公开(公告)号：US07582274B2

公开(公告)日：2009-09-01

申请号：US10849932

申请日：2004-05-21

申请人： Daniel Cossement ,  Richard Chahine ,  Tapan K. Bose

发明人： Daniel Cossement ,  Richard Chahine ,  Tapan K. Bose

IPC分类号： D01F9/12 ,  C01B31/34

CPC分类号： B82Y30/00 ,  C01B32/05 ,  C01B32/90 ,  H01M4/9083 ,  H01M2008/1095 ,  Y10S977/842

摘要： Carbon nanostructures for use as catalyst supports in hydrogen fuel cells are produced by mixing a carbon material with at least one transition metal such as iron and cobalt, subjecting the mixture thus produced to mechanical grinding, e.g. ball milling in a hydrogen atmosphere for a time sufficient for hydrogen to be absorbed into the mixture, and heating the mixture in an inert atmosphere at a temperature sufficient to crystallize at least one of the carbon material and carbide nanocrystals.

摘要翻译： 用于氢燃料电池中的催化剂载体的碳纳米结构是通过将碳材料与至少一种过渡金属（例如铁和钴）混合，将如此制备的混合物进行机械研磨， 在氢气气氛中球磨一段足以使氢气吸收到混合物中的时间，并在足以使至少一种碳材料和碳化物纳米晶体结晶的惰性气氛中加热该混合物。

公开(公告)号：US07579182B2

公开(公告)日：2009-08-25

申请号：US11979172

申请日：2007-10-31

申请人： Christopher Sikora ,  Bradley Berger ,  John Cherwonogrodzky

发明人： Christopher Sikora ,  Bradley Berger ,  John Cherwonogrodzky

IPC分类号： C12N1/00

CPC分类号： A61K39/02 ,  A61K2039/52 ,  C07K14/195 ,  G01N2469/20 ,  Y02A50/405

摘要： This invention discloses methods for identifying Francisella tularensis vaccine candidates. It enables identification of novel vaccine candidates and quality assurance for vaccine batches, assessment of protection in vaccinates and identification of the infecting agent in vaccinates. Mice were first vaccinated with Brucella abortus O-polysaccharide (OPS) vaccine. These animals were then given 10 LD50s of F. tularensis live vaccine strain (LVS). Sixty percent (60%) of the vaccinated mice survived the multiple lethal doses. Sera were collected from these surviving mice and the antibodies were used to probe supernatant and cell lysates of live F. tularensis LVS cultures. Several F. tularensis components were identified only by the noted “survivor” antisera. Of these identified proteins, enzyme digestions and chemical oxidation suggest post-translational modifications of some proteins e.g. a 52 kDa glycoprotein, a 45 kDa lipoprotein and a 19 kDa nucleoprotein. The 52 kDa component caused nitrous oxide induction in tissue cultures at low concentrations, cell death at high concentrations. Vaccination with this gave partial protection while addition of other components acted synergistically to give enhanced protection from 250 LD50s of F. tularensis LVS.

摘要翻译： 本发明公开了用于鉴定土拉弗朗西丝杆菌疫苗候选物的方法。 它能够识别新型疫苗候选物和疫苗批次的质量保证，疫苗接种中的保护评估和疫苗接种中感染剂的鉴定。 首先用Brucella abortus O-polysaccharide（OPS）疫苗接种小鼠。 然后给予这些动物10只LD50的土拉曼杆菌活疫苗株（LVS）。 接种疫苗的小鼠中有60％（60％）存活多次致死剂量。 从这些存活的小鼠中收集血清，并使用抗体来探测活的土拉氏木霉LVS培养物的上清液和细胞裂解物。 几种罗非鱼片组分仅由所述的“幸存者”抗血清鉴定。 在这些鉴定的蛋白质中，酶消化和化学氧化表明某些蛋白质的翻译后修饰，例如 一个52 kDa的糖蛋白，一个45 kDa的脂蛋白和一个19 kDa的核蛋白。 52 kDa组分在低浓度组织培养物中引起氧化亚氮诱导，高浓度细胞死亡。 用这种疫苗接种给予部分保护，而加入其他成分则协同作用，从而提高了对土拉氏杆菌LVS的250 LD50的保护。

公开(公告)号：US06894494B2

公开(公告)日：2005-05-17

申请号：US10608141

申请日：2003-06-30

申请人： Stergios Stergiopoulos ,  Miroslaw Wrobel ,  Andreas Freibert ,  Waheed Younis ,  Amar Dhanantwari

发明人： Stergios Stergiopoulos ,  Miroslaw Wrobel ,  Andreas Freibert ,  Waheed Younis ,  Amar Dhanantwari

