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    METHOD AND KIT FOR DETECTING HEPCIDIN
    2.
    发明申请
    METHOD AND KIT FOR DETECTING HEPCIDIN 有权
    用于检测HEPCIDIN的方法和试剂盒

    公开(公告)号：US20140217277A1

    公开(公告)日：2014-08-07

    申请号：US14123679

    申请日：2012-06-01

    申请人： Guangjun Nie ,  Tony Hu ,  Jia Fan ,  Yuliang Zhao ,  Mauro Ferrari

    发明人： Guangjun Nie ,  Tony Hu ,  Jia Fan ,  Yuliang Zhao ,  Mauro Ferrari

    IPC分类号： H01J49/00 ,  G01N1/38

    CPC分类号： H01J49/0027 ,  G01N1/38 ,  G01N33/6848 ,  G01N33/74 ,  H01J49/00

    摘要： A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in the elution product. The enrichment method substantially enhances the sensitivity and accuracy of mass spectrometric detection. A kit for detecting hepcidin comprising a sample diluent and a nanochip, the sample diluent comprising water, trifluoroacetic acid, and acetonitrile.

    摘要翻译： 检测铁调素的方法。 使样品液体与具有氧化硅的比表面涂层结构的纳米芯片接触，使得铁调素富集特异性; 用洗脱剂洗脱纳米芯片; 通过对洗脱产物进行质谱检测，测定洗脱产物中的铁调素含量。 浓缩法大大提高了质谱检测的灵敏度和准确性。 用于检测包含样品稀释剂和纳米芯片的铁调素的试剂盒，所述样品稀释剂包含水，三氟乙酸和乙腈。

    Metallofullerols and their Applications for Preparation of Medicine for Inhibition of Tumor Growth
    3.
    发明申请
    Metallofullerols and their Applications for Preparation of Medicine for Inhibition of Tumor Growth 有权
    金属富勒烯及其在制备抑制肿瘤生长的药物中的应用

    公开(公告)号：US20090076171A1

    公开(公告)日：2009-03-19

    申请号：US11992249

    申请日：2006-09-15

    申请人： Yuliang Zhao ,  Chunying Chen ,  Gengmei Xing

    发明人： Yuliang Zhao ,  Chunying Chen ,  Gengmei Xing

    IPC分类号： A61K31/045 ,  C07C31/28

    CPC分类号： A61K33/24 ,  A61K31/28 ,  Y10S977/736 ,  Y10S977/915

    摘要： This invention provides a composition of polyhydroxylated metallofullerene compound and its application in the preparation of antitumor pharmaceutical. In one embodiment, metallofullerol comprising the formula, M@C2m(OH)x, wherein M is selected from rare earth elements such as La or Gd; m is carbon atoms of 41 or 30; x is a number of hydroxyl group of from 10 to about 50. Actually, due to the reset of the neighboring hydroxyl, the numbers of O and H in Carbon cage are different, formula are thus written as M@C2mOxHy. Comparing to the clinical anticancer drugs such as Paclitaxel, Cyclophosphamide, and Cisplatin, metallofullerol of M@C2m(OH)x or M@C2mOxHy has superior advantages of higher antitumor efficiency, low dosage, low toxicity, and better biocompatibility.

    摘要翻译： 本发明提供多羟基化金属富勒烯化合物的组合物及其在制备抗肿瘤药物中的应用。 在一个实施方案中，包含式M 2 C 2m（OH）x的金属富勒烯，其中M选自稀土元素如La或Gd; m为41或30的碳原子; x是10〜50左右的羟基数。实际上，由于相邻羟基的复位，碳笼中O和H的数目不同，所以公式被写为M @ C2mOxHy。 与紫杉醇，环磷酰胺和顺铂等临床抗癌药物相比，M @ C2m（OH）x或M @ C2mOxHy的金属富勒醇具有较高的抗肿瘤效率，低剂量，低毒性，更好的生物相容性等优点。

    Metallofullerols and their applications for preparation of medicine for inhibition of tumor growth
    4.
    发明授权
    Metallofullerols and their applications for preparation of medicine for inhibition of tumor growth 有权
    金属富勒烯及其用于制备抑制肿瘤生长的药物的应用

    公开(公告)号：US08124657B2

    公开(公告)日：2012-02-28

    申请号：US11992249

    申请日：2006-09-15

    申请人： Yuliang Zhao ,  Chunying Chen ,  Gengmei Xing

    发明人： Yuliang Zhao ,  Chunying Chen ,  Gengmei Xing

    IPC分类号： A61K31/047 ,  C07C35/00

    CPC分类号： A61K33/24 ,  A61K31/28 ,  Y10S977/736 ,  Y10S977/915

    摘要： This invention provides a composition of polyhydroxylated metallofullerene compound and its application in the preparation of antitumor pharmaceutical. In one embodiment, metallofullerol comprising the formula, M@C2m(OH)x, wherein M is selected from rare earth elements such as La or Gd; m is carbon atoms of 41 or 30; x is a number of hydroxyl group of from 10 to about 50. Actually, due to the reset of the neighboring hydroxyl, the numbers of O and H in Carbon cage are different, formula are thus written as M@C2mOxHy. Comparing to the clinical anticancer drugs such as Paclitaxel, Cyclophosphamide, and Cisplatin, metallofullerol of M@C2m(OH)x or M@C2mOxHy has superior advantages of higher antitumor efficiency, low dosage, low toxicity, and better biocompatibility.

    摘要翻译： 本发明提供多羟基化金属富勒烯化合物的组合物及其在制备抗肿瘤药物中的应用。 在一个实施方案中，包含式M 2 C 2m（OH）x的金属富勒烯，其中M选自稀土元素如La或Gd; m为41或30的碳原子; x是10〜50左右的羟基数。实际上，由于相邻羟基的复位，碳笼中O和H的数目不同，所以公式被写为M @ C2mOxHy。 与紫杉醇，环磷酰胺和顺铂等临床抗癌药物相比，M @ C2m（OH）x或M @ C2mOxHy的金属富勒醇具有较高的抗肿瘤效率，低剂量，低毒性，更好的生物相容性等优点。