Pharmaceutical composition including laminin fragments to treat or prevent the disease, disorder or symptom of tooth dentin and/or dental pulp

    公开(公告)号:US12083166B2

    公开(公告)日:2024-09-10

    申请号:US18057110

    申请日:2022-11-18

    申请人: Takashi Saito

    IPC分类号: A61K38/39 A61K33/42 A61K38/01

    摘要: A tooth dentin, pulp or pulp tissue composition for treating or preventing a disease, disorder, or symptom of a tooth dentin and/or pulp or pulp tissue includes: (a) an integrin binding fragment of Laminin, the Laminin being selected from the group consisting of Laminin 511 and Laminin 411, the integrin binding fragment comprising an integrin-binding domain of the Laminin; and (b) a mixture of odontoblast and mineralized nodules secreted from the odontoblast. A coating density of the integrin binding fragment is 1 to 8 μg/cm2. The material (b) has been mixed with the material (a) in the composition so as to form pulp capping applicable to a tooth, such that the composition is able to treat or prevent the disease, disorder or symptom of the tooth dentin and/or pulp tissue including dental caries when applied to the tooth.

    Pharmaceutical composition including laminin fragments to treat or prevent the disease, disorder or symptom of tooth dentin and/or dental pulp

    公开(公告)号:US20230190882A1

    公开(公告)日:2023-06-22

    申请号:US18057110

    申请日:2022-11-18

    申请人: Takashi Saito

    IPC分类号: A61K38/39 A61K38/01 A61K33/42

    摘要: A tooth dentin, pulp or pulp tissue composition for treating or preventing a disease, disorder, or symptom of a tooth dentin and/or pulp or pulp tissue includes: (a) an integrin binding fragment of Laminin, the Laminin being selected from the group consisting of Laminin 511 and Laminin 411, the integrin binding fragment comprising an integrin-binding domain of the Laminin; and (b) a mixture of odontoblast and mineralized nodules secreted from the odontoblast. A coating density of the integrin binding fragment is 1 to 8 μg/cm2. The material (b) has been mixed with the material (a) in the composition so as to form pulp capping applicable to a tooth, such that the composition is able to treat or prevent the disease, disorder or symptom of the tooth dentin and/or pulp tissue including dental caries when applied to the tooth.

    Sheet processing device and image forming device provided with the same

    公开(公告)号:US10131107B2

    公开(公告)日:2018-11-20

    申请号:US15202010

    申请日:2016-07-05

    摘要: The present invention is to provide a sheet processing device including: a receiving tray capable of accommodating therein a sheet having, at a part thereof, a protruding portion and a sheet not having the protruding portion in a mixed state; a first binding member that binds the accommodated sheet bundle at a substantially center thereof in a sheet conveying direction; a folding section that folds the sheet bundle bound by the first binding member in two; and a second binding member that binds protruding portions of the sheet bundle folded by the folding section on a fore edge side of the sheet bundle. With this configuration, the fore edge side of the folded and saddle-stitched sheet bundle can be bound by temporary binding. Thus, a sheet processing device capable of ensuring the security of a saddle-stitched sheet bundle can be provided.