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1.发明申请PASSIVE SOLID TUMOR TARGETING ANTICANCER PRODRUG AND PREPARATION METHOD THEREOF 审中-公开被动固体肿瘤靶向抗体制剂及其制备方法公开(公告)号：US20120244193A1
公开(公告)日：2012-09-27
申请号：US13381483
申请日：2010-05-19
申请人： Xiaohai Tang , Yu Qiu , Xin Song
发明人： Xiaohai Tang , Yu Qiu , Xin Song
IPC分类号： A61K9/00 , A61P35/00 , A61K31/704
CPC分类号： A61K31/704 , A61K47/61 , A61K47/6939
摘要： The invention relates to a passive solid tumor-targeted anticancer prodrug and a preparation method thereof, belonging to the field of antitumor drugs. The preparation method includes the following steps: reacting low molecular weight pectin with Mw of 5,000-45,000 with doxorubicin to obtain a pectin-doxorubicin conjugate with Mw of 100,000-1,000,000, preparing the conjugate into a suspension, and treating the suspension in an ultra-high pressure nano homogenizer to obtain the passive solid tumor-targeted anticancer prodrug with particle size of 100 nm-200 nm and melting point of 220-245°, wherein the pectin and doxorubicin are linked by an amide bond, and the pectin is linked by an ester bond formed by condensing carboxyl groups and hydroxyl groups of pectin molecules. Cell inhibition rate of the anticancer prodrug for humanized lung cancer cells NCI-H446 and A549 is equivalent to that of doxorubicin hydrochloride. In the efficacy research of melanoma B16 pulmonary metastasis model mice, the life span of tumor-bearing mice is 42.3±12.4 days, which is remarkably higher than that of the doxorubicin hydrochloride group (23.1±10.2 days).
摘要翻译： 本发明涉及一种属于抗肿瘤药物领域的被动实体肿瘤靶向抗癌药物及其制备方法。 该制备方法包括以下步骤：使用多柔比星使低分子量果胶与5,000〜45,000的Mw反应，得到Mw为100,000-1,000,000的果胶 - 多柔比星缀合物，将该缀合物制备成悬浮液， 高压纳米均化器，得到粒径为100nm-200nm，熔点为220-245°的被动实体肿瘤靶向抗癌前药，其中果胶和多柔比星通过酰胺键连接，果胶通过 通过缩合果胶分子的羧基和羟基形成的酯键。 人源化肺癌细胞NCI-H446和A549的抗癌前药的细胞抑制率与盐酸多柔比星的细胞抑制率相当。 在黑色素瘤B16肺转移模型小鼠的功效研究中，荷瘤小鼠的寿命为42.3±12.4天，明显高于盐酸多柔比星组（23.1±10.2天）。
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公开(公告)号：US20200253826A1
公开(公告)日：2020-08-13
申请号：US15776072
申请日：2016-11-13
摘要： This invention discloses a single-needle medication mixer, dual hard ports, and a soft intravenous bag, pertaining to the field of medical apparatus technologies. The medication mixer comprises a base, a medication mixing passage, a medication mixing cup, and a piercing needle. The base, the medication mixing passage and the medication mixing cup are integrally formed, the medication mixing cup consists of cup wall and cup bottom, the lower end of the medication mixing passage penetrates through the base, and the upper end penetrates through the cup bottom; the upper end of the medication mixing passage is provided with the piercing needle having a hollow passage, the lower end of the piercing needle is connected to the upper end of the medication mixing passage in a sealing way, and the hollow passage is communicated therewith. The medication mixer of this invention is convenient to use and has no potential safety hazard.
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3.发明授权公开(公告)号：US11235976B2
公开(公告)日：2022-02-01
申请号：US16480567
申请日：2018-01-26
发明人： Xiaohai Tang , Yu Qiu , Yuanfang Huang , Pingfang Xia
摘要： The present invention provides a nanocarbon-iron composite system which is a composite structure formed by interaction of acid-treated nanocarbon serving as a carrier, with and ferrous ions and/or ferric ions in an iron salt. In an in-vitro experiment and an animal experiment, the nanocarbon-iron composite system of the present invention shows a very efficient inhibition effect on solid tumors containing liver cancer, breast cancer and cervical cancer and has an excellent targeting property. Accordingly, the present invention further provides a preparation method of the nanocarbon-iron composite system, use of the nanocarbon-iron composite system in preparation of a drug for treating solid tumors, and a suspension for injection based on the nanocarbon-iron composite system.
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公开(公告)号：US20160106623A1
公开(公告)日：2016-04-21
申请号：US14415130
申请日：2012-08-01
CPC分类号： A61J1/10 , A61J1/1406 , A61J1/1475 , A61M1/02 , F04C2270/041
摘要： A double-headed transfusion container comprises a body portion (1), both the top and the bottom of the body portion (1) being provided with an opening portion (2). The body portion (1) and the opening portion (2) are integrally formed of polypropylene blending plastic through blow molding, so as to obtain a seamless transparent polypropylene blending plastic transfusion container, which has advantages of a light weight and a low cost, further has good self-draining performance, and can steadily drain the liquid in the container from the container without any vent needle. Both the top and the bottom of the body portion (1) are provided with the opening portion (2), which facilitates connection to another independent auxiliary instrument better and can improve the safety of the transfusion product.
