利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.018 秒)

    Method for bonding soft tissue with collagen-based adhesives and sealants
    2.
    发明授权
    Method for bonding soft tissue with collagen-based adhesives and sealants 失效
    用胶粘剂粘合剂和密封剂粘合软组织的方法

    公开(公告)号：US5354336A

    公开(公告)日：1994-10-11

    申请号：US31665

    申请日：1993-03-15

    申请人： Charles D. Kelman ,  Dale P. DeVore

    发明人： Charles D. Kelman ,  Dale P. DeVore

    IPC分类号： A61F9/008 ,  A61L24/10 ,  C08F2/46 ,  C08H1/06 ,  C09J189/06 ,  A61F2/16

    CPC分类号： C08H1/06 ,  A61L24/102 ,  C09J189/06 ,  A61F9/0079 ,  A61F9/00819

    摘要： The present invention relates to a method for bonding soft tissues. The method comprises the steps of (a) applying a polymerizable collagen composition onto at least portion of a surface of at least one of a first tissue and a second tissue, (b) exposing the polymerizable collagen composition to an initiator so as to initiate polymerization of the polymerizable collagen composition and (c) contacting the first tissue and the second tissue so that the exposed polymerizable collagen composition forms a bond between the first tissue and the second tissue.

    摘要翻译： 本发明涉及一种粘合软组织的方法。 该方法包括以下步骤：（a）将可聚合胶原蛋白组合物施加到至少一个第一组织和第二组织的表面的至少部分上，（b）将可聚合的胶原组合物暴露于引发剂以引发聚合 的可聚合胶原组合物和（c）使第一组织和第二组织接触，使得暴露的可聚合胶原蛋白组合物在第一组织和第二组织之间形成结合。

    Collagen-based adhesives and sealants and methods of preparation and use thereof
    3.
    发明授权
    Collagen-based adhesives and sealants and methods of preparation and use thereof 失效
    基于胶原蛋白的粘合剂和密封剂及其制备和使用方法

    公开(公告)号：US5219895A

    公开(公告)日：1993-06-15

    申请号：US646944

    申请日：1991-01-29

    申请人： Charles D. Kelman ,  Dale P. DeVore

    发明人： Charles D. Kelman ,  Dale P. DeVore

    IPC分类号： A61F9/008 ,  A61L24/10 ,  C08F2/46 ,  C08H1/06 ,  C09J189/06

    CPC分类号： C08H1/06 ,  A61L24/102 ,  C09J189/06 ,  A61F9/0079 ,  A61F9/00819

    摘要： Collagen-based compositions as adhesives and sealants for medical use and preparation thereof are described. Prior to polymerization, soluble or partially fibrillar collagen monomers in solution are chemically modified with an acylating agent, sulfonating agent or a combination of the foregoing. The collagen compositions prepared accordingly can be used as medical adhesives for bonding soft tissues or be made in to a sealant film for a variety of medical uses such as wound closures and tendon wraps for preventing adhesion formation following surgery.

    摘要翻译： 描述了基于胶原的组合物作为用于医疗用途的粘合剂和密封剂及其制备。 在聚合之前，溶液中的可溶性或部分原纤维胶原单体用酰化剂，磺化剂或前述的组合进行化学修饰。 相应地制备的胶原组合物可以用作粘合软组织的医用粘合剂，或制成用于各种医疗用途的密封剂膜，例如用于防止手术后粘连形成的伤口闭合物和腱包裹物。

    Method of making intraocular lenses with injectable collagen-based compositions
    5.
    发明授权
    Method of making intraocular lenses with injectable collagen-based compositions 失效
    利用可注射胶原蛋白的组合物制造眼内透镜的方法

