公开(公告)号：US20080078929A1

公开(公告)日：2008-04-03

申请号：US10580355

申请日：2004-11-24

申请人： Geoffrey Charles Peck

发明人： Geoffrey Charles Peck

IPC分类号： H01J49/04

CPC分类号： H01J49/4215 ,  H01J49/004 ,  H01J49/0404

摘要： A SIFT or SIFDT apparatus in which the upstream quadrupole and the downstream quadrupole are housed within a single evacuated chamber (20) with the upstream quadrupole (22) being (24). connected to the downstream quadrupole (29) by a curved flow tube sections by an electrostatic shield (27) which shields the upstream quadrupole and source connection from the downstream quadrupole and detector.

摘要翻译： SIFT或SIFDT装置，其中上游四极杆和下游四极杆容纳在具有上游四极杆（22）的（24）的单个抽真空室（20）内。 通过弯曲的流管部分通过屏蔽上游四极杆和来自下游四极杆和检测器的源连接的静电屏蔽（27）连接到下游四极杆（29）。

公开(公告)号：US20050233471A1

公开(公告)日：2005-10-20

申请号：US10520074

申请日：2003-07-04

申请人： Murray McEwan ,  Somasuntharam Senthilmohan

发明人： Murray McEwan ,  Somasuntharam Senthilmohan

IPC分类号： G01N24/00 ,  G01N27/62 ,  G01N31/00 ,  G01N33/00 ,  G01N33/497 ,  H01J49/00 ,  H01J49/04

CPC分类号： H01J49/04 ,  Y10T436/24

摘要： A direct comparisons of the antioxidant activities of various pure compounds (eg., Trolox®(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), extracts and biological fluids (eg. human plasma) can be effected by means of standardisable, objective method of determining and measuring the antioxidative and oxidative radical scavenging activities of a natural or synthetic substance, including the measurement of an indicator reaction product gas, ethylene, in the reaction headspace using Selective Ion Flow Tube Mass Spectrometry (SIFT-MS). This method assays ethylene liberated from α-keto-γ-methiolbutyric acid (KMBA) on reaction with peroxy radicals, other radicals or other reactive oxygen species that can oxidise KMBA to ethylene. From the production rate and concentration of the ethylene, the total antioxidant activity of an added analyte in question and its rate of reaction with oxidative free radicals may be determined.

摘要翻译： 各种纯化合物（例如，Trolox（6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-羧酸）），提取物和生物流体（例如人血浆）的抗氧化活性的直接比较， 可以通过可靠的，客观的方法来确定和测量天然或合成物质的抗氧化和氧化自由基清除活性，包括使用选择性离子流管质量测量反应顶部空间中的指示剂反应产物气体，乙烯 光谱法（SIFT-MS）测定从α-酮基-γ-甲硫醇丁酸（KMBA）中释放的乙烯与过氧自由基，其他自由基或其他能够将KMBA氧化成乙烯的活性氧的反应，从生产速率和浓度 的乙烯，可以确定所讨论的添加的分析物的总抗氧化活性及其与氧化自由基的反应速率。

公开(公告)号：US07785893B2

公开(公告)日：2010-08-31

申请号：US10520369

申请日：2003-07-08

申请人： Murray James McEwan ,  Paul Francis Wilson

发明人： Murray James McEwan ,  Paul Francis Wilson

IPC分类号： G01N33/00

CPC分类号： H01J49/04 ,  Y10T436/15 ,  Y10T436/156666 ,  Y10T436/17 ,  Y10T436/21

摘要： A method of detecting a substance present in a gas or a gas mixture using SIFT-MS technology comprising the steps of inducing a supply of alkoxymethyl cations into the inlet of the flow tube, reacting a sample of the as with the alkoxymethyl cations, analysing the reacted gas sample, and calculating the concentration of trace levels of molecules containing heteroatoms in the reacted gas sample.

