公开(公告)号：US20230010923A1

公开(公告)日：2023-01-12

申请号：US17778832

申请日：2020-11-05

申请人： SHIMADZU CORPORATION ,  Kyoto University

发明人： Jun YANAGIBAYASHI ,  Shinya IMAMURA ,  Kenichi YASUNAGA ,  Yasushi ISHIHAMA ,  Koshi IMAMI ,  Tomoya NIINAE ,  Yumi KOMORI

IPC分类号： G01N30/32 ,  G01N30/14

摘要： A pump unit includes a pump and a metal ion trap. The pump includes a metal member that comes into contact with a mobile phase. The pump pumps a mobile phase through a flow path. The metal ion trap includes a filter element. The filter element includes a metal ion retention structure for retaining metal ions by interacting with the metal ions included in a mobile phase. The filter element is provided in the flow path for a mobile phase pumped by the pump. The pump unit may be provided in a chromatograph.

公开(公告)号：US20220341897A1

公开(公告)日：2022-10-27

申请号：US17730553

申请日：2022-04-27

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Martin Seifried ,  Sam Wouters ,  Irina Spuling

IPC分类号： G01N30/20 ,  G01N30/14 ,  G01N30/32

摘要： An injector is configured for injecting a fluidic sample from an injector path into a mobile phase in a separation path between a fluid drive and a sample separation unit of a sample separation device. The injector includes a control unit configured for generating a first overpressure in a blocked first partial path of the injector path by a first pressure source, for generating a second overpressure in a blocked second partial path of the injector path by a second pressure source, for subsequently fluidically coupling the first partial path with the second partial path for generating an expansion stroke for releasing a gas bubble in the injector path, and for rinsing the released gas bubble from the injector path.

公开(公告)号：US20220341895A1

公开(公告)日：2022-10-27

申请号：US17725892

申请日：2022-04-21

申请人： SHIMADZU CORPORATION

发明人： Kosuke NAKAJIMA

IPC分类号： G01N30/14 ,  G01N30/38 ,  G01N30/32

摘要： A preparative chromatograph includes a separation column, and a detector provided downstream of the separation column. Furthermore, the preparative chromatograph includes a fractionator including a gas-liquid separator configured to separate a fluid containing components of a sample into a gas and a liquid, the fractionator being provided downstream of the detector. The preparative chromatograph is configured to supply carbon dioxide to a flow path between the separation column and the fractionator.

公开(公告)号：US20220299485A1

公开(公告)日：2022-09-22

申请号：US17669909

申请日：2022-02-11

申请人： SHIMADZU CORPORATION

发明人： Yusuke NAGAI ,  Yohei TOJI

IPC分类号： G01N30/14 ,  G01N30/16 ,  G01N30/76 ,  G01N30/32

摘要： A preparative liquid chromatograph includes a liquid feeding pump (2) that feeds a mobile phase, an injector (4) that injects a sample into the mobile phase at a downstream of the liquid feeding pump (2), a separation column (6) for separating components in the sample injected into the mobile phase by the injector (4) at a downstream of the injector (4), and an eluate fractionator (8) configured to divide a flow of the eluate from the separation column (6) into a flow of a minute flow rate and another flow at a downstream of the separation column (6) and to extract at least a part of an eluate that forms the flow of a minute flow rate into an fractionation container (22).

公开(公告)号：US20220291099A1

公开(公告)日：2022-09-15

申请号：US17832113

申请日：2022-06-03

申请人： Dylan Elmer WILKS

发明人： Dylan Elmer WILKS

IPC分类号： G01N1/44 ,  G01N30/14 ,  B01D15/32 ,  G01N1/40

摘要： In accordance with embodiments of the present invention, a terpene-rich sample is prepared for terpene analysis using liquid chromatography via an extraction method that takes little time, uses minimal external equipment, and permits direct injection of extracted terpenes into a liquid chromatography instrument for analysis. An embodiment of the invention involves preparing a terpene-containing sample for analysis by liquid chromatography by liquid extraction; heating the liquid extract in a vial that contains a filter medium or solvent; collecting the terpenes in the medium by the vapor pressure forced through the filter from heating; and eluting the collected terpenes into a vial or directly into a chromatography injector.

