公开(公告)号：US20090148417A1

公开(公告)日：2009-06-11

申请号：US11989475

申请日：2006-07-27

申请人： Sung Su Kim ,  Yoo Hun Noh ,  Ok Ja Yoon ,  Seung Hoon Yoo

发明人： Sung Su Kim ,  Yoo Hun Noh ,  Ok Ja Yoon ,  Seung Hoon Yoo

IPC分类号： A61K35/12 ,  A61P9/10 ,  A61P25/00

CPC分类号： C12N5/0068 ,  A61K35/12 ,  A61L27/08 ,  A61L27/3804 ,  A61L2400/12 ,  B82Y5/00 ,  C12N5/0623 ,  C12N2533/10

摘要： The present invention relates to a scaffold for transplanting a stem cell comprising a carbon nanotube without cytotoxicity, and a composition for stem cell therapy comprising (a) a stem cell; and (b) a carbon nanotube serving as a stem cell scaffold without cytotoxicity. The scaffold for transplanting stem cells comprising carbon nanotubes show excellent effects without cytotoxicity on networking between differentiated stem cells and tissues present in transplantation sites, thereby showing significant cell therapy efficacy.

摘要翻译： 本发明涉及用于移植包含碳纳米管而不具有细胞毒性的干细胞的支架，和用于干细胞治疗的组合物，其包含（a）干细胞; 和（b）作为无细胞毒性的干细胞支架的碳纳米管。 用于移植包含碳纳米管的干细胞的支架显示出优异的效果，而不会在存在于移植部位的分化干细胞和组织之间的联网上具有细胞毒性，从而显示出显着的细胞治疗功效。

公开(公告)号：US20110105402A1

公开(公告)日：2011-05-05

申请号：US11572944

申请日：2004-07-31

申请人： Sung Su Kim ,  Yong Koo Kang ,  Cheol Hyoung Park ,  Sang-Hyung Lee ,  Wan-Seok Joo ,  Won Bok Lee ,  Hee Sun Chae ,  Hye Kyung Na

发明人： Sung Su Kim ,  Yong Koo Kang ,  Cheol Hyoung Park ,  Sang-Hyung Lee ,  Wan-Seok Joo ,  Won Bok Lee ,  Hee Sun Chae ,  Hye Kyung Na

IPC分类号： A61K38/16 ,  A61P25/00

CPC分类号： A61K38/011 ,  C07K14/43586

摘要： A silk peptide having neuroprotective and neurofunctional activities and its preparation method are discussed. One method relates to preparing silk protein preferably having neuroprotective activity with weight average molecular weight of 200-100,000 by hydrolysis of silk fibroin; also discussed are a composition for preventing or treating brain disease comprising silk peptide and pharmaceutically acceptable carrier, and a composition for improving brain function.

摘要翻译： 讨论了具有神经保护和神经功能活性的丝肽及其制备方法。 一种方法涉及通过丝素蛋白水解制备优选具有重均分子量为200-100,000的神经保护活性的丝蛋白; 还讨论了用于预防或治疗包含丝肽和药学上可接受的载体的脑疾病的组合物和用于改善脑功能的组合物。

公开(公告)号：US20100093641A1

公开(公告)日：2010-04-15

申请号：US12445284

申请日：2007-10-17

申请人： Sung Su Kim ,  Do Yeon Lee ,  Yoo Hun Noh

发明人： Sung Su Kim ,  Do Yeon Lee ,  Yoo Hun Noh

IPC分类号： A61K38/08 ,  A61K38/07 ,  A61K38/03 ,  C07K7/00 ,  C07K5/00 ,  C07K4/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/16 ,  A61P25/24

CPC分类号： C07K5/1008 ,  A61K38/00 ,  C07K7/06 ,  C07K14/43586

摘要： The present invention relates to a silk protein-mimicking peptide represented by the following Formula 1, a composition for preventing or treating a brain disease, a composition for improving a brain or cognitive function and a composition for preventing or treating diseases, disorders or conditions associated with oxidative stress comprising the peptide: Gly-Xaa1-Gly-Xaa2   (1) wherein Xaa1 is Ala, Val, Ser, Tyr, Asp, Glu, Thr, Met, Ile, Leu, Phe, His, Lys or Arg; Xaa2 is Ala, Tyr, Val, Ser, Asp, Glu, Thr, Met, Ile, Leu, Phe, His, Lys or Arg; or Xaa2 represents Ala, Tyr, Val, Ser, Asp, Glu, Thr, Met, Ile, Leu, Phe, His, Lys or Arg residue linked to Gly-Xaa3; and Xaa3 is Tyr, Val, Ala, Ser, Asp, Glu, Thr, Met, Ile, Leu, Phe, His, Lys or Arg.

