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公开(公告)号：US08591495B2
公开(公告)日：2013-11-26
申请号：US13431526
申请日：2012-03-27
IPC分类号： A61M25/00
CPC分类号： A61M25/01 , A61M25/0012 , A61M25/005 , A61M25/0108 , A61M25/02 , A61M25/0662 , A61M39/0606 , A61M2025/0266 , A61M2025/028 , A61M2025/0286 , B21C37/042
摘要： A thin-walled introducer sheath is described. In some embodiments, the introducer sheath includes structural support components, such as wires, used in connection with a polymeric inner coating, a polymeric outer coating, or both. Further, in some embodiments, the wire components are annealed to reduce cold-work-related stresses and hardness. Use of annealed components may enable a reduction in the thickness of the polymeric outer coating in some applications.
摘要翻译： 描述了薄壁导引鞘。 在一些实施例中，引入器护套包括与聚合物内涂层，聚合物外涂层或两者结合使用的结构支撑部件，例如导线。 此外，在一些实施例中，将线材部件退火以减少与冷加工有关的应力和硬度。 在一些应用中，退火组分的使用可以使聚合物外涂层的厚度减小。
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公开(公告)号：US08483812B2
公开(公告)日：2013-07-09
申请号：US12059146
申请日：2008-03-31
CPC分类号： A61L27/54 , A61L2300/236 , A61L2300/254 , A61L2300/42
摘要： Disclosed are methods for detecting an acute myocardial infarction (i.e., a heart attack) at the earliest possible time and promptly warning the patient that he should immediately seek medical care. The present invention includes an implantable electronic system that can sense a change in the patient's electrogram that is indicative of a heart attack. If a heart attack is sensed, the device would then cause an implantable and/or externally located alarm to be actuated to warn the patient of his condition and a medical practitioner at a remote diagnostic center would receive the patient's electrogram for analysis. The patient or a caretaker would then be informed to self-inject medication through a subcutaneous, pass-through drug port that can be a separate device or integrated into the implanted device that is designed for the early detection of a heart attack. The methods of the present invention include determining if a human patient is likely to have a heart attack and, if he is, then implanting within that patient a device that can sense when a heart attack occurs and alarm the patient to take appropriate actions if a heart attack does occur.
摘要翻译： 公开了在早期检测急性心肌梗塞（即心脏病发作）的方法，并且及时警告患者他应该立即求医。 本发明包括可以感测指示心脏病发作的患者电描记图变化的可植入电子系统。 如果感测到心脏病发作，则该装置然后将致动可植入和/或外部定位的警报器，以警告患者其状况，并且远程诊断中心的医务人员将接收患者的电描记图以进行分析。 然后将患者或看守者通知皮下，通过的药物口，自动注射药物，该药物口可以是单独的装置，也可以集成到设计用于早期发现心脏病发作的植入装置中。 本发明的方法包括确定人类患者是否可能患有心脏病发作，并且如果他是，则在患者体内植入可以感测发生心脏病发作的装置，并且如果 心脏病发作确实发生。
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3.发明申请HIEARCHICAL COMMUNICATION SYSTEM FOR A CHRONICALLY IMPLANTED MEDICAL DEVICE 审中-公开一种用于慢性植入式医疗器械的研究通讯系统公开(公告)号：US20090240156A1
公开(公告)日：2009-09-24
申请号：US12437973
申请日：2009-05-08
申请人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson
发明人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson
IPC分类号： A61B5/0402
CPC分类号： A61B5/02455 , A61B5/0031 , A61B5/04012 , A61B5/0422 , A61B5/0452 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/746 , A61B5/7465 , A61B2560/0209
摘要： A system for providing alerts with regard to a patient's heart. An implanted medical device includes a sensor as well as a processor configured to detect a cardiac event. An internal alarm is configured for producing an alarm signal. An internal transceiver acting in cooperation with an external transceiver within an external device is provided. The processor is configured to determine whether the external and internal transceivers are able to communicate with each other and send a command to the internal alarm if there is no communication.