摘要翻译： 使用SIFT-MS技术检测存在于气体或气体混合物中的物质的方法，包括以下步骤：将烷氧基甲基阳离子供应到流动管的入口，使与烷氧基甲基阳离子的样品反应，分析 反应的气体样品，并计算在反应气体样品中含有杂原子的微量水平的分子的浓度。

公开(公告)号：US07429730B2

公开(公告)日：2008-09-30

申请号：US10580355

申请日：2004-11-24

申请人： Geoffrey Charles Peck

发明人： Geoffrey Charles Peck

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/4215 ,  H01J49/004 ,  H01J49/0404

摘要： A SIFT or SIFDT apparatus in which the upstream quadrupole and the downstream quadrupole are housed within a single evacuated chamber with the upstream quadrupole being connected to the downstream quadrupole by a curved flow tube. In a preferred form the interior of the chamber is divided into sections by an electrostatic shield which shields the upstream quadrupole and source connection from the downstream quadrupole and detector.

摘要翻译： SIFT或SIFDT装置，其中上游四极杆和下游四极杆容纳在单个真空室内，上游四极杆通过弯曲的流管连接到下游四极杆。 在优选形式中，室的内部通过屏蔽上游四极杆和来自下游四极杆和检测器的源连接的静电屏蔽分成多个部分。

公开(公告)号：US20110024614A1

公开(公告)日：2011-02-03

申请号：US12445817

申请日：2007-10-19

申请人： Paul Francis Wilson ,  Geoffrey Charles Peck

发明人： Paul Francis Wilson ,  Geoffrey Charles Peck

IPC分类号： H01J49/40 ,  H01J49/28

CPC分类号： H01J49/0027 ,  H01J49/004 ,  H01J49/42

摘要： A method of improving signal intensity of precursor ions constrained in a carrier gas in the flow tube of a SIFT-MS instrument, and an apparatus to carry out the method. The method applies an electrical potential to the flow tube to lower the diffusive loss of ions within the flow tube. The lowered diffusive loss of ions increases the sensitivity of the technique.

摘要翻译： 一种改进在SIFT-MS仪器的流管中限制在载气中的前体离子的信号强度的方法以及执行该方法的装置。 该方法对流管施加电势以降低流管内离子的扩散损失。 降低的离子扩散损失增加了该技术的灵敏度。

公开(公告)号：US20080261263A1

公开(公告)日：2008-10-23

申请号：US11884410

申请日：2006-02-14

申请人： Randall Alexander Allardyce ,  Vaughan Stephen Langford ,  Jennifer Margaret Scotter ,  David Roger Murdoch

发明人： Randall Alexander Allardyce ,  Vaughan Stephen Langford ,  Jennifer Margaret Scotter ,  David Roger Murdoch

IPC分类号： C12Q1/18

CPC分类号： C12Q1/04 ,  C12Q1/18

摘要： A method of identifying a micro-organism and determining the susceptibility of the micro-organism to an antimicrobial agent by inserting a sample of the micro-organism in a primary culture container and allowing the micro-organism to multiply. The primary culture is then divided into a plurality of secondary cultures and the metabolic volatile or semi-volatile compounds (VCs) in the headspace above the cultures are analysed by SIFT-MS to ascertain whether micro-organisms exist in the culture and determine the type of micro-organism. The secondary cultures are then divided into a number of tertiary cultures and an antimicrobial agent is introduced whereupon the VCs in the headspace above the tertiary cultures are analysed by SIFT-MS to determine the susceptibility of the micro-organism to the antimicrobial agent at various concentrations of the antimicrobial agent.

摘要翻译： 通过将微生物样品插入原代培养容器并允许微生物繁殖，鉴定微生物并确定微生物对抗微生物剂的敏感性的方法。 然后将原代培养物分成多个次级培养物，并通过SIFT-MS分析培养物上方顶部空间中的代谢挥发性或半挥发性化合物（VC），以确定微生物是否存在于培养物中并确定其类型 的微生物。 然后将次级培养物分成若干级培养物，并引入抗微生物剂，然后通过SIFT-MS分析高等级培养物顶部空间中的VC，以确定微生物对各种浓度的抗微生物剂的敏感性 的抗菌剂。