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公开(公告)号：US11660592B2
公开(公告)日：2023-05-30
申请号：US17175287
申请日：2021-02-12
申请人： DENOVIX, INC.
发明人： Daniel A. Schieffer , David L. Ash , David B. Ward
IPC分类号： B01L3/02
CPC分类号： B01L3/0224 , B01L3/0227 , B01L3/0237 , B01L3/0279 , B01L2400/049 , B01L2400/0478
摘要： Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.
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公开(公告)号：US10598598B2
公开(公告)日：2020-03-24
申请号：US16392030
申请日：2019-04-23
申请人： Denovix, Inc.
发明人： Fernando F. Kielhorn , Daniel A. Schieffer , David L. Ash , Kevin Kelley , Andrew William Jones
IPC分类号： G01N21/64 , G01N21/03 , G01N15/14 , G01N33/487 , G02B21/06 , G06K9/00 , G06M11/02 , C12M1/34 , C12Q1/06
摘要： Cell counters and methods of their use are disclosed herein. The cell counters include a sample mounting system that includes a base, which includes a mounted lower sample surface and a cover having a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.
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3.发明公开公开(公告)号：US20240066518A1
公开(公告)日：2024-02-29
申请号：US18239609
申请日：2023-08-29
申请人： DeNovix Inc.
发明人： Benayah Ben-Avraham , Daniel Schieffer , David L. Ash , Fernando Frederick Kielhorn , David B. Ward
IPC分类号： B01L3/02
CPC分类号： B01L3/0227 , B01L3/0237
摘要： Broad volumetric range pipettes with multi-tiered pipette tip holder and ejection assemblies and methods of using such pipettes are disclosed herein. These pipettes typically include a concentric cylinder arrangement with each outer cylinder configured for contacting and dislodging a pipette tip attached to the tip holder portion of the immediately adjacent inner cylinder. In this manner, different sized pipette tips can be used on a single device. In addition, a locking mechanism is described for locking the large tip holder into a downward position to minimize the extension of the small tip holder and thereby enabling attachment of large, filtered pipette tips and reducing/eliminating the risk that the liquid being transferred will contaminate the pipetting device.
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公开(公告)号：US11679383B2
公开(公告)日：2023-06-20
申请号：US17875235
申请日：2022-07-27
申请人： DeNovix, INC.
发明人： Daniel A. Schieffer , David L. Ash , David B. Ward
IPC分类号： B01L3/02
CPC分类号： B01L3/0224 , B01L3/0227 , B01L3/0237 , B01L3/0279 , B01L2400/049 , B01L2400/0478
摘要： Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.
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公开(公告)号：US20220362759A1
公开(公告)日：2022-11-17
申请号：US17875235
申请日：2022-07-27
申请人： DENOVIX, INC.
发明人： Daniel A. Schieffer , David L. Ash , David B. Ward
IPC分类号： B01L3/02
摘要： Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.
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公开(公告)号：US20210252496A1
公开(公告)日：2021-08-19
申请号：US17175287
申请日：2021-02-12
申请人： DENOVIX, INC.
发明人： Daniel A. SCHIEFFER , David L. Ash , David B. Ward
IPC分类号： B01L3/02
摘要： Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.
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公开(公告)号：US20190310197A1
公开(公告)日：2019-10-10
申请号：US16392030
申请日：2019-04-23
申请人： Denovix, Inc.
发明人： Fernando F. Kielhorn , Daniel A. Schieffer , David L. Ash , Kevin Kelley , Andrew William Jones
IPC分类号： G01N21/64 , G01N33/487 , G02B21/06 , G06K9/00 , G01N15/14
摘要： Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.
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公开(公告)号：US10302568B2
公开(公告)日：2019-05-28
申请号：US15628394
申请日：2017-06-20
申请人： DeNovix, Inc.
IPC分类号： G01N21/64 , G01N21/03 , G01N15/14 , G01N33/487 , G02B21/06 , G06M11/02 , C12M1/34 , C12Q1/06 , G06K9/00
摘要： Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.
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公开(公告)号：US09442009B2
公开(公告)日：2016-09-13
申请号：US14181295
申请日：2014-02-14
申请人： DeNovix Inc.
CPC分类号： G01J3/0218 , G01J3/0291 , G01N21/03 , G01N21/31 , G01N2201/08
摘要： An improved apparatus and method for making optical measurements of a sample is described. In one embodiment, the apparatus is a microvolume sampling mechanism comprised of two opposing optical measurement surfaces. A sample is held by surface tension between the two opposing optical measurement surfaces. Light is transmitted through the sample and received by optical fibers, which measure the absorbance of the sample. This absorbance can be used to determine the concentration of the sample.
摘要翻译： 描述了用于进行样品的光学测量的改进的装置和方法。 在一个实施例中，该装置是由两个相对的光学测量表面组成的微卷采样机构。 样品通过两个相对的光学测量表面之间的表面张力保持。 光通过样品传输并被光纤接收，测量样品的吸光度。 该吸光度可用于测定样品的浓度。
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公开(公告)号：US20150233760A1
公开(公告)日：2015-08-20
申请号：US14181295
申请日：2014-02-14
申请人： DeNovix Inc.
CPC分类号： G01J3/0218 , G01J3/0291 , G01N21/03 , G01N21/31 , G01N2201/08
摘要： An improved apparatus and method for making optical measurements of a sample is described. In one embodiment, the apparatus is a microvolume sampling mechanism comprised of two opposing optical measurement surfaces. A sample is held by surface tension between the two opposing optical measurement surfaces. Light is transmitted through the sample and received by optical fibers, which measure the absorbance of the sample. This absorbance can be used to determine the concentration of the sample.
摘要翻译： 描述了用于进行样品的光学测量的改进的装置和方法。 在一个实施例中，该装置是由两个相对的光学测量表面组成的微卷采样机构。 样品通过两个相对的光学测量表面之间的表面张力保持。 光通过样品传输并被光纤接收，测量样品的吸光度。 该吸光度可用于测定样品的浓度。
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