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公开(公告)号：US20240358485A1
公开(公告)日：2024-10-31
申请号：US18649689
申请日：2024-04-29
发明人： Brian D. Overshiner , William Roy Thompson , Parker Evans , Perla Reyes Fernandez , Daniel Georgiev Simeonov
CPC分类号： A61D7/00 , A61M15/0066 , A61M2205/3306 , A61M2205/581 , A61M2205/8206
摘要： Animal drug delivery systems and methods. Such a system includes a carrier cartridge to carry and dispense a plurality of drug doses, a monitoring device, and a controller operatively coupled with the carrier cartridge and the monitoring device. The controller operates the carrier cartridge to dispense at least one of the drug doses to an animal subject at each of a plurality of preselected dispensing intervals. The controller is also configured to operate the monitoring device to record the animal subject ingesting the dispensed drug doses. The system may be configured to provide drug pellets to mice based on researcher needs, allow for mouse monitoring to confirm drug delivery, enable behavioral studies to be conducted using operant condition, and/or to fit into a specific lab research animal cage.
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公开(公告)号：US12102734B2
公开(公告)日：2024-10-01
申请号：US17239322
申请日：2021-04-23
CPC分类号： A61L27/3839 , A61L27/04 , A61L27/3633 , A61L27/50 , B33Y80/00 , A61L27/14 , A61L2300/414 , A61L2420/04 , A61L2420/08
摘要： A method of producing bioengineered tissue includes coating a microstructured fiber with a bioink containing a plurality of living cells. The microstructured fiber is embedded with microfluidic channels defining periodic outlet apertures, a plurality of ultrasonic transducers, at least one chemical sensor, and at least one temperature sensor. The method further includes applying the coated fiber to an anatomic model of an organ. The microfluidic channels and outlet apertures of the fiber are configured to function as an artificial blood-vessel system to the bioengineered tissue, thereby supplying building material for the proliferation of the plurality of living cells, and allowing the bioengineered tissue to mature into functional tissue.
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公开(公告)号：US20240313644A1
公开(公告)日：2024-09-19
申请号：US18434035
申请日：2024-02-06
CPC分类号： H02M3/003 , H01F27/2847 , H02M7/003 , B82Y30/00 , B82Y40/00 , H02M3/01 , H02M3/1582
摘要： Provided is planar electro-magnetic device with both inductive and capacitive characteristics comprising a calcium copper titanate CCTO nanoparticle film. The planar electro-magnetic device may be used in a circuit of a power electronic device, such as a converter, signal electronic, and/or communication device. Further, a method of making the CCTO nanoparticle film is provided. The method comprising combining gOLAc and OLAm, heating the OLAc and OLAm, adding metal alkoxide precursors to the OLAc and OLAm to create CCTO NPs, purifying the CCTO NPs, adding sulfide ions to the NP, dispersing the sulfide ion passivated CCTO NP in solvent, and spin coating a film of CCTO NP onto aluminum foil.
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公开(公告)号：US12090127B2
公开(公告)日：2024-09-17
申请号：US17584031
申请日：2022-01-25
发明人： Jingwu Xie
IPC分类号： A61P11/00 , A61K31/166 , A61K33/36 , A61P9/10 , A61B5/318 , A61B5/329 , A61B8/08 , A61K31/395 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/444 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/505 , A61K31/517 , A61K31/5377 , A61K31/58 , A61K39/395 , A61P1/16 , C07K16/18
CPC分类号： A61K31/166 , A61K33/36 , A61P9/10 , A61P11/00 , A61B5/318 , A61B5/329 , A61B8/0883 , A61K31/395 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/444 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/505 , A61K31/517 , A61K31/5377 , A61K31/58 , A61K39/3955 , A61P1/16 , C07K16/18
摘要： Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.
