中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

10 records (took 0.015 seconds)

    Biomolecule transduction motif Mph-1-BTM and the use thereof
    1.
    发明申请
    Biomolecule transduction motif Mph-1-BTM and the use thereof 失效
    生物分子转导基序Mph-1-BTM及其用途

    公开(公告)号：US20060148060A1

    公开(公告)日：2006-07-06

    申请号：US11267817

    申请日：2005-11-07

    Applicant: Sang-Kyou Lee ,  Seung-Kyou Lee

    Inventor： Sang-Kyou Lee ,  Seung-Kyou Lee

    IPC: C12N9/24 ,  C07K14/56 ,  C07K14/54 ,  C07K14/52 ,  C07K14/435

    CPC classification number: C07K7/06 ,  C07K2319/01

    Abstract: This invention relates to a novel Biomolecule Transduction Motif (BTM), Mph-1 peptide, which has the potential to transduce many biological response modifiers effectively into the cytoplasm, intracellular organelles or nucleus of prokaryotic or eukaryotic cells in vivo and in vitro, and the related technological methods using Mph-1 BTM. This Mph-1 BTM can be used in the development of new recombinant protein vaccines or DNA/RNA vaccines, gene and protein therapy, production of pharmacologically or medicinally useful proteins, or pharmaco-medicinal drug therapy.

    Abstract translation: 本发明涉及一种新的生物分子转导基序（BTM），Mph-1肽，其具有在体内和体外有效转导许多生物反应调节剂到原核或真核细胞的细胞质，细胞内细胞核或细胞核中的潜力， 使用Mph-1 BTM的相关技术方法。 这种Mph-1 BTM可用于开发新的重组蛋白疫苗或DNA / RNA疫苗，基因和蛋白质治疗，药理学或医学上有用的蛋白质的生产或药物药物治疗。

    Biomolecule transduction motif Mph-1-BTM and the use thereof
    2.
    发明授权
    Biomolecule transduction motif Mph-1-BTM and the use thereof 失效
    生物分子转导基序Mph-1-BTM及其用途

    公开(公告)号：US07700109B2

    公开(公告)日：2010-04-20

    申请号：US11267817

    申请日：2005-11-07

    Applicant: Sang-Kyou Lee ,  Seung-Kyou Lee

    Inventor： Sang-Kyou Lee ,  Seung-Kyou Lee

    IPC: A61K39/00 ,  A61K39/02 ,  A61K39/38

    CPC classification number: C07K7/06 ,  C07K2319/01

    Abstract: This invention relates to a novel Biomolecule Transduction Motif (BTM), Mph-1 peptide (Mph-1-BTM), which has the potential to transduce many biological response modifiers effectively into the cytoplasm, intracellular organelles or nucleus of prokaryotic or eukaryotic cells in vivo and in vitro, and the related technological methods using Mph-1-BTM. This Mph-1-BTM can be used in the development of new recombinant protein vaccines or DNA/RNA vaccines, gene and protein therapy, production of pharmacologically or medicinally useful proteins, or pharmaco-medicinal drug therapy.

    Abstract translation: 本发明涉及一种新型的生物分子转导基序（BTM），Mph-1肽（Mph-1-BTM），其具有将许多生物反应调节剂有效转导入原核或真核细胞的细胞质，细胞内细胞核或细胞核的潜力 体外和相关技术方法使用Mph-1-BTM。 该Mph-1-BTM可用于开发新的重组蛋白疫苗或DNA / RNA疫苗，基因和蛋白质治疗，药理学或药物有用的蛋白质的生产或药物药物治疗。

    Methods for fusion polypeptide delivery into a cell
    3.
    发明申请
    Methods for fusion polypeptide delivery into a cell 失效
    将多肽融合到细胞中的方法

    公开(公告)号：US20070105775A1

    公开(公告)日：2007-05-10

    申请号：US11592227

    申请日：2006-11-03

    Applicant: Sang-Kyou Lee ,  Seung-Kyou Lee ,  Je-Min Choi

    Inventor： Sang-Kyou Lee ,  Seung-Kyou Lee ,  Je-Min Choi

    IPC: A61K38/17

    CPC classification number: C07K14/70521 ,  A61K38/00

    Abstract: The present invention relates to methods for delivery of fusion polypeptides into cells. Methods are provided for local delivery of fusion polypeptides, e.g., through the skin, eye and the airway, to prevent allergic inflammation, airway hyper-responsiveness and to block T cell activation. Methods for delivery of fusion polypeptides to suppress graft rejection are also provided.

