利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

22 条记录 (耗时 0.012 秒)

    Method of preparing an osteogenic bone graft
    1.
    发明授权
    Method of preparing an osteogenic bone graft 有权

    公开(公告)号：US11278644B2

    公开(公告)日：2022-03-22

    申请号：US15747942

    申请日：2016-07-20

    申请人： DEPUY SYNTHES PRODUCTS, INC. ,  ThermoGenesis Corp.

    发明人： Michael Lehmicke ,  Philip H. Coelho

    IPC分类号： A61L27/38 ,  A61L27/54

    摘要： The present disclosure is directed to a method of preparing an osteogenic bone graft. The method includes introducing an anticoagulant compound into a volume of cellular material including a mononuclear cell population from the intramedullary canal of a long bone; collecting an effluent including the volume of cellular material containing the anticoagulant compound at a collection point; separating a concentrated cell fraction from the effluent, the concentrated cell fraction including the mononuclear cell population and the anticoagulant compound; and preparing an osteogenic bone graft from the concentrated cell fraction.

    Instrumentality for sequestering liquids based on density:method and apparatus
    3.
    发明授权
    Instrumentality for sequestering liquids based on density:method and apparatus 有权
    基于密度隔离液体的手段：方法和装置

    公开(公告)号：US08066127B2

    公开(公告)日：2011-11-29

    申请号：US11664212

    申请日：2005-08-16

    申请人： Philip H. Coelho ,  Eric Sommer ,  Richard Klosinski ,  Jim Hobbs ,  Bruce Baker ,  Brian Malone

    发明人： Philip H. Coelho ,  Eric Sommer ,  Richard Klosinski ,  Jim Hobbs ,  Bruce Baker ,  Brian Malone

    IPC分类号： B01D24/32 ,  B04B5/02 ,  A61M37/00 ,  B04B5/00

    CPC分类号： A61M1/3693 ,  A61M1/0231 ,  A61M1/0272 ,  A61M1/0281 ,  B04B5/0428 ,  B04B2005/0435

    摘要： An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. The sensor may be reading one or more of the following characteristics: infrared, optics, density, weight, radioactive, fluorescence, color, magnetism, ultrasonic, capacitance wherein the characteristic is inherent in the blood and blood component or is an additive. Each component may then be separated into its own storage container. The preferred sensors include optics and weight. Besides blood density separation, the device may contain a solution including cells, proteins, subcellular particles or viruses which may be mixed with affinity media or antibodies prior to separation.

    摘要翻译： 一种用于收集全血，然后将其分离成组件以供随后使用或储存的装置和方法。 使用独立的袋组来收集样品，然后可以将样品放置在适于装配到离心机中用于分离组分的装置中。 然后根据密度依次提取每个组分，传感器存在于装置中以控制导向各组分收集的阀的操作。 传感器可以读取以下特征中的一个或多个：红外线，光学，密度，重量，放射性，荧光，颜色，磁性，超声波，电容，其特征是血液和血液成分中固有的或者是添加剂。 然后可以将每个组件分离成其自己的存储容器。 优选的传感器包括光学和重量。 除了血液密度分离之外，该装置可以含有可以在分离前可与亲和介质或抗体混合的细胞，蛋白质，亚细胞颗粒或病毒的溶液。

    Apparatus and method for separating and isolating components of a biological fluid
    7.
    发明授权
    Apparatus and method for separating and isolating components of a biological fluid 有权
    用于分离和分离生物流体组分的装置和方法

    公开(公告)号：US08511479B2

    公开(公告)日：2013-08-20

    申请号：US13374988

    申请日：2012-01-24

    申请人： John R. Chapman ,  Vijay Kumar ,  Brian K. Cinquini ,  Phillip D. Kingsley

    发明人： John R. Chapman ,  Vijay Kumar ,  Brian K. Cinquini ,  Phillip D. Kingsley

    IPC分类号： B01D21/26

    CPC分类号： B01D21/26 ,  A61M1/029 ,  A61M2202/0413 ,  A61M2202/0464 ,  A61M2202/10 ,  B01D21/262 ,  B01D21/307 ,  B01D21/34 ,  B01D2221/10 ,  B01L3/50215 ,  B01L2300/048 ,  B01L2300/049 ,  B01L2300/0681 ,  B01L2400/0605 ,  B01L2400/0611 ,  G01N2035/00495

    摘要： A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.