摘要翻译： 用于提供关于患者心脏的警报的系统。 植入式医疗装置包括传感器以及配置成检测心脏事件的处理器。 内部报警被配置为产生报警信号。 提供了与外部设备内的外部收发器协同工作的内部收发器。 处理器被配置为确定外部和内部收发器是否能够彼此通信，并且如果没有通信则将命令发送到内部警报。
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公开(公告)号：US07558623B2
公开(公告)日：2009-07-07
申请号：US10853058
申请日：2004-05-26
申请人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson
发明人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7465 , A61B2560/0209 , A61N1/3627 , A61N1/3702
摘要： Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.
摘要翻译： 公开了一种用于检测心脏事件的系统，其包括称为心脏切除器，医生程序员和外部警报系统的植入装置。 该系统旨在提供心脏事件的早期检测，例如由心率增加或运动引起的急性心肌梗死或运动诱发的心肌缺血。 如果检测到心律失常，该系统还可以警告患者不太紧急的警报。 使用不同的算法，心脏检查器可以在发生后五分钟内检测到指示心脏事件的患者电描记图的变化，然后自动向患者发出事件发生。 为了提供此警告，系统包括在心电图的ST段超过预设阈值之后激活的心律师内部的内部报警子系统（内部报警装置）和/或外部报警系统（外部报警装置）。
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公开(公告)号：US20090105807A1
公开(公告)日：2009-04-23
申请号：US12286558
申请日：2008-09-30
IPC分类号： A61F2/06
CPC分类号： A61F2/844 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91533 , A61F2002/9155 , A61F2210/0019
摘要： A method for implanting a balloon expandable stent at a site within a passageway of a curved coronary article. The stent includes at least two longitudinally spaced apart circumferential rings. At least one longitudinally extending connector extends between adjacent rings. The connector has at least one turn back portion that can expand or contract in length while being passed through a curved passageway. The stent is disposed on a stent delivery catheter having an inflatable balloon. The stent delivery catheter and the stent is delivered through the passageway to the site of implementation with the connector member expanding or contracting in length to facilitate delivery and placement of the stent. The stent is expanded at the site of implantation by inflating the balloon to force the stent radially outward against the wall of the coronary artery.
摘要翻译： 一种用于将球囊可扩张支架植入弯曲冠状动脉制品通道内的部位的方法。 支架包括至少两个纵向间隔开的周向环。 至少一个纵向延伸的连接器在相邻的环之间延伸。 连接器具有至少一个回转部分，其能够在穿过弯曲通道的同时膨胀或收缩。 支架设置在具有可膨胀气囊的支架输送导管上。 支架输送导管和支架通过通道被输送到实现位置，连接器构件的长度膨胀或收缩以便于支架的输送和放置。 通过使气囊膨胀来使支架在植入部位扩张，以使支架径向向外抵靠冠状动脉壁。
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公开(公告)号：US07494458B2
公开(公告)日：2009-02-24
申请号：US11974712
申请日：2007-10-15
IPC分类号： A61N2/04
CPC分类号： A61N2/02
摘要： Disclosed is a system and method for treating headaches. The system employs a self-contained, battery operated, readily portable and easy-to-operate head-mounted magnetic depolarizer to generate a transient or time-varying high-intensity magnetic field into and around the user's head or neck. The magnetic depolarizer system can be used to depolarize the neurons of the brain and/or the trigeminal nerve. This type of neuronal depolarization has the capability for terminating migraine or other types of headaches.
摘要翻译： 公开了一种治疗头痛的系统和方法。 该系统采用独立的电池供电，易于携带和易于操作的头戴磁性去极化器，以在用户的头部或颈部内和周围产生瞬时或时变的高强度磁场。 磁去极化系统可用于去极化脑和/或三叉神经的神经元。 这种类型的神经元去极化具有终止偏头痛或其他类型头痛的能力。
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公开(公告)号：US06716240B2
公开(公告)日：2004-04-06
申请号：US10345531
申请日：2003-01-16
IPC分类号： A61M2900
CPC分类号： A61F2/844 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91533 , A61F2002/9155 , A61F2210/0019
摘要： A stent which is adapted for placement in the vessels of a human body is provided. The stent may be in the form of a thin-walled metal cylinder having a longitudinal axis. The stent has a proximal end and a distal end and includes a number of circumferentially relatively rigid portions. The relatively rigid portions are joined to each other by one or more longitudinals which extend in a substantially longitudinal direction. At least a portion of at least one of the longitudinals has an undulating shape where a first relatively rigid portion is located at the proximal end of the stent and a second relatively rigid portion is located at the distal end of the stent.
