-
公开(公告)号：US10889574B2
公开(公告)日：2021-01-12
申请号：US16557180
申请日：2019-08-30
发明人： Hee-kyoon Yoon , Se-Hwan Park , Ji-sung Yoon , Soongyu Choi , Hee Jeong Seo , Eun-Jung Park , Younggyu Kong , Kwang-Seop Song , Min Ju Kim , So Ok Park
IPC分类号： C07D409/04 , C07D407/04 , C07D307/78 , B01D9/00 , C07B51/00
摘要： The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.
-
公开(公告)号：US10239873B2
公开(公告)日：2019-03-26
申请号：US15080068
申请日：2016-03-24
发明人： Soongyu Choi , Kwang-Seop Song , Hee Jeong Seo , Sang-ho Ma , Eun-Jung Park , Younggyu Kong , So Ok Park , Kisoo Park , Ickhwan Son , Min Ju Kim , Man-Young Cha , Mi-Soon Kim , Sang Mi Kang , Dong Hyuk Jang , Jangwon Hong
IPC分类号： C07D471/04 , C07D519/00 , C07D487/04
摘要： Provided are 7-azaindole or 4,7-diazaindole derivatives as an IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor. The 7-azaindole or 4,7-diazaindole derivative effectively inhibits IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.
-
3.发明授权公开(公告)号：US09856216B2
公开(公告)日：2018-01-02
申请号：US15134987
申请日：2016-04-21
发明人： Soongyu Choi , Eun-Jung Park , Hee Jeong Seo , Younggyu Kong , Ickhwan Son , Sang-ho Ma , Man-Young Cha , Mi-Soon Kim , Kisoo Park
IPC分类号： C07D209/14 , C07D209/48 , C07D209/46 , C07D417/04 , C07D403/04 , C07D401/04 , C07D403/14 , C07D409/12 , C07D405/12 , C07D409/04 , C07D413/04 , C07D409/14 , C07D403/12 , C07D405/06 , C07D409/06 , C07D471/04 , C07D217/24 , C07D401/12
CPC分类号： C07D209/46 , C07D209/48 , C07D217/24 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Provided is a compound of formula (I) as a TNIK (Traf2- and NCK-interacting kinase), IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor; the compound according to the present invention effectively inhibits TNIK, IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.
-
4.发明授权Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives 有权使用二苯基甲烷衍生物双重抑制SGLT1和SGLT2的方法公开(公告)号：US09340521B2
公开(公告)日：2016-05-17
申请号：US13845466
申请日：2013-03-18
发明人： Soongyu Choi , Jae Eun Kim , Kwang-Seop Song , Suk Ho Lee , Kisoo Park , Hee Jeong Seo , Min Ju Kim , Eun-Jung Park , So Ok Park , Younggyu Kong , Hyunku Kang , Ickhwan Son , Myung Eun Jung , Man-Young Cha , Hyun Jung Kim , Jun Sung Lee , Mi-Soon Kim , Min Woo Lee , Kinam Lee
IPC分类号： C07D309/10 , C07D407/04 , C07D409/04 , C07D409/14
CPC分类号： C07D309/10 , C07D407/04 , C07D409/04 , C07D409/14
摘要： The present invention relates to a method for dual inhibition of sodium-dependent glucose cotransporter 1 (SGLT1) and sodium-dependent glucose cotransporter 2 (SGLT2) present in the intestine and kidney by using the compound of formula I or a pharmaceutically acceptable salt or a prodrug thereof: wherein ring A, ring B, X and Y have the same meanings as defined in the specification.
摘要翻译： 本发明涉及通过使用式I化合物或其药学上可接受的盐或其药学上可接受的盐或其药学上可接受的盐或其药学上可接受的盐或其盐 其前药：其中环A，环B，X和Y具有与说明书中定义相同的含义。
-
5.发明授权公开(公告)号：US10294207B2
公开(公告)日：2019-05-21
申请号：US15083503
申请日：2016-03-29
发明人： Soongyu Choi , Kisoo Park , Hee Jeong Seo , Eun-Jung Park , Younggyu Kong , Ickhwan Son , Sang-ho Ma , Kwang-Seop Song , Min Ju Kim , So Ok Park , Man-Young Cha , Mi-Soon Kim , Sang Mi Kang , Dong Hyuk Jang , Jangwon Hong
IPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D495/04 , C07D409/04 , C07D417/12
摘要： Provided is pyrazole derivatives as a TNIK (Traf2- and NCK-interacting kinase), IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor; the pyrazole derivative according to the present invention effectively inhibits TNIK, IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.
-
公开(公告)号：US09371303B2
公开(公告)日：2016-06-21
申请号：US14593071
申请日：2015-01-09
发明人： Soongyu Choi , Kwang-Seop Song , Suk Ho Lee , Min Ju Kim , Hee Jeong Seo , Eun-Jung Park , Younggyu Kong , So Ok Park , Hyunku Kang , Myung Eun Jung , Kinam Lee , Hyun Jung Kim , Jun Sung Lee , Min Woo Lee , Mi-Soon Kim , Dong Ho Hong , Misuk Kang
IPC分类号： A61K31/351 , C07D407/04 , C07D309/10 , C07D405/10 , C07D407/10 , C07D407/14 , C07D409/04 , C07D409/10 , C07D411/10 , C07D413/04 , C07D405/14 , C07D413/10 , C07D409/14 , C07D413/12 , C07D413/14
CPC分类号： C07D309/10 , C07D405/10 , C07D405/14 , C07D407/04 , C07D407/10 , C07D407/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D411/10 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： A compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney is disclosed. A pharmaceutical composition including the compound as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes is disclosed. A method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound is provided.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.026 秒)
