公开(公告)号：US09956301B2

公开(公告)日：2018-05-01

申请号：US14593882

申请日：2015-01-09

申请人： Indus Biotech Private Limited

发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

IPC分类号： A61K31/122 ,  A61K47/48 ,  C07C45/79 ,  B82Y5/00 ,  C07C49/835 ,  C08B37/16 ,  A61K47/69

CPC分类号： A61K47/6951 ,  A61K31/122 ,  B82Y5/00 ,  C07B2200/01 ,  C07C45/79 ,  C07C49/835 ,  C07C2602/46 ,  C08B37/0015

摘要： The present disclosure discloses a pharmaceutical molecule of Garcinol chemically complexed with cyclodextrins and the use of the complexed molecule in prevention and management of cardiac dysfunction induced by chemotherapy, drugs and/or other insults to the heart caused by lifestyle and disease conditions. The disclosure also relates to a method of extraction and purification of high yield of 95-99% pure Garcinol from Garcinia species and a method of chemically complexing Garcinol with cyclodextrins to improve its stability and bioavailability.

公开(公告)号：US20160113897A1

公开(公告)日：2016-04-28

申请号：US14891746

申请日：2014-05-19

申请人： INDUS BIOTECH PRIVATE LIMITED

发明人： Sunil BHASKARAN ,  Mohan VISHWARAMAN

IPC分类号： A61K31/353

CPC分类号： A61K31/353 ,  A61K9/4866

摘要： The present disclosure relates to management of Hepatitis C Virus (HCV) and associated condition. The present disclosure also relates to management of Hepatic Fibrosis. The present disclosure relates to administration of composition comprising pentameric type A procyanidin, trimeric procyanidin and tetrameric procyanidin, optionally along with pharmaceutically acceptable excipient, for management of Hepatic Fibrosis, Hepatitis C virus and associated conditions. The composition acts as an inhibitor at the entry stage of Hepatitis C virus into a cell. The composition inhibits different genotypes of Hepatitis C Virus.

摘要翻译： 本公开涉及丙型肝炎病毒（HCV）和相关病症的管理。 本公开还涉及肝纤维化的治疗。 本公开内容涉及包含五聚体A型原花青素，三聚原花青素和四聚原花青素的组合物，任选与药学上可接受的赋形剂一起施用，用于治疗肝纤维化，丙型肝炎病毒和相关病症。 该组合物在丙型肝炎病毒进入阶段作为抑制剂进入细胞。 该组合物抑制丙型肝炎病毒的不同基因型。

公开(公告)号：US09254269B2

公开(公告)日：2016-02-09

申请号：US13196625

申请日：2011-08-02

申请人： Sunil Bhaskaran ,  Mohan Vishwaraman

发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

IPC分类号： A01N65/00 ,  A61K9/48 ,  A23L1/30 ,  A61K9/00 ,  A61K9/08 ,  A61K31/704 ,  A61K36/23 ,  A61K47/40 ,  A61K47/48 ,  B82Y5/00 ,  C08B37/00 ,  C08B37/16 ,  C08L5/16 ,  A61K9/16

CPC分类号： A61K9/4808 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0043 ,  A61K9/08 ,  A61K9/1652 ,  A61K31/704 ,  A61K36/23 ,  A61K47/40 ,  A61K47/6951 ,  B82Y5/00 ,  C08B37/0003 ,  C08B37/0015 ,  C08B37/006 ,  C08L5/16 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2250/21

摘要： The present disclosure relates to treatment and management of Cushing's syndrome, Headache disorders and Neuropathic using a composition comprising asiaticoside and madecasosside optionally along with at least one excipient. The treatment can be extended to Myalgia and other related disease conditions.

摘要翻译： 本公开涉及库欣综合征，头痛障碍和神经病变的治疗和治疗，其使用包含积雪草苷和十八烷基酰肼的组合物，任选地与至少一种赋形剂一起使用。 治疗可延伸至肌痛和其他相关疾病状况。

公开(公告)号：US08835415B2

公开(公告)日：2014-09-16

申请号：US12566061

申请日：2009-09-24

申请人： Sunil Bhaskaran ,  Mohan Vishwaraman

发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

IPC分类号： A61K31/395 ,  A61K31/353 ,  A61K36/77 ,  A61K36/54 ,  A61K36/48

CPC分类号： A61K31/353 ,  A61K36/48 ,  A61K36/54 ,  A61K36/77

摘要： The present disclosure is in relation to antiviral preparations obtained from plant sources namely Cinnamon, Litchi and Arachis. It provides a composition and a process to prepare the composition comprising pentameric procyanidin flavonoid, trimers and tetramers. The composition improves immunity response and found to be useful in treatment and management of HIV infection and AIDS and for the prevention, treatment and management of Influenza virus and infection.

摘要翻译： 本公开涉及从植物来源（即肉桂，荔枝和花生）获得的抗病毒制剂。 它提供组合物和方法来制备包含五聚原花青素类黄酮，三聚体和四聚体的组合物。 该组合物提高免疫反应，被认为可用于治疗和管理艾滋病毒感染和艾滋病以及预防，治疗和管理流感病毒和感染。

公开(公告)号：US20120148504A1

公开(公告)日：2012-06-14

申请号：US13016541

申请日：2011-01-28

申请人： Sunil Bhaskaran ,  Mohan Vishwaraman

发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

IPC分类号： A61K31/724 ,  A61P9/00 ,  C07C45/78 ,  A61K9/12 ,  C08B37/16 ,  C07C49/747

CPC分类号： A61K47/6951 ,  A61K31/122 ,  B82Y5/00 ,  C07B2200/01 ,  C07C45/79 ,  C07C49/835 ,  C07C2602/46 ,  C08B37/0015

摘要： The present disclosure discloses a pharmaceutical molecule of Garcinol chemically complexed with cyclodextrins and the use of the complexed molecule in prevention and management of cardiac dysfunction induced by chemotherapy, drugs and/or other insults to the heart caused by lifestyle and disease conditions. The disclosure also relates to a method of extraction and purification of high yield of 95-99% pure Garcinol from Garcinia species and a method of chemically complexing Garcinol with cyclodextrins to improve its stability and bioavailability.