摘要翻译： 提供适于放置在人体容器中的支架。 支架可以是具有纵向轴线的薄壁金属圆筒的形式。 支架具有近端和远端，并且包括多个周向相对刚性的部分。 相对刚性的部分通过一个或多个在大致纵向方向延伸的纵骨彼此连接。 至少一个纵骨的至少一部分具有起伏的形状，其中第一相对刚性的部分位于支架的近端，并且第二相对刚性的部分位于支架的远端。
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公开(公告)号：US06427086B1
公开(公告)日：2002-07-30
申请号：US09557168
申请日：2000-04-21
申请人： Robert E. Fischell , David R. Fischell , Adrian R. M. Upton , Dennis R. Potts , Benjamin D. Pless
发明人： Robert E. Fischell , David R. Fischell , Adrian R. M. Upton , Dennis R. Potts , Benjamin D. Pless
IPC分类号： A61N136
CPC分类号： A61B5/6814 , A61B5/0476 , A61B5/4094 , A61N1/36017 , A61N1/36025 , A61N1/3605 , A61N1/36064 , A61N1/37235
摘要： Disclosed is a means and method for placing an implantable neurostimulator control module into a place in the cranium where cranial bone has been removed. The method for accomplishing this cranial implantation is by first removing a patient's hair over the site of the implant, then cutting the scalp at that site and pulling it back to expose the cranium. A neurosurgeon would then remove a portion of the cranial bone to accept a control module to be implanted within that hole. The control module would then be placed into that hole. It is also conceived that the control module would be fixed in place by the use of one or more attachment devices such as a multiplicity of bone screws placed through holes in one or more flanges that extend over the cranium beyond the control module. The implantation could also include a fairing placed around the control module to provide a smooth contour under the patient's scalp. Also described is a spacer shim placed under the flange(s) to adjust the position of the control module so that its bottom surface does not put pressure on the dura mater lying directly over the brain tissue at the bottom of the hole. It is also envisioned that a resorbable disk could be placed under the bottom surface of the control module to further protect the brain and/or to elute an anti-biotic or anti-inflammatory substance to reduce the possibility of infection and/or inflammation.
摘要翻译： 公开了一种用于将可植入的神经刺激器控制模块放置在颅骨已被移除的头颅中的位置的手段和方法。 完成这种颅骨植入的方法是首先将患者的头发去除植入物的部位，然后在该部位切割头皮并将其拉回以暴露颅骨。 然后，神经外科医生将去除颅骨的一部分以接受待植入该孔内的控制模块。 然后将控制模块放入该孔中。 还可以想到，控制模块将通过使用一个或多个附接装置固定在适当的位置，例如通过一个或多个凸缘中的孔布置的多个骨螺钉，所述多个骨螺钉在颅骨上延伸超过控制模块。 植入还可以包括放置在控制模块周围的整流罩，以在患者的头皮下面提供平滑的轮廓。 还描述了放置在凸缘下方的间隔垫片，以调节控制模块的位置，使得其底部表面不对直接位于孔底部的脑组织的硬脑膜施加压力。 还可以设想，可再吸收的盘可以放置在控制模块的底表面下方以进一步保护大脑和/或洗脱抗生素或抗炎物质以减少感染和/或炎症的可能性。
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9.发明授权Implantable responsive system for sensing and treating acute myocardial infarction 有权用于感染和治疗急性心肌梗死的植入式反应系统
公开(公告)号：US6112116A
公开(公告)日：2000-08-29
申请号：US253872
申请日：1999-02-22
CPC分类号： A61N1/3702 , A61B5/0031 , A61N1/3956
摘要： Disclosed is a completely implantable system that can detect the occurrence of a myocardial infarction, i.e., a heart attack, and automatically inject a thrombolytic and/or anti-thrombogenic agent into the bloodstream to promptly dissolve the thrombus that caused the myocardial infarction and prevent the formation of additional thrombi. It is well known that a myocardial infarction can be detected from a patient's electrocardiogram by noting an ST segment voltage deviation as compared to the voltage of the patient's TP or PQ segments. Upon detection of a myocardial infarction, an ST segment deviation electronic detection circuit within the implanted device can produce an output signal that can cause a thrombolytic and/or anti-thrombogenic agent contained within an implanted, pressurized reservoir to immediately and automatically release medications into the patient's bloodstream. A patient warning system is provided by an audio alarm or an electrical tickle within the human body indicating that a myocardial infarction has been detected. The implanted system can also send a radio message to an externally located receiver that automatically dials an emergency rescue team to take the patient to a hospital for continuing treatment of his myocardial infarction. An implantable defibrillator or pacemaker that includes the capability for informing the patient that myocardial infarction has been detected is also disclosed. Still further, this invention could also be used without a defibrillator or pacemaker but as an implanted system (without medications) whose only function would be the detection and warning of myocardial infarction at the earliest possible time.
