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    Manually directed, multi-channel electronic pipetting system
    1.
    发明授权
    Manually directed, multi-channel electronic pipetting system 有权
    手动导向，多通道电子移液系统

    公开(公告)号：US08372356B2

    公开(公告)日：2013-02-12

    申请号：US13099782

    申请日：2011-05-03

    申请人： Julian Warhurst ,  Gary Nelson ,  Richard Cote

    发明人： Julian Warhurst ,  Gary Nelson ,  Richard Cote

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0227 ,  B01L3/0234 ,  B01L3/0237 ,  B01L9/523 ,  B01L2200/087 ,  B01L2200/146 ,  B01L2300/027 ,  B01L2300/06 ,  B01L2300/0829 ,  B01L2400/0478

    摘要： A manually directed, multi-channel electronic pipetting system is designed to transfer liquids from a standard multi-well plate, deep-well plate or reservoir into another multi-well plate. The preferred pipetting head includes an array of 96-tip fittings. A deck with at least one but preferably two or more wellplate nesting receptacles holds one or more multi-well plates or reagent reservoirs for access by an array of disposable pipette tips mounted to the pipetting head. The electronic motion control system includes a control handle that is mounted to a load cell, the carriage for the pipetting head and is held in the palm of the user. In use, the user grasps the control handle and operates the system in a manner similar to one using a handheld electronic pipettor.

    摘要翻译： 手动导向的多通道电子移液系统被设计成将液体从标准的多孔板，深井板或储存器转移到另一个多孔板中。 优选的移液头包括96针头配件的阵列。 具有至少一个但优选两个或更多个孔板嵌套容器的甲板容纳一个或多个多孔板或试剂储存器，用于通过安装到移液头的一次性吸头的阵列进入。 电子运动控制系统包括安装到称重传感器的控制手柄，用于移液头的托架并保持在使用者手掌中。 在使用中，用户抓住控制手柄并以类似于使用手持电子移液器的方式操作系统。

    Manually Directed, Multi-Channel Electronic Pipetting System
    2.
    发明申请
    Manually Directed, Multi-Channel Electronic Pipetting System 有权
    手动导向，多通道电子移液系统

    公开(公告)号：US20110268627A1

    公开(公告)日：2011-11-03

    申请号：US13099782

    申请日：2011-05-03

    申请人： Julian Warhurst ,  Gary Nelson ,  Richard Cote

    发明人： Julian Warhurst ,  Gary Nelson ,  Richard Cote

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0227 ,  B01L3/0234 ,  B01L3/0237 ,  B01L9/523 ,  B01L2200/087 ,  B01L2200/146 ,  B01L2300/027 ,  B01L2300/06 ,  B01L2300/0829 ,  B01L2400/0478

    摘要： A manually directed, multi-channel electronic pipetting system is designed to transfer liquids from a standard multi-well plate, deep-well plate or reservoir into another multi-well plate. The preferred pipetting head includes an array of 96-tip fittings. A deck with at least one but preferably two or more wellplate nesting receptacles holds one or more multi-well plates or reagent reservoirs for access by an array of disposable pipette tips mounted to the pipetting head. The electronic motion control system includes a control handle that is mounted to a load cell, the carriage for the pipetting head and is held in the palm of the user. In use, the user grasps the control handle and operates the system in a manner similar to one using a handheld electronic pipettor.

    摘要翻译： 手动导向的多通道电子移液系统被设计成将液体从标准的多孔板，深井板或储存器转移到另一个多孔板中。 优选的移液头包括96针头配件的阵列。 具有至少一个但优选两个或更多个孔板嵌套容器的甲板容纳一个或多个多孔板或试剂储存器，用于通过安装到移液头的一次性吸头的阵列进入。 电子运动控制系统包括安装到称重传感器的控制手柄，用于移液头的托架并保持在使用者手掌中。 在使用中，用户抓住控制手柄并以类似于使用手持电子移液器的方式操作系统。

    Unintended motion control for manually directed multi-channel electronic pipettor
    3.
    发明授权
    Unintended motion control for manually directed multi-channel electronic pipettor 有权
    手动定向多通道电子移液器的意外运动控制

    公开(公告)号：US08367022B2

    公开(公告)日：2013-02-05

    申请号：US13099953

    申请日：2011-05-03

    申请人： Julian Warhurst ,  Richard Cote

    发明人： Julian Warhurst ,  Richard Cote

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0234 ,  B01L3/0227 ,  B01L3/0237 ,  B01L2200/087 ,  B01L2300/027 ,  B01L2300/0829 ,  B01L2400/0478 ,  G01N35/1074

    摘要： A manually directed, electronic multi-channel pipettor uses servo controlled motors to drive a carriage and pipetting head in response to a user's manipulation of a control handle. The pipetting head include an array of tip fittings, e.g. 96. The system includes a check processor to avoid unintended motion in case of system faults or crashes. The system requires substantial force to attach the array of tips, and therefore includes controls that require both of the user's hands be occupied during the tip attachment process.

