公开(公告)号：US11654555B2

公开(公告)日：2023-05-23

申请号：US17102853

申请日：2020-11-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soonkyum Kim ,  Woosub Lee ,  Alchan Yun ,  Junhyoung Ha ,  Deaho Moon

IPC: B25J9/16

CPC classification number: B25J9/163

Abstract: The present disclosure relates to a robot teaching system, which moves a robot according to an external force applied from the outside so that the robot has a location and posture intended for teaching and then teaches a location and posture of the moved robot, and the robot teaching system comprises: an arm including a plurality of articular shafts and a plurality of links connected by the plurality of articular shafts; a plurality of strain gauges respectively coupled to frames of the plurality of links to measure a deformation value of the link that is deformed by the external force; and a calculating device configured to estimate the external force from the deformation value of the link obtained by the plurality of strain gauges, calculate a teaching force from the external force and move the robot by an operation corresponding to the teaching force.

公开(公告)号：US11649282B2

公开(公告)日：2023-05-16

申请号：US16771918

申请日：2020-03-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Mihue Jang ,  Eunsung Jun ,  Anna Ju

IPC: C07K16/28 ,  A61K35/17 ,  C07K14/705 ,  C12N15/86 ,  A61P35/00 ,  C07K14/725 ,  C12N5/0783 ,  A61K38/00 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K35/17 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70575 ,  C07K14/70578 ,  C12N5/0646 ,  C12N15/86 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/33 ,  C12N2510/00 ,  C12N2740/15043

Abstract: Provided are a genetically modified immunocyte expressing a chimeric antigen receptor (CAR) comprising an antigen binding domain specifically binding to cancer cells and/or expressing TRAIL, a composition for preventing or treating cancer, the composition comprising the immunocytes, a cell therapeutic agent, a method of providing information for cancer diagnosis, and a method of preparing the genetically modified immunocyte.

公开(公告)号：US20230142462A1

公开(公告)日：2023-05-11

申请号：US17972912

申请日：2022-10-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyung-jun KIM ,  Seunghwan KIM ,  Daeyoon BAEK

IPC: H01L29/10 ,  H01L29/66 ,  H01L29/78 ,  H01L29/04

CPC classification number: H01L29/1033 ,  H01L29/66795 ,  H01L29/7851 ,  H01L29/045

Abstract: Embodiments relate to a semiconductor device including a trench with undercut structure including a substrate made of a first material; an insulation layer formed on an upper surface of the substrate; at least one trench penetrating the insulation layer toward the substrate; and at least one seed layer formed in the trench, the seed layer made of a second material which is different from the first material, and a method for manufacturing the same.

公开(公告)号：US20230140453A1

公开(公告)日：2023-05-04

申请号：US18052282

申请日：2022-11-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KOREA FOOD RESEARCH INSTITUTE

Inventor： Eun Mi HWANG ,  Ajung KIM ,  Jaekwang LEE ,  Seoyoung JUNG

IPC: G01N33/50

Abstract: The present invention relates to obesity control by regulating the expression level of TREK1.

公开(公告)号：US20230136591A1

公开(公告)日：2023-05-04

申请号：US17570386

申请日：2022-01-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chong Min KOO ,  Tae Gon OH ,  Seung Jun LEE ,  Seon Joon KIM ,  Soon Man HONG ,  Seung Sang HWANG ,  Albert Lee

IPC: C09K13/06

Abstract: The present invention relates to an etching composition and a method of producing a MXene. The etching composition of the present invention can stably and quickly produce a MXene at high temperature. The etching composition of the present invention can produce a MXene in high yield. The etching composition of the present invention can easily produce various types of MXenes. A method using the etching composition of the present invention can produce a MXene having excellent electrochemical and mechanical properties.

公开(公告)号：US11639891B2

公开(公告)日：2023-05-02

申请号：US17498755

申请日：2021-10-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Joonhyun Kang ,  Il Ki Han ,  S. Joon Kwon ,  Young Min Jhon

IPC: G01N21/17 ,  G01N33/00

Abstract: The present disclosure relates to a photoacoustic gas sensor for detecting the presence or absence of gas using the interaction of a laser beam and gas molecules. The integrated photoacoustic gas sensor according to an embodiment includes a light output unit; a lens unit configured to concentrate a laser beam output from the light output unit; and a photoacoustic sensing unit having a quartz tuning fork aligned on the lens unit and configured to convert a vibration, generated when the laser beam passing through the lens unit interacts with gas molecules, into an electric signal.