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5.发明公开公开(公告)号：US20240271103A1
公开(公告)日：2024-08-15
申请号：US18568607
申请日：2022-06-10
发明人： Ping LI , Burcin EKSER
IPC分类号： C12N5/071
CPC分类号： C12N5/069 , C12N2502/1164 , C12N2503/00 , C12N2510/04
摘要： Disclosed are genetically modified porcine cells, tissues, organoids, and animals and methods of using the same for transplantation, and testing for xenoreactivity.
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公开(公告)号：US20240269163A1
公开(公告)日：2024-08-15
申请号：US18567972
申请日：2022-06-08
发明人： Thomas A. KENT , Paul J. DERRY , Kenneth R. OLSON
IPC分类号： A61K31/765 , A61K9/00 , A61K31/385 , A61K47/69 , A61P43/00
CPC分类号： A61K31/765 , A61K9/0053 , A61K31/385 , A61K47/6921 , A61P43/00
摘要： A method of treating a Down syndrome (DS) subject with functional or at risk of decline of organ systems associated with accelerated aging due to over-production of H2S is disclosed. That method contemplates administering a pharmaceutical composition containing a H2S-reducing effective amount of hydrophilic polymer-substituted oxidized carbon nanoparticles (OCNPs) and an optional potentiating amount of lipoic acid or dihydrolipoic acid dissolved or dispersed in a physiologically acceptable diluent to the subject. The pharmaceutical composition can be administered parenterally as a liquid or per os as a solid or liquid.
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公开(公告)号：US12030901B2
公开(公告)日：2024-07-09
申请号：US18056089
申请日：2022-11-16
发明人： Tom G. Driver , Roberto F. Machado , Naijing Su , Xinyu Guan , Wrickban Mazumdar , Kira Ratia , Jason Ralph Hickok , Angelia Denise Lockett
IPC分类号： C07F7/08 , C07D401/12 , C07D491/056
CPC分类号： C07F7/0816 , C07D401/12 , C07D491/056
摘要： Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase (“NAMPT”), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
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8.发明公开公开(公告)号：US20240197709A1
公开(公告)日：2024-06-20
申请号：US18541121
申请日：2023-12-15
IPC分类号： A61K31/4545 , A61K31/352 , A61P35/00
CPC分类号： A61K31/4545 , A61K31/352 , A61P35/00
摘要： Methods are provided for treating cancer, particularly non-small cell lung cancers and pancreatic ductal adenocarcinomas, by administering both a sublethal dose of NAD(P)H:quinone oxidoreductase 1 (NQO1) bioactivatable drug and a sublethal dose of mesenchymal-epithelial transition factor (cMET) inhibitor to the cancer patient. Treatment of other cancers which overexpress cMET and NQO1 are also provided.
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9.发明公开公开(公告)号：US20240186483A1
公开(公告)日：2024-06-06
申请号：US18535605
申请日：2023-12-11
发明人： Jian Xie
IPC分类号： H01M4/04 , B82Y30/00 , H01M4/1393 , H01M4/36 , H01M4/583
CPC分类号： H01M4/049 , B82Y30/00 , H01M4/1393 , H01M4/364 , H01M4/5835 , H01M10/0525
摘要： Cathode active materials for lithium-ion batteries comprise a hybrid nanocomposite of graphene and copper fluoride. Such cathode active materials are used, together with a polymeric binder material and optionally a conductive additive to form a cathode for a lithium-ion battery. Methods of producing hybrid nanocomposites of graphene and copper fluoride include hydrothermally reacting functionalized graphene, such as graphene oxide, and precursors of copper fluoride, such as aqueous fluorosilicic acid. Such hydrothermal reactions include sequential heating and freeze drying steps to produce a CuF2-graphene nanocomposite.
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10.发明公开公开(公告)号：US20240142469A1
公开(公告)日：2024-05-02
申请号：US18546910
申请日：2022-02-17
CPC分类号： G01N33/6893 , G01N33/92 , G01N2800/325 , G01N2800/52 , G01N2800/7076
摘要： Methods to assess a pediatric subject having a single ventricle heart include identifying a difference between concentration levels of metabolic biomarkers and reference concentration levels and then assessing the pediatric subject based on the identified differences.
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