    摘要翻译： 一种用于分离和分离生物流体组分的装置，包括用于容纳待处理流体的容器，用于在提供与其进行填充和抽出连通的同时关闭容器的管帽组件;设置在容器内用于漏斗和控制生物 流体流入浮子内的反向圆顶形隔离室，并控制生物流体流出隔离室，用于在离心过程中进行隔离室内至少一种组分或分离的生物流体流的密封隔离 处理。 所述装置还包括用于连接设置在所述浮子组件内的抽吸通道的柔性管和所述管帽组件的抽吸阀，用于允许至少提取在所述室内封装或隔离的所述一个部件或部件。

    Fibrin glue line and dot dispenser
    9.
    发明授权
    Fibrin glue line and dot dispenser 失效
    纤维蛋白胶线和点阵机

    公开(公告)号：US5975367A

    公开(公告)日：1999-11-02

    申请号：US722558

    申请日：1996-09-27

    申请人： Philip H. Coelho ,  Terry L. Wolf ,  Pete J. Menke ,  Jerry M. Alcone

    发明人： Philip H. Coelho ,  Terry L. Wolf ,  Pete J. Menke ,  Jerry M. Alcone

    IPC分类号： A61B17/00 ,  B67D5/62

    CPC分类号： A61B17/00491 ,  A61B2017/00495

    摘要： A fibrin glue dispenser including a spring biased rack. The rack spring is a coil spring having substantially linear characteristics along its operating length. The rack spring forces first and second plungers into first and second loaded syringes to dispense thrombin and fibrinogen into first and second exits such that the admixture of the two occurs for forming fibrin glue away from the exists. A dispensing lever can be controlled as to the fibrin glue formation to dispense either drops of fibrin glue or an elongate line of fibrin glue.

    摘要翻译： 一种纤维蛋白胶分配器，包括弹簧偏置架。 齿条弹簧是沿其工作长度具有基本线性特征的螺旋弹簧。 齿条弹簧迫使第一和第二柱塞进入第一和第二加载的注射器，以将凝血酶和纤维蛋白原分配到第一和第二出口，使得两者的混合物发生用于形成远离存在的纤维蛋白胶。 可以控制分配杆对于纤维蛋白胶的形成，以分配纤维蛋白胶水滴或纤维蛋白胶的细长线。

    Method and apparatus for cryogenic storage of thermolabile products
    10.
    发明授权
    Method and apparatus for cryogenic storage of thermolabile products 失效
    用于低温储存的不耐热产品的方法和装置

    公开(公告)号：US5964095A

    公开(公告)日：1999-10-12

    申请号：US877763

    申请日：1997-06-16

    申请人： Philip Henry Coelho ,  Terry Wolf ,  Pablo Rubinstein

    发明人： Philip Henry Coelho ,  Terry Wolf ,  Pablo Rubinstein

    IPC分类号： B65D81/38 ,  B65G1/00 ,  B65G1/137 ,  F25C5/14 ,  F25D3/10 ,  F25D25/00 ,  G01N35/00

    CPC分类号： F25D3/10 ,  F25D25/00 ,  F25D3/105 ,  G01N35/0099

    摘要： A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.

    摘要翻译： 用于低温保护耐热产品的装置。 容器（20）容纳由壳体（60）密封的环形齿条（40）。 外壳（60）包括外固定环形（70）和可旋转芯（90）。 机械臂（160）适于移动并被芯（90）支撑。 机械手臂（160）进入外壳（60）的内部。 入口入口（80）允许移除和放置由保持器（150）约束的热不稳定产品。 机器人手臂（160）进入产品和支架（150），并开始控制产品的冻结及其在支架（40）中的位置，直到随后的取回。 计算机控制冷冻速率并在存储器中存储所有存储的产品的位置。 机器人手臂（160）在存储器中读取产品，以确保访问正确的产品。