公开(公告)号：US11638737B2

公开(公告)日：2023-05-02

申请号：US17023447

申请日：2020-09-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyoung Ja Kim ,  Chang Bae Jin ,  Hyun Beom Lee ,  Hyun Soo Choi ,  You Bin Cho

IPC: A61K36/73 ,  A61K9/00 ,  C07H15/24

Abstract: Disclosed are a Filipendula glaberrima alcoholic extract and solvent fractions fractionated therefrom or novel compounds 1 and 2 purely isolated from a Filipendula glaberrima ethyl acetate fraction that have an excellent inhibitory effect against HMG-CoA reductase activity, an excellent antioxidant effect and a remarkably excellent effect of suppressing the formation of foam cells in macrophages. Also, disclosed is a pharmaceutical composition or health food composition for treating, preventing and ameliorating vascular diseases, hypercholesterolemia, or heart diseases caused by hypercholesterolemia, or lowering blood cholesterol levels, containing, as active ingredients, the Filipendula glaberrima alcoholic extract and the solvent fractions or the novel compounds 1 and 2.

公开(公告)号：US11631878B2

公开(公告)日：2023-04-18

申请号：US17212261

申请日：2021-03-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ho Il Ji ,  Jong Ho Lee ,  Byung Kook Kim ,  Ji Won Son ,  Kyung Joong Yoon ,  Hyoung Chul Kim ,  Sang Baek Park ,  Sung Eun Yang ,  Jun Seok Kim

IPC: H01M8/1253 ,  H01M4/90 ,  H01M4/88 ,  H01M4/86 ,  H01M8/12

Abstract: Disclosed is a method of manufacturing a solid oxide fuel cell including a multi-layered electrolyte layer using a calendering process. The method for manufacturing a solid oxide fuel cell is a continuous process, thus providing high productivity and maximizing facility investment and processing costs. In addition, the solid oxide fuel cell manufactured by the method includes an anode that is free of interfacial defects and has a uniform packing structure, thereby advantageously greatly improving the production yield and power density. In addition, the solid oxide fuel cell has excellent interfacial bonding strength between respective layers included therein, and includes a multi-layered electrolyte layer in which the secondary phase at the interface is suppressed and which has increased density, thereby advantageously providing excellent output characteristics and long-term stability even at an intermediate operating temperature.

公开(公告)号：US20230114565A1

公开(公告)日：2023-04-13

申请号：US17962026

申请日：2022-10-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Hak Cheol KWON ,  Jaeyoung KWON ,  Seong-Hwan KIM ,  Jin Wook CHA ,  Soon Kwang LEE ,  Won Kyu KIM ,  Yujin KWON ,  Suyeon CHO ,  Taek Joo LEE ,  Jung Hwa KANG ,  Wan Hee LEE ,  Hyunki KIM

IPC: A61K36/73 ,  A61K36/268 ,  A61P35/00 ,  A61P1/00

Abstract: Provided are compositions for preventing or treating cancer, the compositions including Rubus longisepalus var. tozawai (Nakai) T.B.Lee extracts, or a fraction thereof as an active ingredient.
According to an aspect, a Rubus longisepalus var. tozawai (Nakai) T.B.Lee extract has an excellent anticancer efficacy against various cancers including diffuse-type gastric cancer, and thus, a cancer treatment agent having an excellent effect may be developed by using the extract as an active ingredient.

公开(公告)号：US11618916B2

公开(公告)日：2023-04-04

申请号：US16568363

申请日：2019-09-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Ick Chan Kwon ,  Ju Hee Ryu ,  Young-Ji Ko ,  Hye-Sun Kim ,  Nam-Hyuk Cho ,  Eun-Jeong Yang ,  Jae Won Lee

IPC: C12Q1/37 ,  G01N33/573

Abstract: A probe for measuring the activity of caspase-1 according to the present disclosure can specifically image cells or tissues where inflammatory response is induced because it is cleaved by reacting specifically with the active caspase-1 enzyme in vivo and in vitro and re-emits fluorescence. The probe for measuring the activity of caspase-1 can be used for various purposes, such as for imaging of cells or tissues where inflammatory response is induced, as a drug carrier, for screening of a drug inhibiting inflammatory response, etc.
The probe for measuring the activity of caspase-1 is applicable both in vivo and in vitro, and can be used for various applications such as high-throughput screening for new drug development, early diagnosis of diseases, etc.