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88 条记录 (耗时 0.028 秒)

    Targeted delivery of antimicrobial agents
    81.
    发明授权
    Targeted delivery of antimicrobial agents 有权
    靶向递送抗微生物剂

    公开(公告)号：US08404636B2

    公开(公告)日：2013-03-26

    申请号：US12502420

    申请日：2009-07-14

    申请人： Barney Bishop ,  Monique van Hoek ,  Keith M. Davies

    发明人： Barney Bishop ,  Monique van Hoek ,  Keith M. Davies

    IPC分类号： A61K38/08

    CPC分类号： A61K47/64 ,  A61K31/15 ,  A61K31/165 ,  A61K31/5383 ,  A61K47/645

    摘要： A cationic antimicrobial peptide (CAMP) conjugate is disclosed. The CAMP conjugate may be made by identifying a suitable carrier peptide; identifying a suitable antimicrobial agent; creating a conjugate by conjugating the peptide with the antimicrobial agent; and evaluating and refining the conjugate. The peptide may be short peptide based on the sequence of a CAMP, such as human β-defensin-3. The peptide can be directly connected to the antimicrobial agent or through a linker segment. The antimicrobial agent may be connected to the peptide or the linker segment through stable or cleavable bonding. The peptide may carry and facilitate the delivery of the conjugated antimicrobial agent to a microbe.

    摘要翻译： 公开了一种阳离子抗微生物肽（CAMP）缀合物。 可以通过鉴定合适的载体肽来制备CAMP缀合物; 鉴定合适的抗微生物剂; 通过将肽与抗微生物剂缀合而产生结合物; 并评估和改良缀合物。 肽可以是基于CAMP的序列的短肽，例如人和防腐素-3。 肽可以直接连接到抗微生物剂或通过接头片段。 抗微生物剂可以通过稳定或可切割的结合连接到肽或接头片段。 肽可以携带和促进缀合的抗微生物剂递送到微生物。

    Therapeutic Peptide-Polysaccharide Biomaterials
    83.
    发明申请
    Therapeutic Peptide-Polysaccharide Biomaterials 审中-公开
    治疗性肽 - 多糖生物材料

    公开(公告)号：US20100016546A1

    公开(公告)日：2010-01-21

    申请号：US11556366

    申请日：2006-11-03

    申请人： Barney Bishop

    发明人： Barney Bishop

    IPC分类号： C07K9/00

    CPC分类号： C07K14/4723

    摘要： Peptide-polysaccharide conjugates may be created by linking at least one peptide to a polysaccharide. The peptide may be a defensin having at least a portion of the amino acid sequence of human-β-defensin-3. The portion may be the last 10-14 residues of the amino acid sequence. The polysaccharide may be functionalized with at least one R group prior to the linkage to aid in the linkage.

    摘要翻译： 肽 - 多糖缀合物可以通过将至少一种肽连接到多糖而产生。 肽可以是具有人-β-防御素-3的氨基酸序列的至少一部分的防御素。 该部分可以是氨基酸序列的最后10-14个残基。 在连接之前，多糖可以用至少一个R基官能化以辅助连接。

    Smart Hydrogel Particles for Biomarker Harvesting
    87.
    发明申请
    Smart Hydrogel Particles for Biomarker Harvesting 有权
    用于生物标记收获的智能水凝胶颗粒

    公开(公告)号：US20120164749A1

    公开(公告)日：2012-06-28

    申请号：US12194360

    申请日：2008-08-19

    申请人： Alessandra Luchini ,  Lance Liotta ,  Emanuel Petricoin ,  Barney Bishop ,  Caterina Longo ,  Virginia Espina ,  Alexis Patanarut

    发明人： Alessandra Luchini ,  Lance Liotta ,  Emanuel Petricoin ,  Barney Bishop ,  Caterina Longo ,  Virginia Espina ,  Alexis Patanarut

    IPC分类号： G01N1/18 ,  C08F220/56 ,  B82Y40/00

    CPC分类号： G01N33/5432 ,  G01N33/5436 ,  Y10T428/2989 ,  Y10T428/2998 ,  Y10T436/25375

    摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.

    摘要翻译： 描述从溶液中收集分析物的捕获颗粒和使用它们的方法。 捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。 当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。 捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。 捕获颗粒可用于分离和鉴定混合物中存在的分析物。 它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。