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81.发明申请Isolated Ny-Eso-1 Peptides Which Bind To Hla Class II Molecules And Uses Thereof 审中-公开隔离的Ny-Eso-1肽，其绑定到Hla II类分子及其用途公开(公告)号：US20080139464A1
公开(公告)日：2008-06-12
申请号：US10556853
申请日：2004-05-27
申请人： Sacha Gnjatic , Djordje Atanackovic , Lloyd J. Old
发明人： Sacha Gnjatic , Djordje Atanackovic , Lloyd J. Old
CPC分类号： C07K14/4748
摘要： The invention relates to peptides which consist of amino acid sequences found in the NY-ESO-1 molecule, which bind to MHC-Class II molecules. These can be used alone, or in combination with other peptides.
摘要翻译： 本发明涉及由NY-ESO-1分子中发现的结合MHC-II类分子的氨基酸序列组成的肽。 这些可以单独使用，也可以与其他肽组合使用。
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公开(公告)号：US07335467B2
公开(公告)日：2008-02-26
申请号：US10146473
申请日：2002-05-15
申请人： Matthew J. Scanlan , Ivan Gout , Elisabeth Stockert , Lloyd J. Old , Ali Gure , Yao-Tseng Chen
发明人： Matthew J. Scanlan , Ivan Gout , Elisabeth Stockert , Lloyd J. Old , Ali Gure , Yao-Tseng Chen
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/567 , G01N33/574 , G01N1/00 , G01N33/48 , C12P19/34
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/158 , Y10T436/25
摘要： The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses in breast cancer. The identified antigens can be utilized as markers for diagnosing breast cancer, and for following the course of treatment of breast cancer.
摘要翻译： 本发明提供了鉴定某些乳腺癌相关多肽作为在乳腺癌中引起免疫反应的抗原来诊断包括乳腺癌在内的癌症的方法。 鉴定的抗原可用作诊断乳腺癌的标志物，并用于跟踪乳腺癌的治疗过程。
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83.发明授权公开(公告)号：US06846910B2
公开(公告)日：2005-01-25
申请号：US09265606
申请日：1999-03-10
申请人： Rainer Zimmermann , John E. Park , Wolfgang Rettig , Lloyd J. Old
发明人： Rainer Zimmermann , John E. Park , Wolfgang Rettig , Lloyd J. Old
IPC分类号： C07K14/705 , C12N9/48 , C12P21/04 , C07K14/745 , C07K14/52 , C07K19/00
CPC分类号： C07K14/705 , C12N9/48
摘要： The invention involves dimeric forms of the protein known as fibroblast activation protein alpha, or “FAPα” and its uses.
摘要翻译： 本发明涉及称为成纤维细胞激活蛋白α或“FAPalpha”的蛋白质的二聚体形式及其用途。
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84.发明授权Isolated nucleic acid molecule encoding cancer associated antigens, the antigens per se, and uses thereof 失效编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US06830924B1
公开(公告)日：2004-12-14
申请号：US09270437
申请日：1999-03-16
申请人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
发明人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
IPC分类号： C12N1563
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The invention relates to newly identified cancer associated antigens, referred to as CT7, KOC-2 and KOC-3. The invention also relates to observations regarding known molecule KOC-1. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌相关抗原，称为CT7，KOC-2和KOC-3。 本发明还涉及关于已知分子KOC-1的观察。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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85.发明授权Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof 有权对应于NY-ESO-1的氨基酸序列的分离的肽，其结合MHC I类和II类分子，以及其用途公开(公告)号：US06723832B1
公开(公告)日：2004-04-20
申请号：US09165546
申请日：1998-10-02
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
IPC分类号： C07K700
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K16/18
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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86.发明授权公开(公告)号：US06576756B2
公开(公告)日：2003-06-10
申请号：US09899651
申请日：2001-07-06
申请人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jäger , Knuth Alexander , Lloyd J. Old
发明人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jäger , Knuth Alexander , Lloyd J. Old
IPC分类号： C07H2104
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The invention relates to the isolation of a nucleic acid molecule which encodes a cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen, and peptides derived from it.
