公开(公告)号：US20120195811A1

公开(公告)日：2012-08-02

申请号：US13358790

申请日：2012-01-26

申请人： Gary Nelson

发明人： Gary Nelson

IPC分类号： B01L3/02

CPC分类号： G01N35/0099 ,  B01J2219/00315 ,  B01J2219/00355 ,  B01J2219/00364 ,  B01J2219/00691 ,  G01N35/1067 ,  G01N35/1083 ,  G01N2035/0437 ,  G01N2035/103

摘要： A multi-channel wellplate filling system has a peristaltic pump for pumping fluid through multiple flexible tubes. The system also includes multiple pipette tip mounting shafts arranged in a linear array and in fluid communication with a respective flexible tube of the tubing set. Disposable pipette tips are mounted on the pipette tip mounting shafts. A controller operates the peristaltic pump in reverse and forward directions respectively in order to aspirate liquid into disposable pipette tips mounted on the pipette tip mounting shafts and dispense liquid in a metered amount from the disposable pipette tips into a wellplate positioned on a wellplate platform in the system. The system can also be converted into a wellplate wash station.

摘要翻译： 多通道孔板灌装系统具有蠕动泵，用于通过多个柔性管泵送流体。 该系统还包括布置成线性阵列并与管组的相应柔性管流体连通的多个移液管尖端安装轴。 一次性移液管尖端安装在移液管尖端安装轴上。 控制器分别在反向和前进方向上操作蠕动泵，以便将液体吸入安装在移液管尖端安装轴上的一次性移液管尖端，并将一定量的液体从一次性移液管尖端分配到位于孔板平台上的孔板中 系统。 该系统也可以转换成一个井眼清洗站。

公开(公告)号：US08128892B2

公开(公告)日：2012-03-06

申请号：US13219823

申请日：2011-08-29

申请人： David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

发明人： David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC分类号： B01L3/00 ,  B01L3/02 ,  G01N1/14

CPC分类号： B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

摘要： A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

摘要翻译： 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US20150030513A1

公开(公告)日：2015-01-29

申请号：US13952726

申请日：2013-07-29

申请人： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

发明人： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC分类号： B01L3/02

CPC分类号： B01L3/0237 ,  B01L3/0227 ,  B01L2200/022 ,  B01L2300/0829

摘要： A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

摘要翻译： 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US08468900B2

公开(公告)日：2013-06-25

申请号：US13099854

申请日：2011-05-03

申请人： Julian Warhurst

发明人： Julian Warhurst

IPC分类号： B01L3/02

CPC分类号： B01L3/0234 ,  B01L3/0227 ,  B01L3/0237 ,  B01L2200/025 ,  B01L2200/087 ,  B01L2200/14 ,  B01L2300/027 ,  B01L2300/0829 ,  B01L2400/0487

摘要： A manually directed, multi-channel electronic pipettor includes a software biasing mode to assure proper alignment over wells in the 96-well plate and the 384-well plate. The system also includes manual repositioning levers for nesting receptacles which are customized for 96 well-plates and 384 well-plates respectively.

摘要翻译： 手动导向的多通道电子移液器包括软件偏置模式，以确保在96孔板和384孔板中的孔正确对准。 该系统还包括针对96孔板和384孔板定制的嵌套容器的手动重新定位杆。

公开(公告)号：US08367022B2

公开(公告)日：2013-02-05

申请号：US13099953

申请日：2011-05-03

申请人： Julian Warhurst ,  Richard Cote

发明人： Julian Warhurst ,  Richard Cote

IPC分类号： B01L3/02

CPC分类号： B01L3/0234 ,  B01L3/0227 ,  B01L3/0237 ,  B01L2200/087 ,  B01L2300/027 ,  B01L2300/0829 ,  B01L2400/0478 ,  G01N35/1074

摘要： A manually directed, electronic multi-channel pipettor uses servo controlled motors to drive a carriage and pipetting head in response to a user's manipulation of a control handle. The pipetting head include an array of tip fittings, e.g. 96. The system includes a check processor to avoid unintended motion in case of system faults or crashes. The system requires substantial force to attach the array of tips, and therefore includes controls that require both of the user's hands be occupied during the tip attachment process.

摘要翻译： 手动导向的电子多通道移液器使用伺服控制的电动机来响应用户对控制手柄的操纵来驱动支架和移液头。 移液头包括尖端配件的阵列，例如 96.系统包括一个检查处理器，以避免系统故障或崩溃时的意外运动。 该系统需要相当大的力来附接尖端阵列，因此包括需要在尖端附着过程期间使用者的双手被占用的控制。

公开(公告)号：US08277757B2

公开(公告)日：2012-10-02

申请号：US12568801

申请日：2009-09-29

申请人： Terrence Kelly ,  Richard Cote ,  Gregory Mathus

发明人： Terrence Kelly ,  Richard Cote ,  Gregory Mathus

IPC分类号： B01L3/00 ,  G01F19/00 ,  G01F25/00

CPC分类号： B01L3/0279 ,  B01L3/021 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2400/0487

摘要： A pipette tip mounting shaft includes outwardly circumferentially extending locking lobes over which the pipette tip collar is mounted. The locking lobes preferably include an inclining ramp portion that gently flexes and distorts the pipette tip collar out-of-round as the mounting shaft is inserted into the pipette tip, rather than the stretching tip collar. Each locking lobe also includes a declining ramp portion which extends upward along the mounting shaft. The peak of the lobes is preferably curved. When the pipette tip is fully mounted on the mounting shaft, a locking ring on the inside surface of the tip collar engages the declining ramp of the lobes to provide an over-center engagement, however, the required ejection force is small.

