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144 条记录 (耗时 0.035 秒)

    Imidazolidin-2-one derivatives as selective androgen receptor modulators (SARMS)
    82.
    发明授权
    Imidazolidin-2-one derivatives as selective androgen receptor modulators (SARMS) 有权
    咪唑啉-2-酮衍生物作为选择性雄激素受体调节剂（SARMS）

    公开(公告)号：US07531565B2

    公开(公告)日：2009-05-12

    申请号：US11223187

    申请日：2005-09-09

    申请人： James C. Lanter ,  Zhihua Sui

    发明人： James C. Lanter ,  Zhihua Sui

    IPC分类号： A61K31/4166 ,  C07D233/30

    CPC分类号： C07D233/34

    摘要： The present invention is directed to novel imidazolidin-2-one derivatives having a structure according to Formula I wherein a, b, R1, R2, R3, and R4 are as defined above, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

    摘要翻译： 本发明涉及具有式I结构的新的咪唑烷-2-酮衍生物，其中a，b，R1，R2，R3和R4如上定义，含有它们的药物组合物及其在治疗疾病中的用途 和由雄激素受体调节的条件。

    Indole derivatives useful as progesterone receptor modulators
    86.
    发明申请
    Indole derivatives useful as progesterone receptor modulators 有权
    吲哚衍生物可用作孕激素受体调节剂

    公开(公告)号：US20060111427A1

    公开(公告)日：2006-05-25

    申请号：US11255444

    申请日：2005-10-21

    申请人： Weiqin Jiang ,  James Fiordeliso ,  Zhihua Sui

    发明人： Weiqin Jiang ,  James Fiordeliso ,  Zhihua Sui

    IPC分类号： A61K31/404 ,  C07D209/36

    CPC分类号： C07D209/30

    摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of these compounds are related to contraception, the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minication of side effects of cyclid menstrual bleeding. Additional uses of the invention include stimulation of food intake.

    摘要翻译： 本发明涉及新颖的吲哚衍生物，含有它们的药物组合物及其在治疗或预防由孕酮受体的激动剂和拮抗剂介导的病症和疾病中的用途。 这些化合物的临床应用与避孕，继发性闭经，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症的治疗和/或预防有关; 多囊卵巢综合征，子宫内膜癌，卵巢癌，乳腺癌，结肠癌，前列腺癌，腺瘤，子宫内膜异位症，副周围性月经出血副作用。 本发明的额外用途包括刺激食物摄取。

    Novel thiazoline derivatives as selective androgen receptor modulators (SARMS)
    89.
    发明申请
    Novel thiazoline derivatives as selective androgen receptor modulators (SARMS) 审中-公开
    新型噻唑啉衍生物作为选择性雄激素受体调节剂（SARMS）

    公开(公告)号：US20050014952A1

    公开(公告)日：2005-01-20

    申请号：US10866591

    申请日：2004-06-12

    申请人： Raymond Ng ,  Zhihua Sui

    发明人： Raymond Ng ,  Zhihua Sui

    IPC分类号： A61P5/26 ,  C07D277/12 ,  C07D417/02 ,  C07D277/18

    CPC分类号： C07D277/12

    摘要： The present invention is directed to novel thiazoline derivatives of the general formula (I) wherein all variables are as herein defined, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

    摘要翻译： 本发明涉及通式（I）的新型噻唑啉衍生物，其中所有变量如本文所定义，含有它们的药物组合物及其用于治疗由雄激素受体调节的病症和状况。