IPC分类号： G01R33/567 ,  G01V3/00

CPC分类号： G01R33/5673 ,  G01R33/56325

摘要： The present invention relates to a signal processing method and system for correcting organ motion artifacts for cardiac and brain imaging. A plurality of sets of MRI measurement data indicative of at least an image of an object is received. Each set corresponds to one row kx of a k-space matrix of at least a k-space matrix. For each set a k-space matrix of the at least a k-space matrix is determined for allocation thereto based on motion information of the object occurring during acquisition of the plurality of sets of the MRI measurement data. In a following step a location within the allocated k-space matrix corresponding to a row of the k-space matrix allocated thereto is determined for each set. At least a k-space matrix is then generated by re-arranging the plurality of sets. Each of the at least a k-space matrix comprises the sets of the plurality of sets of the MRI measurement data allocated thereto. Inverse Fourier transforming of the plurality of k-space matrices provides at least a reconstructed image. Through careful selection of the phases of the cardiac and respiratory cycles and corresponding ranges MRI data acquisition periods are of the order of seconds or a few minutes. Furthermore, integration of motion artifact free MRI images of different phases of organ motion using the coherent k-space synthesis according to the invention allows provision of an animation showing different phases of a cardiac or lung cycle. In an embodiment for correcting motion artifacts for brain imaging a motion vector describing translational and rotational motion of a patient's head is tracked during the MRI data acquisition process. The motion artifacts are then corrected based on coherent k-space synthesis using the motion vector data.

摘要翻译： 本发明涉及用于校正心脏和脑成像的器官运动假象的信号处理方法和系统。 接收指示对象的至少一个图像的多组MRI测量数据。 每个集合对应于至少一个k空间矩阵的k空间矩阵的一行k×××。 对于每个集合，基于在获取多组MRI测量数据的采集期间发生的对象的运动信息，确定至少k空间矩阵的k空间矩阵用于分配。 在随后的步骤中，针对每个集合确定与分配给其的k空间矩阵的行相对应的所分配的k空间矩阵内的位置。 然后，通过重新排列多个集合来生成至少一个k空间矩阵。 所述至少k空间矩阵中的每一个包括分配给其的所述多个MRI测量数据的集合。 多个k空间矩阵的逆傅立叶变换提供至少一个重构图像。 通过仔细选择心脏和呼吸周期的相位和相应范围，MRI数据采集周期大约为数秒或数分钟。 此外，使用根据本发明的相干k空间合成的器官运动的不同阶段的运动伪像自由MRI图像的集成允许提供显示心脏或肺循环的不同阶段的动画。 在用于校正脑成像的运动伪像的实施例中，描述了在MRI数据采集过程期间描述患者头部的平移和旋转运动的运动矢量。 然后基于使用运动矢量数据的相干k空间合成校正运动假象。

公开(公告)号：US5770547A

公开(公告)日：1998-06-23

申请号：US823115

申请日：1997-03-25

申请人： Linh Ngo Phong

发明人： Linh Ngo Phong

IPC分类号： C01G1/00 ,  C01G3/00 ,  C01G29/00 ,  C23C14/58 ,  C23C16/40 ,  H01L39/12 ,  H01L39/24 ,  B29C71/00 ,  C04B40/00

CPC分类号： C23C14/5806 ,  C23C14/5853 ,  C23C16/408 ,  H01L39/2419

摘要： A process for making a superconducting, Pb-doped, 2:2:2:3 BiSrCaCuO thin film includes heating deposited thin film material at between 1083K and 1103K for no more than 20 minutes in oxygen with a flow rate of 500 sccm, followed by quenching the material in air to room temperature, heating the material in air between 1103K and 1143K for no more than 40 minutes and finally quenching the material in air to room temperature.

摘要翻译： 制造超导Pb掺杂的2：2：2：3：BiSrCaCuO薄膜的方法包括在1083K和1103K之间的加热沉积的薄膜材料在氧气中以不超过20分钟的流速为500sccm，随后是 将空气中的材料淬火至室温，将空气中的材料在1103K和1143K之间加热不超过40分钟，最后将材料在空气中淬火至室温。

