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27 条记录 (耗时 0.02 秒)

    Centering device for waveguide
    1.
    发明授权
    Centering device for waveguide 有权

    公开(公告)号：US10393566B2

    公开(公告)日：2019-08-27

    申请号：US15656311

    申请日：2017-07-21

    申请人： Endress+Hauser Inc.

    发明人： Eugene E. Henry ,  Trevor Yenna

    IPC分类号： G01F23/28 ,  G01F23/284

    摘要： According to at least one aspect of the present disclosure, a centering device includes a body including a first part and a second part connected by a hinge, the hinge structured to enable the first part and the second part to pivot relatively each other about the hinge to form a center channel extending through the body and defining a center axis. The body further includes a clasp, structured to reversibly hold the first part adjacent the second part in an assembled state, and a plurality of members extending radially from the body where, in the assembled state, the center channel and the clasp structured to reversibly attach to a body passing through the center channel.

    Cephalomannine epoxide, its analogues and a method for preparing the same
    5.
    发明授权
    Cephalomannine epoxide, its analogues and a method for preparing the same 失效
    Cephalomannine环氧化物，其类似物及其制备方法

    公开(公告)号：US5892063A

    公开(公告)日：1999-04-06

    申请号：US861286

    申请日：1997-05-21

    申请人： Qun Y. Zheng ,  Christopher K. Murray ,  Randall J. Daughenbaugh

    发明人： Qun Y. Zheng ,  Christopher K. Murray ,  Randall J. Daughenbaugh

    IPC分类号： A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14 ,  C07D407/12

    CPC分类号： C07D407/12 ,  C07D305/14

    摘要： An antitumor compound of formula (5) ##STR1## in which R is Ac or H, and R.sub.1, R.sub.2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R.sub.3 is H; R.sub.1 and R.sub.2 and R.sub.3 are H; R.sub.1 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R.sub.2, R.sub.3 is H; R.sub.1 and R.sub.3 are H, R.sub.2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R.sub.1 is H, R.sub.2 and R.sub.3 are an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R.sub.1 and R.sub.2 and R.sub.3 are an alkyl group Me, Et, Pr, i-Pr, n-Bu or t-Bu. Me is an abbreviation for methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, n-Bu is n-butyl, and t-Bu is tert-butyl. Also provided by the invention is a one step method of preparing a compound of formula (5) whereby a taxane having a tiglate group attached to the side chain is contacted with an oxidizing reagent resulting in the formation of an epoxide having antitumor activity.

    摘要翻译： 式（5）的抗肿瘤化合物其中R为Ac或H，R1，R2为烷基，例如Me，Et，Pr，i-Pr，n-Bu或t-Bu，R3为H ; R1和R2和R3是H; R1是Me，Et，Pr，i-Pr，n-Bu或t-Bu的烷基，R2，R3是H; R1和R3为H，R2为Me，Et，Pr，i-Pr，n-Bu或t-Bu等烷基; R1是H，R2和R3是烷基，例如Me，Et，Pr，i-Pr，n-Bu或t-Bu; R1和R2和R3是烷基Me，Et，Pr，i-Pr，n-Bu或t-Bu。 Me是甲基的缩写，Et是乙基，Pr是丙基，i-Pr是异丙基，n-Bu是正丁基，t-Bu是叔丁基。 本发明还提供制备式（5）化合物的一步法，其中具有连接到侧链上的特加根基团的紫杉烷与氧化剂接触，导致形成具有抗肿瘤活性的环氧化物。

    Control system for a capacitive level sensor
    6.
    发明授权
    Control system for a capacitive level sensor 失效
    电容式液位传感器的控制系统

    公开(公告)号：US4347741A

    公开(公告)日：1982-09-07

    申请号：US169835

    申请日：1980-07-17

    申请人： Wolfgang Geiger

    发明人： Wolfgang Geiger

    IPC分类号： G01F23/26 ,  H03J1/02

    CPC分类号： G01F23/263

    摘要： A capacitive system for sensing the level of material includes a conductive member electrically connected to ground potential, a probe including a sensing element arranged to establish a capacitance between the sensing element and conductive member which is determined by the level of the material and a shielding element interposed between the conductive member and the sensing element to form an electrically neutral zone therebetween to thereby reduce the effect of a conductive buildup of the material on the probe on the capacitance between the conductive member and the sensing element, and a first circuit electrically connected to the sensing and shielding elements for applying generally the same electrical potential to both the sensing and shielding elements, the first circuit having an output which varies in response to a change in the capacitance between the conductive member and the sensing element. A device for measuring an electrical characteristic of the shielding element which is related to the conductivity of the buildup of material on the probe is electrically connected to a second circuit which, through a feedback loop connected to the first circuit, automatically adjusts the sensitivity of the first circuit in response to changes in the electrical characteristic to compensate for a highly conductive buildup of material on the probe.