摘要翻译： 双头输液容器包括主体部分（1），主体部分（1）的顶部和底部均设有开口部分（2）。 主体部分（1）和开口部分（2）通过吹塑成型由聚丙烯共混塑料整体形成，从而获得具有重量轻且成本低的优点的无缝透明聚丙烯共混输塑容器 具有良好的自排水性能，可以从容器中不间断地排放容器中的液体，而无需排气孔。 主体部分（1）的顶部和底部均设置有开口部分（2），其更好地连接到另一个独立的辅助仪器，并且可以提高输血产品的安全性。
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公开(公告)号：US20150174006A1
公开(公告)日：2015-06-25
申请号：US14415605
申请日：2012-08-02
申请人： Yu Qiu , Ke Li , Yuan Yuan , Hongyu Li , Yeli Huang
发明人： Yu Qiu , Ke Li , Yuan Yuan , Hongyu Li , Yeli Huang
CPC分类号： A61J1/2089 , A61J1/10 , A61J1/1406 , A61J1/1462 , A61J1/16 , A61J1/201 , A61J1/2013 , A61J1/2065
摘要： A preassembled medicine mixer comprises a rotary sleeve (4), a guide sleeve I (3), a guide sleeve II (6), a guide part, a dosing barrel (1), and a dosing double needle (2). The guide sleeve I (3) extends into the guide sleeve II (6) and is connected to the rotary sleeve (4). A guide groove (8) is provided on the side wall of the guide sleeve I (3), and two ends of the guide groove (8) are extended by a distance towards opposite directions. A guide spiral groove (7) is provided on an inner wall of the guide sleeve II (6). The guide part is disposed in the guide sleeve I (3) and has a guide block (9) at the outer side thereof. The guide block (9) penetrates through the guide groove (8) and extends into the guide spiral groove (7). In use, the rotary sleeve (4) is rotated to drive the guide part to rapidly move downwards and push a medicine container (17); an upper needle tip of the dosing double needle (2) pierces a sealing plug on the medicine container (17), and a lower needle tip pierces a diaphragm (23) in an interface (22), so that the medicine container (17) is instantly communicated with an infusion container (14), thereby implementing sterile closeness during the entire process of transportation, storage, butt joint, medicine mixing, and infusion.
摘要翻译： 预组装的药物混合器包括旋转套筒（4），引导套筒I（3），导向套筒II（6），引导部件，计量筒（1）和计量双针（2）。 引导套筒I（3）延伸到导向套筒II（6）中并连接到旋转套筒（4）上。 引导槽（8）设置在导向套筒I（3）的侧壁上，并且引导槽（8）的两端向相反方向延伸一定距离。 引导螺旋槽（7）设置在导向套筒II（6）的内壁上。 引导部分设置在引导套筒I（3）中并且在其外侧具有引导块（9）。 引导块（9）穿过引导槽（8）并延伸到引导螺旋槽（7）中。 在使用中，旋转套筒（4）旋转以驱动引导部件快速向下移动并推动药物容器（17）; 给药双针（2）的上针尖刺穿药剂容器（17）上的密封塞，下针尖刺穿界面（22）中的隔膜（23），使药药容器（17） 与输液容器（14）立即连通，从而在运输，储存，对接，药物混合和输液的整个过程中实现无菌接近。
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公开(公告)号：US20190283192A1
公开(公告)日：2019-09-19
申请号：US16317519
申请日：2017-07-11
摘要： The present invention discloses an assembly machine for a medicine mixer, comprising a rack, a medicine mixing cup mounting device, a rubber plug mounting device, an elastic clip mounting device, a puncture needle mounting device, a coverplate mounting device, a soldering device and an output device. The medicine mixing cup mounting device, the rubber plug mounting device, the elastic clip mounting device, the puncture needle mounting device, the coverplate mounting device, the soldering device and the output device are arranged annularly along an outer circumference of the dividing table successively. The assembly machine for a medicine mixer according to the present invention is controlled by PLC. A feeding system consisting of a plurality of groups of oscillating disks and tracks conveys each part at an interface of the medicine mixer to given positions of the equipment.