    Abstract translation: 本发明涉及将融合多肽递送到细胞中的方法。 提供了用于局部递送融合多肽的方法，例如通过皮肤，眼睛和气道，以防止过敏性炎症，气道高反应性和阻断T细胞活化。 还提供了用于递送融合多肽以抑制移植排斥的方法。

    Methods for treating rheumatoid arthritis using a CTLA-4 fusion protein
    4.
    发明授权
    Methods for treating rheumatoid arthritis using a CTLA-4 fusion protein 失效
    使用CTLA-4融合蛋白治疗类风湿关节炎的方法

    公开(公告)号：US07723299B2

    公开(公告)日：2010-05-25

    申请号：US11592227

    申请日：2006-11-03

    Applicant: Sang-Kyou Lee ,  Seung-Kyou Lee ,  Je-Min Choi

    Inventor： Sang-Kyou Lee ,  Seung-Kyou Lee ,  Je-Min Choi

    IPC: A61K38/16 ,  C07K14/00

    CPC classification number: C07K14/70521 ,  A61K38/00

    Abstract: The present invention relates to methods for delivery of fusion polypeptides into cells. Methods are provided for local delivery of fusion polypeptides, e.g., through the skin, eye and the airway, to prevent allergic inflammation, airway hyper-responsiveness and to block T cell activation. Methods for delivery of fusion polypeptides to suppress graft rejection are also provided.

    Abstract translation: 本发明涉及将融合多肽递送到细胞中的方法。 提供了用于局部递送融合多肽的方法，例如通过皮肤，眼睛和气道，以防止过敏性炎症，气道高反应性和阻断T细胞活化。 还提供了用于递送融合多肽以抑制移植排斥的方法。

    Pharmaceutical compositions and methods for delivering nucleic acids into cells
    8.
    发明授权
    Pharmaceutical compositions and methods for delivering nucleic acids into cells 失效
    用于将核酸递送到细胞中的药物组合物和方法

    公开(公告)号：US07981446B2

    公开(公告)日：2011-07-19

    申请号：US12277000

    申请日：2008-11-24

    Applicant: Sang-Kyou Lee ,  Seung-Kyou Lee ,  Ki-Doo Choi

    Inventor： Sang-Kyou Lee ,  Seung-Kyou Lee ,  Ki-Doo Choi

    IPC: A61K9/16 ,  A61K48/00 ,  A61K35/16 ,  C12N15/87

    CPC classification number: C12N15/87 ,  A61K47/64 ,  C07K2319/10 ,  C07K2319/95 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/916

    Abstract: The present invention relates to methods of delivering nucleic acids into cells using a nucleic acid binding molecule containing a multimeric or spacer-incorporated protein transduction domain (PTD). The invention also relates to novel compositions that contain a nucleic acid complexed or conjugated with a nucleic acid binding molecule. The nucleic acid binding molecule may contain a multimeric or spacer-incorporated PTD, and may further contain a nucleic acid binding region. The nucleic acid complexes or conjugations of the present invention may be employed to inhibit expression of a target gene, and/or determine the function of a target gene.