    公开(公告)号：US5476515A

    公开(公告)日：1995-12-19

    申请号：US158019

    申请日：1993-11-24

    申请人： Charles D. Kelman ,  Dale P. DeVore

    发明人： Charles D. Kelman ,  Dale P. DeVore

    IPC分类号： A61F2/00 ,  A61F2/16 ,  A61L27/24 ,  C08H1/06

    CPC分类号： A61L27/24 ,  A61F2/16 ,  A61F2/1616 ,  C08H1/06 ,  A61F2310/00365 ,  Y10S623/901

    摘要： Injectable collagen-based compositions can be used in methods to fill a lens capsular sac, following lens extraction procedures, to form a new intraocular lens. Purified soluble or partially fibrillar collagen may be modified with acylating agents, sulfonating agents or combinations thereof to form a clear, transparent collagen composition having indices of refraction between about 1.2 to 1.6. The modified collagen may injected into a lens capsular sac to form an intraocular lens (IOL) in situ. The IOL is clear, transparent, resistant to epithelialization and is capable of accommodation. The collagen-based IOL produced by the method of the present invention may remain in its original viscous liquid state or may be polymerized into a soft gel. The collagen-based IOL may be used to replace diseased or natural lens to treat cataracts, presbyopia, myopia and hyperopia.

    摘要翻译： 可注射的基于胶原的组合物可以用于填充镜片囊囊的方法，在镜片提取程序之后，形成新的眼内透镜。 可以用酰化剂，磺化剂或其组合来修饰纯化的可溶性或部分原纤维胶原，以形成折射率在约1.2至1.6之间的透明，透明的胶原组合物。 改性胶原蛋白可以注射到晶状体囊囊中以形成眼内晶状体（IOL）。 IOL是透明的，透明的，耐上皮化，并且能够适应。 通过本发明的方法制备的基于胶原的IOL可以保持其原始的粘性液体状态，或者可以聚合成软凝胶。 基于胶原的IOL可用于替代患病或天然晶状体以治疗白内障，老花眼，近视和远视。

    Human collagen processing and autoimplant use
    6.
    发明授权
    Human collagen processing and autoimplant use 失效
    人体胶原蛋白加工和自体植物使用

    公开(公告)号：US5332802A

    公开(公告)日：1994-07-26

    申请号：US897562

    申请日：1992-06-11

    申请人： Charles D. Kelman ,  Dale P. DeVore

    发明人： Charles D. Kelman ,  Dale P. DeVore

    IPC分类号： A61F2/00 ,  A61K38/00 ,  A61L27/24 ,  C07K14/78 ,  C08H1/06 ,  A61K37/12 ,  A61F13/00

    CPC分类号： C08H1/06 ,  A61L27/24 ,  C07K14/78 ,  A61F2310/00365 ,  A61K38/00 ,  Y10S128/08 ,  Y10S623/915

    摘要： Production of a chemically modified, crosslinkable, telopeptide-containing, naturally crosslinked, solubilized collagen from tissue obtained from a sole human donor, for implanting in the same donor, by chemically modifying the tissue, e.g. by acylation and/or esterification, to form an autoimplantable, crosslinkable, telopeptide-containing, naturally crosslinked, collagen product, as a completely solubilized collagen solution, optionally of high index of refraction for correcting sight or as a partially solubilized collagen suspension; and use of the product for altering the condition of in situ tissue of the same human donor by autoimplantation, such as by crosslinking the product to form an implant device, by placing an effective amount of the product at the tissue site and crosslinking the product in situ, or by partially crosslinking the product and placing an effective amount thereof at the tissue site and optionally further crosslinking the product in situ.

    摘要翻译： 通过化学修饰组织，例如通过化学修饰组织来生产由从唯一人供体获得的组织中经化学修饰的，可交联的，含端肽的天然交联的溶解胶原蛋白，用于植入同一供体。 通过酰化和/或酯化形成可自动移植的，可交联的，含有端肽的天然交联的胶原产品，作为完全溶解的胶原溶液，任选地具有高折射率以矫正视力或作为部分溶解的胶原悬浮液; 以及使用产品通过自动植入来改变相同人类供体的原位组织的状况，例如通过将产物交联以形成植入装置，通过将有效量的产物放置在组织部位并将产物交联 或通过将产物部分交联并将其有效量置于组织部位并任选地进一步原位交联产物。