摘要翻译： 公开了一种完全可植入的系统，其可以检测心肌梗死的发生，即心脏病发作，并自动将血栓溶解和/或抗血栓形成剂注射到血流中，以迅速溶解引起心肌梗死的血栓，并防止 形成额外的血栓。 众所周知，与患者的TP或PQ区段的电压相比，通过注意到ST段电压偏差，可以从患者的心电图中检测到心肌梗死。 在检测到心肌梗塞时，植入装置内的ST段偏移电子检测电路可以产生输出信号，其可以引起包含在植入的加压贮存器内的血栓溶解和/或抗血栓形成剂立即并自动将药物释放到 病人的血液。 病人警报系统由人体内的音频警报器或电子痒痒声提供，表明已经检测到心肌梗塞。 植入系统还可以向外部定位的接收器发送无线电消息，该接收机自动拨打紧急救援队以将病人带到医院继续治疗其心肌梗死。 还公开了一种植入式除颤器或起搏器，其包括通知患者已经检测到心肌梗死的能力。 此外，本发明还可以在没有除颤器或起搏器的情况下使用，但作为植入系统（无药物），其唯一功能将是尽可能早地检测和警告心肌梗死。
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10.发明授权EEG d-c voltage shift as a means for detecting the onset of a neurological event 失效EEG d-c电压偏移作为检测神经系统事件发作的手段
公开(公告)号：US6061593A
公开(公告)日：2000-05-09
申请号：US65739
申请日：1998-04-24
IPC分类号： A61N1/36 , A61D5/0476
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/6814 , A61N1/3605 , A61N1/36025 , A61N1/36082 , A61N1/37211
摘要： Disclosed herein is a multiple electrode, closed-loop system for the treatment of certain neurological disorders such as epilepsy, migraine headaches and Parkinson's disease. Specifically, the present invention combines a multi-electrode array with sophisticated signal processing techniques to achieve reliable detection of the onset of a neurological event (such as an epileptic seizure or migraine headache) typically originating from a focus of limited spatial extent within the brain. It is highly desirable to detect an epileptic seizure at least 5 seconds before the onset of clinical symptoms. Since there is often a d-c shift in the EEG voltage more than 5 seconds before the seizure, disclosed herein is a means for utilizing the d-c shift of the EEG for early detection of the seizure.
摘要翻译： 本文公开了用于治疗某些神经障碍如癫痫，偏头痛和帕金森病的多电极闭环系统。 具体地，本发明将多电极阵列与复杂的信号处理技术相结合，以实现通常来自脑内有限空间范围内的焦点的神经系统事件（例如癫痫发作或偏头痛头痛）的发作的可靠检测。 在临床症状发作前至少5秒检测癫痫发作是非常需要的。 由于在癫痫发作前超过5秒脑电图经常发生d-c偏移，所以这里公开了利用脑电图的d-c位移来早期检测癫痫发作的手段。
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