公开(公告)号：US08825131B2

公开(公告)日：2014-09-02

申请号：US13444731

申请日：2012-04-11

申请人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

IPC分类号： A61B5/05

CPC分类号： A61B5/055 ,  A61B5/4514 ,  A61B5/4566 ,  A61B5/4824 ,  A61B5/743 ,  A61B5/748 ,  A61B2576/02 ,  G01R33/485

摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.

摘要翻译： 提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获取椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。 接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并且被配置为通过自动化系统来优化信噪比，所述自动系统选择性地进行最佳信道选择，相位和频率校正以及帧编辑 一个给定的收购系列。 诊断处理器基于使用从获得和处理的MRS谱中提取的MRS数据的加权因子集来计算盘的诊断值，所述MRS数据已经与疼痛与非痛苦的盘相关联的多种化学物质。 显示器提供用于分析的光盘作为腰椎MRI图像上的覆盖物的结果的指示。

公开(公告)号：US20140064586A1

公开(公告)日：2014-03-06

申请号：US13843117

申请日：2013-03-15

申请人： NOCIMED, LLC

发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane ,  Ricardo Dario Pradenas

IPC分类号： G01R33/46 ,  G06T7/00 ,  A61B5/055 ,  G01R33/56 ,  G01R33/48

CPC分类号： A61B5/055 ,  A61B5/0075 ,  A61B5/4566 ,  A61B5/4824 ,  A61B5/7257 ,  G01R33/4625 ,  G01R33/4828 ,  G01R33/483 ,  G01R33/5608 ,  G06T7/0012 ,  Y10S128/922 ,  Y10S128/923

摘要： Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit. Sections of the ROF may be excluded from the polynomial fit, such as for example sections determined to be associated with relevant spectral peaks.

摘要翻译： 提供了系统和方法，用于从来自受试者的感兴趣区域（ROI）的多帧MRS采集系列处理一组多个串行获取的磁共振波谱（MRS）无感应衰减（FID）帧，并且用于提供 后处理MRS谱。 处理参数是动态变化的，同时测量结果以确定最佳后处理结果。 对来自感兴趣化学区域的水相对的光谱区域进行评估，并在至少一个处理操作中使用。 通过自由感应衰减（FID）帧和参考光谱之间的频谱相关估计频移误差。 所获取的集合内的多组FID帧被识别为与采集的相位阶跃循环相对应的不同阶段。 基线校正也通过秩序滤波（ROF）估计和多项式拟合进行。 可以从多项式拟合中排除ROF的部分，例如被确定为与相关光谱峰相关联的部分。

公开(公告)号：US20130230224A1

公开(公告)日：2013-09-05

申请号：US13830632

申请日：2013-03-14

申请人： NOCIMED, LLC

发明人： John P. Claude ,  James C. Peacock ,  Paul H. Kane

IPC分类号： G06K9/34

CPC分类号： A61B5/055 ,  A61B5/4566 ,  G01R33/4835 ,  G01R33/485 ,  G01R33/543 ,  G06K9/34 ,  G06T7/11 ,  G06T7/12 ,  G06T7/62 ,  G06T2207/10088 ,  G06T2207/30012

摘要： A system and method for automating an appropriate voxel prescription in a uniquely definable region of interest (ROI) in a tissue of a patient is provided, such as for purpose of conducting magnetic resonance spectroscopy (MRS) in the ROI. The dimensions and coordinates of a single three dimensional rectilinear volume (voxel) within a single region of interest (ROI) are automatically identified. This is done, in some embodiments by: (1) applying statistically identified ROI search areas within a field of view (FOV); (2) image processing an MRI image to smooth the background and enhance a particular structure useful to define the ROI; (3) identifying a population of pixels that define the particular structure; (4) performing a statistical analysis of the pixel population to fit a 2D model such as an ellipsoid to the population and subsequently fit a rectilinear shape within the model; (5) repetiting elements (1) through (4) using multiple images that encompass the 3D ROI to create a 3D rectilinear shape; (6) a repetition of elements (1) through (5) for multiple ROIs with a common FOV. A manual interface may also be provided, allowing for override to replace by manual prescription, assistance to identify structures (e.g. clicking on disc levels), or modifying the automated voxel (e.g. modify location, shape, or one or more dimensions).

摘要翻译： 提供了一种用于在患者组织中的唯一可定义的感兴趣区域（ROI）中自动化适当体素处方的系统和方法，例如用于在ROI中进行磁共振波谱（MRS）的目的。 自动识别单个感兴趣区域（ROI）内单个三维直线体积（体素）的尺寸和坐标。 这在一些实施例中通过以下方式完成：（1）在视场（FOV）内应用统计识别的ROI搜索区域; （2）图像处理MRI图像以平滑背景并增强用于定义ROI的特定结构; （3）识别定义特定结构的像素群; （4）对像素群体进行统计分析，以将诸如椭圆体的2D模型拟合到群体中，并随后在模型内拟合直线形状; （5）使用包含3D ROI的多个图像重复元件（1）至（4）以产生3D直线形状; （6）用于具有公共FOV的多个ROI的元件（1）至（5）的重复。 也可以提供手动界面，允许通过手动处方来替代，以识别结构（例如，点击盘级别）或修改自动体素（例如，修改位置，形状或一个或多个维度）。

公开(公告)号：US08965094B2

公开(公告)日：2015-02-24

申请号：US13843117

申请日：2013-03-15

申请人： Nocimed, LLC

发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane ,  Ricardo Dario Pradenas

IPC分类号： G06K9/00 ,  G01R33/48 ,  A61B5/055 ,  G01R33/46 ,  A61B5/00 ,  G01R33/56 ,  G06T7/00 ,  G01R33/483

CPC分类号： A61B5/055 ,  A61B5/0075 ,  A61B5/4566 ,  A61B5/4824 ,  A61B5/7257 ,  G01R33/4625 ,  G01R33/4828 ,  G01R33/483 ,  G01R33/5608 ,  G06T7/0012 ,  Y10S128/922 ,  Y10S128/923

摘要： Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit. Sections of the ROF may be excluded from the polynomial fit, such as for example sections determined to be associated with relevant spectral peaks.