    摘要翻译： 手动导向的电子多通道移液器使用伺服控制的电动机来响应用户对控制手柄的操纵来驱动支架和移液头。 移液头包括尖端配件的阵列，例如 96.系统包括一个检查处理器，以避免系统故障或崩溃时的意外运动。 该系统需要相当大的力来附接尖端阵列，因此包括需要在尖端附着过程期间使用者的双手被占用的控制。

    Unintended Motion Control For Manually Directed Multi-Channel Electronic Pipettor
    4.
    发明申请
    Unintended Motion Control For Manually Directed Multi-Channel Electronic Pipettor 有权
    手动定向多通道电子移液器的非预期运动控制

    公开(公告)号：US20110268628A1

    公开(公告)日：2011-11-03

    申请号：US13099953

    申请日：2011-05-03

    申请人： Julian Warhurst ,  Richard Cote

    发明人： Julian Warhurst ,  Richard Cote

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0234 ,  B01L3/0227 ,  B01L3/0237 ,  B01L2200/087 ,  B01L2300/027 ,  B01L2300/0829 ,  B01L2400/0478 ,  G01N35/1074

    摘要： A manually directed, electronic multi-channel pipettor uses servo controlled motors to drive a carriage and pipetting head in response to a user's manipulation of a control handle. The pipetting head include an array of tip fittings, e.g. 96. The system includes a check processor to avoid unintended motion in case of system faults or crashes. The system requires substantial force to attach the array of tips, and therefore includes controls that require both of the user's hands be occupied during the tip attachment process.

    摘要翻译： 手动导向的电子多通道移液器使用伺服控制的电动机来响应用户对控制手柄的操纵来驱动支架和移液头。 移液头包括尖端配件的阵列，例如 96.系统包括一个检查处理器，以避免系统故障或崩溃时的意外运动。 该系统需要相当大的力来附接尖端阵列，因此包括需要在尖端附着过程期间使用者的双手被占用的控制。

    Method of using a disposable pipette tip
    5.
    发明申请
    Method of using a disposable pipette tip 有权
    使用一次性吸头的方法

    公开(公告)号：US20130306155A1

    公开(公告)日：2013-11-21

    申请号：US13952731

    申请日：2013-07-29

    申请人： Gregory Mathus ,  Terrance Kelly ,  Richard Cote

    发明人： Gregory Mathus ,  Terrance Kelly ,  Richard Cote

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

    摘要： The pipetting method is directed to mounting and ejecting a disposable pipette tip. The pipetting system has one or more tip mounting shafts with an upper locking section and a lower sealing section. The upper locking section has outwardly extending lobes spaced around the mounting shaft and located above a stop member. The lower sealing section on the tip mounting shaft is located below the stop. As the mounting shaft is inserted into the collar of the disposable pipette, the collar distorts out of round and engages the lobes on the upper locking section of the tip mounting shaft. Contemporaneously, the lower sealing section of the mounting shaft seals against the barrel of the disposable pipette tip.

    摘要翻译： 移液方法涉及安装和喷射一次性吸头。 移液系统具有一个或多个具有上部锁定部分和下部密封部分的尖端安装轴。 上锁定部分具有围绕安装轴间隔开并位于止动件上方的向外延伸的凸角。 刀片安装轴上的下密封部分位于挡块下方。 当安装轴插入到一次性移液管的轴环中时，套环从圆形变形并与尖端安装轴的上部锁定部分上的凸角接合。 同时，安装轴的下密封部分密封在一次性移液管尖端的筒体上。

    CALIBRATION METHODS FOR MULTIPLEXED SENSOR ARRAYS
    7.
    发明申请
    CALIBRATION METHODS FOR MULTIPLEXED SENSOR ARRAYS 审中-公开
    多传感器阵列校准方法

    公开(公告)号：US20100204062A1

    公开(公告)日：2010-08-12

    申请号：US12614239

    申请日：2009-11-06

    申请人： Mark Thompson ,  Richard Roberts ,  Richard Cote ,  Chongwu Zhou

    发明人： Mark Thompson ,  Richard Roberts ,  Richard Cote ,  Chongwu Zhou

    IPC分类号： C40B40/06 ,  C40B40/10 ,  G01N35/00

    CPC分类号： B82Y15/00 ,  B82Y35/00 ,  G01N27/4146 ,  G01N33/54373 ,  G01N35/00693

    摘要： The present invention relates to the calibration of devices using a secondary binding agent or reference material. In one embodiment, the present invention provides a method of calibrating a nanosensor by providing a nanosensor comprising an analyte binder attached to a reference binder, extracting a calibration curve from binding a reference material to the reference binder, and calibrating the nanosensor by using the calibration curve to correct for device variation.

