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81.发明授权公开(公告)号：US07799758B2
公开(公告)日：2010-09-21
申请号：US11678535
申请日：2007-02-23
CPC分类号： C07K14/75 , A61K38/00 , Y02A50/385
摘要： Therapeutic compositions can include modified peptides which are derived from the chain of the Bbeta(15-42)-fibrin fragment and wherein one or several of the amino acids of the sequence have been substituted by genetically encoded or not genetically encoded amino acids or peptidomimetics. They may exist as free peptides or as C-terminal derivative and/or being linked to a polyethylene glycol (PEG)-polymer, and have anti-inflammatory and/or endothelium stabilizing effects. Esters or amides may for instance be taken into consideration as C-terminal derivatives. Processes for production of the peptides and derivatives thereof are also described.
摘要翻译： 治疗组合物可以包括衍生自Bβ（15-42） - 纤维蛋白片段的链的修饰肽，并且其中序列的一个或几个氨基酸已被遗传编码的或未经遗传编码的氨基酸或肽模拟物取代。 它们可以作为游离肽或C末端衍生物存在和/或与聚乙二醇（PEG） - 聚合物连接，并具有抗炎和/或内皮稳定作用。 酯或酰胺可以例如被考虑为C末端衍生物。 还描述了肽及其衍生物的制备方法。
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82.发明申请公开(公告)号：US20090018310A1
公开(公告)日：2009-01-15
申请号：US12280544
申请日：2007-02-23
IPC分类号： C07K14/00
CPC分类号： C07K14/75
摘要： The invention relates to peptides and peptide derivatives of the following general Formulas (Ia) and (Ib) as well as in particular anti-inflammatory drugs containing these peptides.
摘要翻译： 本发明涉及以下通式（Ia）和（Ib）的肽和肽衍生物，特别是含有这些肽的抗炎药。
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公开(公告)号：US20050223940A1
公开(公告)日：2005-10-13
申请号：US10510962
申请日：2003-05-08
申请人： Oliver Seeger , Norbert Mronga , Rainer Henning , Raimund Schmid
发明人： Oliver Seeger , Norbert Mronga , Rainer Henning , Raimund Schmid
CPC分类号： C09C1/0015 , C01P2004/20 , C01P2004/84 , C09C2200/1054 , C09C2200/402 , C09C2200/408 , C09C2200/409
摘要： Goniochromatic luster pigments comprising at least one dielectric low-refractive interference-colored layer which includes a polar organic solvent which can interact with the layer material via functional groups.
摘要翻译： 包含至少一个电介质低折射干涉着色层的色度光泽颜料，其包括可通过官能团与层材料相互作用的极性有机溶剂。
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公开(公告)号：US06858612B1
公开(公告)日：2005-02-22
申请号：US09357212
申请日：1999-07-20
IPC分类号： A61K31/505 , A61K31/519 , A61P7/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/28 , A61P43/00 , C07D475/04 , C07D475/06 , C07D475/08 , A61K31/495 , A61K31/50
CPC分类号： C07D475/08 , C07D475/04
摘要： The present invention relates to the use of pteridine derivatives of the formula I in which X is O or NH and R4, for example, is hydrogen, phenyl or the radical R4a—CH2— and R4a, for example, is hydrogen, (C1-C4)-alkylmercapto, the radical —NR11R12 or the radical —OR13, and in which R1, R2, R3, R5, R6, R7, R11, R12 and R13 have the meanings given in claim 1, which are nitric oxide synthase inhibitors, for the treatment of diseases which are caused by an increased nitric oxide level.
摘要翻译： 本发明涉及式Iin的蝶啶衍生物，其中X为O或NH，R 4为例如氢，苯基或基团R 4a -CH 2 - 和R 4a的基团，用于 例如，是氢，（C 1 -C 4） - 烷基巯基，基团-NR 11 R 12或基团-OR 13，其中R 1，R 2，R 3， R 5，R 6，R 7，R 11，R 12和R 13具有权利要求1中给出的含义，其为一氧化氮合酶抑制剂，用于治疗疾病 这是由一氧化氮水平升高引起的。
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公开(公告)号：US5550255A
公开(公告)日：1996-08-27
申请号：US202478
申请日：1994-02-28
IPC分类号： C07D209/42 , A61K31/40 , C07D207/42 , C07D209/02 , C07D209/52 , A61K31/405
CPC分类号： C07D207/42 , C07D209/52
摘要： The invention relates to compounds of the formula I ##STR1## in which n is 1, 2 or 3,Z.sup.1 and Z.sup.2, and Z.sup.3 and Z.sup.4, in each case together represent a chemical bond orZ.sup.1, Z.sup.2, Z.sup.3 and Z.sup.4 in each case represent hydrogen,Z.sup.1 and Z.sup.2 being in the cis configuration relative to one another and the COR.sup.1 group on C atom 3 being in the endo configuration relative to the bicyclic ring system,R.sup.1 denotes hydroxyl, alkoxy, aralkoxy, amino, alkylamino or dialkylamino andR.sup.2 denotes hydrogen, alkyl, aryl, aralkyl, cycloalkyl or alkylcycloalkyl,processes for their preparation and their use.
摘要翻译： 本发明涉及式Ⅰ（I）化合物，其中n为1,2或3，Z 1和Z 2，Z 3和Z 4各自在一起代表化学键或Z 1，Z 2，Z 3和Z 4 在每种情况下代表氢，Z1和Z2相对于彼此处于顺式构型，并且C原子3上的COR1基团相对于双环系统处于内部构型，R1表示羟基，烷氧基，芳烷氧基，氨基，烷基氨基或 二烷基氨基，R 2表示氢，烷基，芳基，芳烷基，环烷基或烷基环烷基，其制备及其用途。
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公开(公告)号：US5122398A
公开(公告)日：1992-06-16
申请号：US618331
申请日：1990-11-26
申请人： Erhard Seiler , Klaus-Dieter Ruempler , Norbert Jung , Udo Haardt , Rainer Henning , Juergen Hamprecht
发明人： Erhard Seiler , Klaus-Dieter Ruempler , Norbert Jung , Udo Haardt , Rainer Henning , Juergen Hamprecht
CPC分类号： B60R19/03 , B60R2019/1853 , B60R2019/1873 , B60R2019/1886 , Y10T428/233 , Y10T428/24744 , Y10T428/249992
摘要： A recyclable bumper system based on polypropylene comprises a bumper support A of glass fiber reinforced polypropylene, an energy-absorbing foam core B of foamed polypropylene and a tough shell C of EP-rubber modified polypropylene which may be coated, and can be recycled by mechanical comminution, extrusion and granulation, resulting in granules from which injection moldings having good mechanical properties can be produced.
摘要翻译： 基于聚丙烯的可回收保险杠系统包括玻璃纤维增强聚丙烯的保险杠支撑件A，发泡聚丙烯的能量吸收泡沫芯B和可以被涂覆的EP-橡胶改性聚丙烯的韧性壳体C，并且可以通过机械 粉碎，挤出和造粒，从而可以生产具有良好机械性能的注射成型品的颗粒。
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