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公开(公告)号：US08696760B2
公开(公告)日：2014-04-15
申请号：US13037559
申请日：2011-03-01
申请人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha , Oluwatoyin A. Knight
发明人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha , Oluwatoyin A. Knight
IPC分类号： A61F2/04
CPC分类号： A61F2/02 , A61F2/042 , A61F2002/047 , A61F2002/048 , A61L27/3813 , A61L27/3826 , A61L27/383 , A61L27/3882 , A61L27/3891 , C12N5/0697 , C12N2502/1347 , C12N2502/253 , C12N2533/40
摘要： Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.
摘要翻译： 生物相容的合成或天然支架用于需要这种治疗的患者中的器官或组织结构的重建，修复，增加或替换。 支架被成形为符合器官或组织结构的至少一部分，并且可以用一个或多个细胞群体接种。 还提供了插入物，容器和端口用于将管状容器附接到新器官支架。 将种子支架植入需要治疗的部位的患者中以形成有组织的器官或组织结构。 支架可用于形成器官或组织，例如膀胱，尿道，瓣膜和血管。
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公开(公告)号：US08318484B2
公开(公告)日：2012-11-27
申请号：US12617721
申请日：2009-11-12
申请人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. Ilagan
发明人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. Ilagan
IPC分类号： C12N5/00
CPC分类号： A61K35/22 , A61K35/12 , C12N5/0686 , C12N2500/02
摘要： The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.
摘要翻译： 本发明涉及分离的肾细胞，包括产生肾细胞群的管状和促红细胞生成素（EPO），以及分离和培养肾细胞群的方法，以及用细胞群治疗需要的受试者的方法。
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公开(公告)号：US20130330364A1
公开(公告)日：2013-12-12
申请号：US13883433
申请日：2011-11-10
申请人： Joydeep Basu , Richard Payne , Neil F. Robbins , Oluwatoyin A. Knight , Deepak Jain , Craig R. Halberstadt , Monica A. Serban
发明人： Joydeep Basu , Richard Payne , Neil F. Robbins , Oluwatoyin A. Knight , Deepak Jain , Craig R. Halberstadt , Monica A. Serban
CPC分类号： A61K35/22 , A61K45/06 , A61L27/222 , A61L27/54 , A61L2400/06 , A61L2430/26
摘要： The present invention concerns therapeutic formulations containing active agents, such bioactive cell populations, and methods of making and using the same.
摘要翻译： 本发明涉及含有活性剂，这种生物活性细胞群体的治疗制剂及其制备和使用方法。
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公开(公告)号：US07918897B2
公开(公告)日：2011-04-05
申请号：US11706081
申请日：2007-02-12
申请人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha
发明人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha
IPC分类号： A61F2/04
CPC分类号： A61F2/02 , A61F2/042 , A61F2002/047 , A61F2002/048 , A61L27/3813 , A61L27/3826 , A61L27/383 , A61L27/3882 , A61L27/3891 , C12N5/0697 , C12N2502/1347 , C12N2502/253 , C12N2533/40
摘要： Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.
摘要翻译： 生物相容的合成或天然支架用于需要这种治疗的患者中的器官或组织结构的重建，修复，增加或替换。 支架被成形为符合器官或组织结构的至少一部分，并且可以用一个或多个细胞群体接种。 还提供了插入物，容器和端口用于将管状容器附接到新器官支架。 将种子支架植入需要治疗的部位的患者中以形成有组织的器官或组织结构。 支架可用于形成器官或组织，例如膀胱，尿道，瓣膜和血管。
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公开(公告)号：US20140107804A1
公开(公告)日：2014-04-17
申请号：US14029129
申请日：2013-09-17
申请人： Tengion, Inc.
发明人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha , Oluwatoyin A. Knight
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , A61F2/042 , A61F2002/047 , A61F2002/048 , A61L27/3813 , A61L27/3826 , A61L27/383 , A61L27/3882 , A61L27/3891 , C12N5/0697 , C12N2502/1347 , C12N2502/253 , C12N2533/40
摘要： Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.
摘要翻译： 生物相容的合成或天然支架用于需要这种治疗的患者中的器官或组织结构的重建，修复，增加或替换。 支架被成形为符合器官或组织结构的至少一部分，并且可以用一个或多个细胞群体接种。 还提供了插入物，容器和端口用于将管状容器附接到新器官支架。 将种子支架植入需要治疗的部位的患者中以形成有组织的器官或组织结构。 支架可用于形成器官或组织，例如膀胱，尿道，瓣膜和血管。
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公开(公告)号：US20130173015A1
公开(公告)日：2013-07-04
申请号：US13682614
申请日：2012-11-20
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
IPC分类号： A61F2/04
CPC分类号： A61F2/042 , A61L27/18 , A61L27/3804 , A61L27/3826 , A61L27/3882 , A61L2430/22 , C08L67/04
摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
摘要翻译： 本发明涉及使用不衍生自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。
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公开(公告)号：US20150030657A1
公开(公告)日：2015-01-29
申请号：US13696051
申请日：2011-05-03
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha , Jacob E. Shokes , Teresa B. Burnette , Sarah A. Boyd , Craig R. Halberstadt , Dominic M. Justewicz , Elias A. Rivera , Wendy Sharp , Neil F. Robbins
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha , Jacob E. Shokes , Teresa B. Burnette , Sarah A. Boyd , Craig R. Halberstadt , Dominic M. Justewicz , Elias A. Rivera , Wendy Sharp , Neil F. Robbins
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61F2/042 , A61L27/3826 , A61L2430/22
摘要： The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.
摘要翻译： 本发明涉及在有需要的受试者中使用自体或非自体细胞群体接种的支架的再生，重建，增加或替代，所述自体或非自体细胞群是衍生自相应器官或组织结构的或不衍生自相应器官或组织结构的支架 重建，重建，增加或更换的主题。
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公开(公告)号：US20130149347A1
公开(公告)日：2013-06-13
申请号：US13661668
申请日：2012-10-26
申请人： Tengion, Inc.
发明人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. ILAGAN
CPC分类号： A61K35/22 , A61K35/12 , C12N5/0686 , C12N2500/02
摘要： The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.
摘要翻译： 本发明涉及分离的肾细胞，包括产生肾细胞群的管状和促红细胞生成素（EPO），以及分离和培养肾细胞群体的方法，以及用细胞群治疗需要的受试者的方法。
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公开(公告)号：US08337485B2
公开(公告)日：2012-12-25
申请号：US12612606
申请日：2009-11-04
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
CPC分类号： A61F2/042 , A61L27/18 , A61L27/3804 , A61L27/3826 , A61L27/3882 , A61L2430/22 , C08L67/04
摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
摘要翻译： 本发明涉及使用不衍生自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。
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