Abstract:
A drill-bit seismic method where the seismic receivers are located in the BHA. The data detected by these receivers is processed by a downhole processing unit in order to estimate the interval velocity of the seismic wave between the sensors and between the bit and a sensor. Additionally, the processed data might provide the distance to a seismic reflector close to the borehole and the average seismic velocity between the well and this reflector. The processed data can be transmitted to surface location by mud-pulse telemetry. The pilot signal can be also used to process seismic data recorded by receivers located at the earth surface (or close to it).
Abstract:
An apparatus for forming a wellbore in a formation may include a bit body and a sensor in the bit body. The sensor may include at least one cutting element and may be configured to generate information relating to a parameter of interest when the drill bit engages a wellbore surface.
Abstract:
The present invention relates to isolated nucleic acid molecules of SEQ ID NO: 1 to SEQ ID NO: 14 which show a single polymorphic change at position 501, where the wildtype nucleotide is replaced by an indicator nucleotide, respectively. The present invention further relates to the mentioned nucleic acid molecules wherein a panel of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 of the polymorphic, changed sequences comprising the mentioned indicator nucleotides constitutes a marker for beta thalassemia, in particular of beta thalassemia minor. Further envisaged are specific panels comprising SEQ ID NO: 1; or SEQ ID NO 1 and 2; or SEQ ID NO: 1, 2 and 3, or SEQ ID NO: 1, 2, 3 and 4; or SEQ ID NO: 1 to 5; or SEQ ID NO: 1 to 6; or SEQ ID NO: 1 to 7; or SEQ ID NO: 1 to 14; or SEQ ID NO: 8 and 14; or SEQ ID NO: 8 and 9; or SEQ ID NO: 2, 4 and 13. The present invention further relates to a method of detecting or diagnosing beta thalassemia, preferably of beta thalassemia minor, in a subject, comprising the steps of: (a) isolating a nucleic acid from a subject's sample, (b) determining the nucleotide sequence and/or molecular structure present at one or more of the mentioned polymorphic sites, wherein the presence of an indicator nucleotide indicative of the presence of beta thalassemia. Also envisaged are a corresponding composition for detecting or diagnosing beta thalassemia, the use of the mentioned nucleic acid molecules for detecting or diagnosing beta thalassemia or for screening a population for the presence of beta thalassemia, as well as a corresponding kit. The methods, compositions, uses and kits of the invention also relate to the assessment of the risk of developing beta thalassemia in a subject and/or in a subject's progeny.
Abstract translation:本发明涉及SEQ ID NO:1至SEQ ID NO:14的分离的核酸分子,其分别在位置501显示单个多态性变化,其中野生型核苷酸被指示剂核苷酸替代。 本发明还涉及所述核酸分子,其中所述多态性改变的序列的1,2,3,4,5,6,7,8,9,10,11,12,13或14的片段包含 提及的指示剂核苷酸构成β地中海贫血的标志物,特别是β地中海贫血的标记物。 进一步设想的是包含SEQ ID NO:1的特定面板; 或SEQ ID NO 1和2; 或SEQ ID NO:1,2和3,或SEQ ID NO:1,2,3和4; 或SEQ ID NO:1至5; 或SEQ ID NO:1至6; 或SEQ ID NO:1至7; 或SEQ ID NO:1至14; 或SEQ ID NO:8和14; 或SEQ ID NO:8和9; 或SEQ ID NO:2,4和13.本发明还涉及检测或诊断受试者中β地中海贫血,优选地中海贫血地区贫血的方法,包括以下步骤:(a)从核酸 (b)确定存在于一个或多个所述多态性位点处的核苷酸序列和/或分子结构,其中存在指示β-地中海贫血存在的指示剂核苷酸。 还设想了用于检测或诊断β地中海贫血的相应组合物,所述核酸分子用于检测或诊断β地中海贫血或用于筛选群体以获得β地中海贫血以及相应的试剂盒。 本发明的方法,组合物,用途和试剂盒还涉及在受试者和/或受试者的后代中发展β地中海贫血的风险的评估。
Abstract:
An apparatus for measuring strain on a downhole component includes: at least one strain sensitive device disposed proximate to a surface of a component of a drilling assembly or disposed within a material forming the component; and a processor in operable communication with the at least one strain sensitive device, the processor configured to detect changes in the at least one strain sensitive device and detect at least one of erosion, crack formation and crack propagation in the component surface. An apparatus for measuring strain on a downhole component includes: at least one strain gauge deposited on a surface of a drive shaft or disposed within a material forming the drive shaft; and a processor in operable communication with the at least one strain gauge, the processor configured to detect changes in the at least one strain gauge and detect conditions affecting operation of the drive shaft.
