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公开(公告)号：US20210032103A1
公开(公告)日：2021-02-04
申请号：US16525898
申请日：2019-07-30
摘要： Methods for forming alane are described. The method includes addition of toluene at a temperature above the crystallization temperature of alane to a lower temperature solution that includes alane adduct, ether, and toluene. Upon the addition, a crystallization mixture is formed that is at or near the crystallization temperature of alane. The alane of the mixture crystallizes over a period of time to form a high purity alane polymorph.
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公开(公告)号：US10889574B2
公开(公告)日：2021-01-12
申请号：US16557180
申请日：2019-08-30
发明人： Hee-kyoon Yoon , Se-Hwan Park , Ji-sung Yoon , Soongyu Choi , Hee Jeong Seo , Eun-Jung Park , Younggyu Kong , Kwang-Seop Song , Min Ju Kim , So Ok Park
IPC分类号： C07D409/04 , C07D407/04 , C07D307/78 , B01D9/00 , C07B51/00
摘要： The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.
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公开(公告)号：US10815549B2
公开(公告)日：2020-10-27
申请号：US16177652
申请日：2018-11-01
发明人： Ian Manson
IPC分类号： C22B7/00 , C01G23/047 , C01F5/06 , C01G23/053 , C01C1/02 , C01B17/74 , C01F7/76 , C01C1/26 , C01F7/00 , C07C51/41 , B01D9/00
摘要： Digestion of impure alumina with sulfuric acid dissolves all constituents except silica. Resulting sulfates, produced from contaminants in the impure alumina, remain in solution at approximately 90° C. Hot filtration separates silica. Solution flow over metallic iron reduces ferric sulfate to ferrous sulfate. Controlled ammonia addition promotes hydrolysis and precipitation of hydrated titania from titanyl sulfate that is removed by filtration. Addition of ammonium sulfate forms ferrous ammonium sulfate and ammonium aluminum sulfate solutions. Alum is preferentially separated by crystallization. Addition of ammonium bicarbonate to ammonium alum solution precipitates ammonium aluminum carbonate which may be heated to produce alumina, ammonia, and carbon dioxide. The remaining iron rich liquor also contains magnesium sulfate. Addition of oxalic acid generates insoluble ferrous oxalate which is thermally decomposed to ferrous oxide. Carbon monoxide reduces the ferrous oxide to metallic iron. Further oxalic acid addition precipitates magnesium oxalate which is thermally decomposed to magnesium oxide.
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公开(公告)号：US20200308013A1
公开(公告)日：2020-10-01
申请号：US16755155
申请日：2018-10-11
摘要： Systems and methods of producing potassium sulfate can involve converting a mixed salts feed stream into a conversion end slurry in a conversion unit, the mixed salts feed comprising at least one potassium-containing salt, at least one chloride-containing salt, at least one magnesium-containing salt and at least one sulfate-containing salt and the conversion end slurry comprising schoenite; separating conversion end slurry into a conversion end solids stream and a conversion brine; leaching the conversion end solids stream in a crystallization unit to produce a potassium sulfate product stream comprising potassium sulfate and a crystallizer mother liquor comprising magnesium sulfate and potassium sulfate; collecting heat generated in the conversion unit by a heat pump; and providing at least a portion of the heat collected to the crystallization unit to regulate a temperature of the potassium sulfate product stream and the crystallizer mother liquor stream contained in the crystallization unit.
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公开(公告)号：US20200306664A1
公开(公告)日：2020-10-01
申请号：US16313666
申请日：2017-06-27
发明人： Gangli WANG , Yan LI , Maksim M. KVETNY
摘要： Disclosed herein are systems and methods for the controlled crystallization of a compound. The controlled crystallization is achieved by applying an electric field across solutions of target compound and precipitant, whereby the electric field controls the rate of mixing.
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公开(公告)号：US10766895B2
公开(公告)日：2020-09-08
申请号：US16405722
申请日：2019-05-07
发明人： Haisheng Fan , Xiaowen Guo , Luning Huang , Hong Gu
IPC分类号： C07D487/04 , C07D471/04 , B01D9/00 , A61K31/519
摘要： Disclosed is a preparation method for a Palbociclib free base crystal form A as shown in Formula I, comprising the following steps: treating a Palbociclib free base and/or a Palbociclib salt compound by using an inorganic base in a water solvent at the temperature of 35 to 100′C. to obtain a Palbociclib free base crystal form A, the water solvent being water or mixed solvent obtained by water and an organic solvent capable of being mixed and disclosed in the water. Also disclosed is a preparation method for a Palbociclib free base crystal form B, comprising the following steps: treating a Palbociclib salt compound by using an inorganic base in a water solvent at the temperature of 0 to 20° C. to obtain a Palbociclib free crystal form B, the water solvent being water or a mixed solvent obtained by water and an organic solvent capable of being mixed and dissolved in the water. The method is safe and convenient in operation and low in pollution, and facilitates industrial production.