摘要翻译： 本公开公开了一种与环糊精化学络合的Garcinol的药物分子，以及复合分子在预防和控制由生理和疾病状况引起的由化学疗法，药物和/或其他侮辱引起的心脏功能障碍中的用途。 本公开还涉及从藤黄属物种中提取和纯化高产量的95-99％纯的Garcinol的方法，以及将Garcinol与环糊精化学络合以提高其稳定性和生物利用度的方法。

公开(公告)号：US20110039923A1

公开(公告)日：2011-02-17

申请号：US12566061

申请日：2009-09-24

申请人： Sunil BHASKARAN ,  Mohan VISHWARAMAN

发明人： Sunil BHASKARAN ,  Mohan VISHWARAMAN

IPC分类号： A61K31/352

CPC分类号： A61K31/353 ,  A61K36/48 ,  A61K36/54 ,  A61K36/77

摘要： The present disclosure is in relation to antiviral preparations obtained from plant sources namely Cinnamon, Litchi and Arachis. It provides a composition and a process to prepare the composition comprising pentameric procyanidin flavonoid, trimers and tetramers. The composition improves immunity response and found to be useful in treatment and management of HIV infection and AIDS and for the prevention, treatment and management of Influenza virus and infection.

摘要翻译： 本公开涉及从植物来源（即肉桂，荔枝和花生）获得的抗病毒制剂。 它提供组合物和方法来制备包含五聚原花青素类黄酮，三聚体和四聚体的组合物。 该组合物提高免疫反应，被认为可用于治疗和管理艾滋病毒感染和艾滋病以及预防，治疗和管理流感病毒和感染。

公开(公告)号：US10046003B2

公开(公告)日：2018-08-14

申请号：US14888538

申请日：2014-04-02

申请人： INDUS BIOTECH PRIVATE LIMITED

发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

IPC分类号： A61K31/075 ,  A61K31/7028 ,  A61K36/48 ,  A61K31/70

摘要： The present disclosure relates to a composition comprising eleutheroside-C, pinitol and sugars optionally along with pharmaceutically acceptable excipient or a combination thereof; a process of obtaining said composition from fenugreek seeds, a method of treating neuropathic pain or managing neuropathy, and the use of the said composition in treating neuropathic pain or managing neuropathy.

公开(公告)号：US08513203B2

公开(公告)日：2013-08-20

申请号：US13160347

申请日：2011-06-14

申请人： Sunil Bhaskaran ,  Mohan Vishwaraman

发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

IPC分类号： A01N45/00

CPC分类号： A61K36/48 ,  A61K9/48 ,  A61K31/7048 ,  A61K2236/00

摘要： The present disclosure relates to a composition comprising Trigoneoside Ib and Vicenin-1 for treatment and management of Goodpasture's disease, Glomerulonephritis, Rheumatoid Arthritis, Systemic Lupus Erythematosus and Idiopathic Thrombocytopenia Purpura. The present disclosure also relates to a method of obtaining the said composition from Trigonella foenum-graecum.

摘要翻译： 本公开内容涉及用于治疗和治疗古德帕斯彻氏病，肾小球性肾炎，类风湿关节炎，系统性红斑狼疮和特发性血小板减少性紫癜的组合物，其包含Trigoneoside Ib和Vicenin-1。 本公开还涉及从Trigonella foenum-graecum获得所述组合物的方法。

公开(公告)号：US20120282332A1

公开(公告)日：2012-11-08

申请号：US13160347

申请日：2011-06-14

申请人： Sunil Bhaskaran ,  Mohan Vishwaraman

发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

IPC分类号： A61K31/7048 ,  A61P13/12 ,  A61P29/00 ,  A61K9/66 ,  A61P37/06

CPC分类号： A61K36/48 ,  A61K9/48 ,  A61K31/7048 ,  A61K2236/00

摘要： The present disclosure relates to a composition comprising Trigoneoside Ib and Vicenin-1 for treatment and management of Goodpasture's disease, Glomerulonephritis, Rheumatoid Arthritis, Systemic Lupus Erythematosus and Idiopathic Thrombocytopenia Purpura. The present disclosure also relates to a method of obtaining the said composition from Trigonella foenum-graecum.

摘要翻译： 本公开内容涉及用于治疗和治疗古德帕斯彻氏病，肾小球性肾炎，类风湿关节炎，系统性红斑狼疮和特发性血小板减少性紫癜的组合物，其包含Trigoneoside Ib和Vicenin-1。 本公开还涉及从Trigonella foenum-graecum获得所述组合物的方法。

公开(公告)号：US20180344755A1

公开(公告)日：2018-12-06

申请号：US16023068

申请日：2018-06-29

申请人： Indus Biotech Private Limited

发明人： Sunil BHASKARAN ,  Mohan VISHWARAMAN

IPC分类号： A61K31/7028 ,  A61K31/70 ,  A61K31/075 ,  A61K36/48

摘要： The present disclosure relates to a composition comprising eleutheroside-C, pinitol and sugars optionally along with pharmaceutically acceptable excipient or a combination thereof; a process of obtaining said composition from fenugreek seeds, a method of treating neuropathic pain or managing neuropathy, and the use of the said composition in treating neuropathic pain or managing neuropathy.