公开(公告)号：US08710054B2

公开(公告)日：2014-04-29

申请号：US13681840

申请日：2012-11-20

Applicant: UCB Pharma, S.A.

Inventor： Rikki Peter Alexander ,  Pavandeep Singh Aujla ,  Karen Viviane Lucile Crepy ,  Anne Marie Foley ,  Richard Jeremy Franklin

IPC: A61K31/535 ,  C07D413/14

CPC classification number: C07D495/04 ,  C07D513/04 ,  C07D513/12 ,  C07D519/00

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract translation: 一系列在二位被取代的吗啉-4-基部分取代的6,7-二氢[1,3]噻唑并[5,4-c]吡啶-4（5H） - 酮衍生物是 因此PI3激酶的选择性抑制剂在医学中是有益的，例如在治疗炎症，自身免疫，心血管，神经变性，代谢，肿瘤，伤害性或眼科疾病中。

公开(公告)号：US08679494B2

公开(公告)日：2014-03-25

申请号：US12989373

申请日：2009-04-22

Applicant: Thomas Allen Ceska ,  Alistair James Henry

Inventor： Thomas Allen Ceska ,  Alistair James Henry

IPC: A61K39/395

CPC classification number: C07K16/244 ,  C07K14/54 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates neutralising epitopes of IL-17A and IL-17F and antibodies which bind those epitopes. The present invention also relates to the therapeutic uses of the antibody molecules and methods for producing them.

Abstract translation: 本发明涉及IL-17A和IL-17F的中和表位和与这些表位结合的抗体。 本发明还涉及抗体分子的治疗用途及其制备方法。

公开(公告)号：US08633194B2

公开(公告)日：2014-01-21

申请号：US10599451

申请日：2005-07-06

Applicant: Domenico Fanara ,  Jean Scouvart ,  Claire Poulain ,  Michel Deleers

Inventor： Domenico Fanara ,  Jean Scouvart ,  Claire Poulain ,  Michel Deleers

IPC: A61K31/48

CPC classification number: A61K47/14 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/0095 ,  A61K31/495

Abstract: The present invention relates to a liquid composition containing an active substance belonging to the family of substituted benzhydryl piperazines with reduced amounts of preservatives.

Abstract translation: 本发明涉及含有具有减少量的防腐剂的取代的二苯甲基哌嗪类的活性物质的液体组合物。

公开(公告)号：US08629246B2

公开(公告)日：2014-01-14

申请号：US12679873

申请日：2008-09-26

Applicant: David Paul Humphreys ,  Emma Dave ,  Laura Griffin ,  Sam Philip Heywood

Inventor： David Paul Humphreys ,  Emma Dave ,  Laura Griffin ,  Sam Philip Heywood

IPC: C12P21/08

CPC classification number: C07K16/468 ,  C07K16/00 ,  C07K16/18 ,  C07K16/245 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2317/64 ,  C07K2317/92

Abstract: The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab′ fragment with specificity for an antigen of interest, the fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.

Abstract translation: 本发明提供双重特异性抗体融合蛋白，其包含对感兴趣的抗原具有特异性的抗体Fab或Fab'片段，所述片段与至少一种对目标第二抗原具有特异性的单结构域抗体融合。

公开(公告)号：US08624022B2

公开(公告)日：2014-01-07

申请号：US13269321

申请日：2011-10-07

Applicant: Andrew David Carr ,  Judi Charlotte Neuss ,  Michael Glen Orchard ,  David William Porter

Inventor： Andrew David Carr ,  Judi Charlotte Neuss ,  Michael Glen Orchard ,  David William Porter

IPC: C07C237/06 ,  C07C229/28

CPC classification number: C07D207/14 ,  C07D211/72 ,  C07D223/12 ,  C07D267/10 ,  C07D281/06 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.

