可吸收的止血纱网状片材，其具有约4mm的相对较短的有效范围，可生物降解的网孔将作为屏障 细胞增殖，从而成为粘连形成的阻碍。
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87.发明授权
公开(公告)号：US5759174A
公开(公告)日：1998-06-02
申请号：US790447
申请日：1997-01-29
CPC分类号： A61F2/91 , A61F2/915 , A61F2/958 , A61B90/39 , A61F2002/91558 , A61F2230/0013 , A61F2250/0098 , A61M2025/1079 , A61M25/104
摘要： An expandable external radiopaque marker band is situated external to the balloon of a balloon angioplasty catheter typically at the balloon's longitudinal center. When the balloon is inflated to dilate an arterial stenosis, the external radiopaque marker band is moved radially outward by the balloon thereby forcing the external radiopaque marker band into the arterial wall. When the balloon is then deflated, the external radiopaque marker band remains in place against the wall of the dilated stenosis. The balloon angioplasty catheter can then be removed from the artery while the expanded external radiopaque marker band remains in place to indicate (typically) the center position of the dilated stenosis. The external radiopaque marker band is typically made from a dense, radiopaque metal such as tantalum, gold, platinum or an alloy of those dense metals.
摘要翻译： 可膨胀的外部不透射线标记带位于球囊血管成形术导管的气球的外部，通常位于气囊的纵向中心。 当气囊膨胀以扩张动脉狭窄时，外部不透射线的标记带通过气囊径向向外移动，从而迫使外部不透射线的标记带进入动脉壁。 当气囊然后放气时，外部不透射线的标记带保持在扩张狭窄的壁上的适当位置。 然后可以从动脉移除球囊血管成形术导管，而扩张的外部不透射线标记带保持在适当位置以指示（通常）扩张狭窄的中心位置。 外部不透射线标记带通常由致密的不透射线的金属如钽，金，铂或这些致密金属的合金制成。
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公开(公告)号：US5743874A
公开(公告)日：1998-04-28
申请号：US298214
申请日：1994-08-29
CPC分类号： A61M25/104 , A61F2/95 , A61F2/958 , A61F2/966 , A61M2025/0183 , A61M2025/1079
摘要： A single, integrated catheter is capable of performing balloon angioplasty followed by delivery of a stent without removing the catheter from the patient's body. In one embodiment, a balloon placed near the catheter's distal end is first used for pre-dilatation of a vascular stenosis. The catheter is then advanced until a stent placed within a stent containment cavity located just proximal to the balloon is placed within the dilated stenosis. An outer sheath is then pulled back which allows a self-expanding stent to be deployed radially outward. The balloon is then pulled back inside the stent and reinflared to embed the stent into the dilated stenosis. An alternative embodiment of the invention uses a side opening in the catheter located just proximal to the stent containment cavity as an entry port for a flexible guide wire thus providing a "rapid exchange" capability for the integrated catheter.
摘要翻译： 单个整合的导管能够执行气囊血管成形术，随后输送支架而不从患者身体移除导管。 在一个实施例中，放置在导管远端附近的气囊首先用于血管狭窄的预扩张。 然后将导管推进到放置在位于气囊附近的支架容纳腔内的支架置于扩张的狭窄内。 然后将外护套拉回，这允许自扩张支架径向向外展开。 然后将气囊拉回到支架内并重新张开以将支架植入扩张的狭窄。 本发明的替代实施例使用位于刚好靠近支架容纳腔的导管中的侧开口作为柔性引导线的入口，从而为集成导管提供“快速交换”能力。
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公开(公告)号：US5730698A
公开(公告)日：1998-03-24
申请号：US437400
申请日：1995-05-09
CPC分类号： A61F2/86 , A61F2/958 , A61N5/1002 , A61F2220/0033 , A61F2230/005 , A61N2005/1004 , A61N2005/1021
摘要： An expandable temporary stent system (10) is provided for creating a temporary stent within a vessel of a human body and includes an over-the-wire balloon angioplasty catheter (20) having a central lumen (26) and a distal section having an inflatable balloon (23). The balloon angioplasty catheter (20) has a proximal section that remains outside the body. A stent assembly (30) is slidably mounted on the balloon angioplasty catheter (20) in a coaxial manner and has a proximal section as well as a distal section where a temporary stent (31) is located at the distal section. The distal end of the stent assembly (30) is fixed to the distal section of the balloon angioplasty catheter (20). The proximal end of the temporary stent (31) is fixed to a distal end of a pusher tube (32). The pusher tube (32) cooperates with the proximal section of the balloon angioplasty catheter (20) and allows the temporary stent (31) to be reversibly deployed in a radial outward manner responsive to inflation of the balloon and, retracted so that the temporary stent (31) reforms around the balloon (23) of the balloon angioplasty catheter (20) for providing blood flow through the vessel and removal of the system from the vessel of the human body.
摘要翻译： 提供了可扩张的临时支架系统（10），用于在人体的容器内产生临时支架，并且包括具有中心腔（26）和远侧部分的线上球囊血管成形术导管（20） 气球（23）。 球囊血管成形术导管（20）具有保留在体外的近端部分。 支架组件（30）以同轴方式可滑动地安装在球囊血管成形术导管（20）上，并且具有近端部分以及远端部分，其中临时支架（31）位于远端部分。 支架组件（30）的远端固定到球囊血管成形术导管（20）的远端部分。 临时支架（31）的近端固定在推动管（32）的远端。 推动管（32）与球囊血管成形术导管（20）的近端部分协作，并允许临时支架（31）以径向向外的方式可逆地展开，以响应气囊的膨胀并且缩回，使得临时支架 （31）围绕球囊血管成形术导管（20）的球囊（23）周围进行改造，用于提供通过血管的血液流动并将系统从人体血管中移出。
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公开(公告)号：US5697971A
公开(公告)日：1997-12-16
申请号：US661562
申请日：1996-06-11
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/91558
摘要： The present invention is a multi-cell stent having at least two different types of cells with each type of cell accomplishing a different purpose. For example, a first type of cell is intended to provide a maximum radial rigidity after stent deployment. A second type of cell is designed to provide increased longitudinal flexibility prior to stent deployment and after stent deployment into a main artery, the second type of cell can be readily balloon expanded at the ostium of a side branch artery to a comparatively large diameter without breaking any of the struts of the stent cell. By this technique, unobstructed blood flow into the side branch can be provided.
摘要翻译： 本发明是具有至少两种不同类型的细胞的多细胞支架，每种类型的细胞实现不同的目的。 例如，第一类型的细胞旨在在支架展开之后提供最大径向刚度。 第二种类型的细胞被设计成在支架展开之前和在支架展开到主动脉之后提供增加的纵向柔性，第二类型的细胞可以容易地在侧支动脉的口处膨胀到相对较大的直径而不破裂 支架细胞的任何支柱。 通过这种技术，可以提供进入侧枝的畅通无阻的血液。
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