公开(公告)号：US11660592B2

公开(公告)日：2023-05-30

申请号：US17175287

申请日：2021-02-12

Applicant: DENOVIX, INC.

Inventor： Daniel A. Schieffer ,  David L. Ash ,  David B. Ward

IPC: B01L3/02

CPC classification number: B01L3/0224 ,  B01L3/0227 ,  B01L3/0237 ,  B01L3/0279 ,  B01L2400/049 ,  B01L2400/0478

Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.

公开(公告)号：US11679383B2

公开(公告)日：2023-06-20

申请号：US17875235

申请日：2022-07-27

Applicant: DeNovix, INC.

Inventor： Daniel A. Schieffer ,  David L. Ash ,  David B. Ward

IPC: B01L3/02

CPC classification number: B01L3/0224 ,  B01L3/0227 ,  B01L3/0237 ,  B01L3/0279 ,  B01L2400/049 ,  B01L2400/0478

Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.

公开(公告)号：US10598598B2

公开(公告)日：2020-03-24

申请号：US16392030

申请日：2019-04-23

Applicant: Denovix, Inc.

Inventor： Fernando F. Kielhorn ,  Daniel A. Schieffer ,  David L. Ash ,  Kevin Kelley ,  Andrew William Jones

IPC: G01N21/64 ,  G01N21/03 ,  G01N15/14 ,  G01N33/487 ,  G02B21/06 ,  G06K9/00 ,  G06M11/02 ,  C12M1/34 ,  C12Q1/06

Abstract: Cell counters and methods of their use are disclosed herein. The cell counters include a sample mounting system that includes a base, which includes a mounted lower sample surface and a cover having a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.

公开(公告)号：US20170370848A1

公开(公告)日：2017-12-28

申请号：US15628394

申请日：2017-06-20

Applicant: DeNovix, Inc.

Inventor： Fernando F. Kielhorn ,  Daniel A. Schieffer ,  David L. Ash ,  Kevin Kelley

IPC: G01N21/64 ,  G06K9/00 ,  G02B21/06 ,  G01N33/487 ,  G06M11/02 ,  G01N15/14

CPC classification number: G01N21/6458 ,  G01N15/14 ,  G01N15/1434 ,  G01N15/1468 ,  G01N21/6456 ,  G01N33/487 ,  G01N2015/144 ,  G01N2015/1481 ,  G01N2021/035 ,  G01N2201/062 ,  G02B21/06 ,  G06K9/00127 ,  G06M11/02

Abstract: Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.

公开(公告)号：US20220362759A1

公开(公告)日：2022-11-17

申请号：US17875235

申请日：2022-07-27

Applicant: DENOVIX, INC.

Inventor： Daniel A. Schieffer ,  David L. Ash ,  David B. Ward

IPC: B01L3/02

Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.

公开(公告)号：US20190310197A1

公开(公告)日：2019-10-10

申请号：US16392030

申请日：2019-04-23

Applicant: Denovix, Inc.

Inventor： Fernando F. Kielhorn ,  Daniel A. Schieffer ,  David L. Ash ,  Kevin Kelley ,  Andrew William Jones

IPC: G01N21/64 ,  G01N33/487 ,  G02B21/06 ,  G06K9/00 ,  G01N15/14

Abstract: Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.

公开(公告)号：US10302568B2

公开(公告)日：2019-05-28

申请号：US15628394

申请日：2017-06-20

Applicant: DeNovix, Inc.

Inventor： Fernando F. Kielhorn ,  Daniel A. Schieffer ,  David L. Ash ,  Kevin Kelley

IPC: G01N21/64 ,  G01N21/03 ,  G01N15/14 ,  G01N33/487 ,  G02B21/06 ,  G06M11/02 ,  C12M1/34 ,  C12Q1/06 ,  G06K9/00

Abstract: Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.