Abstract translation: 本发明涉及新型苯胺衍生物及其在治疗中的用途，特别是其用于治疗真菌感染。

公开(公告)号：US08614295B2

公开(公告)日：2013-12-24

申请号：US12706993

申请日：2010-02-17

Applicant: Alastair David Griffiths Lawson ,  Andrew Malcolm Nesbitt ,  Andrew George Popplewell ,  Stevan Graham Shaw ,  Diana Shpektor ,  Yi Zhang

Inventor： Alastair David Griffiths Lawson ,  Andrew Malcolm Nesbitt ,  Andrew George Popplewell ,  Stevan Graham Shaw ,  Diana Shpektor ,  Yi Zhang

IPC: C07K16/00 ,  A61K39/395 ,  C07H21/04 ,  C12N5/16

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/70578 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：US08518943B2

公开(公告)日：2013-08-27

申请号：US13441451

申请日：2012-04-06

Applicant: Benoit Kenda ,  Yannick Quesnel ,  Ali Ates ,  Philippe Michel ,  Laurent Turet ,  Joel Mercier

Inventor： Benoit Kenda ,  Yannick Quesnel ,  Ali Ates ,  Philippe Michel ,  Laurent Turet ,  Joel Mercier

IPC: A01N43/58 ,  A01N43/60 ,  A01N43/90 ,  A01N43/42 ,  A01N43/40 ,  A01N43/82 ,  A61K31/50 ,  A61K31/495 ,  A61K31/501 ,  A61K31/519 ,  A61K31/52 ,  A61K31/44

CPC classification number: C07D513/04 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04

Abstract: The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：US20130203968A1

公开(公告)日：2013-08-08

申请号：US13854455

申请日：2013-04-01

Applicant: Amgen Inc. ,  UCB Pharma S.A.

Inventor： Martin K. Robinson ,  Christopher J. Paszty ,  Alistair James Henry ,  Alastair Lawson ,  Andy Popplewell

IPC: C07K16/18

CPC classification number: C07K16/18 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.

Abstract translation: 提供了与硬骨素结合剂（例如能够结合硬化蛋白的抗体和多肽）相关的组合物和方法。

公开(公告)号：US20130178607A1

公开(公告)日：2013-07-11

申请号：US13812350

申请日：2011-07-27

Applicant: Gavin Barry Wild

Inventor： Gavin Barry Wild

IPC: C07K16/00

CPC classification number: C07K16/00 ,  C07K1/30 ,  C07K16/241 ,  C07K2317/14 ,  C07K2317/55 ,  C12N9/90 ,  C12P21/00

Abstract: The present invention provides method for purifying a recombinant protein from a gram-negative bacterial host cell sample or extract thereof wherein said host cell expresses a recombinant protein and a recombinant disulphide isomerase DsbC; comprising: a. adjusting the pH of the host cell sample or extract thereof to a pH of 5 or less to precipitate the recombinant disulphide isomerase; and b. separating precipitated recombinant disulphide isomerase DsbC from the recombinant protein to produce a recombinant protein sample.

Abstract translation: 本发明提供从革兰氏阴性细菌宿主细胞样品或其提取物中纯化重组蛋白的方法，其中所述宿主细胞表达重组蛋白和重组二硫异构酶DsbC; 包括：a。 将宿主细胞样品或其提取物的pH调节至5以下的pH以沉淀重组二硫异构酶; 和b。 从重组蛋白中分离沉淀的重组二硫化异构酶DsbC以产生重组蛋白质样品。

公开(公告)号：US20130079717A1

公开(公告)日：2013-03-28

申请号：US13532382

申请日：2012-06-25

Applicant: Anthony Torris ,  Alistair Bramley ,  Dan Formosa ,  Eric Freitag

Inventor： Anthony Torris ,  Alistair Bramley ,  Dan Formosa ,  Eric Freitag

IPC: A61M5/32 ,  A61M5/315

CPC classification number: A61M5/3232 ,  A61M5/3134 ,  A61M5/3137 ,  A61M5/31573 ,  A61M5/3204 ,  A61M5/321 ,  A61M5/326 ,  A61M5/34 ,  A61M5/5066 ,  A61M2005/3264 ,  A61M2005/3289 ,  A61M2207/00 ,  Y10T29/49826

Abstract: Systems, devices, and methods are provided for providing safe syringe assemblies for injections. The syringe assemblies include a shielding mechanism that covers a syringe needle after an injection is delivered, thereby reducing the risk of a subsequent accidental stab from the needle. The shielding mechanism has a pre-injection configuration in which the needle extends beyond the housing and a post-injection configuration in which at least one component of the syringe assembly covers the needle. In some implementations, the syringe assembly includes a lock that inhibits the assembly from returning to the pre-injection configuration once an injection is delivered. The syringe assemblies may also include a bevel orientation mechanism that allows a user to align a needle bevel to accurately insert a needle for injection.