    摘要翻译： 用于感测材料水平的电容系统包括电连接到地电势的导电构件，包括感测元件的探针，该感测元件布置成在感测元件和导电构件之间建立电容，该电容由材料的水平确定，屏蔽元件 插入在导电构件和感测元件之间以在其间形成电中性区域，从而减少材料在探针上的导电积聚对导电构件和感测元件之间的电容的影响，以及电连接到 用于将感应和屏蔽元件大致相同的电位施加到感测和屏蔽元件的第一电路具有响应于导电构件和感测元件之间的电容变化而变化的输出。 用于测量屏蔽元件的电特性的装置，其与探针上的材料积聚的电导率相关，电连接到第二电路，第二电路通过连接到第一电路的反馈回路自动调节 第一电路响应于电特性的变化以补偿探针上材料的高导电性积聚。

    Hydrocarbon transfer standard certified to provide in situ calibration of measuring devices
    7.
    发明授权
    Hydrocarbon transfer standard certified to provide in situ calibration of measuring devices 有权

    公开(公告)号：US10921174B2

    公开(公告)日：2021-02-16

    申请号：US15605562

    申请日：2017-05-25

    申请人： Endress+Hauser Inc.

    发明人： Brian Hoover ,  Christopher Brent Miller ,  Ron Onwezen

    IPC分类号： G01F25/00

    摘要： One aspect of the present disclosure includes a transfer standard apparatus for in situ calibration of measuring devices including a manifold having a first header in fluid communication with a second header via two or more flow lines, the first header and the second header each having ports at each end structured to accept external flow lines, two or more flow meters, each disposed in one of the flow lines such that the flow meters are connected in parallel relative to the first header and second header, and valves disposed in the flow lines adjacent the first header and the second header and operable to selectively isolate each flow meter from the first header and the second header. The transfer standard apparatus may include a mobile platform on which the manifold is mounted, including access to the ports of the first header and second header.

    Preparation of taxol and docetaxel through primary amines
    9.
    发明授权
    Preparation of taxol and docetaxel through primary amines 失效
    通过伯胺制备紫杉醇和多西紫杉醇

    公开(公告)号：US5679807A

    公开(公告)日：1997-10-21

    申请号：US380679

    申请日：1995-01-30

    申请人： Christopher K. Murray ,  Qun Y. Zheng ,  Xiaoqin Cheng ,  S. Kent Peterson

    发明人： Christopher K. Murray ,  Qun Y. Zheng ,  Xiaoqin Cheng ,  S. Kent Peterson

    IPC分类号： C07D305/14

    CPC分类号： C07D305/14

    摘要： The invention relates to a process for converting Taxol A, B and C to Taxol primary amine which can then be easily and efficiently converted to Taxol A or docetaxel, thereby significantly increasing the yield of these products from biomass. The method includes the removal of the amide from the side-chain with Schwartz's reagent to form an imine, followed by the hydrolysis of the imine to the primary amine. The primary amine can then be converted to Taxol A or docetaxel. New Taxol imine compounds and primary amine salts have been formed by this process.

    摘要翻译： 本发明涉及将紫杉醇A，B和C转化为紫杉醇伯胺的方法，其可以容易且有效地转化为紫杉醇A或多西紫杉醇，从而显着提高这些产物从生物质中的产量。 该方法包括用Schwartz's试剂从侧链除去酰胺以形成亚胺，然后将亚胺水解成伯胺。 然后将伯胺转化成紫杉醇A或多西紫杉醇。 通过该方法已经形成了新的紫杉醇亚胺化合物和伯胺盐。

    Selective process for the deacylation and deacetylation of taxol and taxanes
    10.
    发明授权
    Selective process for the deacylation and deacetylation of taxol and taxanes 失效
    紫杉醇和紫杉烷的脱酰基和脱乙酰化的选择性过程

    公开(公告)号：US5629433A

    公开(公告)日：1997-05-13

    申请号：US276254

    申请日：1994-07-18

    申请人： Qun Y. Zheng ,  Lynn G. Darbie ,  Christopher K. Murray

    发明人： Qun Y. Zheng ,  Lynn G. Darbie ,  Christopher K. Murray

    IPC分类号： C07D305/14

    CPC分类号： C07D305/14

    摘要： The present invention relates to a highly selective method for the deacetylation and deacylation of taxol and taxanes compounds. Specifically, the present invention relates to a one step process wherein acyl groups located at the carbon 2', 10, and 7 positions of taxol and other taxane compounds may be selectively removed.

    摘要翻译： 本发明涉及紫杉醇和紫杉烷化合物的脱乙酰化和脱酰基的高度选择性方法。 具体地，本发明涉及一步法，其中可以选择性地除去位于紫杉醇和其他紫杉烷化合物的碳2'，10和7位的酰基。