Abstract:
An apparatus and method for estimating a parameter of interest in a downhole fluid using fluid testing module. The fluid testing module may include: a substrate comprising at least one microconduit, and a sensor. The sensor may be disposed within the at least one microconduit or external. The apparatus may include a fluid transporter for moving fluid within the microconduit. The method includes estimating a parameter of interest using the fluid testing module.
Abstract:
The present disclosure is related to an apparatus for taking a sample in a wellbore during drilling operations. The apparatus may include a drill bit configured to form a core and at least one retractable cutter internal to the drill bit for taking the sample from the core. The apparatus may also include equipment for analyzing the sample, extracting fluid from the sample, testing fluid from the sample, encapsulating the sample, and/or tagging the sample. The present disclosure is also related to a method for taking a core sample without interrupting drilling operations. The method includes taking a core sample using a drill bit configured to take a core sample using internal cutters. The method may also include analyzing the sample, extracting fluid from the sample, analyzing fluid from the sample, encapsulating the sample, and/or tagging the sample.
Abstract:
The present disclosure relates to an apparatus and method for estimating a parameter of interest of a downhole fluid using a fluid analysis module. The fluid analysis module may include: at least one nano element and a processor configured to estimate an impedance of the at least one nano element. The fluid analysis module may include an AC power supply configured to supply electrical signals at a plurality of frequencies through the at least one nano element. The method may include bringing the downhole fluid into contact with the at least one nano element; supplying electrical signals through the at least one nano element at a plurality of frequencies; generating impedance information for the at least one nano element in response to the electrical signals; and estimating the at least one parameter of interest using the impedance information.
Abstract:
A component of a wellbore tool comprises a plurality of compartments disposed over a body of the component and a coating disposed over at least a portion of a surface of the body. Each compartment comprises a healing agent formulated to form or catalyze the formation of a barrier upon release from the compartment. A matrix material separates the plurality of compartments. Methods of forming wellbore tools include forming a body, forming a plurality of capsules, and forming a coating comprising the capsules over the body. Methods of utilizing a wellbore tool in a subterranean borehole include contacting at least a portion of a body with a fluid comprising a healing agent formulated to a barrier. Coatings for wellbore tools include a fiber comprising a plurality of discrete cells and a matrix material contacting and at least partially surrounding the fiber. Each cell comprises a healing agent.
Abstract:
The present disclosure relates to an apparatus and method for estimating a parameter of interest in a downhole fluid using a fluid analysis module. The fluid analysis module may include: a first transducer configured to generate a surface wave in a fluid. The first transducer may include one or more of: a piezoelectric crystal, a electromagnetic transducer, and a surface acoustic wave crystal. The apparatus may use the first transducer or a second transducer to generate a signal indicative of the dissipation of the surface wave in the fluid. The apparatus may include a compensator configured to reduce mechanical pressure on the transducer. The method may include estimating a parameter of interest of the fluid using a signal indicative of the dissipation of the surface wave.
Abstract:
In an aspect, a drilling apparatus is provided, wherein the apparatus includes a drill string to be disposed in a borehole. The drill string includes a tubular, a borehole assembly coupled to the tubular and a drill bit disposed at an end of the borehole assembly. Further, the apparatus includes a strain gauge directly deposited on the drill string.