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公开(公告)号：US09839581B2
公开(公告)日：2017-12-12
申请号：US14415605
申请日：2012-08-02
申请人： Yu Qiu , Ke Li , Yuan Yuan , Hongyu Li , Yeli Huang
发明人： Yu Qiu , Ke Li , Yuan Yuan , Hongyu Li , Yeli Huang
CPC分类号： A61J1/2089 , A61J1/10 , A61J1/1406 , A61J1/1462 , A61J1/16 , A61J1/201 , A61J1/2013 , A61J1/2065
摘要： A preassembled medicine mixer comprises a rotary sleeve (4), a guide sleeve I (3), a guide sleeve II (6), a guide part, a dosing barrel (1), and a dosing double needle (2). The guide sleeve I (3) extends into the guide sleeve II (6) and is connected to the rotary sleeve (4). A guide groove (8) is provided on the side wall of the guide sleeve I (3), and two ends of the guide groove (8) are extended by a distance towards opposite directions. A guide spiral groove (7) is provided on an inner wall of the guide sleeve II (6). The guide part is disposed in the guide sleeve I (3) and has a guide block (9) at the outer side thereof. The guide block (9) penetrates through the guide groove (8) and extends into the guide spiral groove (7). In use, the rotary sleeve (4) is rotated to drive the guide part to rapidly move downwards and push a medicine container (17); an upper needle tip of the dosing double needle (2) pierces a sealing plug on the medicine container (17), and a lower needle tip pierces a diaphragm (23) in an interface (22), so that the medicine container (17) is instantly communicated with an infusion container (14), thereby implementing sterile closeness during the entire process of transportation, storage, butt joint, medicine mixing, and infusion.
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8.发明申请LYOPHILIZED FORMULATION OF PECTIN-ADRIAMYCIN CONJUGATE AND PREPARATION METHOD THEREOF 审中-公开哌嗪 - 阿德米霉素联合化合物的制备及其制备方法公开(公告)号：US20130172283A1
公开(公告)日：2013-07-04
申请号：US13695048
申请日：2011-04-22
申请人： Xiaohai Tang , Yu Qiu
发明人： Xiaohai Tang , Yu Qiu
IPC分类号： A61K31/704
CPC分类号： A61K31/704 , A61K9/0019 , A61K9/19 , A61K47/32 , A61K47/61
摘要： The invention belongs to the pharmaceutical field, and particularly relates to a lyophilized formulation of pectin-adriamycin conjugate and a preparation method thereof. In order to solve insolubility problem of the pectin-adriamycin conjugate (hereinafter referred to as PAC), improve bioavailability and facilitate preparation, the inventor prepared the PAC into a nanosuspension. However, as long-term stability of the nanosuspension is poor, the inventor proposed to prepare the nanosuspension into a lyophilized formulation, that is, an insoluble pectin-adriamycin conjugate is prepared into a suspension or nanosuspension, and a lyophilized support agent is added to the suspension for lyophilization treatment to prepare the lyophilized formulation. Lyophilized products prepared from the nanosuspension are characterized by enhanced stability of nano-particle size and enhanced stability of drug loading rate, which provides a new solution for clinical application of the PAC.
摘要翻译： 本发明属于制药领域，特别涉及果胶 - 阿霉素缀合物的冻干制剂及其制备方法。 为了解决果胶 - 阿霉素缀合物（以下简称PAC）的不溶性问题，提高生物利用度和促进制剂，本发明人将PAC制备成纳米悬浮液。 然而，由于纳米悬浮液的长期稳定性差，本发明人提出将纳米悬浮液制备成冻干制剂，即将不溶性果胶 - 阿霉素缀合物制备成悬浮液或纳米悬浮液，并将冻干的载体添加到 用于冻干处理以制备冻干制剂的悬浮液。 从纳米悬浮液制备的冻干产品的特征在于增强了纳米粒径的稳定性和药物加载速率的稳定性，为临床应用PAC提供了新的解决方案。
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公开(公告)号：US20200253827A1
公开(公告)日：2020-08-13
申请号：US15776073
申请日：2016-11-13
摘要： This invention discloses a medication mixer, dual hard dual ports, and a soft intravenous bag. The medication mixer comprises a base, a medication mixing passage, a medication mixing cup, and a cross needle which are integrally formed. The medication mixing cup consists of a cup wall and a cup bottom. The cross needle consists of an integrated needle plate, and an upper needle and lower needle with hollow passages which are communicated with each other. The lower end of the medication mixing passage penetrates through the base, with the upper ends penetrating through the cup bottom. A membrane is arranged in the medication mixing passage between the base and the cup bottom, and a rubber plug is arranged in the medication mixing passage between the membrane and the cup bottom. A limit protrusion is arranged on an inner wall of the cup wall.
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公开(公告)号：US09775778B2
公开(公告)日：2017-10-03
申请号：US14415131
申请日：2012-08-02
CPC分类号： A61J1/2089 , A61J1/10 , A61J1/1481 , A61J1/2013 , A61J1/2051 , A61J1/2055 , B01F13/0023 , B01F2215/0032
摘要： An integrated medicine mixing interface comprising a medicine mixing mouth (1), hard double interfaces (2) and a medicine feed needle (3). The hard double interfaces (2) comprise a base (21), a medicine mixing interface (22) and an infusion interface (23). The medicine mixing mouth (1) and the medicine mixing interface (22) are integrated. When using the integrated medicine mixing interface, it is only necessary to weld the base (21) to the bag body of a soft infusion bag (11) and integrate the medicine mixing mouth (1) with the medicine mixing interface on the hard double interfaces (2) without adopting a hose connection and an easily folding handle, which not only reduces hose installation location, but also avoids welding leakage brought about by hose welding defects. Moreover, the structure is simple and the costs are low.
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