公开(公告)号：US20220178886A1

公开(公告)日：2022-06-09

申请号：US17594195

申请日：2020-04-07

申请人： R.P. Scherer Technologies, LLC

发明人： William Derek Bush ,  Ryan Scott Cormier ,  Karunakar Sukuru

IPC分类号： G01N30/14 ,  A61K9/48

摘要： Disclosed herein are methods, systems, and kits for determining the total amount of a coating polymer in a dosage form. The coating polymer may be a polydisperse polymer having a plurality of molecular weights. The instant disclosure enables to accurately, reliably, and efficiently determine the total amount of a polydisperse polymer in a dosage form that includes one or more other constituents that have a molecular weight range that overlap with at least some of the polydisperse polymer's molecular weight.

公开(公告)号：US20220090165A1

公开(公告)日：2022-03-24

申请号：US17287194

申请日：2019-10-21

申请人： Toray Industries, Inc.

发明人： Shota Sekiguchi ,  Takahiro Motoshiromizu ,  Masateru Ito

IPC分类号： C12Q1/6806 ,  G01N30/14 ,  G01N30/88

摘要： A method of collecting a nucleic acid from a sample containing a nucleic acid using a support of aluminum oxide having a surface where a water-soluble neutral polymer is adsorbed, the method including steps a to c: step a: a step of bringing the support into contact with the sample containing a nucleic acid to adsorb the nucleic acid on the support; step b: a step of bringing the support on which the nucleic acid is adsorbed into contact with a solution A containing 1 mM or more and 40 mM or less of a chelating agent; and step c: after the step b, a step of bringing the support on which the nucleic acid is adsorbed into contact with a solution B containing 50 mM or more of a chelating agent to elute the nucleic acid.

公开(公告)号：US11275060B2

公开(公告)日：2022-03-15

申请号：US16638476

申请日：2018-08-13

申请人： TRASIS S.A.

发明人： Alexander Janus ,  Reinhard Grugel-Endress

IPC分类号： B01D71/36 ,  G01N30/02 ,  G01N30/06 ,  G01N30/16 ,  G01N30/60 ,  B01D71/40 ,  G01N30/14

摘要： A device for preparing a liquid sample for a direct injection of a corresponding gaseous sample to a micro-gas chromatograph includes: a fluid space and a gas space, which spaces are separated by a semipermeable separating layer, the fluid space including a supply line for the liquid sample, and the gas space having an outlet connectable with the gas chromatograph. The fluid space and/or the gas space is associated with at least one heating element. The device absorbs a sample volume of approximately 10 μl to 30 μl. The separating layer has a thickness of 10 μl to 300 μl and pores having a size between 0.05 μl and 5 μl.

公开(公告)号：US11249060B2

公开(公告)日：2022-02-15

申请号：US16605704

申请日：2018-07-16

申请人： LG Chem, Ltd.

发明人： Sangwoo Kim ,  Hyun Kyung Yoon ,  Sumin Na ,  Jieun Kim ,  Hyun Woo Nho

IPC分类号： G01N31/12 ,  G01N30/06 ,  G01N30/14 ,  G01N1/22 ,  G01N30/88 ,  G01N30/96

摘要： The present invention relates to a method for quantitatively analyzing Cl, remaining after synthesis, in zinc ferrite synthesized using chloride precursors such as zinc chloride and iron chloride, and provides a method capable of using, in a quantitative analysis method of Cl remaining after synthesis of an inorganic material, AQF-IC, which has been used only in the quantitative analysis of an organic sample since gaseous Cl, discharged after burning zinc ferrite in an automatic quick furnace (AQF) by using an Sn capsule and tungsten oxide (WO3), is analyzed through ion chromatography (IC).

公开(公告)号：US11249056B1

公开(公告)日：2022-02-15

申请号：US17203991

申请日：2021-03-17

申请人： Piyush Govindbhai Patel ,  Jayrajsinh Sarvaiya

发明人： Piyush Govindbhai Patel ,  Jayrajsinh Sarvaiya

IPC分类号： G01N30/14 ,  G01N33/15 ,  G01N30/86 ,  G01N30/02

摘要： The present invention relates to dialysis based in vitro drug release study method which mainly involves the use of a dialysis cartridge (A), a dissolution vessel (B), a receiver media vessel (C) and tubing's on the inlet and outlet ports (D, E, F, G) of the cartridge. When the pharmaceuticals complex dosage form is added to the dissolution vessel, diffusion of the soluble drug through the membrane of the dissolution cartridge assists in determining the release of drug from the complex dosage form. This study can be done by various methods as required by the complex dosage form. If the dosage form needs to go through dissolution followed by diffusion, the setup as described in Experiment 1 is arranged and the study is performed accordingly and if the dosage form needs to go through diffusion step only, the setup as described in Experiment 2 is arranged and the study is performed accordingly.