摘要翻译： 提供了系统和方法，用于从来自受试者的感兴趣区域（ROI）的多帧MRS采集系列处理一组多个串行获取的磁共振波谱（MRS）无感应衰减（FID）帧，并且用于提供 后处理MRS谱。 处理参数是动态变化的，同时测量结果以确定最佳后处理结果。 对来自感兴趣化学区域的水相对的光谱区域进行评估，并在至少一个处理操作中使用。 通过自由感应衰减（FID）帧和参考光谱之间的频谱相关估计频移误差。 所获取的集合内的多组FID帧被识别为与采集的相位阶跃循环相对应的不同阶段。 基线校正也通过秩序滤波（ROF）估计和多项式拟合进行。 可以从多项式拟合中排除ROF的部分，例如被确定为与相关光谱峰相关联的部分。

公开(公告)号：US08761860B2

公开(公告)日：2014-06-24

申请号：US12579371

申请日：2009-10-14

申请人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

IPC分类号： A61B5/05

CPC分类号： A61B5/055 ,  A61B5/407 ,  A61B5/4514 ,  A61B5/4824 ,  A61B5/7203 ,  G01R33/34069 ,  G01R33/3415 ,  G01R33/4616 ,  G01R33/485 ,  G01R33/565 ,  G01R33/56527 ,  G06F19/00

摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2-weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.

摘要翻译： 提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获取椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。 接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并配置为通过选择性地进行最佳信道选择，相位和频率校正以及帧编辑的自动化系统来优化信噪比（SNR） 适用于给定的采集系列。 诊断处理器基于加权因子集合来计算盘的诊断值，该加权因子集合使用从与获得和处理的MRS光谱中提取的MRS数据沿着与多个化学物质相关联的区域，所述化学物质与疼痛与非痛苦盘相关。 诊断显示器提供经缩放的颜色编码的图例和针对被分析为被诊断的患者的腰椎的矢状T2加权MRI图像上的覆盖层的每个椎间盘的结果的指示。 实施例的临床应用提供了通过简单地扩展和增强腰椎否则的标准MRI检查的实用性来诊断疼痛与非痛性椎间盘的非侵入性，客观，无痛，可靠的方法。

公开(公告)号：US09280718B2

公开(公告)日：2016-03-08

申请号：US13830632

申请日：2013-03-14

申请人： NociMed, LLC

发明人： John P. Claude ,  James C. Peacock, III ,  Paul H. Kane

IPC分类号： G06K9/00 ,  G06K9/34 ,  A61B5/055 ,  G01R33/485 ,  G01R33/54 ,  G06T7/00

CPC分类号： A61B5/055 ,  A61B5/4566 ,  G01R33/4835 ,  G01R33/485 ,  G01R33/543 ,  G06K9/34 ,  G06T7/11 ,  G06T7/12 ,  G06T7/62 ,  G06T2207/10088 ,  G06T2207/30012

摘要： A system and method for automating an appropriate voxel prescription in a uniquely definable region of interest (ROI) in a tissue of a patient is provided, such as for purpose of conducting magnetic resonance spectroscopy (MRS) in the ROI. The dimensions and coordinates of a single three dimensional rectilinear volume (voxel) within a single region of interest (ROI) are automatically identified. This is done, in some embodiments by: (1) applying statistically identified ROI search areas within a field of view (FOV); (2) image processing an MRI image to smooth the background and enhance a particular structure useful to define the ROI; (3) identifying a population of pixels that define the particular structure; (4) performing a statistical analysis of the pixel population to fit a 2D model such as an ellipsoid to the population and subsequently fit a rectilinear shape within the model; (5) repetiting elements (1) through (4) using multiple images that encompass the 3D ROI to create a 3D rectilinear shape; (6) a repetition of elements (1) through (5) for multiple ROIs with a common FOV. A manual interface may also be provided, allowing for override to replace by manual prescription, assistance to identify structures (e.g. clicking on disc levels), or modifying the automated voxel (e.g. modify location, shape, or one or more dimensions).

摘要翻译： 提供了一种用于在患者组织中的唯一可定义的感兴趣区域（ROI）中自动化适当体素处方的系统和方法，例如用于在ROI中进行磁共振波谱（MRS）的目的。 自动识别单个感兴趣区域（ROI）内单个三维直线体积（体素）的尺寸和坐标。 这在一些实施例中通过以下方式完成：（1）在视场（FOV）内应用统计识别的ROI搜索区域; （2）图像处理MRI图像以平滑背景并增强用于定义ROI的特定结构; （3）识别定义特定结构的像素群; （4）对像素群体进行统计分析，以将诸如椭圆体的2D模型拟合到群体中，并随后在模型内拟合直线形状; （5）使用包含3D ROI的多个图像重复元件（1）至（4）以产生3D直线形状; （6）用于具有公共FOV的多个ROI的元件（1）至（5）的重复。 也可以提供手动界面，允许通过手动处方来替代，以识别结构（例如，点击盘级别）或修改自动体素（例如，修改位置，形状或一个或多个维度）。