公开(公告)号：US20230064975A1

公开(公告)日：2023-03-02

申请号：US17961863

申请日：2022-10-07

申请人： PSOMAGEN, INC. ,  MACROGEN INC.

发明人： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Jeongsun Seo ,  Inseon KIM ,  Dongjun Kim ,  Nak Jung Kwon ,  Su Hong

IPC分类号： A61K35/742 ,  A61K35/747 ,  A61K35/745 ,  C12Q1/04 ,  C12Q1/689

摘要： A composition and a method for an antibiotic-inducing imbalance in microbiota, or specifically, a microbiota recovery composition for an antibiotic-inducing imbalance of gut microbiota are provided.

公开(公告)号：US20210130812A1

公开(公告)日：2021-05-06

申请号：US16830565

申请日：2020-03-26

申请人： MACROGEN, INC. ,  PSOMAGEN, INC.

发明人： JOSHUA SUNGWOO YANG ,  JAEKYUNG CHON ,  IK JUNG CHOI ,  HYUN MIN PARK ,  JIEUN PARK ,  JEONGSUN SEO ,  CHANGHOON KIM ,  JONG YEON SHIN ,  HAN SOL SEO ,  JIWON SHIN ,  IN HEE HWANG ,  SEON HYE SIM ,  CHANG WOO CHO ,  KYUIN HWANG ,  IN SEON KIM ,  HYUNG IL LEE ,  JUNG HYUN CHO

IPC分类号： C12N15/10 ,  C12Q1/6806 ,  C12Q1/6844

摘要： Disclosed are a method for DNA extraction in a sample for next generation sequencing (NGS) and a method of constructing a NGS library using the extracted DNA. The method for DNA extraction includes: preparing a mixture by mixing a biological sample with a buffer; applying microwaves to the mixture; and recovering DNA. The method of constructing a NGS library includes: extracting DNA according to the method for DNA extraction; amplifying a target DNA using primers; and purifying the amplified product and subjecting the purified product to library pooling.

公开(公告)号：US20190303362A1

公开(公告)日：2019-10-03

申请号：US16222332

申请日：2018-12-17

申请人： MACROGEN, INC. ,  Macrogen Corp.

发明人： SUNGWOO YANG ,  JAEKYUNG CHON ,  IK JUNG CHOI ,  HYUN MIN PARK ,  JIEUN PARK ,  JEONGSUN SEO ,  CHANGHOON KIM ,  HANSOL SEO ,  NAMHEE KIM

IPC分类号： G06F16/23 ,  H04L9/06

摘要： Provided is a data sharing method based on a plurality of blockchains. The method includes registering, by a management server, user block data which includes user information and a hash key of each user of a plurality of users in a user information blockchain, receiving, by the management server, storage information of data provided by a first user from a storage server, and receiving, by the management server, a request for specific data from a second user and transmitting storage information of the specific data to the second user.

公开(公告)号：US10417219B1

公开(公告)日：2019-09-17

申请号：US16222332

申请日：2018-12-17

申请人： MACROGEN, INC. ,  Macrogen Corp.

发明人： Sungwoo Yang ,  Jaekyung Chon ,  Ik Jung Choi ,  Hyun Min Park ,  Jieun Park ,  Jeongsun Seo ,  Changhoon Kim ,  Hansol Seo ,  Namhee Kim

IPC分类号： G06F17/30 ,  G06F16/23 ,  H04L9/06

摘要： Provided is a data sharing method based on a plurality of blockchains. The method includes registering, by a management server, user block data which includes user information and a hash key of each user of a plurality of users in a user information blockchain, receiving, by the management server, storage information of data provided by a first user from a storage server, and receiving, by the management server, a request for specific data from a second user and transmitting storage information of the specific data to the second user.

公开(公告)号：US11004544B2

公开(公告)日：2021-05-11

申请号：US16743514

申请日：2020-01-15

申请人： MACROGEN, INC. ,  PSOMAGEN, INC.

发明人： Joshua Sungwoo Yang ,  Jaekyung Chon ,  Ik Jung Choi ,  Hyun Min Park ,  Jieun Park ,  Jeongsun Seo ,  Changhoon Kim ,  Han Sol Seo ,  Jiwon Shin ,  In Hee Hwang ,  Seon Hye Sim ,  Chang Woo Cho ,  Nam Hee Kim ,  Hye Eun Lee ,  Kyuin Hwang

IPC分类号： H04L9/08 ,  G16B50/40 ,  G16B40/00 ,  H04L9/32

摘要： Disclosed is a method of providing biological data. The method includes the following steps performed by a data processing device: selecting a biological data set from a biological data pool; encrypting biological data included in the biological data set to produce encrypted biological data; transferring the encrypted biological data to a user; receiving a result of analysis on the encrypted biological data from the user; and transferring information on the encrypted biological data included in the result of the analysis to the user. The data processing device encrypts the biological data with a key determined according to a combination of biological data constituting the biological data set.

公开(公告)号：US20200303040A1

公开(公告)日：2020-09-24

申请号：US16743514

申请日：2020-01-15

申请人： MACROGEN, INC. ,  PSOMAGEN, INC.