摘要翻译： 移液管尖端安装轴包括向外周向延伸的锁定凸耳，移液管尖端套环安装在该凸起上。 锁定凸耳优选地包括倾斜斜面部分，当倾斜安装轴插入移液管尖端而不是拉伸尖端套环时，倾斜斜坡部分轻轻地弯曲和扭曲移液管尖端轴环。 每个锁定凸耳还包括沿安装轴向上延伸的下降斜面部分。 裂片的峰最好是弯曲的。 当移液管末端完全安装在安装轴上时，尖端套环的内表面上的锁定环接合凸角的下降斜面以提供过中心接合，然而，所需的弹出力很小。

公开(公告)号：US20120164037A1

公开(公告)日：2012-06-28

申请号：US13411675

申请日：2012-03-05

申请人： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

发明人： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC分类号： B01L3/02

CPC分类号： B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

摘要： A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

摘要翻译： 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US08122779B2

公开(公告)日：2012-02-28

申请号：US12422336

申请日：2009-04-13

申请人： Gary E. Nelson ,  George P. Kalmakis ,  R. Laurence Keene ,  Joel Novak ,  Kenneth Steiner ,  Jonathon Finger ,  Gregory Mathus ,  Richard Cote

发明人： Gary E. Nelson ,  George P. Kalmakis ,  R. Laurence Keene ,  Joel Novak ,  Kenneth Steiner ,  Jonathon Finger ,  Gregory Mathus ,  Richard Cote

IPC分类号： G01N1/14

CPC分类号： B01L3/0234 ,  B01L2200/0605 ,  B01L2200/087 ,  B01L2200/148

摘要： A hand-held electronic pipettor is designed particularly to be programmed and operated with one hand for the convenience of the user. It uses a capacitance touchpad control for programming, and a separate run button for the operating mode. Internal components are located so that the center of gravity of the pipettor is located within the palm of the user. Flash memory stores an empirically derived table that correlates aspiration volume to motor steps and a separate empirically derived table the correlates dispensing volumes to motor steps.

摘要翻译： 手持式电子移液器特别设计为一方面进行编程和操作，方便用户使用。 它使用电容式触摸板控件进行编程，另外还有一个运行模式的运行按钮。 内部部件被定位成使得移液器的重心位于使用者的手掌内。 闪存存储经验导出的表，其将抽吸体积与运动步骤相关联，以及单独的经验派生表将分配体积与运动步骤相关联。

公开(公告)号：US20110311410A1

公开(公告)日：2011-12-22

申请号：US13219823

申请日：2011-08-29

申请人： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

发明人： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC分类号： B01L3/02

CPC分类号： B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

摘要： A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

摘要翻译： 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US20110268627A1

公开(公告)日：2011-11-03

申请号：US13099782

申请日：2011-05-03

申请人： Julian Warhurst ,  Gary Nelson ,  Richard Cote

发明人： Julian Warhurst ,  Gary Nelson ,  Richard Cote

IPC分类号： B01L3/02

CPC分类号： B01L3/0227 ,  B01L3/0234 ,  B01L3/0237 ,  B01L9/523 ,  B01L2200/087 ,  B01L2200/146 ,  B01L2300/027 ,  B01L2300/06 ,  B01L2300/0829 ,  B01L2400/0478

摘要： A manually directed, multi-channel electronic pipetting system is designed to transfer liquids from a standard multi-well plate, deep-well plate or reservoir into another multi-well plate. The preferred pipetting head includes an array of 96-tip fittings. A deck with at least one but preferably two or more wellplate nesting receptacles holds one or more multi-well plates or reagent reservoirs for access by an array of disposable pipette tips mounted to the pipetting head. The electronic motion control system includes a control handle that is mounted to a load cell, the carriage for the pipetting head and is held in the palm of the user. In use, the user grasps the control handle and operates the system in a manner similar to one using a handheld electronic pipettor.

摘要翻译： 手动导向的多通道电子移液系统被设计成将液体从标准的多孔板，深井板或储存器转移到另一个多孔板中。 优选的移液头包括96针头配件的阵列。 具有至少一个但优选两个或更多个孔板嵌套容器的甲板容纳一个或多个多孔板或试剂储存器，用于通过安装到移液头的一次性吸头的阵列进入。 电子运动控制系统包括安装到称重传感器的控制手柄，用于移液头的托架并保持在使用者手掌中。 在使用中，用户抓住控制手柄并以类似于使用手持电子移液器的方式操作系统。