    摘要翻译： 本发明涉及使用二次结合剂或参考物质的装置的校准。 在一个实施方案中，本发明提供了一种校准纳米传感器的方法，该方法通过提供纳米传感器，该纳米传感器包括附着于参考粘合剂的分析物粘合剂，从校正曲线结合参考物质到参考粘合剂，以及通过使用校准来校准纳米传感器 曲线以校正设备变化。

    Common Signal Eliminator From a Stereo Source
    9.
    发明申请
    Common Signal Eliminator From a Stereo Source 审中-公开
    来自立体声源的常见信号消除器

    公开(公告)号：US20080285763A1

    公开(公告)日：2008-11-20

    申请号：US10588987

    申请日：2004-12-06

    申请人： Richard Cote ,  Simon Roy

    发明人： Richard Cote ,  Simon Roy

    IPC分类号： H04R5/00

    CPC分类号： H04S3/00

    摘要： To increase the stereophonic potential of an ordinary stereo source, a device (20) eliminates the common signals from a stereo source. The device is installed in relation to four loudspeakers, two primary (38, 40) and two secondary (42, 44), and it includes a stereo input (34, 36) and an electric circuit that links the two secondary loudspeakers. The primary loudspeakers reproduce unaltered stereo signals and the secondary loudspeakers reproduce altered signals where (by hand: when) the circuit has eliminated the common signals from the two channels of the primary stereo source. Since all “mono” components of the sound [by hand: same amplitude, same frequency] have been eliminated from the secondary outputs, we obtain a “purely stereo” source. An additional channel (45) can be added in order to reproduce the common components of the stereo source.

    摘要翻译： 为了增加普通立体声源的立体声电位，设备（20）消除了来自立体声源的公共信号。 该装置相对于四个扬声器，两个主要（38,40）和两个次要（42,44）安装，并且其包括立体声输入（3​​4,36）和连接两个二次扬声器的电路。 主扬声器再现未改变的立体声信号，次级扬声器再​​现改变的信号，其中（手动：何时）电路已经消除了来自主立体声源的两个声道的公共信号。 由于二次输出中已经消除了声音[手动相同的幅度，相同频率]的所有“单声道”分量，所以我们获得了一个“纯立体声”源。 可以添加附加通道（45）以便再现立体声源的公共部件。

    Hand held pipette
    10.
    发明申请
    Hand held pipette 有权
    手持移液器

    公开(公告)号：US20050262951A1

    公开(公告)日：2005-12-01

    申请号：US10855690

    申请日：2004-05-27

    申请人： Richard Cote

    发明人： Richard Cote

    IPC分类号： B01L3/02 ,  G01N1/00

    CPC分类号： B01L3/0224 ,  B01L2300/027

    摘要： A hand-held pipette includes a piston driven by an actuator assembly contained within a housing having first and second mutually spaced non-adjustable stops. The actuator assembly is subdivided into first and second sections respectively provided with first and second contact surfaces. The actuator assembly is arranged to reciprocate between a rest position at which the first contact surface is in contact with the first stop and the second contact surface is spaced from the second stop by a control distance, and an advanced position at which the second contact surface is in contact with the second stop and the first contact surface is spaced from the first stop, with the stroke of the actuator assembly and the stroke of the piston being equal to the control distance. A motor-driven mechanism is arranged to displace one section of the actuator assembly relative to the other section, resulting in a corresponding change to both the overall length of the actuator assembly and the control distance.

    摘要翻译： 手持移液器包括由容纳在具有第一和第二相互间隔的不可调节止挡件的壳体内的致动器组件驱动的活塞。 致动器组件被细分为分别具有第一和第二接触表面的第一和第二部分。 所述致动器组件布置成在所述第一接触表面与所述第一止动件接触的静止位置和所述第二接触表面与所述第二止动件间隔一个控制距离之间往复运动，并且所述第二接触表面 与第二止动件接触，并且第一接触表面与第一止动件间隔开，致动器组件的行程和活塞的行程等于控制距离。 电机驱动机构布置成相对于另一部分移动致动器组件的一部分，导致致动器组件的总长度和控制距离的相应变化。