    Abstract translation: 本发明涉及使用含有多聚体或间隔基掺入蛋白转导结构域（PTD）的核酸结合分子将核酸递送至细胞的方法。 本发明还涉及含有与核酸结合分子复合或缀合的核酸的新型组合物。 核酸结合分子可以含有多聚体或间隔基掺入的PTD，并且还可以含有核酸结合区。 可以使用本发明的核酸复合物或缀合物来抑制靶基因的表达和/或确定靶基因的功能。

    Pharmaceutical composition for alleviation and treatment of ischemic conditions and method for delivering the same
    9.
    发明授权
    Pharmaceutical composition for alleviation and treatment of ischemic conditions and method for delivering the same 有权
    用于缓解和治疗缺血性疾病的药物组合物及其递送方法

    公开(公告)号：US07902154B2

    公开(公告)日：2011-03-08

    申请号：US11878431

    申请日：2007-07-24

    Applicant: Sang-Kyou Lee ,  Seung-Kyou Lee ,  Yang-Soo Jang ,  Ki-Chul Hwang

    Inventor： Sang-Kyou Lee ,  Seung-Kyou Lee ,  Yang-Soo Jang ,  Ki-Chul Hwang

    IPC: A61K38/00 ,  A61K38/16

    CPC classification number: C12N9/16 ,  A61K38/00 ,  C07K2319/01 ,  C07K2319/10 ,  Y02A50/414

    Abstract: The present invention relates to pharmaceutical compositions for treating diseases and conditions caused by ischemia. The pharmaceutical compositions contain a conjugate of a phospholipase (PL) polypeptide and a protein transduction domain (PTD). PLC-δ plays a major role in the regulation of cytosolic calcium levels. During myocardial ischemia, cytosolic calcium accumulation mediates pathogenic changes. According to the present invention, ischemic diseases or conditions leading to hypoxia in tissues, such as the heart and the brain, can be prevented or alleviated by administration of a PTD-PL conjugate.

    Abstract translation: 本发明涉及用于治疗由缺血引起的疾病和病症的药物组合物。 药物组合物含有磷脂酶（PL）多肽和蛋白质转导结构域（PTD）的缀合物。 PLC-δ在调节细胞溶质钙水平方面起主要作用。 在心肌缺血期间，细胞溶质钙积累介导病理变化。 根据本发明，可以通过施用PTD-PL缀合物来预防或减轻导致脑，脑等组织缺氧的缺血性疾病或病症。

    Biomolecule transduction motif Sim-2-BTM and the use thereof
    10.
    发明授权
    Biomolecule transduction motif Sim-2-BTM and the use thereof 失效
    生物分子转导基序Sim-2-BTM及其用途

    公开(公告)号：US07354737B2

    公开(公告)日：2008-04-08

    申请号：US10501964

    申请日：2003-01-20

    Applicant: Sang-Kyou Lee ,  Seung-Kyou Lee ,  Byung-Fhy Suh ,  Wook-Jin Chae ,  Jong-Bum Kim ,  Jong-Sun Lee ,  Jung-Jin Yang

    Inventor： Sang-Kyou Lee ,  Seung-Kyou Lee ,  Byung-Fhy Suh ,  Wook-Jin Chae ,  Jong-Bum Kim ,  Jong-Sun Lee ,  Jung-Jin Yang

    IPC: C07H21/04 ,  C12N15/09 ,  C07K14/705

    CPC classification number: C07K7/06

    Abstract: This invention is about a novel Biomolecule Transducton Motif (BTM), Sim-2 peptide, which has a potential to transduce many biological response modifiers effectively into the cytoplasm, intracellular organelles or nucleus of prokaryotic or eukaryotic cells in vivo and in vitro, and the related technological methods using Sim-2 BTM. This Sim-2 BTM can be used for Drug Delivery System, development of new recombinant protein vaccines or DNA/RNA vaccines, gene and protein therapy, production of pharmacologically or medicinally useful proteins or pharmacomedicinal drug therapy.

    Abstract translation: 本发明涉及一种新的生物分子转录母体（BTM），Sim-2肽，其具有在体内和体外有效转导许多生物反应调节剂到原核或真核细胞的细胞质，细胞内细胞核或细胞核中的潜力， 使用Sim-2 BTM的相关技术方法。 该Sim-2 BTM可用于药物递送系统，开发新的重组蛋白疫苗或DNA / RNA疫苗，基因和蛋白质治疗，药理学或药物有用蛋白质的生产或药物药物治疗。

Patent Agency Ranking