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公开(公告)号：US20200277280A1
公开(公告)日：2020-09-03
申请号：US16780780
申请日：2020-02-03
发明人： Lan Huang , Aniruddh Singh
IPC分类号： C07D403/06 , B01D9/00
摘要： Disclosed herein are plinabulin polymorphs, compositions, their use and preparation as therapeutic agents. In particular, some embodiments relate to plinabulin monohydrate in a crystalline form.
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公开(公告)号：US10745292B2
公开(公告)日：2020-08-18
申请号：US16099415
申请日：2017-07-10
发明人： Tomer Efrat , Alex Drak
摘要： A water treatment system comprising a mechanical vapour compression apparatus (11), the mechanical vapour apparatus having a evaporation/condensation vessel (11a) and a recirculation circuit (20) whereby recirculated water is pumped from an outlet (18a) of the evaporation/condensation vessel (11A) to an inlet (18B) of the evaporation/condensation vessel (11A), wherein the recirculation circuit (20) comprises a fluidized bed crystallizer (22), and at least part of the recirculated brine is passed through the fluidized bed crystallizer (22) to remove dissolved minerals therefrom.
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公开(公告)号：US10738248B2
公开(公告)日：2020-08-11
申请号：US16082131
申请日：2017-08-31
申请人： Sulzer Chemtech AG
发明人： Mathias Pfeil
IPC分类号： C10G73/02 , C10G73/00 , C10G73/38 , B01D9/00 , C11B3/16 , C11B3/00 , C11B7/00 , C11B3/10 , C11B3/12 , C10G73/42
摘要： The present invention relates to a method for fractionating a crude mixture comprising at least one oil and at least one wax, which comprises the following method steps: (a) carrying out a pre-fractionation stage as a layer crystallization (i) with a crude mixture comprising at least one oil and at least one wax or (ii) with a crude solvent mixture obtained by adding prior to the pre-fractionation stage at most 100% by weight of solvent relative to the weight of the crude mixture, to prepare a first fraction containing low waxy oil and a second fraction containing low oily wax, (b) carrying out a first crystallization stage including (b1) a first suspension crystallization sub-stage with the first fraction containing low waxy oil to prepare a third fraction containing dewaxed oil and a fourth fraction and (b2) after the first suspension crystallization sub-stage, a second suspension crystallization sub-stage with a mixture of the fourth fraction obtained in method step (b1) and the second fraction containing low oily wax obtained in the pre-fractionation stage of method step (a) to prepare a fifth fraction containing slack wax and a sixth fraction.
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公开(公告)号：US20200215454A1
公开(公告)日：2020-07-09
申请号：US16819719
申请日：2020-03-16
发明人： Paul Steven Wallace
摘要： A method includes supplying a supersaturated brine stream having a plurality of minerals and anti-scalant from a water treatment system to a gypsum removal system disposed within a mineral removal system. The gypsum removal system includes a gypsum reactor that may receive the supersaturated brine, may deactivate the anti-scalant such that gypsum precipitates from the supersaturated brine, and may generate a gypsum slurry having a mixture of desupersaturated brine, precipitated gypsum, and the anti-scalant in solution with the desupersaturated brine. The method also includes supplying gypsum seed crystals to the gypsum reactor. The gypsum seed crystals may precipitate the gypsum from the supersaturated brine to generate the gypsum slurry. The method also includes directing a first portion of the gypsum slurry from the gypsum reactor to a gypsum settler. The gypsum settler may reactivate the anti-scalant such that the anti-scalant absorbs onto the precipitated gypsum to remove the anti-scalant from the desupersaturated brine and may generate anti-scalant-gypsum crystals and a desupersaturated overflow having at least a portion of the plurality of minerals. The method further includes generating the gypsum seed crystals supplied to the gypsum reactor using the anti-scalant-gypsum crystals.
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