摘要翻译： 本发明涉及由下式1表示的丝蛋白模仿肽，用于预防或治疗脑疾病的组合物，用于改善脑或认知功能的组合物和用于预防或治疗相关疾病，病症或病症的组合物 （1）其中Xaa1是Ala，Val，Ser，Tyr，Asp，Glu，Thr，Met，Ile，Leu，Phe，His，Lys或Arg的氧化应激; Gly-Xaa1-Gly-Xaa2 Xaa2是Ala，Tyr，Val，Ser，Asp，Glu，Thr，Met，Ile，Leu，Phe，His，Lys或Arg; 或Xaa2表示与Gly-Xaa3连接的Ala，Tyr，Val，Ser，Asp，Glu，Thr，Met，Ile，Leu，Phe，His，Lys或Arg残基; Xaa3是Tyr，Val，Ala，Ser，Asp，Glu，Thr，Met，Ile，Leu，Phe，His，Lys或Arg。

公开(公告)号：US10010574B2

公开(公告)日：2018-07-03

申请号：US11572944

申请日：2004-07-31

申请人： Sung Su Kim ,  Cheol Hyoung Park ,  Sang-Hyung Lee ,  Wan-Seok Joo ,  Won Bok Lee

发明人： Sung Su Kim ,  Cheol Hyoung Park ,  Sang-Hyung Lee ,  Wan-Seok Joo ,  Won Bok Lee

IPC分类号： A61P25/28 ,  A61P25/16 ,  A61K38/01 ,  C07K14/435

CPC分类号： A61K38/011 ,  C07K14/43586

摘要： A silk peptide having neuroprotective and neurofunctional activities and its preparation method are discussed. One method relates to preparing silk protein preferably having neuroprotective activity with weight average molecular weight of 200-100,000 by hydrolysis of silk fibroin; also discussed are a composition for preventing or treating brain disease comprising silk peptide and pharmaceutically acceptable carrier, and a composition for improving brain function.

公开(公告)号：US20130195937A1

公开(公告)日：2013-08-01

申请号：US13809617

申请日：2011-07-14

申请人： Yoonhwa Jeong ,  Hyun Jung Lee ,  Do Yeon Lee ,  Yoo Hun Noh ,  Do Hee Kim ,  Ok Hyeon Kim ,  Ji Ae Park ,  Jiwon Lee

发明人： Yoonhwa Jeong ,  Hyun Jung Lee ,  Do Yeon Lee ,  Yoo Hun Noh ,  Do Hee Kim ,  Ok Hyeon Kim ,  Ji Ae Park ,  Jiwon Lee

IPC分类号： A61K33/44 ,  A61K31/166 ,  A61K31/235 ,  A61K9/00 ,  A61K31/192

CPC分类号： A61K33/44 ,  A61B5/04001 ,  A61B5/04002 ,  A61B5/4082 ,  A61B5/4848 ,  A61K9/0092 ,  A61K31/166 ,  A61K31/192 ,  A61K31/235

摘要： A method for preventing or treating a brain nervous disease includes administering to a subject in need thereof a therapeutically effective amount of a carbon nanotube, wherein the nervous disease is a brain disease or a traumatic central nervous system injury. The composition of the present invention enables patients to recover from physical damage to the brain, exhibits superior efficacy for inhibiting the onset of Parkinson's disease and strokes in animal models for Parkinson's disease and strokes, and the cytotoxic effects of beta amyloid in beta amyloid toxicity tests. Therefore, the composition of the present invention can be effectively used in the preparation of medicine for protecting cranial nerves, therapeutic agents for preventing or treating brain disease, or therapeutic agents for treating traumatic injuries to the central nervous system.

摘要翻译： 用于预防或治疗脑神经疾病的方法包括向有需要的受试者施用治疗有效量的碳纳米管，其中所述神经疾病是脑疾病或创伤性中枢神经系统损伤。 本发明的组合物使得患者能够从对脑的物理损伤中恢复，在帕金森病和中风的动物模型中显示出优异的抑制帕金森病发作和中风的功效，以及β淀粉样蛋白在β淀粉样蛋白毒性试验中的细胞毒性作用 。 因此，本发明的组合物可以有效地用于制备用于保护颅神经的药物，用于预防或治疗脑部疾病的治疗剂，或用于治疗对中枢神经系统的创伤性损伤的治疗剂。