公开(公告)号：US20240175029A1

公开(公告)日：2024-05-30

申请号：US18555012

申请日：2022-03-31

申请人： KYLONOVA (XIAMEN) BIOPHARMA CO., LTD.

发明人： Zhuo MU ,  Shengjun WANG

IPC分类号： C12N15/113 ,  A61K47/54 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61K47/54 ,  A61K47/548 ,  A61K47/549 ,  A61P31/20 ,  C12N2310/321

摘要： Provided are an RNA inhibitor for inhibiting hepatitis B virus (HBV) gene expression and an application thereof. The RNA inhibitor is formed of a sense strand and an antisense strand by means of base pairing; the sense strand and the antisense strand are at least 85% complementary to each other, and —OH at 2′ position of glycosyl of some or all of nucleotides is replaced by fluorine or methoxy, and phosphates between at least 3 consecutive nucleotides at the end are thioated. In the structure of the RNA inhibitor, 5′MVIP and 3′MVIP are also comprised, such that the RNA inhibitor has specific liver targeting. The RNA inhibitor can continuously inhibit the synthesis of an HBV surface antigen (HBsAg), can promote the production of HBV surface antibody (HBsAb), has an inhibitory effect on the most common types of HBV.

公开(公告)号：US20240174734A1

公开(公告)日：2024-05-30

申请号：US18059759

申请日：2022-11-29

申请人： YntoAb Co., Ltd.

发明人： Sung Young LEE ,  Na Ra Shin

IPC分类号： C07K16/08 ,  A61P31/20

CPC分类号： C07K16/081 ,  A61P31/20 ,  A61K2039/505

摘要： Antibodies that bind parvovirus are disclosed. The antibodies can be used in methods for preventing or treating parvovirus infection.

公开(公告)号：US20240173291A1

公开(公告)日：2024-05-30

申请号：US18540435

申请日：2023-12-14

申请人： THE TRUSTEES OF INDIANA UNIVERSITY ,  KOVINA THERAPEUTICS, INC

发明人： ELLIOT J. ANDROPHY ,  SAMY MEROUEH ,  ZHIJIAN LU ,  Anne RIETZ

IPC分类号： A61K31/381 ,  A61K9/00 ,  A61K38/10 ,  A61P31/20 ,  C07D215/06 ,  C07D487/04 ,  C07D495/04

CPC分类号： A61K31/381 ,  A61K9/0002 ,  A61K38/10 ,  A61P31/20 ,  C07D215/06 ,  C07D487/04 ,  C07D495/04

摘要： Compositions and methods are provided for treating HPV infections including pre-malignant and cancers. Compounds that specifically bind to the HPV E6 protein and inactivate the protein are disclosed.

公开(公告)号：US20240166699A1

公开(公告)日：2024-05-23

申请号：US18058516

申请日：2022-11-23

申请人： National Yang Ming Chiao Tung University

发明人： Ming-Han TSAI ,  Tung-Yi LIN

IPC分类号： C07K14/375 ,  A61P31/20 ,  A61P35/00

CPC分类号： C07K14/375 ,  A61P31/20 ,  A61P35/00

摘要： Provided herein is a method for preventing or treating an Epstein-Barr virus (EBV) infection, including administering to the subject in need thereof with an effective amount of immunomodulatory protein of Ganoderma, a recombinant thereof, or a fungal immunomodulatory protein of a similar structure. Also provided is a method for preventing or treating an EBV-associated cancer.

公开(公告)号：US20240139325A1

公开(公告)日：2024-05-02

申请号：US17769131

申请日：2020-10-19

申请人： AI-BIOPHARMA

发明人： Cyril B. DOUSSON ,  David DUKHAN

IPC分类号： A61K47/54 ,  A61P31/20

CPC分类号： A61K47/548 ,  A61P31/20

摘要： Disclosed herein are identified compound fragments, compounds and their pharmaceutically acceptable salts, isotopes or solvates, useful as antiviral drug and/or as a hepatic-targeted drug, such as for the treatment of HBV, HDV and/or HIV. Formula (I).

公开(公告)号：US20240124617A1

公开(公告)日：2024-04-18

申请号：US18546073

申请日：2022-02-10

申请人： DANSTAR FERMENT AG

发明人： Frédéric DURMONT

IPC分类号： C08B37/00 ,  A01N43/16 ,  A61K31/715 ,  A61P31/16 ,  A61P31/20 ,  C12P19/04

CPC分类号： C08B37/006 ,  A01N43/16 ,  A61K31/715 ,  A61P31/16 ,  A61P31/20 ,  C12P19/04

摘要： The present disclosure relates to exopolysaccharides produced by marine bacteria, compositions thereof, the use of aid compositions, and a method for attenuating the virulence of a microbial pathogen infection, either bacterial or viral infections, by inhibiting or reducing colonization of said microbial pathogens onto biological and/or non-biological surfaces.

公开(公告)号：US11912757B2

公开(公告)日：2024-02-27

申请号：US17335792

申请日：2021-06-01

申请人： HUMABS BIOMED SA

发明人： Davide Corti

IPC分类号： C07K16/10 ,  A61K9/00 ,  A61P31/14 ,  A61P31/20 ,  G01N33/569 ,  A61K39/00

CPC分类号： C07K16/1081 ,  A61K9/0019 ,  A61P31/20 ,  G01N33/56983 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  Y02A50/30

摘要： The invention relates to antibodies, and antigen binding fragments thereof, that potently neutralize infection of ZIKV. The invention also relates to antigenic sites to which the antibodies and antigen binding fragments bind, as well as to nucleic acids that encode and immortalized B cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in screening methods as well as in the diagnosis, prophylaxis and treatment of ZIKV infection.

公开(公告)号：US20240052349A1

公开(公告)日：2024-02-15

申请号：US18035695

申请日：2021-11-05

申请人： ARBUTUS BIOPHARMA CORPORATION

发明人： Owen M. DALY ,  Amy C. H. LEE ,  Michael J. SOFIA ,  Emily P. THI

IPC分类号： C12N15/113 ,  A61K47/54 ,  A61K45/06 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61K47/549 ,  A61K45/06 ,  A61P31/20

摘要： The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, an siRNA, and optional linking groups. The conjugates are useful to target siRNA.

公开(公告)号：US20240050463A1

公开(公告)日：2024-02-15

申请号：US18071353

申请日：2022-11-29

申请人： ARBUTUS BIOPHARMA CORPORATION

发明人： Andrea CUCONATI ,  Amy C. H. LEE ,  Cornelis A. RIJNBRAND ,  Michael J. SOFIA

IPC分类号： A61K31/713 ,  A61P31/20 ,  A61K31/18 ,  A61K31/352 ,  A61K31/4375 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/7068

CPC分类号： A61K31/713 ,  A61P31/20 ,  A61K31/18 ,  A61K31/352 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/7068 ,  A61K31/4375

摘要： The invention provides therapeutic combinations and therapeutic methods that are useful for treating Hepatitis B.

公开(公告)号：US11891398B2

公开(公告)日：2024-02-06

申请号：US17058308

申请日：2019-05-24

申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

发明人： Haiying He ,  Jianhua Xia ,  Zhen Gong ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D487/04 ,  A61P31/20

CPC分类号： C07D487/04 ,  A61P31/20

摘要： The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.