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    AN X-RAY TRANSFOCATOR AND FOCUS VARIATION METHOD
    1.
    发明公开
    AN X-RAY TRANSFOCATOR AND FOCUS VARIATION METHOD 审中-公开

    公开(公告)号：US20230187097A1

    公开(公告)日：2023-06-15

    申请号：US17794769

    申请日：2021-07-12

    申请人： INSTITUTE OF HIGH ENERGY PHYSICS, CHINESE ACADEMY OF SCIENCES

    发明人： Shanzhi TANG ,  Zhongrui REN ,  Weiwei Zhang ,  Weifan SHENG ,  Ming LI

    IPC分类号： G21K1/06

    CPC分类号： G21K1/065

    摘要： The invention discloses an X-ray zoom lens system (Transfocator) and a focus variation method. The system is characterized in that it includes a main frame, many switched arms arranged on one side of the main frame, and a driving component set at the top of the main frame, and a positioning groove set at the bottom of the main frame; For them, each switched arm is composed of successively connected a push rod, a push-push ratchet mechanism, a preload spring and a guide stick, two-dimensional flexible axis, and a CRLs holder from top to bottom; CRLs are stacked and arranged in the mentioned above CRLs holder; The push-push ratchet mechanism contains that an extension spring, a slider with ratchet guide slot, a guide baseplate, a C-shaped tie rod, in which the slider with ratchet guide slot and the guide baseplate form a linear guide motion pair by a linear groove and a guide structure. The upper end of the slider with ratchet guide slot is connected to the upper end of the guide plate by the extension spring; The lower end of the slider with ratchet guide slot is successively connected with the preload spring and guide stick, the two-dimensional flexible axis, and the CRLs holder; The upper end of the C-shaped tie rod is used to slide in the ratchet guide slot of the slider with ratchet guide slot, and its lower end is connected with the bottom end of the guide baseplate by an elastic clamping.

    Method for preparing tricarbonyl technetium-99m intermediate
    2.
    发明授权
    Method for preparing tricarbonyl technetium-99m intermediate 有权

    公开(公告)号：US10968245B2

    公开(公告)日：2021-04-06

    申请号：US16464919

    申请日：2016-12-28

    申请人： Institute of High Energy Physics, Chinese Academy of Sciences

    发明人： Wenjiang Yang ,  Yu Liu ,  Jingquan Xue ,  Yanhua Zhang

    IPC分类号： A61K51/00 ,  A61M36/14 ,  C07F17/00

    摘要： The invention provides a method for preparing a technetium-99m tricarbonyl intermediate. The method comprises reacting a manganese carbonyl compound used as a carbon monoxide source with pertechnetate and water to obtain the technetium-99m tricarbonyl intermediate. The method for preparing a technetium-99m tricarbonyl intermediate in an embodiment of the invention can complete the preparation of the intermediate at atmospheric pressure and room temperature. The method is easy to operate, uses easily obtained raw materials, has a high labeling yield, and can be used to prepare various types of technetium tricarbonyl labeled probes.

    Photomultiplier tube for collecting photoelectrons from a photocathode covering a whole inner surface of a vacuum container
    3.
    发明授权
    Photomultiplier tube for collecting photoelectrons from a photocathode covering a whole inner surface of a vacuum container 有权
    用于从覆盖真空容器的整个内表面的光电阴极收集光电子的光电倍增管

    公开(公告)号：US08324807B2

    公开(公告)日：2012-12-04

    申请号：US13259861

    申请日：2009-07-20

    申请人： Yi fang Wang ,  Sen Qian ,  Tian chi Zhao ,  Jun Cao

    发明人： Yi fang Wang ,  Sen Qian ,  Tian chi Zhao ,  Jun Cao

    IPC分类号： H01J43/04

    CPC分类号： H01J43/28

    摘要： A photomultiplier tube including a photocathode, an electron multiplier, an electron collector, and a power lead, wherein the photocathode and the electron multiplier are disposed in a sealed transparent vacuum envelope, the electron collector and the power lead are connected with an external circuit outside the vacuum envelope, the photocathode is formed on the entire inner surface of the vacuum envelope, and the electron multiplier is located on the internal center of the vacuum envelope to receive photoelectrons from the photocathode in all directions for electrons multiplication. Because the effective photocathode area is increased, the detection efficiency of unit light-receiving area is improved.

    摘要翻译： 包括光电阴极，电子倍增器，电子收集器和功率引线的光电倍增管，其中光电阴极和电子倍增器设置在密封的透明真空外壳中，电子收集器和电源引线与外部电路连接 真空外壳中，在真空外壳的整个内表面上形成光电阴极，并且电子倍增器位于真空外壳的内部中心，以从光电阴极沿着所有方向接收光电子用于电子倍增。 由于有效光电面积增加，单位受光面积的检测效率提高。

    Metallofullerols and their applications for preparation of medicine for inhibition of tumor growth
    4.
    发明授权
    Metallofullerols and their applications for preparation of medicine for inhibition of tumor growth 有权
    金属富勒烯及其用于制备抑制肿瘤生长的药物的应用

