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86 条记录 (耗时 0.044 秒)

    Cis, endo-2-azabicycloalkane-3-carboxylic acid derivatives
    1.
    发明授权
    Cis, endo-2-azabicycloalkane-3-carboxylic acid derivatives 失效
    Cis，内-2-氮杂双环链烷-3-羧酸衍生物

    公开(公告)号：US5550255A

    公开(公告)日：1996-08-27

    申请号：US202478

    申请日：1994-02-28

    申请人： Hansj org Urbach ,  Rainer Henning ,  Winfried Hertzsch

    发明人： Hansj org Urbach ,  Rainer Henning ,  Winfried Hertzsch

    IPC分类号： C07D209/42 ,  A61K31/40 ,  C07D207/42 ,  C07D209/02 ,  C07D209/52 ,  A61K31/405

    CPC分类号： C07D207/42 ,  C07D209/52

    摘要： The invention relates to compounds of the formula I ##STR1## in which n is 1, 2 or 3,Z.sup.1 and Z.sup.2, and Z.sup.3 and Z.sup.4, in each case together represent a chemical bond orZ.sup.1, Z.sup.2, Z.sup.3 and Z.sup.4 in each case represent hydrogen,Z.sup.1 and Z.sup.2 being in the cis configuration relative to one another and the COR.sup.1 group on C atom 3 being in the endo configuration relative to the bicyclic ring system,R.sup.1 denotes hydroxyl, alkoxy, aralkoxy, amino, alkylamino or dialkylamino andR.sup.2 denotes hydrogen, alkyl, aryl, aralkyl, cycloalkyl or alkylcycloalkyl,processes for their preparation and their use.

    摘要翻译： 本发明涉及式Ⅰ（I）化合物，其中n为1,2或3，Z 1和Z 2，Z 3和Z 4各自在一起代表化学键或Z 1，Z 2，Z 3和Z 4 在每种情况下代表氢，Z1和Z2相对于彼此处于顺式构型，并且C原子3上的COR1基团相对于双环系统处于内部构型，R1表示羟基，烷氧基，芳烷氧基，氨基，烷基氨基或 二烷基氨基，R 2表示氢，烷基，芳基，芳烷基，环烷基或烷基环烷基，其制备及其用途。

    Cis,endo-2-azabicycloalkane-3-carboxylic acid derivatives, their use and intermediates in their preparation
    2.
    发明授权
    Cis,endo-2-azabicycloalkane-3-carboxylic acid derivatives, their use and intermediates in their preparation 失效
    顺式，内-2-氮杂双环链烷-3-羧酸衍生物，其用途及其制备中间体

    公开(公告)号：US4886827A

    公开(公告)日：1989-12-12

    申请号：US205001

    申请日：1988-06-02

    申请人： Hansjorg Urbach ,  Rainer Henning ,  Winfried Hertzsch

    发明人： Hansjorg Urbach ,  Rainer Henning ,  Winfried Hertzsch

    IPC分类号： C07D209/42 ,  A61K31/40 ,  C07D207/42 ,  C07D209/02 ,  C07D209/52

    CPC分类号： C07D207/42 ,  C07D209/52

    摘要： The invention relates to compounds of the formula I ##STR1## in which n is 1, 2 or 3,Z.sup.1 and Z.sup.2, and Z.sup.3 and Z.sup.4, in each case together represent a chemical bond orZ.sup.1, Z.sup.2, Z.sup.3 and Z.sup.4 in each case represent hydrogen,Z.sup.1 and Z.sup.2 being in the cis configuration relative to one another and the COR.sup.1 group on C atom 3 being in the endo configuration relative to the bicyclic ring system,R.sup.1 denotes hydroxyl, alkoxy, aralkoxy, amino, alkylamino or dialkylamino andR.sup.2 denotes hydrogen, alkyl, aryl, aralkyl, cycloalkyl or alkylcycloalkyl,processes for their preparation and their use.

