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公开(公告)号：US20230148365A1
公开(公告)日：2023-05-11
申请号：US17918497
申请日：2021-03-23
Applicant: APTABIO THERAPEUTICS INC.
Inventor： Sung Hwan MOON , Soo Jin LEE , Hyunkyung YU , Yoo-Kyung GOH
IPC: A61K31/4439 , A61K45/06 , A61P11/00 , A61P31/14
CPC classification number: A61K31/4439 , A61K45/06 , A61P11/00 , A61P31/14
Abstract: A pharmaceutical composition or an antiviral agent for the treatment of pulmonary fibrosis is disclosed. The composition or the antiviral agent contains a compound of Formula 1, which is a pyrazole derivative, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240308983A1
公开(公告)日：2024-09-19
申请号：US18644412
申请日：2024-04-24
Applicant: Aptabio Therapeutics Inc.
Inventor： Soo Jin LEE , Sung Hwan MOON , Sooho BAN , Eunsil LEE , Eun Jung SHIN , Yoo-Kyung GOH
IPC: C07D401/14 , A61P1/16 , A61P11/00 , A61P35/00 , A61P39/06 , C07D231/54 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D495/04
CPC classification number: C07D401/14 , A61P1/16 , A61P11/00 , A61P35/00 , A61P39/06 , C07D231/54 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D495/04
Abstract: The Present invention provides a novel pyrazole derivative compound represented by Chemical formula 1, a stereoisomer thereof, a solvate thereof, an isotopic variant thereof, a tautomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
(In the above, A, B and R, and the like are the same as defined in the description of the invention.)-
3.发明授权Guanosine-rich modified oligonucleotides and antiproliferative activity thereof 有权富含肌氨酸的修饰的寡核苷酸及其抗增殖活性公开(公告)号：US09056886B2
公开(公告)日：2015-06-16
申请号：US13381326
申请日：2010-06-29
Applicant: Soo Jin Lee , Sung Hwan Moon
Inventor： Soo Jin Lee , Sung Hwan Moon
IPC: C07H19/173 , C07H21/00
CPC classification number: C07H19/173 , C07H21/00
Abstract: The present invention relates to a novel modified oligonucleotide comprising at least one guanosine molecule and a modified nucleic acid with therapeutic efficacies. The present invention also relates to a pharmaceutical composition having cell apoptotic activity against cancer cells for preventing or treating cancer comprising a guanosine-rich modified oligonucleotide with at least one therapeutically effective modified nucleic acid (N), or its pharmaceutically acceptable salt as active ingredient.
Abstract translation: 本发明涉及包含至少一种鸟苷分子和具有治疗功效的修饰的核酸的新型修饰寡核苷酸。 本发明还涉及具有细胞凋亡活性的药物组合物，其具有用于预防或治疗癌症的细胞凋亡活性，其包含富含鸟嘌呤的修饰的寡核苷酸与至少一种治疗有效的修饰的核酸（N）或其药学上可接受的盐作为活性成分。
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公开(公告)号：US20230201179A1
公开(公告)日：2023-06-29
申请号：US17917689
申请日：2021-03-23
Applicant: APTABIO THERAPEUTICS INC.
Inventor： Soo Jin LEE , Sung Hwan MOON
IPC: A61K31/4439 , A61P13/12
CPC classification number: A61K31/4439 , A61P13/12
Abstract: A method of protecting a kidney by reducing contrast media-induced nephrotoxicity or for preventing or treating contrast media-induced acute kidney injury is disclosed. The method includes administering an effective amount of a compound of following Formula 1 or a pharmaceutically acceptable salt thereof to a mammal:
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公开(公告)号：US20230025836A1
公开(公告)日：2023-01-26
申请号：US17756266
申请日：2020-11-20
Applicant: Samjin Pharmaceutical Co., Ltd. , AptaBio Therapeutics Inc.
Inventor： Min-hyo Ki , Jin-cheul Kim , Mee-Hwa Choi , Dong-Ha Lee , Sung Hwan Moon , Soo Jin Lee
IPC: A61K31/4155 , A61K9/00 , A61P27/02
Abstract: The present invention relates to an ophthalmic preparation containing an active ingredient selected from 3-phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol compound or a pharmaceutically acceptable salt thereof. The eye drop according to the present invention is excellent in stability and safety and shows an excellent effect on prevention or treatment of eye diseases in such a way that an active ingredient thereof reaches a posterior segment of an eyeball simply through instillation rather than a direct injection into an eyeball.
