中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

17 records (took 0.019 seconds)

    9-aminoacridine derivatives and process for the preparation thereof
    2.
    发明申请
    9-aminoacridine derivatives and process for the preparation thereof 失效
    9-氨基吖啶衍生物及其制备方法

    公开(公告)号：US20020111491A1

    公开(公告)日：2002-08-15

    申请号：US09855530

    申请日：2001-05-16

    Applicant: Samjin Pharmaceutical Co., Ltd.

    Inventor： Eui-Hwan Cho ,  Sun-Gan Chung ,  Sun-Hwan Lee ,  Ho-Seok Kwon ,  Dong-Wook Kang ,  Jeong-Ho Joo

    IPC: C07D219/10 ,  C07D219/12

    CPC classification number: C07D219/10 ,  Y02P20/55

    Abstract: The present invention relates to new 9-aminoacridine derivatives of general formula (I), wherein A is hydrogen or (II) (wherein X is oxygen or sulfur, R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, amino, hydroxy, C1-C4 lower alkylhydroxy, C1-C4 lower alkylamino, C1-C8 alkyl, C1-C4 lower alkoxy or C1-C4 lower alkyloxycarbonyl and m and n are independently an integer of 0, 1 or 2), R6, R7, R8 and R9 are independently C1-C8 alkyl or C1-C4 lower alkoxy, and Y is hydrogen, amino, -NnullCHRnull(wherein Rnull is hydrogen, benzyl, C1-C8 alkyl or C1-C6 lower alkylamino), (III) (wherein Rnull is hydrogen, benzyl, C1-C8 alkyl or C1-C6 lower alkylamino, and Rnullnull is hydrogen, benzyl, C1-C8 alkyl or amino protecting group) or (IV) (wherein, X is as defined above, R1null, R2null, R3null, R4null and R5null are independently hydrogen, halogen, nitro, amino, hydroxy, C1-C4 lower alkylhydroxy, C1-C4 lower alkylamino, C1-C8 alkyl, C1-C4 lower alkoxy or C1-C4 lower alkylcarboxy, and q and r are independently an integer of 0, 1 or 2) or its pharmaceutically acceptable salt, and process for the preparation thereof.

    Abstract translation: 本发明涉及通式（I）的新的9-氨基吖啶衍生物，其中A是氢或（II）（其中X是氧或硫，R1，R2，R3，R4和R5独立地是氢，卤素，硝基， 氨基，羟基，C1-C4低级烷基羟基，C1-C4低级烷基氨基，C1-C8烷基，C1-C4低级烷氧基或C1-C4低级烷氧基羰基，m和n分别为0,1或2的整数），R6， R7，R8和R9独立地为C1-C8烷基或C1-C4低级烷氧基，Y为氢，氨基，-N = CHR'（其中R'为氢，苄基，C1-C8烷基或C1-C6低级烷基氨基） ，（III）（其中R“为氢，苄基，C 1 -C 8烷基或C 1 -C 6低级烷基氨基，R”'为氢，苄基，C 1 -C 8烷基或氨基保护基）或（Ⅳ）（其中 ，X'如上定义，R 1'，R 2'，R 3'，R 4'和R 5'独立地是氢，卤素，硝基，氨基，羟基，C 1 -C 4低级烷基羟基，C 1 -C 4低级烷基氨基， C1-C4低级烷氧基或C1-C4低级烷基羧基，q和r独立地为a 0,1或2的整数）或其药学上可接受的盐，以及其制备方法。

Patent Agency Ranking