    公开(公告)号：US08124657B2

    公开(公告)日：2012-02-28

    申请号：US11992249

    申请日：2006-09-15

    申请人： Yuliang Zhao ,  Chunying Chen ,  Gengmei Xing

    发明人： Yuliang Zhao ,  Chunying Chen ,  Gengmei Xing

    IPC分类号： A61K31/047 ,  C07C35/00

    CPC分类号： A61K33/24 ,  A61K31/28 ,  Y10S977/736 ,  Y10S977/915

    摘要： This invention provides a composition of polyhydroxylated metallofullerene compound and its application in the preparation of antitumor pharmaceutical. In one embodiment, metallofullerol comprising the formula, M@C2m(OH)x, wherein M is selected from rare earth elements such as La or Gd; m is carbon atoms of 41 or 30; x is a number of hydroxyl group of from 10 to about 50. Actually, due to the reset of the neighboring hydroxyl, the numbers of O and H in Carbon cage are different, formula are thus written as M@C2mOxHy. Comparing to the clinical anticancer drugs such as Paclitaxel, Cyclophosphamide, and Cisplatin, metallofullerol of M@C2m(OH)x or M@C2mOxHy has superior advantages of higher antitumor efficiency, low dosage, low toxicity, and better biocompatibility.

    摘要翻译： 本发明提供多羟基化金属富勒烯化合物的组合物及其在制备抗肿瘤药物中的应用。 在一个实施方案中，包含式M 2 C 2m（OH）x的金属富勒烯，其中M选自稀土元素如La或Gd; m为41或30的碳原子; x是10〜50左右的羟基数。实际上，由于相邻羟基的复位，碳笼中O和H的数目不同，所以公式被写为M @ C2mOxHy。 与紫杉醇，环磷酰胺和顺铂等临床抗癌药物相比，M @ C2m（OH）x或M @ C2mOxHy的金属富勒醇具有较高的抗肿瘤效率，低剂量，低毒性，更好的生物相容性等优点。

    PHOTOMULTIPLIER TUBE
    5.
    发明申请
    PHOTOMULTIPLIER TUBE 有权
    光电管

    公开(公告)号：US20120019132A1

    公开(公告)日：2012-01-26

    申请号：US13259861

    申请日：2009-07-20

    申请人： Yi fang Wang ,  Sen Qian ,  Tian chi Zhao ,  Jun Cao

    发明人： Yi fang Wang ,  Sen Qian ,  Tian chi Zhao ,  Jun Cao

    IPC分类号： H01J40/16 ,  H01J40/02

    CPC分类号： H01J43/28

    摘要： a photomultiplier tube including a photocathode, an electron multiplier, an electron collector, and a power lead, wherein the photocathode and the electron multiplier are disposed in a sealed transparent vacuum envelope, the electron collector and the power lead are connected with an external circuit outside the vacuum envelope, the photocathode is formed on the entire inner surface of the vacuum envelope, and the electron multiplier is located on the internal center of the vacuum envelope to receive photoelectrons from the photocathode in all directions for electrons multiplication. Because the effective photocathode area is increased, the detection efficiency of unit light-receiving area is improved.

    摘要翻译： 包括光电阴极，电子倍增器，电子收集器和电源引线的光电倍增管，其中光电阴极和电子倍增器设置在密封的透明真空外壳中，电子收集器和电源引线与外部电路外部连接 真空外壳中，在真空外壳的整个内表面上形成光电阴极，并且电子倍增器位于真空外壳的内部中心，以从光电阴极沿着所有方向接收光电子用于电子倍增。 由于有效光电面积增加，单位受光面积的检测效率提高。

    X-ray transfocator and focus variation method
    6.
    发明授权
    X-ray transfocator and focus variation method 有权

    公开(公告)号：US12014839B2

    公开(公告)日：2024-06-18

    申请号：US17794769

    申请日：2021-07-12

    申请人： INSTITUTE OF HIGH ENERGY PHYSICS, CHINESE ACADEMY OF SCIENCES

    发明人： Shanzhi Tang ,  Zhongrui Ren ,  Weiwei Zhang ,  Weifan Sheng ,  Ming Li

    IPC分类号： G21K1/06

    CPC分类号： G21K1/065

    摘要： The invention discloses an X-ray zoom lens system (Transfocator) and a focus variation method. The system includes a main frame, many switched arms arranged on one side of the main frame, and a driving component set at the top of the main frame, and a positioning groove set at the bottom of the main frame; For them, each switched arm is composed of successively connected a push rod, a push-push ratchet mechanism, a preload spring and a guide stick, two-dimensional flexible axis, and a CRLs holder from top to bottom; CRLs are stacked and arranged in the mentioned above CRLs holder.

    METHOD FOR PREPARING TRICARBONYL TECHNETIUM-99M INTERMEDIATE
    8.
    发明申请
    METHOD FOR PREPARING TRICARBONYL TECHNETIUM-99M INTERMEDIATE 审中-公开

    公开(公告)号：US20200010496A1

    公开(公告)日：2020-01-09

    申请号：US16464919

    申请日：2016-12-28

    申请人： Institute of High Energy Physics, Chinese Academy of Sciences

    发明人： Wenjiang Yang ,  Yu Liu ,  Jingquan Xue ,  Yanhua Zhang

    IPC分类号： C07F17/00

    摘要： The invention provides a method for preparing a technetium-99m tricarbonyl intermediate. The method comprises reacting a manganese carbonyl compound used as a carbon monoxide source with pertechnetate and water to obtain the technetium-99m tricarbonyl intermediate. The method for preparing a technetium-99m tricarbonyl intermediate in an embodiment of the invention can complete the preparation of the intermediate at atmospheric pressure and room temperature. The method is easy to operate, uses easily obtained raw materials, has a high labeling yield, and can be used to prepare various types of technetium tricarbonyl labeled probes.