    摘要翻译： 本发明涉及式Ⅰ（I）化合物，其中n为1,2或3，Z 1和Z 2，Z 3和Z 4各自在一起代表化学键或Z 1，Z 2，Z 3和Z 4 在每种情况下代表氢，Z1和Z2相对于彼此处于顺式构型，并且C原子3上的COR1基团相对于双环系统处于内部构型，R1表示羟基，烷氧基，芳烷氧基，氨基，烷基氨基或 二烷基氨基，R 2表示氢，烷基，芳基，芳烷基，环烷基或烷基环烷基，其制备及其用途。

    Pharmaceutical composition for treating haemorrhagic shock and its consecutive symptoms
    4.
    发明授权
    Pharmaceutical composition for treating haemorrhagic shock and its consecutive symptoms 失效
    用于治疗出血性休克及其连续症状的药物组合物

    公开(公告)号：US07897574B2

    公开(公告)日：2011-03-01

    申请号：US12158670

    申请日：2006-11-10

    申请人： Peter Petzelbauer ,  Rainer Henning

    发明人： Peter Petzelbauer ,  Rainer Henning

    IPC分类号： A61K38/36

    CPC分类号： A61K38/16 ,  Y02A50/411

    摘要： The invention is concerned with the use of a peptide comprising the N-terminal sequence Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro-Ala- Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg (SEQ ID NO: 1) or any allelic variant or derivative of said peptide possessing the biological property of matching the inducible VE-cadherin binding motif on the Bβ-chain (i.e. Bβ15-42) of human fibrin for the preparation of a pharmaceutical preparation for the treatment of shock, more specifically of hemorrhagic shock.

    摘要翻译： 本发明涉及使用包含N-末端序列Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro- （SEQ ID NO：1）或具有与诱导型VE-钙粘蛋白结合基序匹配的生物学特性的所述肽的任何等位基因变体或衍生物（Pro-Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg 在人类纤维蛋白的B＆bgr-chain（即B＆Bgr; 15-42）上制备用于治疗休克的药物制剂，更具体地说是出血性休克。

    (En) Pharmaceutical Composition for Treating Haemorrhagic Shock and its Consecutive Symptoms
    6.
    发明申请
    (En) Pharmaceutical Composition for Treating Haemorrhagic Shock and its Consecutive Symptoms 失效
    （En）用于治疗出血性休克及其连续症状的药物组合物

    公开(公告)号：US20090005310A1

    公开(公告)日：2009-01-01

    申请号：US12158670

    申请日：2006-11-10

    申请人： Peter Petzelbauer ,  Rainer Henning

    发明人： Peter Petzelbauer ,  Rainer Henning

    IPC分类号： A61K38/17 ,  A61P7/04 ,  C12Q1/02

    CPC分类号： A61K38/16 ,  Y02A50/411

    摘要： The invention is concerned with the use of a peptide comprising the N-terminal sequence Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala- Pro-Ser-Leu-Arg-Pro-Ala-Pro-Pro-Pro-Ile-Ser-Gly- Gly-Gly-Tyr-Arg or any allelic variant or derivative of said peptide possessing the biological property of matching the inducible VE-cadherin binding motif on the Bβ-chain (i.e. Bβ15-42) of human fibrin for the preparation of a pharmaceutical preparation for the treatment of shock, more specifically of hemorrhagic shock.

    摘要翻译： 本发明涉及使用包含N-末端序列的肽

    Pro-Ser-Leu-Arg-Pro-Ala-Pro -Pro-Pro-Ile-Ser-Gly - Gly-Gly-Tyr-Arg 或具有与Bbeta链上的诱导型VE-钙粘蛋白结合基序匹配的生物学特性的所述肽的任何等位基因变体或衍生物（即Bbeta15 -42），用于制备用于治疗休克的药物制剂，更具体地说是出血性休克。