发明人： JOSHUA SUNGWOO YANG ,  JAEKYUNG CHON ,  IK JUNG CHOI ,  HYUN MIN PARK ,  JIEUN PARK ,  JEONGSUN SEO ,  CHANGHOON KIM ,  HAN SOL SEO ,  JIWON SHIN ,  IN HEE HWANG ,  SEON HYE SIM ,  CHANG WOO CHO ,  NAM HEE KIM ,  HYE EUN LEE ,  KYUIN HWANG

IPC分类号： G16B50/40 ,  G16B40/00 ,  H04L9/32 ,  H04L9/08

摘要： Disclosed is a method of providing biological data. The method includes the following steps performed by a data processing device: selecting a biological data set from a biological data pool; encrypting biological data included in the biological data set to produce encrypted biological data; transferring the encrypted biological data to a user; receiving a result of analysis on the encrypted biological data from the user; and transferring information on the encrypted biological data included in the result of the analysis to the user. The data processing device encrypts the biological data with a key determined according to a combination of biological data constituting the biological data set.

公开(公告)号：US20140128635A1

公开(公告)日：2014-05-08

申请号：US14001123

申请日：2011-02-23

申请人： Jae-Young Kim ,  Sang-Heum Shin ,  Hyon-Yong Chong ,  Kap-Seok Yang ,  Jeong-Sun Seo

发明人： Jae-Young Kim ,  Sang-Heum Shin ,  Hyon-Yong Chong ,  Kap-Seok Yang ,  Jeong-Sun Seo

IPC分类号： C12P7/56 ,  C07C59/08

CPC分类号： C12P7/56 ,  C07C59/08 ,  C12N9/0006 ,  C12N15/74 ,  C12Y101/01028 ,  Y02P20/52

摘要： Disclosed is the biological production of lactic acid using a microorganism. A transformant capable of producing lactic acid of high optical purity at high yield, a method for the preparation thereof, and a method for producing lactic acid in a convenient and economically beneficial manner using the same are provided. The Zymomonas mobilis transformant can produce lactic acid of high optical purity at high yield without a stringent limitation to production conditions and a regulation of the intracellular metabolism pathway. Because it requires no additional separation and purification steps, the use of the transformant allows the production of lactic acid in a short process, resulting in a significant reduction in production cost, and avoiding the environment problems caused by precipitate wastes, which brings about environmental issues.

摘要翻译： 公开了使用微生物的乳酸的生物生产。 提供能够以高收率生产高光学纯度的乳酸的转化体，其制备方法，以及使用该乳酸的方便且经济有益的方法生产乳酸的方法。 运动发酵单胞菌转化体可以以高产率生产高光学纯度的乳酸，而不会严格限制生产条件和细胞内代谢途径的调节。 因为不需要额外的分离和纯化步骤，因此转化体的使用允许在短时间内生产乳酸，导致生产成本显着降低，并避免沉淀废物引起的环境问题，从而带来环境问题 。

公开(公告)号：US11781132B2

公开(公告)日：2023-10-10

申请号：US16830565

申请日：2020-03-26

申请人： MACROGEN, INC. ,  PSOMAGEN, INC.

发明人： Joshua Sungwoo Yang ,  Jaekyung Chon ,  Ik Jung Choi ,  Hyun Min Park ,  Jieun Park ,  Jeongsun Seo ,  Changhoon Kim ,  Jong Yeon Shin ,  Han Sol Seo ,  Jiwon Shin ,  In Hee Hwang ,  Seon Hye Sim ,  Chang Woo Cho ,  Kyuin Hwang ,  In Seon Kim ,  Hyung Il Lee ,  Jung Hyun Cho

IPC分类号： C12N15/10 ,  C12Q1/6806 ,  C12Q1/6844

CPC分类号： C12N15/1082 ,  C12N15/1003 ,  C12Q1/6806 ,  C12Q1/6844

摘要： Disclosed are a method for DNA extraction in a sample for next generation sequencing (NGS) and a method of constructing a NGS library using the extracted DNA. The method for DNA extraction includes: preparing a mixture by mixing a biological sample with a buffer; applying microwaves to the mixture; and recovering DNA. The method of constructing a NGS library includes: extracting DNA according to the method for DNA extraction; amplifying a target DNA using primers; and purifying the amplified product and subjecting the purified product to library pooling.

公开(公告)号：US10560272B2

公开(公告)日：2020-02-11

申请号：US16221829

申请日：2018-12-17

申请人： MACROGEN, INC. ,  Macrogen Corp.

发明人： Sungwoo Yang ,  Jaekyung Chon ,  Ik Jung Choi ,  Hyun Min Park ,  Jieun Park ,  Jeongsun Seo ,  Changhoon Kim

IPC分类号： H04L9/32 ,  G16H10/60 ,  G06F21/62 ,  G16B20/00 ,  G06F21/64 ,  H04L9/06

摘要： Disclosed is a method of providing bio-information data based on a plurality of blockchains. The method includes enabling a user blockchain node to store user block data including user information, a shared key, and a hash key for each user of a plurality of users, enabling an electronic contract blockchain node to store contract block data including contract information for a first user requesting a second user to generate bio-information data, the first user and the second user being included in the plurality of users, enabling a data transfer blockchain node to store transfer block data including storage information for at least one storage server that stores the bio-information data, and delivering the transfer block data from the data transfer blockchain node to the first user.

公开(公告)号：US10023855B2

公开(公告)日：2018-07-17

申请号：US13663565

申请日：2012-10-30

申请人： MACROGEN INC.

发明人： Young-Seok Ju ,  Jeong-Sun Seo ,  Eun-Hee Kim

IPC分类号： C12N9/96 ,  C12Q1/6886 ,  C12N9/12

摘要： A fusion protein including N-terminal domain of a fusion partner at N-terminal and C-terminal domain of RET protein at C-terminal, a fusion gene encoding the fusion protein, and a use of the fusion protein or the fusion gene as a diagnosing marker for a cancer, are provided.