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Patent Agency Ranking
公开(公告)号：US20220218685A1
公开(公告)日：2022-07-14
申请号：US17614705
申请日：2020-05-29
Applicant: Samjin Pharmaceutical Co., Ltd. , AptaBio Therapeutics Inc.
Inventor： Min-hyo Ki , Kyung-wan Nam , Jin-cheul Kim , Kyung-jin Ahn , Sung Hwan Moon , Soo Jin Lee
IPC: A61K31/4439 , A61K47/34 , A61K9/00 , A61P27/02
Abstract: The present invention relates to a composition for treating eye diseases, wherein the composition comprises a pyrazole-based compound, which is a pharmacologically active substance, and a biodegradable polymer, so that a drug effectively reaches a posterior segment of an eyeball, while prolonging an action time of the drug administered into the eyeball.
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公开(公告)号：US20230234940A1
公开(公告)日：2023-07-27
申请号：US18150955
申请日：2023-01-06
Applicant: Aptabio Therapeutics Inc.
Inventor： Soo Jin LEE , Sung Hwan MOON , Sooho BAN , Eunsil LEE , Eun Jung SHIN , Yoo-Kyung GOH
IPC: C07D401/14 , C07D401/04 , C07D471/04 , C07D495/04 , C07D231/54 , C07D401/12 , C07D417/04 , C07D413/04 , C07D405/04 , C07D403/04 , A61P39/06 , A61P35/00 , A61P11/00 , A61P1/16
CPC classification number: C07D401/14 , C07D401/04 , C07D471/04 , C07D495/04 , C07D231/54 , C07D401/12 , C07D417/04 , C07D413/04 , C07D405/04 , C07D403/04 , A61P39/06 , A61P35/00 , A61P11/00 , A61P1/16
Abstract: The Present invention provides a novel pyrazole derivative compound represented by Chemical formula 1, a stereoisomer thereof, a solvate thereof, an isotopic variant thereof, a tautomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
(In the above, A, B and R, and the like are the same as defined in the description of the invention.)-
8.发明授权公开(公告)号：US11174240B2
公开(公告)日：2021-11-16
申请号：US16605380
申请日：2018-04-20
Applicant: Aptabio Therapeutics Inc.
Inventor： Sung Hwan Moon , Soo Jin Lee , Sung Chan Lee
IPC: C07D401/04
Abstract: The present invention relates to a novel crystalline 3-phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol hydrochloride, a method for preparing the compound, and a pharmaceutical composition containing the compound as an active ingredient.
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9.发明申请公开(公告)号：US20210122726A1
公开(公告)日：2021-04-29
申请号：US16605380
申请日：2018-04-20
Applicant: Aptabio Therapeutics Inc.
Inventor： Sung Hwan Moon , Soo Jin Lee , Sung Chan Lee
IPC: C07D401/04
Abstract: The present invention relates to a novel crystalline 3-phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol hydrochloride, a method for preparing the compound, and a pharmaceutical composition containing the compound as an active ingredient.
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公开(公告)号：US11999718B2
公开(公告)日：2024-06-04
申请号：US18150955
申请日：2023-01-06
Applicant: Aptabio Therapeutics Inc.
Inventor： Soo Jin Lee , Sung Hwan Moon , Sooho Ban , Eunsil Lee , Eun Jung Shin , Yoo-Kyung Goh
IPC: C07D401/14 , A61P1/16 , A61P11/00 , A61P35/00 , A61P39/06 , C07D231/54 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D495/04
CPC classification number: C07D401/14 , A61P1/16 , A61P11/00 , A61P35/00 , A61P39/06 , C07D231/54 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D495/04
Abstract: The Present invention provides a novel pyrazole derivative compound represented by Chemical formula 1, a stereoisomer thereof, a solvate thereof, an isotopic variant thereof, a tautomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
(In the above, A, B and R, and the like are the same as defined in the description of the invention.)
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