公开(公告)号：US5364932A

公开(公告)日：1994-11-15

申请号：US918610

申请日：1992-07-27

申请人： Jen-Chang Hsia

发明人： Jen-Chang Hsia

IPC分类号： A61K38/16 ,  A61K38/00 ,  A61K38/42 ,  A61L2/00 ,  A61P7/08 ,  C07K14/805 ,  C07K15/22

CPC分类号： C07K14/805 ,  A61K38/42 ,  A61L2/0023

摘要： The present specification describes a process by which a blood substitute (hereinafter referred to as "HemoSafe") is derived from uniformly stabilized monomers and polymers of deoxyhemoglobin in its tight (T) conformation, with oxygen affinity similar to that of human blood. Two classes of HemoSafe are derived respectively from anima-hemoglobin and human-hemoglobin. HemoSafe (animal) differs from HemoSafe (human) in that it is free of polymers in order to reduce potential immunogenicity if used in man. Both types of HemoSafe may be derived in the following manner. The stabilized deoxyhemoglobins are converted to their carbonmonoxy derivatives (CO-HemoSafe) which are then stable under pasteurization conditions to render them viral disease transmission-free. CO-HemoSafes are stable for 2 months at 56.degree. C. in either the solution or the freeze-dried state. For transfusion CO-HemoSafes are easily oxygenated under sterile conditions by photoconversion yielding oxy-HemoSafe. In addition a transfusable met-hemoglobin derivative for treatment of cyanide poisoning, is derived by converting oxy-HemoSafe to met-HemoSafe.

摘要翻译： 本说明书描述了血液替代物（以下称为“HemoSafe”）来源于其紧密（T）构象中的均匀稳定的单体和脱氧血红蛋白的聚合物，氧亲和力与人血液相似。 HemoSafe两类分别来源于动脉血红蛋白和人血红蛋白。 HemoSafe（动物）与HemoSafe（人类）不同之处在于，如果在人体中使用，则它不含聚合物以降低潜在的免疫原性。 两种类型的HemoSafe可以以下列方式得出。 稳定的脱氧血红蛋白被转化为它们的碳单氧基衍生物（CO-HemoSafe），然后在巴氏灭菌条件下稳定，使其无病毒传播。 CO溶液在溶液或冷冻干燥状态下在56℃下稳定2个月。 对于输血，CO-HemoSafes在无菌条件下通过光转换容易地氧合，产生oxy-HemoSafe。 另外，用于治疗氰化物中毒的可输送的met-hemoglobin衍生物是通过将oxy-HemoSafe转化成met-HemoSafe得到的。

公开(公告)号：US5214110A

公开(公告)日：1993-05-25

申请号：US550823

申请日：1990-07-11

申请人： Elie Ahad

发明人： Elie Ahad

IPC分类号： C06B45/10 ,  C08G65/22 ,  C08G65/24 ,  C08G65/325

CPC分类号： C08G65/325 ,  C06B45/105 ,  C08G65/22 ,  C08G65/24

摘要： The invention disclosed relates to novel branched chain hydroxy-terminated aliphatic polyether copolymers containing glycidyl azide and an additional substituent selected from the group consisting of alkylene oxide, styrene azide oxide and glycidyl units, and a single step method for the manufacture thereof which involves reacting a solid rubbery material selected from epichlorohydrin/alkylene oxide copolymer (PEEC) and polyepichlorohydrin homopolymer (PECH) with various epoxide monomers. The novel polyether copolymers are useful as energetic binders in explosive and solid rocket propellant compositions.

摘要翻译： 所公开的发明涉及含有缩水甘油基叠氮化物的新型支链羟基封端的脂族聚醚共聚物和选自环氧烷烃，叠氮化叠氮化物和缩水甘油基单元的另外的取代基，以及其制备方法，其包括使 选自表氯醇/烯化氧共聚物（PEEC）和聚表氯醇均聚物（PECH）与各种环氧化物单体的固体橡胶材料。 新型聚醚共聚物可用作爆炸和固体火箭推进剂组合物中的高能粘合剂。

公开(公告)号：US5062874A

公开(公告)日：1991-11-05

申请号：US533626

申请日：1990-06-05

申请人： Pierre Legare ,  David W. Pike

发明人： Pierre Legare ,  David W. Pike

IPC分类号： A62B19/00

CPC分类号： A62B19/00 ,  Y10S277/918

摘要： A filter canister assembly utilizes a sealant deflector to seal a particulate filter to the canister wall, even after the canister is sealed. The canister housing has a wall and an aperture with a particulate filter disposed therein. The particulate filter has an edge adjacent the wall, and is designed for removing particles of contaminants from a fluid, such as air, passed through the canister. A sealant deflector includes a plurality of vanes standing proud of a support substrate, and is situated between the aperture and the particulate filter and forms a permanent part of the canister assembly. The sealant deflector deflects a sealant in liquid state toward the wall to form a seal between the edge and the wall when the sealant is deposited on the sealant deflector while spinning. This deposits a sealant ring sealing the wall to the edge. The sealant deflector is self-centered under the aperture, by a bow-tie shaped structure of four arms extending outward radially from the sealant deflector connected in pairs by curved braces.

