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17 条记录 (耗时 0.034 秒)

    Antibody and uses thereof
    1.
    发明授权
    Antibody and uses thereof 有权
    抗体及其用途

    公开(公告)号：US08747849B2

    公开(公告)日：2014-06-10

    申请号：US13051497

    申请日：2011-03-18

    申请人： Christopher Scott ,  Roberta Burden ,  Shane Olwill ,  Brian Walker ,  Jim Johnston

    发明人： Christopher Scott ,  Roberta Burden ,  Shane Olwill ,  Brian Walker ,  Jim Johnston

    IPC分类号： A61K39/395

    CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

    摘要： Described are specific binding members e.g. antibodies which may be used in the treatment of diseases associated with cathepsin S activity. The specific binding members bind cathepsin S and inhibit its proteolytic activity. The binding members may be used in the treatment of diseases such as cancer, inflammatory diseases, neurodegenerative disorders, autoimmune disorders, and other diseases associated with excessive, deregulated or inappropriate angiogenesis.

    摘要翻译： 描述的是具体的结合成员，例如 可用于治疗与组织蛋白酶S活性相关的疾病的抗体。 特异性结合成员结合组织蛋白酶S并抑制其蛋白水解活性。 结合成员可用于治疗诸如癌症，炎性疾病，神经变性疾病，自身免疫性疾病以及与过度，失调或不合适的血管生成相关的其它疾病的疾病。

    Antibody and uses thereof
    6.
    发明授权
    Antibody and uses thereof 有权
    抗体及其用途

    公开(公告)号：US07939642B2

    公开(公告)日：2011-05-10

    申请号：US11918102

    申请日：2006-04-10

    申请人： Christopher Scott ,  Roberta Burden ,  Shane Olwill ,  Brian Walker ,  Jim Johnston

    发明人： Christopher Scott ,  Roberta Burden ,  Shane Olwill ,  Brian Walker ,  Jim Johnston

    IPC分类号： C12P21/08

    CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

    摘要： Described are specific binding members e.g. antibodies which may be used in the treatment of diseases associated with cathepsin S activity. The specific binding members binds cathepsin S and inhibits its proteolytic activity. The binding members may be used in the treatment of diseases such as cancer, inflammatory diseases, neurodegenerative disorders, autoimmune disorders, and other diseases associated with excessive, deregulated or inappropriate angiogenesis.

    摘要翻译： 描述的是具体的结合成员，例如 可用于治疗与组织蛋白酶S活性相关的疾病的抗体。 特异性结合成员结合组织蛋白酶S并抑制其蛋白水解活性。 结合成员可用于治疗诸如癌症，炎性疾病，神经变性疾病，自身免疫性疾病以及与过度，失调或不合适的血管生成相关的其它疾病的疾病。

    DIAGNOSTIC METHOD AND KIT
    7.
    发明申请
    DIAGNOSTIC METHOD AND KIT 审中-公开
    诊断方法和包装

    公开(公告)号：US20110020404A1

    公开(公告)日：2011-01-27

    申请号：US12673798

    申请日：2008-08-18

    申请人： Shane A. Olwill ,  James A. Johnston ,  Hang Fai Kwok ,  Clare Whelan ,  John Clarke

    发明人： Shane A. Olwill ,  James A. Johnston ,  Hang Fai Kwok ,  Clare Whelan ,  John Clarke

    IPC分类号： A61K39/04 ,  C12Q1/04 ,  C12Q1/02 ,  G01N33/53 ,  C12Q1/68 ,  A61P31/06

    CPC分类号： G01N33/5695 ,  A61K39/04

    摘要： The invention relates to methods for diagnosis of tuberculosis in an animal, the methods comprising determining the presence or absence of, or an immune response to a group of antigens comprising (i) the group consisting of Rv3616 antigen, MPB70 antigen, MPB83 antigen, and ESAT 6 antigen; or (ii) at least seven of the antigens of the group consisting of Rv3616 antigen, MPB70 antigen, MPB83 antigen, ESAT 6 antigen, CFP10 antigen, α crystalline 2 antigen, PE35 antigen, and PPE68 antigen. Also provided is a method for the diagnosis of the presence of tuberculosis in a reservoir animal e.g. a badger, said method comprising determining the presence or absence of, or an immune response to Rv3616 antigen, MPB70 antigen, and MPB83 antigen. Kits for carrying out the methods are also provided.

    摘要翻译： 本发明涉及用于诊断动物结核病的方法，所述方法包括确定对抗原组的存在或不存在或免疫应答，所述抗原组包含（i）由Rv3616抗原，MPB70抗原，MPB83抗原和 ESAT 6抗原; 或（ii）由Rv3616抗原，MPB70抗原，MPB83抗原，ESAT6抗原，CFP10抗原，α结晶2抗原，PE35抗原和PPE68抗原组成的组中的至少7种抗原。 还提供了用于诊断储存动物中结核病存在的方法，例如， 所述方法包括确定Rv3616抗原，MPB70抗原和MPB83抗原的存在或不存在或免疫应答。 还提供了实施方法的工具包。

    Protein purification means
    10.
    发明申请
    Protein purification means 审中-公开
    蛋白质纯化手段

    公开(公告)号：US20070110761A1

    公开(公告)日：2007-05-17

    申请号：US10540415

    申请日：2003-12-29

    申请人： Christopher Scott

    发明人： Christopher Scott

    IPC分类号： C07H21/04 ,  A61K39/02 ,  C12N9/48 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C12N15/70 ,  C07K2319/20 ,  C07K2319/21 ,  C07K2319/23 ,  C12N9/104 ,  C12N9/52

    摘要： Described is a novel purification tag, SNUT, based on the gene product of a sortase gene, in particular the srtA gene of Staphylococcus aureus and uses thereof. Also provided are expression constructs comprising DNA enoding the tag for the production of recombinant polypeptides. The tag can be used in methods of purifying soluble domains of a number of proteins previously not able to be isolated efficiently and methods of inducing and/or enhancing an immune response to an antigen of interest.

    摘要翻译： 描述了基于分选酶基因的基因产物，特别是金黄色葡萄球菌的srtA基因的新型纯化标签SNUT及其用途。 还提供了包含编码用于产生重组多肽的标签的DNA的表达构建体。 该标签可用于纯化先前不能有效分离的许多蛋白质的可溶性结构域的方法，以及诱导和/或增强对感兴趣的抗原的免疫应答的方法。