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87.发明授权Compositions containing a p53 derived protein or peptide, an adjuvant, and interleukin-12 and uses thereof 失效含有p53衍生的蛋白质或肽，佐剂和白细胞介素-12的组合物及其用途公开(公告)号：US06355256B1
公开(公告)日：2002-03-12
申请号：US08408915
申请日：1995-03-22
申请人： Yuji Noguchi , Yao-tseng Chen , Lloyd J. Old
发明人： Yuji Noguchi , Yao-tseng Chen , Lloyd J. Old
IPC分类号： A61K3900
CPC分类号： C07K14/82 , A61K39/00 , A61K39/0011 , A61K2039/55538 , A61K2039/55577
摘要： The invention involves the combination of Interleukin-12 with p53 derived peptides and an adjuvant, preferably QS-21. It is found that this combination provokes a surprisingly strong immune response. Further, in an accepted in vivo model, the use of compositions containing these three ingredients led to diamatic decreases in the growth of induced tumors, thus suggesting a therapeutic regime.
摘要翻译： 本发明涉及白细胞介素-12与p53衍生的肽的组合和佐剂，优选QS-21。 发现这种组合引起惊人的强的免疫应答。 此外，在接受的体内模型中，含有这三种成分的组合物的使用导致诱导肿瘤生长的直径降低，从而表明了治疗方案。
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88.发明授权Methods for determining presence of cancer in a sample by determining expression of an SSX gene 失效通过确定SSX基因表达来确定样品中癌症存在的方法公开(公告)号：US06287756B1
公开(公告)日：2001-09-11
申请号：US09105839
申请日：1998-06-26
申请人： Özlem Türeci , Yao-Tseng Chen , Ugur Sahin , Ali O. Gure , Lloyd J. Old , Michael Pfreundschuh
发明人： Özlem Türeci , Yao-Tseng Chen , Ugur Sahin , Ali O. Gure , Lloyd J. Old , Michael Pfreundschuh
IPC分类号： G01N3353
CPC分类号： C07K14/82 , A61K38/00 , G01N33/57484 , G01N2333/82
摘要： The invention relates to members of the SSX family of genes, as well as to their uses.
摘要翻译： 本发明涉及SSX家族基因的成员以及它们的用途
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公开(公告)号：US6057115A
公开(公告)日：2000-05-02
申请号：US491310
申请日：1995-06-16
申请人： Gerd Ritter , Lloyd J. Old
发明人： Gerd Ritter , Lloyd J. Old
IPC分类号： G01N33/53 , A61K39/39 , A61K39/395 , A61P31/04 , A61P35/00 , C07K16/12 , C07K16/44 , C12P21/00 , C12R1/01 , G01N33/569 , G01N33/574
CPC分类号： G01N33/56922 , G01N2333/205 , G01N2400/50
摘要： The invention relates to the production of ganglioside specific antibodies. These antibodies are produced following immunization with lipopolysaccharide antigen of Campylobacter jejuni. The antibodies bind to monosialogangliosides, including GM2 and GM1.
摘要翻译： 本发明涉及神经节苷脂特异性抗体的产生。 这些抗体是在空肠弯曲杆菌的脂多糖抗原免疫后产生的。 抗体结合单神经节神经节苷脂，包括GM2和GM1。
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90.发明授权Isolated nucleic acid molecules associated with colon cancer and methods for diagnosing and treating colon cancer 失效与结肠癌相关的分离的核酸分子以及诊断和治疗结肠癌的方法
公开(公告)号：US6043084A
公开(公告)日：2000-03-28
申请号：US948705
申请日：1997-10-10
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12Q1/68 , G01N33/569 , G01N33/574 , C12N5/10 , C12N15/63
CPC分类号： C07K14/4748 , C12Q1/6886 , G01N33/56977 , G01N33/5748 , A61K38/00
摘要： Various molecules associated with disorders such as colon cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules.
摘要翻译： 公开了与诸如结肠癌的疾病相关的各种分子。 本发明还公开了基于这些分子的诊断和治疗方法。
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