摘要翻译： 过滤罐组件利用密封剂偏转器将微粒过滤器密封到罐壁上，甚至在罐被密封之后。 罐壳体具有壁和孔，其中布置有微粒过滤器。 颗粒过滤器具有邻近壁的边缘，并且被设计用于从通过罐的流体（例如空气）中去除污染物颗粒。 密封剂偏转器包括多个叶片，其支撑着支撑基板，并且位于孔和微粒过滤器之间并形成罐组件的永久部分。 当密封剂在旋转时将密封剂沉积在密封剂偏转器上时，密封剂偏转器将液体状态的密封剂朝向壁偏转以在边缘和壁之间形成密封。 这将一个密封环沉积在边缘上。 密封剂偏转器通过由弯曲的支架成对连接的密封剂偏转器的径向向外延伸的四个臂的弓形结构而在孔下方自对中。

公开(公告)号：US4981738A

公开(公告)日：1991-01-01

申请号：US337412

申请日：1989-04-13

申请人： Brian Farnworth ,  Randall J. Osczevski

发明人： Brian Farnworth ,  Randall J. Osczevski

IPC分类号： A62B17/00 ,  B32B3/14 ,  D06N3/18

CPC分类号： B32B3/14 ,  A62B17/006 ,  D06N3/183 ,  D06N3/186 ,  Y10T428/183 ,  Y10T428/187 ,  Y10T428/195 ,  Y10T428/24091 ,  Y10T428/24107 ,  Y10T428/24752 ,  Y10T428/2476 ,  Y10T428/25 ,  Y10T428/30

摘要： This invention relates to a multi-layer protective fabric for protective suits used in hazardous or toxic environments. A first layer comprises strips of water and vapor impermeable material, there being a gap between adjacent such strips. A second layer comprises a plurality of strips of a wicking material with each such strip covering the inner surface of a first layer strip, passing through the gap between adjacent strips and covering the outer surface of the adjacent first layer strip. Moisture, such as perspiration will pass via the wicking material through the gaps past the first layer for evaporation and diffusion through a third layer of a liquid impermeable/vapor permeable material which extends over the second layer material covering the outer surfaces of the first layer.

摘要翻译： 本发明涉及用于危险或有毒环境的防护服的多层防护织物。 第一层包括水和不透蒸气材料的条，在相邻的这些条之间存在间隙。 第二层包括芯吸材料的多个条带，其中每个这样的条覆盖第一层条带的内表面，穿过相邻条带之间的间隙并覆盖相邻第一层条带的外表面。 诸如排汗之类的水分将经由芯吸材料穿过第一层之间的空隙，以便蒸发和扩散通过覆盖第一层外表面的第二层材料的第三层不透液体/透气材料。

公开(公告)号：US4926853A

公开(公告)日：1990-05-22

申请号：US213263

申请日：1988-06-29

申请人： Pierre P. Meunier

发明人： Pierre P. Meunier

IPC分类号： A62B18/08

CPC分类号： A62B18/08

摘要： An improvement to a face mask is disclosed which has two eyepieces, a pliable full face covering, breathing means and means for sealing and securing the mask to the face of a wearer. The improvement being nose occluding means which include a pair of prong members made of a rigid material. Each prong member is adjustably attached at one end thereof to a lower rim portion of a respective eyepiece at an angle with respect thereto so that it is directed inwardly toward the nose of the wearer. A method of nose occlusion in order to perform the valsalva maneuvre utilizing the improved face mask is also disclosed.

摘要翻译： 公开了一种面罩的改进，其具有两个目镜，柔软的全脸覆盖物，呼吸装置和用于将面罩密封并固定到佩戴者的面部的装置。 改进是鼻塞闭塞装置，其包括由刚性材料制成的一对叉形构件。 每个插脚构件的一端可调节地连接到相应目镜的下边缘部分上，以相对于其相对角度安装，使得其朝向穿用者的鼻子朝内。 还公开了一种使用改进的面罩来进行缬草作用的鼻塞的方法。

公开(公告)号：US4922470A

公开(公告)日：1990-05-01

申请号：US271466

申请日：1988-11-15

申请人： Garfield W. McMahon ,  Dennis F. Jones

发明人： Garfield W. McMahon ,  Dennis F. Jones

IPC分类号： G10K9/12

CPC分类号： G10K9/121 ,  H04R1/44

摘要： An underwater acoustical projector consisting of a spaced apart pair of polygonal shaped end plates, a ceramic driver of smaller cross-sectional size than each end plate, positioned between the end plates, and a set of staves secured from one end plate to the other, each stave being bent concavely inwardly towards the driver and being separated from each other by a gap.

摘要翻译： 一种由间隔开的一对多边形端板组成的水下声学投影仪，位于端板之间的比每个端板更小的横截面尺寸的陶瓷驱动器以及从一个端板固定到另一个端板的一组板条， 每个梯形板朝向驾驶员凹陷地向内弯曲并且通过间隙彼此分离。